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1 OMIM reference -
1 associated gene
7 signs/symptoms
COMMON GENES: 1
COMMON SIGNS: 2
2 OMIM references -
1 associated gene
36 signs/symptoms
Severe achondroplasia - developmental delay - acanthosis nigricans
Thanatophoric dysplasia type 2

FGFR3 FGFR3


COMMON
GENES
FGFR3



Citations in the biomedical literature:


Severe achondroplasia - developmental delay - acanthosis nigricans
FGFR3
Thanatophoric dysplasia type 2



Severe achondroplasia - developmental delay - acanthosis nigricans
Thanatophoric dysplasia type 2

Synonym(s):
- SADDAN

Synonym(s):
- Cloverleaf skull - micromelic bone dysplasia
- TD2
- Thanatophoric dwarfism - cloverleaf skull
- Thanatophoric dwarfism type 2

Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare genetic disease
- Rare skin disease
Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare genetic disease

Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -

Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: childhood
Average age of death: no data available
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: unknown
Average age onset: neonatal/infancy
Average age of death: before age 5
Type of inheritance: autosomal dominant

External references:
1 OMIM reference -
No MeSH references
External references:
2 OMIM references -
No MeSH references


COMMON
SIGNS
- Intellectual deficit / mental / psychomotor retardation / learning disability
- Seizures / epilepsy / absences / spasms / status epilepticus


Severe achondroplasia - developmental delay - acanthosis nigricans
Thanatophoric dysplasia type 2

Very frequent
- Anomalies of bones / skeletal anomalies

Frequent
- Clavicle absent / abnormal
- Femur anomaly / absence / agenesis / hypoplasia / bifurcation
- Fibula anomaly (excluding short) / absence / agenesis / hypoplasia / fibular ray anomaly
- Tibia anomaly (excluding short) / absence / agenesis / hypoplasia / tibial ray anomaly



Very frequent
- Autosomal dominant inheritance
- Cloverleaf skull
- Depressed nasal bridge
- Dysostosis / chondrodysplasia / osteodysplasia / osteochondrosis / skeletal dysplasia
- Flat face
- Hypoplastic lungs / pulmonary hypoplasia / agenesis
- Hypotonia
- Loose skin / skin relaxation / excess skin / creases
- Macrocephaly / macrocrania / megalocephaly / megacephaly
- Metaphyseal anomaly
- Narrow rib cage / thorax
- Platyspondyly
- Respiratory distress / dyspnea / respiratory failure / lung volume reduction
- Rhizomelic micromelia
- Short hand / brachydactyly
- Short rib cage / thorax
- Short stature / dwarfism / nanism
- Stillbirth / neonatal death

Frequent
- Dilated cerebral ventricles without hydrocephaly
- Frontal bossing / prominent forehead
- Hearing loss / hypoacusia / deafness
- Increased nuchal translucency
- Kyphosis
- Polyhydramnios
- Proptosis / exophthalmos

Occasional
- Acanthosis nigricans
- Agyria / micro / pachy / macrogyria / lissencephaly / gyration / neuronal migration defect
- Atrial septal defect / interauricular communication
- Encephalocele / exencephaly
- Holoprosencephaly / arhinencephaly / unique lateral ventricle
- Hydrocephaly
- Patent ductus arteriosus
- Renal / kidney anomalies
- Restricted joint mobility / joint stiffness / ankylosis