ODCs

Click node...

1 OMIM reference -
1 associated gene
14 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

1 OMIM reference -
3 associated genes
14 signs/symptoms

Growth delay due to insulin-like growth factor I resistance

Hemihypertrophy


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	IGF1R	(0.52)	IGF2

Citations in the biomedical literature:

Growth delay due to insulin-like growth factor I resistance		Hemihypertrophy
	Synonym(s): - Resistance to IGF-1		Synonym(s): - Hemi 3 syndrome - Hemicorporal hypertrophy - Isolated hemihyperplasia

	Classification (Orphanet): - Rare endocrine disease - Rare genetic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare genetic disease - Rare maxillo-facial surgical disease - Rare oncologic disease

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: no data available Type of inheritance: autosomal dominant		Epidemiological data: (no data available)

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Intellectual deficit / mental / psychomotor retardation / learning disability

Growth delay due to insulin-like growth factor I resistance		Hemihypertrophy
	Very frequent - Autosomal dominant inheritance - Autosomal recessive inheritance - Chromosomal or genetic anomaly - Intrauterine growth retardation - Short stature / dwarfism / nanism Frequent - Abnormally placed nipples - Broad nasal root - Everted lower lip - Microcephaly - Pectus excavatum - Philtrum flat / large / featureless / absent cupidon bows - Short hand / brachydactyly - Thin / retracted lips		Very frequent - Asymmetric rib cage / thorax - Asymmetry of the body / hemiatrophy / hemihyperthrophy - Scoliosis Frequent - Abnormal dentition / dental position / implantation / unerupted / dental ankylosis - Facial structural asymmetry / facial hemiatrophy / facial hemihypertrophy Occasional - Areflexia / hyporeflexia - Bladder and ureter anomalies - Congenital cardiac anomaly / malformation / cardiopathy - Inguinal / inguinoscrotal / crural hernia - Insensitivity to pain - Myelomeningocele - Nephroblastoma / Wilms tumor - Undescended / ectopic testes / cryptorchidia / unfixed testes