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Progressive non-fluent aphasia

1 OMIM reference -
6 associated genes
No signs/symptoms info

PROTEIN INTERACTIONS: 2

Sea-blue histiocytosis

1 OMIM reference -
1 associated gene
12 signs/symptoms

Progressive non-fluent aphasia

Sea-blue histiocytosis

C9ORF72	(UniProt - OMIM)		APOE	(UniProt - OMIM)
CHMP2B	(UniProt - OMIM)
GRN	(UniProt - OMIM)
MAPT	(UniProt - OMIM)
PSEN1	(UniProt - OMIM)
VCP	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MAPT PSEN1	(0.87) (0.63)	APOE APOE

Citations in the biomedical literature:

Progressive non-fluent aphasia		Sea-blue histiocytosis
	Synonym(s): - Agramatic variant of PPA - Agramatic variant of primary progressive aphasia - Non-fluent variant PPA		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease - Rare systemic or rheumatologic disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: - Type of inheritance: multigenic/multifactorial		Epidemiological data: (no data available)

	External references: 1 OMIM reference - 1 MeSH reference: D057178		External references: 1 OMIM reference - No MeSH references

Sea-blue histiocytosis
	Very frequent - Blepharitis / eyelid inflammation - Cutaneous edema - Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding - Hepatomegaly / liver enlargement (excluding storage disease) - Mediastinal / hilar adenopathies - Purpura / petichiae - Splenomegaly - Subcutaneous nodules / lipomas / tumefaction / swelling - Thrombocytopenia / thrombopenia Frequent - Lung / pulmonary infiltrates Occasional - Irregular / in bands / reticular skin hyperpigmentation - Retinopathy
Progressive non-fluent aphasia
(no data available)