ODCs

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2 OMIM references -
2 associated genes
13 signs/symptoms

COMMON GENES: 1

2 OMIM references -
1 associated gene
8 signs/symptoms

Peripheral resistance to thyroid hormones

Generalized resistance to thyroid hormone

THRA	(UniProt - OMIM)		THRB	(UniProt - OMIM)
THRB	(UniProt - OMIM)

Citations in the biomedical literature:

Peripheral resistance to thyroid hormones		Generalized resistance to thyroid hormone
	Synonym(s): (no synonyms)		Synonym(s): - Deafness - thyroid hormone resistance - Refetoff syndrome

	Classification (Orphanet): - Rare endocrine disease - Rare genetic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare otorhinolaryngologic disease

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: (no data available)		Epidemiological data: (no data available)

	External references: 2 OMIM references - No MeSH references		External references: 2 OMIM references - No MeSH references

Peripheral resistance to thyroid hormones		Generalized resistance to thyroid hormone
	Very frequent - Absent / hypotonic / flaccid abdominal wall muscles - Autosomal dominant inheritance - Coarse face - Constipation - Face / facial anomalies - Failure to thrive / difficulties for feeding in infancy / growth delay - Hepatitis / icterus / cholestasis - Hypothyroidy - Hypotonia - Large fontanelle / delayed fontanelle closure - Macroglossia / tongue protrusion / proeminent / hypertrophic - Sleep and vigilance disorders - Umbilical hernia		Very frequent - Autosomal recessive inheritance - Beaked nose - Delayed bone age - Pectus carinatum - Punctate epiphyses / epiphysis - Scapula structural / position anomaly / congenital elevation / Sprengel anomaly - Sensorineural deafness / hearing loss - Thyroid anomalies