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Parkes Weber syndrome

1 OMIM reference -
1 associated gene
14 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

Cutaneous mastocytoma

1 associated gene
11 signs/symptoms

Parkes Weber syndrome

Cutaneous mastocytoma

(UniProt - OMIM)

(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	RASA1	(0.83)	KIT

Citations in the biomedical literature:

Parkes Weber syndrome		Cutaneous mastocytoma
	Synonym(s): (no synonyms)		Synonym(s): - Cutaneous local mastocytoma - Multiple mastocytoma - Solitary mastocytoma

	Classification (Orphanet): - Rare bone disease - Rare circulatory system disease - Rare developmental defect during embryogenesis - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare allergic disease - Rare hematologic disease - Rare oncologic disease - Rare skin disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: - Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: variable Average age of death: normal Type of inheritance: sporadic

	External references: 1 OMIM reference - No MeSH references		External references: No OMIM references 1 MeSH reference: D054705


COMMON SIGNS	- Facial pain / cephalalgia / migraine

Parkes Weber syndrome		Cutaneous mastocytoma
	Very frequent - Capillary hemangioma / nevus / naevus flammeus / port-wine stain - Global upper and lower limbs anomalies - Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding - Lower limb asymmetry / hemiatrophy / hemihypertrophy - Muscle hypertrophy - Peripheral arteriovenous fistula - Telangiectasiae of the skin - Upper limb asymmetry / hemiatrophy / hemihypertrophy Frequent - Varices / varicous veins / venous insufficiency Occasional - Glaucoma - Heart / cardiac failure - Hemiplegia / diplegia / hemiparesia / limb palsy - Vascular anomalies of skin / mucosae		Very frequent - Abnormal pigmentary skin changes / skin pigmentation anomalies - Macules - Mastocytosis - Pruritus / itching - Subcutaneous nodules / lipomas / tumefaction / swelling - Urticaria - Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment Frequent - Thick skin / pachydermia / orange skin Occasional - Acute abdominal pain / colic - Hot flushes / sensation of cold