ODCs

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2 OMIM references -
2 associated genes
No signs/symptoms info

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
9 signs/symptoms

Generalized arterial calcification of infancy

Insulin-resistance syndrome type A

ABCC6	(UniProt - OMIM)		INSR	(UniProt - OMIM)
ENPP1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	ENPP1	(0.89)	INSR

Citations in the biomedical literature:

Generalized arterial calcification of infancy		Insulin-resistance syndrome type A
	Synonym(s): - Idiopathic infantile arterial calcification - Idiopathic obliterative arteriopathy - Infantile arteriosclerosis - Occlusive infantile arteriopathy		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare circulatory system disease - Rare genetic disease		Classification (Orphanet): - Rare endocrine disease - Rare genetic disease - Rare infertility

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant

	External references: 2 OMIM references - 1 MeSH reference: C537440		External references: 1 OMIM reference - No MeSH references

Insulin-resistance syndrome type A
	Very frequent - Advanced bone age - Autosomal recessive inheritance - Diffuse / generalised skin hyperpigmentation / melanoderma - Hirsutism / hypertrichosis / Increased body hair - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Insulin-independent / type 2 diabetes - Late puberty / hypogonadism / hypogenitalism - Subcutaneous nodules / lipomas / tumefaction / swelling - Tall stature / gigantism / growth acceleration
Generalized arterial calcification of infancy
(no data available)