ODCs

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3 OMIM references -
3 associated genes
4 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 3

1 OMIM reference -
2 associated genes
10 signs/symptoms

Keratosis palmoplantaris striata

Lethal acantholytic epidermolysis bullosa


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	DSG1 DSP KRT1	(0.93) (0.89) (0.78)	JUP JUP DSP

Citations in the biomedical literature:

Keratosis palmoplantaris striata		Lethal acantholytic epidermolysis bullosa
	Synonym(s): - Keratosis palmoplantaris striata et areata - Keratosis palmoplantaris varians of Wachters - Striate palmoplantar keratoderma		Synonym(s): - LAEB

	Classification (Orphanet): - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: - Average age onset: - Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: before age 5 Type of inheritance: autosomal recessive

	External references: 3 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C535493

Keratosis palmoplantaris striata		Lethal acantholytic epidermolysis bullosa
	Very frequent - Autosomal dominant inheritance - Palmoplantar hyperkeratosis / keratoderma Frequent - Hair and scalp anomalies - Nails anomalies		Very frequent - Absent / small fingernails / anonychia of hands - Alopecia - Autosomal recessive inheritance - Chronic skin infection / ulcerations / ulcers / cancrum - Early death / lethality - Enanthema / aphtosa / aphta / leukoplakia - Premature eruption of teeth / natal teeth - Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment Occasional - Cardiomyopathy / hypertrophic / dilated - Epigastralgia / heartburn / gastric / duodenal ulcer / gastritis