ODCs

Click node...

1 OMIM reference -
1 associated gene
10 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

1 OMIM reference -
1 associated gene
14 signs/symptoms

Craniosynostosis, Boston type

Hypodontia - dysplasia of nails


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MSX2	(0.78)	MSX1

Citations in the biomedical literature:

Craniosynostosis, Boston type		Hypodontia - dysplasia of nails
	Synonym(s): - Craniosynostosis, Warman type - Warman-Mulliken-Hayward syndrome		Synonym(s): - Hypodontia - nail dysgenesis - Tooth and nail syndrome - Witkop syndrome

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare genetic disease - Rare odontologic disease - Rare skin disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: no data available Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance

Craniosynostosis, Boston type		Hypodontia - dysplasia of nails
	Very frequent - Basilary impression / invagination / cranio-spinal malformation / platybasia - Craniostenosis / craniosynostosis / sutural synostosis - Flat supraorbital ridge Frequent - Frontal bossing / prominent forehead - Myopia - Turricephaly / oxycephaly / acrocephaly Occasional - Cleft palate without cleft lip / submucosal cleft palate / bifid uvula - Fingerlike / triphalangeal thumb - Seizures / epilepsy / absences / spasms / status epilepticus		Very frequent - Absent / small fingernails / anonychia of hands - Absent / small toenails / anonychia of feet - Anodontia / oligodontia / hypodontia - Anomalies of teeth and dentition - Delayed dentition / eruption of teeth / lack of eruption of teeth - Dysplastic / thick / grooved fingernails - Dysplastic / thick / grooved toenails - Nails anomalies - Thin / hypoplastic toenails - Tooth shape anomaly Frequent - Everted lower lip - Fine hair Occasional - Abnormal / polycystic ovaries