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Mantle cell lymphoma

3 associated genes
7 signs/symptoms

PROTEIN INTERACTIONS: 1

Spondylocarpotarsal synostosis

1 OMIM reference -
1 associated gene
12 signs/symptoms

Mantle cell lymphoma

Spondylocarpotarsal synostosis

ATM	(UniProt - OMIM)		FLNB	(UniProt - OMIM)
CCND1	(UniProt - OMIM)
IGH	(UniProt)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	ATM	(0.63)	FLNB

Citations in the biomedical literature:

Mantle cell lymphoma		Spondylocarpotarsal synostosis
	Synonym(s): - LCM - MCL - Mantle zone lymphoma		Synonym(s): - Synspondylism

	Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: adult Type of inheritance: multigenic/multifactorial		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: normal Type of inheritance: autosomal recessive

	External references: No OMIM references 1 MeSH reference: D020522		External references: 1 OMIM reference - No MeSH references

Mantle cell lymphoma		Spondylocarpotarsal synostosis
	Very frequent - Hematologic / blood / lymphatic cancer - Lymphadenopathy / polyadenopathies Frequent - Anorexia - Asthenia / fatigue / weakness - Bone marrow / medullar infiltration - Splenomegaly - Weight loss / loss of appetite / break in weight curve / general health alteration		Very frequent - Abnormal vertebral size / shape - Autosomal recessive inheritance - Carpal bones fusion / synostosis - Lordosis - Restricted joint mobility / joint stiffness / ankylosis - Short rib cage / thorax - Vertebral segmentation anomaly / hemivertebrae Occasional - Cleft palate without cleft lip / submucosal cleft palate / bifid uvula - Conductive deafness / hearing loss - Pectus excavatum - Polycystic kidneys - Sensorineural deafness / hearing loss