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1 OMIM reference -
1 associated gene
12 signs/symptoms
PROTEIN INTERACTIONS: 1
1 OMIM reference -
1 associated gene
22 signs/symptoms
Kennedy disease
Proteus-like syndrome

AR PTEN


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
AR
(0.79)
PTEN



Citations in the biomedical literature:


Kennedy disease
AR
Proteus-like syndrome
PTEN



Kennedy disease
Proteus-like syndrome

Synonym(s):
- Bulbospinal muscular atrophy
- SBMA
- Spinal and bulbar muscular atrophy
- Spinobulbar muscular atrophy
- X-linked bulbospinal amyotrophy

Synonym(s):
- Cohen-Hayden syndrome

Classification (Orphanet):
- Rare genetic disease
- Rare infertility
- Rare neurologic disease
Classification (Orphanet):
- Rare developmental defect during embryogenesis
- Rare genetic disease
- Rare oncologic disease
- Rare skin disease

Classification (ICD10):
- Diseases of the nervous system -
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -

Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: adulthood
Average age of death: normal
Type of inheritance: x-linked recessive
Epidemiological data:
Class of prevalence: unknown
Average age onset: neonatal/infancy
Average age of death: -
Type of inheritance: autosomal dominant

External references:
1 OMIM reference -
No MeSH references
External references:
1 OMIM reference -
No MeSH references

Kennedy disease
Proteus-like syndrome

Very frequent
- Abnormal gait
- Areflexia / hyporeflexia
- Gynecomastia / breast / mammary gland enlargement / hyperplasia
- Hypotonia
- Impotence / painful erection / priapism / erection troubles
- Movement disorder
- Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy
- Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia
- X-linked recessive inheritance

Occasional
- Hyperlipidemia / hypercholesterolemia / hypertriglyceridemia
- Insulin-independent / type 2 diabetes
- Small / atrophic / hypoplastic testes / monorchism / microorchidism / anorchia


Very frequent
- Asymmetry of the body / hemiatrophy / hemihyperthrophy
- Capillary hemangioma / nevus / naevus flammeus / port-wine stain
- Conjunctival tumor / epibulbar dermoid
- Dental malocclusion
- Exostoses
- Genu recurvatum
- Intellectual deficit / mental / psychomotor retardation / learning disability
- Irregular / in bands / reticular skin hyperpigmentation
- Lower limb asymmetry / hemiatrophy / hemihypertrophy
- Myopia
- Pigmented naevi / naevus pigmentosus / lentigo
- Pupillary anomalies / mydriasis / myosis / tonic pupil
- Xanthomas / lipomas

Frequent
- Cataract / lens opacification
- Communicating hydrocephaly
- Heterochromia / mixed colouring of iris
- Macrocephaly / macrocrania / megalocephaly / megacephaly
- Parathyroids anomalies
- Prognathism / prognathia
- Retinal detachment
- Shagreen patch
- Varices / varicous veins / venous insufficiency