ODCs

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1 OMIM reference -
1 associated gene
14 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

1 OMIM reference -
1 associated gene
3 signs/symptoms

Growth delay due to insulin-like growth factor I resistance

Hereditary cerebral hemorrhage with amyloidosis, Arctic type


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	IGF1R	(0.56)	APP

Citations in the biomedical literature:

Growth delay due to insulin-like growth factor I resistance		Hereditary cerebral hemorrhage with amyloidosis, Arctic type
	Synonym(s): - Resistance to IGF-1		Synonym(s): - HCHWA, Arctic type

	Classification (Orphanet): - Rare endocrine disease - Rare genetic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease - Rare systemic or rheumatologic disease

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: no data available Type of inheritance: autosomal dominant		Epidemiological data: (no data available)

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance

Growth delay due to insulin-like growth factor I resistance		Hereditary cerebral hemorrhage with amyloidosis, Arctic type
	Very frequent - Autosomal recessive inheritance - Chromosomal or genetic anomaly - Intrauterine growth retardation - Short stature / dwarfism / nanism Frequent - Abnormally placed nipples - Broad nasal root - Everted lower lip - Intellectual deficit / mental / psychomotor retardation / learning disability - Microcephaly - Pectus excavatum - Philtrum flat / large / featureless / absent cupidon bows - Short hand / brachydactyly - Thin / retracted lips		Very frequent - Psychic / behavioural troubles - Psychic / psychomotor regression / dementia / intellectual decline