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1 associated gene
No signs/symptoms info
PROTEIN INTERACTIONS: 1
1 OMIM reference -
1 associated gene
26 signs/symptoms
Hyperinsulinism due to HNF1A deficiency
Renal cysts and diabetes syndrome

HNF1A HNF1B


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
HNF1A
(0.75)
HNF1B



Citations in the biomedical literature:


Hyperinsulinism due to HNF1A deficiency
HNF1A
Renal cysts and diabetes syndrome
HNF1B



Hyperinsulinism due to HNF1A deficiency
Renal cysts and diabetes syndrome

Synonym(s):
- Hyperinsulinemic hypoglycemia due to HNF1A deficiency

Synonym(s):
- MODY5
- RCAD syndrome
- Renal cysts - maturity-onset diabetes of the young
- Renal dysfunction - early-onset diabetes

Classification (Orphanet):
- Rare endocrine disease
- Rare genetic disease
Classification (Orphanet):
- Rare developmental defect during embryogenesis
- Rare endocrine disease
- Rare genetic disease
- Rare renal disease

Classification (ICD10):
- Endocrine, nutritional and metabolic diseases -
Classification (ICD10):
- Endocrine, nutritional and metabolic diseases -

Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: neonatal/infancy
Average age of death: -
Type of inheritance: autosomal dominant
Epidemiological data:
(no data available)

External references:
No OMIM references
No MeSH references
External references:
1 OMIM reference -
No MeSH references

Renal cysts and diabetes syndrome

Very frequent
- Multicystic kidney / renal dysplasia
- Renal disease / nephropathy

Frequent
- Autosomal dominant inheritance
- Diabetes mellitus

Occasional
- Abnormal hepatic enzymes / transaminases
- Agenesis / hypoplasia / aplasia of kidneys
- Anomaly of pancreatic hormones
- Arthritis / synovitis / synovial proliferation
- Congenital absence / agenesis / aplasia / hypoplasia of the pancreas
- Ectopic / horseshoe / fused kidneys
- Gastric / pyloric stenosis
- Hearing loss / hypoacusia / deafness
- Hepatitis / icterus / cholestasis
- Hyperextensible joints / articular hyperlaxity
- Hyperuricemia
- Hypospadias / epispadias / bent penis
- Hypothyroidy
- Intellectual deficit / mental / psychomotor retardation / learning disability
- Liver / hepatic steatosis
- Male internal genitalia anomaly / deferent ducts agenesis / ectopy / duplication
- Pancreatic failure / exocrine pancreas disease
- Pollakiuria / polyuria / dysuria / anuria / acute urine retention / oliguria
- Prognathism / prognathia
- Spermatocele / epididymal / funicular / spermatic / vaginal / albugineal cyst
- Thirst
- Uterine / uterus / Fallopian tubes anomalies


Hyperinsulinism due to HNF1A deficiency

(no data available)