ODCs

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1 OMIM reference -
6 associated genes
No signs/symptoms info

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
10 signs/symptoms

Progressive non-fluent aphasia

Infantile-onset ascending hereditary spastic paralysis


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	VCP	(0.63)	ALS2

Citations in the biomedical literature:

Progressive non-fluent aphasia		Infantile-onset ascending hereditary spastic paralysis
	Synonym(s): - Agramatic variant of PPA - Agramatic variant of primary progressive aphasia - Non-fluent variant PPA		Synonym(s): - IAHSP

	Classification (Orphanet): - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: - Type of inheritance: multigenic/multifactorial		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: adult Type of inheritance: autosomal recessive

	External references: 1 OMIM reference - 1 MeSH reference: D057178		External references: 1 OMIM reference - No MeSH references

Infantile-onset ascending hereditary spastic paralysis
	Very frequent - Autosomal recessive inheritance - Elocution disorders / dysarthria / dysphonia - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Hemiplegia / diplegia / hemiparesia / limb palsy - Hypereflexia - Hypertonia / spasticity / rigidity / stiffness - Pyramidal syndrome - Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia Frequent - Abnormal eye movements / oculomotor disorder - Pseudobulbar signs / spasmodic laugh and cry
Progressive non-fluent aphasia
(no data available)