Synonym(s): - Gonadotropin-independent female-limited sexual precocity
Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare gynecologic or obstetric disease - Rare oncologic disease - Rare skin disease Entire classification		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities - See
Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: childhood Average age of death: normal Type of inheritance: sporadic		External references: 1 OMIM reference - See 1 MeSH reference: D005359
More Info - Orphanet

Gene symbol	UniProt reference	OMIM reference
GNAS	P63092	139320

- Bone pain
- Cafe-au-lait spot
- Diffuse / generalised skin hyperpigmentation / melanoderma
- Dysostosis / chondrodysplasia / osteodysplasia / osteochondrosis / skeletal dysplasia
- Hypophosphatemia
- Mutiple fractures / bone fragility
- Osteoporosis / osteopenia / demineralisation / osteomalacia / rickets
- Precocious puberty

- Abnormal hepatic enzymes / transaminases
- Abnormal / polycystic ovaries
- Anomalies of ear and hearing
- Anomalies of eyes and vision
- Anomalies of teeth and dentition
- Breast neoplasm / tumor / carcinoma / cancer
- Cortico-adrenal hyperplasia / hypersecretion
- Cushingoid morphotype
- Dental malocclusion
- Enamel anomaly
- Face / facial anomalies
- Goiter
- Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding
- Hyperparathyroidy
- Hyperthyroidy
- Kyphosis
- Macrocephaly / macrocrania / megalocephaly / megacephaly
- Macroorchidism / macrotestes
- Macropenis / megapenis / large penis
- Multiple caries
- Optic nerve anomaly / optic atrophy / anomaly of the papilla
- Palate anomalies
- Prognathism / prognathia
- Sarcoma
- Tall stature / gigantism / growth acceleration
- Testicular / seminal neoplasm / tumor / carcinoma / cancer (excl. teratoma / germinoma)
- Thyroid neoplasm / tumor / carcinoma / cancer