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Pyogenic bacterial infections due to MyD88 deficiency
1 OMIM reference -
1 associated gene
30 connected diseases
5 signs/symptoms
Disease Type of connection
Waldenström macroglobulinemia
Herpetic encephalitis
Behçet disease
Pediatric systemic lupus erythematosus
Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency
FADD-related immunodeficiency
Oculootodental syndrome
Diffuse cutaneous systemic sclerosis
Limited cutaneous systemic sclerosis
Primary biliary cirrhosis
Common variable immunodeficiency
Aneurysm - osteoarthritis syndrome
Familial thoracic aortic aneurysm and aortic dissection
Smith-Magenis syndrome
Autosomal dominant hypohidrotic ectodermal dysplasia
Hereditary nonpolyposis colon cancer
Autosomal dominant nonsyndromic intellectual deficit
Autosomal recessive hyper-IgE syndrome
Combined immunodeficiency due to DOCK8 deficiency
Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia
Treacher-Collins syndrome
X-linked agammaglobulinemia
Amyotrophic lateral sclerosis
Anhidrotic ectodermal dysplasia - immunodeficiency - osteopetrosis - lymphedema
Dedifferentiated liposarcoma
Hypohidrotic ectodermal dysplasia with immunodeficiency
Incontinentia pigmenti
Well-differentiated liposarcoma
X-linked dominant chondrodysplasia, Chassaing-Lacombe type
X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency
- MyD88 deficiency

Classification (Orphanet):
- Rare genetic disease
- Rare immune disease

Classification (ICD10):
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

Epidemiological data:
Class of prevalence: unknown
Average age onset: childhood
Average age of death: child / adolescent
Type of inheritance: autosomal recessive
External references:
1 OMIM reference -
No MeSH references

Gene symbol UniProt reference OMIM reference
MYD88 Q99836602170
Very frequent
- Autosomal recessive inheritance
- Immunodeficiency / increased susceptibility to infections / recurrent infections

- Chronic skin infection / ulcerations / ulcers / cancrum
- Nasal congestion / sinusitis / rhinitis / rhinorrhea

- Fever / chilling