HHpred - Results      Job-ID: 4715413      Date: 19:52 on Dec 14 2016

 color only SS        colo alignments        colo alignments     
 

Note: Corrupted alignments are the most common source of high-scoring false positives. Check the query alignment by clicking Show Query Alignment above. To check the template alignments use the logos.

hhpredhits

Query Wed_Dec_14_19:52:44_+0100_2016 (seq=MPLHVKWPFP...QLHNHLQPGR Len=292 Neff=8.4  Nseqs=134)  
Parameters  score SS:yes search:local realign with MAP:no  


   No Hit                             Prob E-value P-value  Score    SS Cols Query HMM  Template HMM
  1 1iuq_A Glycerol-3-phosphate ac  99.8 7.3E-21 1.9E-25  176.4  12.1  211   27-289    94-352 (367)
  2 5f2t_A Phosphatidylinositol ma  99.7 1.8E-15 4.7E-20  136.4  16.2  192   16-276    72-274 (308)
  3 5knk_B Lipid A biosynthesis la  99.6 1.5E-14   4E-19  132.0  19.8  197    9-276    62-278 (333)
  4 3twe_A Alpha4H; unknown functi  30.6      79   0.002   16.7   3.0   25  267-291     3-27  (27)
  5 5b16_B Microprocessor complex   29.0      74  0.0019   18.6   2.9   27  265-291     5-31  (39)

  No 1  HistogramsSCOPPDBMMDBMSDPubMed
>1iuq_A Glycerol-3-phosphate acyltransferase; open twisted alpha/beta, four helix bundle; 1.55A {Cucurbita
  moschata} SCOP: c.112.1.1 l.1.1.1 PDB:  1k30 _A
  Probab=99.84  E-value=7.3e-21  Score=176.35  Aligned_cols=211  Identities=16%  Similarity=0.110  Sum_probs=0.0

  Q ss_pred             HHHHHHHHHHHHhh---------cCEEechHHHHHHHHhcCCCCCEEEEeCCCccCchHHHHHHhhh------ccccChh
  Q Wed_Dec_14_19:   27 LVGTYSCFWTKYMN---------HLTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKL------RHIWNLK   91 (292)
  Q Consensus        27 ~~~~~~~~~~~~~~---------~i~v~g~e~l~~~~~~~~~~~~~I~v~NH~s~~D~~~l~~~~~~------~~~~~~~   91 (292)
                        +..+...++.....         ++++.|.|++|       .++|+|+++||+|++|++++...+..      +...+  
  T Consensus        94 ~~~~~~~~~~~l~~~~~~~~~g~~v~v~g~e~lp-------~~~p~IivsNH~S~lD~~~l~~~l~~~~~~~~~~~~f--  164 (367)
  T 1iuq_A           94 YYIFGQNYIRPLIDFGNSFVGNLSLFKDIEEKLQ-------QGHNVVLISNHQTEADPAIISLLLEKTNPYIAENTIF--  164 (367)
  T ss_dssp             HHHHHHHHHGGGBCGGGCEEECHHHHHHHHHHHH-------TTCEEEEEECCCCTTHHHHHHHHHTTTCHHHHHHCEE--
  T ss_pred             HHHHHHHHHHHHHhhhhceEcceEEEEehhhhcC-------CCCcEEEEECCCCcchHHHHHHHHHHhCcchhhhhHH--


  Q ss_pred             hcCcchhHHHHHcCChH---HHHHHHhCCeEEEeCC----------chhccccccCccccccCCcCCCCCcccccCCccc
  Q Wed_Dec_14_19:   92 LMRWTPAAADICFTKEL---HSHFFSLGKCVPVCRG----------AEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVY  158 (292)
  Q Consensus        92 ~~~~~~~~~~~~~~~~~---~~~~~~~~g~ipv~r~----------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~  158 (292)
                              ++++.++..|+   +++.+... +++++|.          +.                             ...
  T Consensus       165 ------vak~~l~~~P~~~~~~~~~~~~-~i~v~R~~g~~p~~~r~~~-----------------------------~~~  208 (367)
  T 1iuq_A          165 ------VAGDRVLADPLCKPFSIGRNLI-CVYSKKHMFDIPELTETKR-----------------------------KAN  208 (367)
  T ss_dssp             ------EECTHHHHCTTTHHHHHTSEEE-ECCCGGGTTSSGGGHHHHH-----------------------------HHH
  T ss_pred             ------hhhhHhhhChHHHHHHHhcCce-EEEEecccCCchhhhhhhH-----------------------------HHH


  Q ss_pred             hHHHHHHHHHHh-CCCeEEEeeCceecCC----C--ccccccchHH----HHHHhcCCCCE--EEEEEeechhccCCCCC
  Q Wed_Dec_14_19:  159 QKGMDFILEKLN-HGDWVHIFPEGKVNMS----S--EFLRFKWGIG----RLIAECHLNPI--ILPLWHVGMNDVLPNSP  225 (292)
  Q Consensus       159 ~~~~~~~~~~l~-~g~~v~IfPEG~~~~~----~--~~~~~k~G~~----~la~~~~~~~~--IvPv~i~g~~~~~~~~~  225 (292)
                        ..+++.+.+.|+ +|.+|+|||||+++.+    +  .+.+|++|++    ++|.++  ++|  |+||++. ....++...
  T Consensus       209 ~~~l~~~~~~L~~~G~~v~IFPEGtrs~~~~~~~~~~l~~fk~G~~~~~~~lA~~~--~~p~~IvPV~i~-~~~~~p~~~  285 (367)
  T 1iuq_A          209 TRSLKEMALLLRGGSQLIWIAPSGGRDRPDPSTGEWYPAPFDASSVDNMRRLIQHS--DVPGHLFPLALL-CHDIMPPPS  285 (367)
  T ss_dssp             HHHHHHHHHHHHHCCCEEEECTTCSCCCBCTTTCCBCCCCCCHHHHHHHHHHHHTS--SSCEEEEEEEEE-CGGGSCCC-
  T ss_pred             HHHHHHHHHHHHhCCeEEEEeCCCCcCCCCccCCccccCCCCchHHHHHHHHHHhc--CCCcEEEEEEEe-eeecCCCcc


  Q ss_pred             -------CCCCCCCCeEEEEECCCcccHHHHHHHHHhCccHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcC
  Q Wed_Dec_14_19:  226 -------PYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQ  289 (292)
  Q Consensus       226 -------~~~~~~~~~v~i~~g~pi~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~l~~l~~~~~~~~~~~~  289 (292)
                               ......+.+++|+||+||..+++..    ...+..+..+++++.+++.+.++..+..+.....+
  T Consensus       286 ~~~~~~~~~~~~~~~~v~v~~g~PI~~~~~~~----~~~~~~~~~~~l~~~v~~~i~~~l~~~~~~~~~~~  352 (367)
  T 1iuq_A          286 QVEIEIGEKRVIAFNGAGLSVAPEISFEEIAA----THKNPEEVREAYSKALFDSVAMQYNVLKTAISGKQ  352 (367)
  T ss_dssp             ---------CCCCCBCCEEEECCCCCHHHHHH----TSSSHHHHHHHHHHHHHHHHHHHHHHHHHHTTTCC
  T ss_pred             hHHHhhchhhccCCceEEEEECCCccHHHhhh----hccCcHHHHHHHHHHHHHHHHHHHHHHHHHhcCcc


  No 2  HistogramsPDBMMDBMSDPubMed
>5f2t_A Phosphatidylinositol mannoside acyltransferase; glycolipid biosynthesis; HET: PLM; 2.06A {Mycobacterium
  smegmatis} PDB:  5f2z _A*  5f31 _A*  5f34 _A*
  Probab=99.67  E-value=1.8e-15  Score=136.38  Aligned_cols=192  Identities=11%  Similarity=0.099  Sum_probs=0.0

  Q ss_pred             HHHHHHHHHHHHHHHHHHHHHHHhhcCEEechHHHHHHHHhcCCCCCEEEEeCCCccCchHHHHHHhhhccccChhhcCc
  Q Wed_Dec_14_19:   16 TWTLASSVVMGLVGTYSCFWTKYMNHLTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRW   95 (292)
  Q Consensus        16 ~~~~~~~~~~~~~~~~~~~~~~~~~~i~v~g~e~l~~~~~~~~~~~~~I~v~NH~s~~D~~~l~~~~~~~~~~~~~~~~~   95 (292)
                        .++......+..+.....--.....+++++|.|++++.+++   ++|+|+++||.+.+|.+.+...........      
  T Consensus        72 ~~~~~~~~~~e~~~~~~~~~~~~~~~~~v~g~e~l~~~~~~---~~~~Ilv~~H~g~~d~~~~~~~~~~~~~~~------  142 (308)
  T 5f2t_A           72 SLASYARYWREAFRLPAMDHGRLGEQLDVIDIDHLWSALDA---GRGAVLALPHSGNWDMAGVWLVQNYGPFTT------  142 (308)
  T ss_dssp             HHHHHHHHHHHHHHGGGSCHHHHHHHCCCBTTHHHHHHHHT---TCCEEEEECSBSCHHHHHHHHHHHTCCCEE------
  T ss_pred             HHHHHHHHHHHHHccCcCChHHHhhHeeecCHHHHHHHHhc---CCCEEEEecCcchHHHHHHHHHhcCCCeEE------


  Q ss_pred             chhHH----HHHcCChHHHHHHHhCCeEEEeCCchhccccccCccccccCCcCCCCCcccccCCccchHHHHHHHHHHhC
  Q Wed_Dec_14_19:   96 TPAAA----DICFTKELHSHFFSLGKCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVYQKGMDFILEKLNH  171 (292)
  Q Consensus        96 ~~~~~----~~~~~~~~~~~~~~~~g~ipv~r~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~  171 (292)
                          ++.    ..++..  +..+++..|+++|++++.                               ....++.+.+.+++
  T Consensus       143 --v~~~~~n~~~~~~--~~~~~~~~g~~~i~~~~~-------------------------------~~~~~~~~~~~L~~  187 (308)
  T 5f2t_A          143 --VAERLKPESLYRR--FVEYRESLGFEVLPLTGG-------------------------------ERPPFEVLAERLTD  187 (308)
  T ss_dssp             --EECCCSSHHHHHH--HHHHHHHTTCEEEESSSS-------------------------------SSCHHHHHHHHHHT
  T ss_pred             --EEecCCCHHHHHH--HHHHHHHCCCEEEecCCC-------------------------------cchHHHHHHHHHhc


  Q ss_pred             CCeEEEeeCceecCC-------CccccccchHHHHHHhcCCCCEEEEEEeechhccCCCCCCCCCCCCCeEEEEECCCcc
  Q Wed_Dec_14_19:  172 GDWVHIFPEGKVNMS-------SEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFS  244 (292)
  Q Consensus       172 g~~v~IfPEG~~~~~-------~~~~~~k~G~~~la~~~~~~~~IvPv~i~g~~~~~~~~~~~~~~~~~~v~i~~g~pi~  244 (292)
                        |..++|||||++..+       |...+++.|+++||.++  ++||+|+++.+.              ...+.+.+++|+.
  T Consensus       188 g~~v~i~pdg~~~~~~~~v~F~g~~~~~~~G~~~lA~~~--~~pVvpv~~~~~--------------~~~~~i~~~~pi~  251 (308)
  T 5f2t_A          188 NRPICLMAERDLTRSGVQVDFFGEATRMPAGPAKLAIET--GAALFPVHCWFE--------------GDGWGMRVYPELD  251 (308)
  T ss_dssp             TCEEEEECSCCCSTTSEEEEETTEEEEECSHHHHHHHHH--CCEEEEEEEEEE--------------TTEEEEEECCCCC
  T ss_pred             CCEEEEEeccCCCCCceEEecCCceecccchHHHHHHHh--CCcEEEEEEEEe--------------CCcEEEEEecCCC


  Q ss_pred             cHHHHHHHHHhCccHHHHHHHHHHHHHHHHHH
  Q Wed_Dec_14_19:  245 ALPVLERLRAENKSAVEMRKALTDFIQEEFQH  276 (292)
  Q Consensus       245 ~~~~~~~~~~~~~~~~~~~~~~~~~i~~~l~~  276 (292)
                        .++.         +..+.++++.+.+++.+.+
  T Consensus       252 ~~~~---------~~~~~~~~~~~~le~~i~~  274 (308)
  T 5f2t_A          252 TSSG---------DVTAITQALADRFAANIAT  274 (308)
  T ss_dssp             CTTC---------CHHHHHHHHHHHHHHHHHH
  T ss_pred             Ccch---------hHHHHHHHHHHHHHHHHHh


  No 3  HistogramsPDBMMDBMSDPubMed
>5knk_B Lipid A biosynthesis lauroyl acyltransferase; LPXM MSBB WAAN, lauryl transferase; HET: LMT 11A; 1.90A
  {Acinetobacter baumannii niph 410} PDB:  5kn7 _B*
  Probab=99.64  E-value=1.5e-14  Score=132.01  Aligned_cols=197  Identities=12%  Similarity=0.087  Sum_probs=0.0

  Q ss_pred             CCCCCchHHHHHHHHHHHHHHHHHHHHHHHhhc---------CEEechHHHHHHHHhcCCCCCEEEEeCCCccCchHHHH
  Q Wed_Dec_14_19:    9 FPAVPPLTWTLASSVVMGLVGTYSCFWTKYMNH---------LTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLW   79 (292)
  Q Consensus         9 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---------i~v~g~e~l~~~~~~~~~~~~~I~v~NH~s~~D~~~l~   79 (292)
                        +|+.+..--+.+..-.+.-++....-....+..         ++++|.|++++.+++   ++|+|+++||.+.+|.+.+.
  T Consensus        62 ~p~~s~~e~~~l~~~~~~~~~~~~~e~~~~~~~~~~~l~~~~v~v~g~e~l~~~~~~---~~~~Ilv~~H~g~~D~~~~~  138 (333)
  T 5knk_B           62 LPYLTPQQRIAITEKAVRNELTSYFEFLSIWGSSNSKNISRIHRIEGEHFFHEALAA---KKGVVLIVPHFGTWAVMNAW  138 (333)
  T ss_dssp             CTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHTSCHHHHHHTEEEEECHHHHHHHHHT---TSCEEEECCSBTTGGGHHHH
  T ss_pred             CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHhcCCHHhhhhceEEecCHHHHHHHHHc---CCCEEEEeccchHHHHHHHH


  Q ss_pred             HHhhhccccChhhcCcchhHHHHHcCChHHHHHHHhC----CeEEEeCCchhccccccCccccccCCcCCCCCcccccCC
  Q Wed_Dec_14_19:   80 GILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLG----KCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGD  155 (292)
  Q Consensus        80 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----g~ipv~r~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~  155 (292)
                        .... .....        ++...  +.++++.++...    |+++|++                                
  T Consensus       139 ~~~~-~~~~~--------v~~~~--~~~~~~~~~~~~r~~~g~~~i~~--------------------------------  175 (333)
  T 5knk_B          139 CAQF-TSMTI--------LYKPV--KNADADRFVREARSREQANLVPT--------------------------------  175 (333)
  T ss_dssp             HHTT-SCEEE--------EECCC--SSHHHHHHHHHHHHHTTCEEEES--------------------------------
  T ss_pred             HHhc-CceEE--------EEeCC--CCHHHHHHHHHHHHhcCCEEEec--------------------------------


  Q ss_pred             ccchHHHHHHHHHHhCCCeEEEeeCceecCC-------CccccccchHHHHHHhcCCCCEEEEEEeechhccCCCCCCCC
  Q Wed_Dec_14_19:  156 GVYQKGMDFILEKLNHGDWVHIFPEGKVNMS-------SEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYF  228 (292)
  Q Consensus       156 ~~~~~~~~~~~~~l~~g~~v~IfPEG~~~~~-------~~~~~~k~G~~~la~~~~~~~~IvPv~i~g~~~~~~~~~~~~  228 (292)
                          ....++.+.+.+++|..++|||||++..+       |...+++.|+++||.++  ++||+|+++.+...         
  T Consensus       176 --~~~~~~~~~~~L~~g~~v~i~pDg~~~~~~~~v~F~g~~~~~~~G~~~LA~~~--~~pVvpv~~~~~~~---------  242 (333)
  T 5knk_B          176 --DESGVRQIFKALKQGETTVILPDHTPNVGGDMVNYFGVPLASSNLSAKLIQKT--KAKALFLYAIRNEN---------  242 (333)
  T ss_dssp             --SHHHHHHHHHHHHTTCEEEECCCSCCSSCCEEEEETTEEEEECCHHHHHHHHH--CCEEEEEEEEECSS---------
  T ss_pred             --CcchHHHHHHHHhcCCeEEEEecCCCCCCceEEeeCCCccccccHHHHHHHhc--CCeEEEEEEEECCC---------


  Q ss_pred             CCCCCeEEEEECCCcccHHHHHHHHHhCccHHHHHHHHHHHHHHHHHH
  Q Wed_Dec_14_19:  229 PRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQH  276 (292)
  Q Consensus       229 ~~~~~~v~i~~g~pi~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~l~~  276 (292)
                            ..+++.|++|++....        .+..+.++++.+.+++.+.+
  T Consensus       243 ----~~~~i~~~~pi~~~~~--------~~~~~~~~~~~~~le~~i~~  278 (333)
  T 5knk_B          243 ----DGFTMHIEPMDEKIYE--------GTADDGTYVIHQAIEQLIYQ  278 (333)
  T ss_dssp             ----SCEEEEEEECCGGGGS--------SCHHHHHHHHHHHHHHHHHH
  T ss_pred             ----CcEEEEEEecCCCCCC--------CCHHHHHHHHHHHHHHHHHc


  No 4  HistogramsPDBMMDBMSDPubMed
>3twe_A Alpha4H; unknown function; HET: PGE; 1.36A {Synthetic} PDB:  3twf _A*  4g4m _A*
  Probab=30.64  E-value=79  Score=16.68  Aligned_cols=25  Identities=24%  Similarity=0.501  Sum_probs=0.0

  Q ss_pred             HHHHHHHHHHHHHHHHHHHhhcCCC
  Q Wed_Dec_14_19:  267 TDFIQEEFQHLKTQAEQLHNHLQPG  291 (292)
  Q Consensus       267 ~~~i~~~l~~l~~~~~~~~~~~~~~  291 (292)
                        ++.+..++.++..+...+..++.+|
  T Consensus         3 adelykeledlqerlrklrkklrsg   27 (27)
  T 3twe_A            3 ADELYKELEDLQERLRKLRKKLRSG   27 (27)
  T ss_dssp             HHHHHHHHHHHHHHHHHHHHHHHC-
  T ss_pred             HHHHHHHHHHHHHHHHHHHHHhcCC


  No 5  HistogramsPDBMMDBMSDPubMed
>5b16_B Microprocessor complex subunit DGCR8; endonuclease, RNAse III, trimeric complex, zinc finger, HYDR; 3.20A
  {Homo sapiens}
  Probab=29.03  E-value=74  Score=18.64  Aligned_cols=27  Identities=22%  Similarity=0.308  Sum_probs=0.0

  Q ss_pred             HHHHHHHHHHHHHHHHHHHHHhhcCCC
  Q Wed_Dec_14_19:  265 ALTDFIQEEFQHLKTQAEQLHNHLQPG  291 (292)
  Q Consensus       265 ~~~~~i~~~l~~l~~~~~~~~~~~~~~  291 (292)
                        .+.+.++++|..+..++++-..+...|
  T Consensus         5 hILnKLqeEM~klaeeree~rkkp~~~   31 (39)
  T 5b16_B            5 HILSKLQEEMKRLAEEREETRHGGSRG   31 (39)
  T ss_dssp             HHHHHHHHHHHHHHHHHHHHC------
  T ss_pred             HHHHHHHHHHHHHHHHHHHhccCCCcc


Done!


Söding J, Biegert A, Lupas AN (2005) The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res 33 (suppl 2), W244-W248.

Söding J (2005) Protein homology detection by HMM-HMM comparison. Bioinformatics 21: 951-960.

Biegert A, Mayer C, Remmert M, Söding J, Lupas AN (2006) The MPI Bioinformatics Toolkit for protein sequence analysis. Nucleic Acids Res 34 (suppl 2), W335-W339.

Hildebrand A, Remmert A, Biegert A, Söding J (2009) Fast and accurate automatic structure prediction with HHpred. Proteins 77 (S9), 128-132.

Remmert M, Biegert A, Hauser A, Söding J (2012) HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment. Nature Methods 9 (2), 173-175.

Meier A, Söding J (2015) Automatic Prediction of Protein 3D Structures by Probabilistic Multi-template Homology Modeling. PLoS Comput Biol 11 (10), e1004343.

PSIPRED: Jones DT (1999) Protein secondary structure prediction based on position-specific scoring matrices. JMB 292: 195-202.

PDB: Bourne PE et al. (2004) The distribution and query systems of the RCSB Protein Data Bank. NAR 32: D223.