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Primary peritoneal carcinoma
1 associated gene
9 signs/symptoms
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 2
Familial thrombocytosis
4 OMIM references -
3 associated genes
26 signs/symptoms
Primary peritoneal carcinoma
Familial thrombocytosis

BRCA1
(UniProt - OMIM)
 JAK2
(UniProt - OMIM)
MPL
(UniProt - OMIM)
THPO
(UniProt - OMIM)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
BRCA1
(0.86)
JAK2


Citations in the biomedical literature:


Primary peritoneal carcinoma
BRCA1
Familial thrombocytosis
JAK2 MPL THPO



Primary peritoneal carcinoma
Familial thrombocytosis

Synonym(s):
- EOPPC
- Extra-ovarian primary peritoneal carcinoma
- PPC
- Primary peritoneal serous carcinoma
- Serous surface papillary carcinoma
Synonym(s):
- Familial thrombocythemia
- Hereditary thrombocythemia
Classification (Orphanet):
- Rare abdominal surgical disease
- Rare oncologic disease
Classification (Orphanet):
- Rare genetic disease
- Rare hematologic disease
Classification (ICD10):
- Neoplasms -
Classification (ICD10):
(no data available)
Epidemiological data:
Class of prevalence: unknown
Average age onset: adulthood
Average age of death: normal
Type of inheritance: unknown
Epidemiological data:
Class of prevalence: unknown
Average age onset: childhood
Average age of death: normal
Type of inheritance: autosomal dominant
External references:
No OMIM references
No MeSH references
External references:
4 OMIM references -
No MeSH references
COMMON
SIGNS 		- Early death / lethality
- Weight loss / loss of appetite / break in weight curve / general health alteration

Primary peritoneal carcinoma
Familial thrombocytosis

Very frequent
- Acute abdominal pain / colic
- Anomalies of the abdominal wall
- Constipation
- Nausea / vomiting / regurgitation / merycism / hyperemesis
- Neoplasms / tumors
- Ovary / Fallopian tube neoplasm / tumor / carcinoma / cancer (excl. teratoma / germinoma)
- Peritoneal diseases



Very frequent
- Arterial embolism / thrombosis
- Autosomal dominant inheritance
- Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding
- Platelet disorders / thrombopathies
- Platelets shape anomalies
- Venous thrombosis / phlebitis / thrombophlebitis

Frequent
- Acute ischemia of the lower limbs
- Acute ischemic syndrome
- Facial pain / cephalalgia / migraine
- Hyperhidrosis / increased sweating
- Paresthesia / dysesthesia / hypoesthesia / anesthesia / numbness
- Pruritus / itching
- Splenomegaly
- Thoracic / chest pain
- Transient cerebral ischemia / stroke

Occasional
- Abnormal visual field / hemianopsia / hemianopia / scotoma / visual peripheral rim
- Acute leukemia
- Dizziness
- Elocution disorders / dysarthria / dysphonia
- Myelodysplastic syndrome
- Myeloproliferative syndrome / chronic leukemia
- Pulmonary hypertension
- Seizures / epilepsy / absences / spasms / status epilepticus
- Spontaneous abortions