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Progressive osseous heteroplasia
1 OMIM reference -
1 associated gene
8 connected diseases
14 signs/symptoms
Disease Type of connection
Mazabraud syndrome
McCune-Albright syndrome
Monostotic fibrous dysplasia
Polyostotic fibrous dysplasia
Pseudohypoparathyroidism type 1A
Pseudohypoparathyroidism type 1B
Pseudohypoparathyroidism type 1C
Pseudopseudohypoparathyroidism
Synonym(s):
- Familial ectopic ossification
Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare genetic disease
- Rare skin disease
Classification (ICD10):
- Diseases of the musculoskeletal system and connective tissue -
Epidemiological data:
Class of prevalence: -
Average age onset: -
Average age of death: -
Type of inheritance: autosomal dominant
External references:
1 OMIM reference -
No MeSH references
Gene symbol UniProt reference OMIM reference
GNAS P63092139320
Very frequent
- Anomalies of bones / skeletal anomalies
- Autosomal dominant inheritance
- Bone pain
- Bone tumefaction / swelling
- Restricted joint mobility / joint stiffness / ankylosis
- Subcutaneous nodules / lipomas / tumefaction / swelling

Frequent
- Muscle ossification

Occasional
- Capillary hemangioma / nevus / naevus flammeus / port-wine stain
- Follicular / erythematous / edematous papules / milium
- Macules
- Osteoarthritis
- Parathyroids anomalies
- Sarcoma
- Short hand / brachydactyly