
HHpred - Results Job-ID: 4715413 Date: 19:52 on Dec 14 2016
Note: Corrupted alignments are the most common source of high-scoring false positives. Check the query alignment by clicking Show Query Alignment above. To check the template alignments use the

Query Wed_Dec_14_19:52:44_+0100_2016 (seq=MPLHVKWPFP...QLHNHLQPGR Len=292 Neff=8.4 Nseqs=134) Parameters score SS:yes search:local realign with MAP:no No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 1iuq_A Glycerol-3-phosphate ac 99.8 7.3E-21 1.9E-25 176.4 12.1 211 27-289 94-352 (367) 2 5f2t_A Phosphatidylinositol ma 99.7 1.8E-15 4.7E-20 136.4 16.2 192 16-276 72-274 (308) 3 5knk_B Lipid A biosynthesis la 99.6 1.5E-14 4E-19 132.0 19.8 197 9-276 62-278 (333) 4 3twe_A Alpha4H; unknown functi 30.6 79 0.002 16.7 3.0 25 267-291 3-27 (27) 5 5b16_B Microprocessor complex 29.0 74 0.0019 18.6 2.9 27 265-291 5-31 (39) No 1>1iuq_A Glycerol-3-phosphate acyltransferase; open twisted alpha/beta, four helix bundle; 1.55A {Cucurbita moschata} SCOP: c.112.1.1 l.1.1.1 PDB: 1k30 _A Probab=99.84 E-value=7.3e-21 Score=176.35 Aligned_cols=211 Identities=16% Similarity=0.110 Sum_probs=0.0 Q ss_pred HHHHHHHHHHHHhh---------cCEEechHHHHHHHHhcCCCCCEEEEeCCCccCchHHHHHHhhh------ccccChh Q Wed_Dec_14_19: 27 LVGTYSCFWTKYMN---------HLTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKL------RHIWNLK 91 (292) Q Consensus 27 ~~~~~~~~~~~~~~---------~i~v~g~e~l~~~~~~~~~~~~~I~v~NH~s~~D~~~l~~~~~~------~~~~~~~ 91 (292) +..+...++..... ++++.|.|++| .++|+|+++||+|++|++++...+.. +...+ T Consensus 94 ~~~~~~~~~~~l~~~~~~~~~g~~v~v~g~e~lp-------~~~p~IivsNH~S~lD~~~l~~~l~~~~~~~~~~~~f-- 164 (367) T 1iuq_A 94 YYIFGQNYIRPLIDFGNSFVGNLSLFKDIEEKLQ-------QGHNVVLISNHQTEADPAIISLLLEKTNPYIAENTIF-- 164 (367) T ss_dssp HHHHHHHHHGGGBCGGGCEEECHHHHHHHHHHHH-------TTCEEEEEECCCCTTHHHHHHHHHTTTCHHHHHHCEE-- T ss_pred HHHHHHHHHHHHHhhhhceEcceEEEEehhhhcC-------CCCcEEEEECCCCcchHHHHHHHHHHhCcchhhhhHH-- Q ss_pred hcCcchhHHHHHcCChH---HHHHHHhCCeEEEeCC----------chhccccccCccccccCCcCCCCCcccccCCccc Q Wed_Dec_14_19: 92 LMRWTPAAADICFTKEL---HSHFFSLGKCVPVCRG----------AEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVY 158 (292) Q Consensus 92 ~~~~~~~~~~~~~~~~~---~~~~~~~~g~ipv~r~----------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 158 (292) ++++.++..|+ +++.+... +++++|. +. ... T Consensus 165 ------vak~~l~~~P~~~~~~~~~~~~-~i~v~R~~g~~p~~~r~~~-----------------------------~~~ 208 (367) T 1iuq_A 165 ------VAGDRVLADPLCKPFSIGRNLI-CVYSKKHMFDIPELTETKR-----------------------------KAN 208 (367) T ss_dssp ------EECTHHHHCTTTHHHHHTSEEE-ECCCGGGTTSSGGGHHHHH-----------------------------HHH T ss_pred ------hhhhHhhhChHHHHHHHhcCce-EEEEecccCCchhhhhhhH-----------------------------HHH Q ss_pred hHHHHHHHHHHh-CCCeEEEeeCceecCC----C--ccccccchHH----HHHHhcCCCCE--EEEEEeechhccCCCCC Q Wed_Dec_14_19: 159 QKGMDFILEKLN-HGDWVHIFPEGKVNMS----S--EFLRFKWGIG----RLIAECHLNPI--ILPLWHVGMNDVLPNSP 225 (292) Q Consensus 159 ~~~~~~~~~~l~-~g~~v~IfPEG~~~~~----~--~~~~~k~G~~----~la~~~~~~~~--IvPv~i~g~~~~~~~~~ 225 (292) ..+++.+.+.|+ +|.+|+|||||+++.+ + .+.+|++|++ ++|.++ ++| |+||++. ....++... T Consensus 209 ~~~l~~~~~~L~~~G~~v~IFPEGtrs~~~~~~~~~~l~~fk~G~~~~~~~lA~~~--~~p~~IvPV~i~-~~~~~p~~~ 285 (367) T 1iuq_A 209 TRSLKEMALLLRGGSQLIWIAPSGGRDRPDPSTGEWYPAPFDASSVDNMRRLIQHS--DVPGHLFPLALL-CHDIMPPPS 285 (367) T ss_dssp HHHHHHHHHHHHHCCCEEEECTTCSCCCBCTTTCCBCCCCCCHHHHHHHHHHHHTS--SSCEEEEEEEEE-CGGGSCCC- T ss_pred HHHHHHHHHHHHhCCeEEEEeCCCCcCCCCccCCccccCCCCchHHHHHHHHHHhc--CCCcEEEEEEEe-eeecCCCcc Q ss_pred -------CCCCCCCCeEEEEECCCcccHHHHHHHHHhCccHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcC Q Wed_Dec_14_19: 226 -------PYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQ 289 (292) Q Consensus 226 -------~~~~~~~~~v~i~~g~pi~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~l~~l~~~~~~~~~~~~ 289 (292) ......+.+++|+||+||..+++.. ...+..+..+++++.+++.+.++..+..+.....+ T Consensus 286 ~~~~~~~~~~~~~~~~v~v~~g~PI~~~~~~~----~~~~~~~~~~~l~~~v~~~i~~~l~~~~~~~~~~~ 352 (367) T 1iuq_A 286 QVEIEIGEKRVIAFNGAGLSVAPEISFEEIAA----THKNPEEVREAYSKALFDSVAMQYNVLKTAISGKQ 352 (367) T ss_dssp ---------CCCCCBCCEEEECCCCCHHHHHH----TSSSHHHHHHHHHHHHHHHHHHHHHHHHHHTTTCC T ss_pred hHHHhhchhhccCCceEEEEECCCccHHHhhh----hccCcHHHHHHHHHHHHHHHHHHHHHHHHHhcCcc No 2
>5f2t_A Phosphatidylinositol mannoside acyltransferase; glycolipid biosynthesis; HET: PLM; 2.06A {Mycobacterium smegmatis} PDB: 5f2z _A* 5f31 _A* 5f34 _A* Probab=99.67 E-value=1.8e-15 Score=136.38 Aligned_cols=192 Identities=11% Similarity=0.099 Sum_probs=0.0 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHhhcCEEechHHHHHHHHhcCCCCCEEEEeCCCccCchHHHHHHhhhccccChhhcCc Q Wed_Dec_14_19: 16 TWTLASSVVMGLVGTYSCFWTKYMNHLTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRW 95 (292) Q Consensus 16 ~~~~~~~~~~~~~~~~~~~~~~~~~~i~v~g~e~l~~~~~~~~~~~~~I~v~NH~s~~D~~~l~~~~~~~~~~~~~~~~~ 95 (292) .++......+..+.....--.....+++++|.|++++.+++ ++|+|+++||.+.+|.+.+........... T Consensus 72 ~~~~~~~~~~e~~~~~~~~~~~~~~~~~v~g~e~l~~~~~~---~~~~Ilv~~H~g~~d~~~~~~~~~~~~~~~------ 142 (308) T 5f2t_A 72 SLASYARYWREAFRLPAMDHGRLGEQLDVIDIDHLWSALDA---GRGAVLALPHSGNWDMAGVWLVQNYGPFTT------ 142 (308) T ss_dssp HHHHHHHHHHHHHHGGGSCHHHHHHHCCCBTTHHHHHHHHT---TCCEEEEECSBSCHHHHHHHHHHHTCCCEE------ T ss_pred HHHHHHHHHHHHHccCcCChHHHhhHeeecCHHHHHHHHhc---CCCEEEEecCcchHHHHHHHHHhcCCCeEE------ Q ss_pred chhHH----HHHcCChHHHHHHHhCCeEEEeCCchhccccccCccccccCCcCCCCCcccccCCccchHHHHHHHHHHhC Q Wed_Dec_14_19: 96 TPAAA----DICFTKELHSHFFSLGKCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVYQKGMDFILEKLNH 171 (292) Q Consensus 96 ~~~~~----~~~~~~~~~~~~~~~~g~ipv~r~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~ 171 (292) ++. ..++.. +..+++..|+++|++++. ....++.+.+.+++ T Consensus 143 --v~~~~~n~~~~~~--~~~~~~~~g~~~i~~~~~-------------------------------~~~~~~~~~~~L~~ 187 (308) T 5f2t_A 143 --VAERLKPESLYRR--FVEYRESLGFEVLPLTGG-------------------------------ERPPFEVLAERLTD 187 (308) T ss_dssp --EECCCSSHHHHHH--HHHHHHHTTCEEEESSSS-------------------------------SSCHHHHHHHHHHT T ss_pred --EEecCCCHHHHHH--HHHHHHHCCCEEEecCCC-------------------------------cchHHHHHHHHHhc Q ss_pred CCeEEEeeCceecCC-------CccccccchHHHHHHhcCCCCEEEEEEeechhccCCCCCCCCCCCCCeEEEEECCCcc Q Wed_Dec_14_19: 172 GDWVHIFPEGKVNMS-------SEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFS 244 (292) Q Consensus 172 g~~v~IfPEG~~~~~-------~~~~~~k~G~~~la~~~~~~~~IvPv~i~g~~~~~~~~~~~~~~~~~~v~i~~g~pi~ 244 (292) |..++|||||++..+ |...+++.|+++||.++ ++||+|+++.+. ...+.+.+++|+. T Consensus 188 g~~v~i~pdg~~~~~~~~v~F~g~~~~~~~G~~~lA~~~--~~pVvpv~~~~~--------------~~~~~i~~~~pi~ 251 (308) T 5f2t_A 188 NRPICLMAERDLTRSGVQVDFFGEATRMPAGPAKLAIET--GAALFPVHCWFE--------------GDGWGMRVYPELD 251 (308) T ss_dssp TCEEEEECSCCCSTTSEEEEETTEEEEECSHHHHHHHHH--CCEEEEEEEEEE--------------TTEEEEEECCCCC T ss_pred CCEEEEEeccCCCCCceEEecCCceecccchHHHHHHHh--CCcEEEEEEEEe--------------CCcEEEEEecCCC Q ss_pred cHHHHHHHHHhCccHHHHHHHHHHHHHHHHHH Q Wed_Dec_14_19: 245 ALPVLERLRAENKSAVEMRKALTDFIQEEFQH 276 (292) Q Consensus 245 ~~~~~~~~~~~~~~~~~~~~~~~~~i~~~l~~ 276 (292) .++. +..+.++++.+.+++.+.+ T Consensus 252 ~~~~---------~~~~~~~~~~~~le~~i~~ 274 (308) T 5f2t_A 252 TSSG---------DVTAITQALADRFAANIAT 274 (308) T ss_dssp CTTC---------CHHHHHHHHHHHHHHHHHH T ss_pred Ccch---------hHHHHHHHHHHHHHHHHHh No 3
>5knk_B Lipid A biosynthesis lauroyl acyltransferase; LPXM MSBB WAAN, lauryl transferase; HET: LMT 11A; 1.90A {Acinetobacter baumannii niph 410} PDB: 5kn7 _B* Probab=99.64 E-value=1.5e-14 Score=132.01 Aligned_cols=197 Identities=12% Similarity=0.087 Sum_probs=0.0 Q ss_pred CCCCCchHHHHHHHHHHHHHHHHHHHHHHHhhc---------CEEechHHHHHHHHhcCCCCCEEEEeCCCccCchHHHH Q Wed_Dec_14_19: 9 FPAVPPLTWTLASSVVMGLVGTYSCFWTKYMNH---------LTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLW 79 (292) Q Consensus 9 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~---------i~v~g~e~l~~~~~~~~~~~~~I~v~NH~s~~D~~~l~ 79 (292) +|+.+..--+.+..-.+.-++....-....+.. ++++|.|++++.+++ ++|+|+++||.+.+|.+.+. T Consensus 62 ~p~~s~~e~~~l~~~~~~~~~~~~~e~~~~~~~~~~~l~~~~v~v~g~e~l~~~~~~---~~~~Ilv~~H~g~~D~~~~~ 138 (333) T 5knk_B 62 LPYLTPQQRIAITEKAVRNELTSYFEFLSIWGSSNSKNISRIHRIEGEHFFHEALAA---KKGVVLIVPHFGTWAVMNAW 138 (333) T ss_dssp CTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHTSCHHHHHHTEEEEECHHHHHHHHHT---TSCEEEECCSBTTGGGHHHH T ss_pred CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHhcCCHHhhhhceEEecCHHHHHHHHHc---CCCEEEEeccchHHHHHHHH Q ss_pred HHhhhccccChhhcCcchhHHHHHcCChHHHHHHHhC----CeEEEeCCchhccccccCccccccCCcCCCCCcccccCC Q Wed_Dec_14_19: 80 GILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLG----KCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGD 155 (292) Q Consensus 80 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~----g~ipv~r~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 155 (292) .... ..... ++... +.++++.++... |+++|++ T Consensus 139 ~~~~-~~~~~--------v~~~~--~~~~~~~~~~~~r~~~g~~~i~~-------------------------------- 175 (333) T 5knk_B 139 CAQF-TSMTI--------LYKPV--KNADADRFVREARSREQANLVPT-------------------------------- 175 (333) T ss_dssp HHTT-SCEEE--------EECCC--SSHHHHHHHHHHHHHTTCEEEES-------------------------------- T ss_pred HHhc-CceEE--------EEeCC--CCHHHHHHHHHHHHhcCCEEEec-------------------------------- Q ss_pred ccchHHHHHHHHHHhCCCeEEEeeCceecCC-------CccccccchHHHHHHhcCCCCEEEEEEeechhccCCCCCCCC Q Wed_Dec_14_19: 156 GVYQKGMDFILEKLNHGDWVHIFPEGKVNMS-------SEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYF 228 (292) Q Consensus 156 ~~~~~~~~~~~~~l~~g~~v~IfPEG~~~~~-------~~~~~~k~G~~~la~~~~~~~~IvPv~i~g~~~~~~~~~~~~ 228 (292) ....++.+.+.+++|..++|||||++..+ |...+++.|+++||.++ ++||+|+++.+... T Consensus 176 --~~~~~~~~~~~L~~g~~v~i~pDg~~~~~~~~v~F~g~~~~~~~G~~~LA~~~--~~pVvpv~~~~~~~--------- 242 (333) T 5knk_B 176 --DESGVRQIFKALKQGETTVILPDHTPNVGGDMVNYFGVPLASSNLSAKLIQKT--KAKALFLYAIRNEN--------- 242 (333) T ss_dssp --SHHHHHHHHHHHHTTCEEEECCCSCCSSCCEEEEETTEEEEECCHHHHHHHHH--CCEEEEEEEEECSS--------- T ss_pred --CcchHHHHHHHHhcCCeEEEEecCCCCCCceEEeeCCCccccccHHHHHHHhc--CCeEEEEEEEECCC--------- Q ss_pred CCCCCeEEEEECCCcccHHHHHHHHHhCccHHHHHHHHHHHHHHHHHH Q Wed_Dec_14_19: 229 PRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQH 276 (292) Q Consensus 229 ~~~~~~v~i~~g~pi~~~~~~~~~~~~~~~~~~~~~~~~~~i~~~l~~ 276 (292) ..+++.|++|++.... .+..+.++++.+.+++.+.+ T Consensus 243 ----~~~~i~~~~pi~~~~~--------~~~~~~~~~~~~~le~~i~~ 278 (333) T 5knk_B 243 ----DGFTMHIEPMDEKIYE--------GTADDGTYVIHQAIEQLIYQ 278 (333) T ss_dssp ----SCEEEEEEECCGGGGS--------SCHHHHHHHHHHHHHHHHHH T ss_pred ----CcEEEEEEecCCCCCC--------CCHHHHHHHHHHHHHHHHHc No 4
>3twe_A Alpha4H; unknown function; HET: PGE; 1.36A {Synthetic} PDB: 3twf _A* 4g4m _A* Probab=30.64 E-value=79 Score=16.68 Aligned_cols=25 Identities=24% Similarity=0.501 Sum_probs=0.0 Q ss_pred HHHHHHHHHHHHHHHHHHHhhcCCC Q Wed_Dec_14_19: 267 TDFIQEEFQHLKTQAEQLHNHLQPG 291 (292) Q Consensus 267 ~~~i~~~l~~l~~~~~~~~~~~~~~ 291 (292) ++.+..++.++..+...+..++.+| T Consensus 3 adelykeledlqerlrklrkklrsg 27 (27) T 3twe_A 3 ADELYKELEDLQERLRKLRKKLRSG 27 (27) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHC- T ss_pred HHHHHHHHHHHHHHHHHHHHHhcCC No 5
>5b16_B Microprocessor complex subunit DGCR8; endonuclease, RNAse III, trimeric complex, zinc finger, HYDR; 3.20A {Homo sapiens} Probab=29.03 E-value=74 Score=18.64 Aligned_cols=27 Identities=22% Similarity=0.308 Sum_probs=0.0 Q ss_pred HHHHHHHHHHHHHHHHHHHHHhhcCCC Q Wed_Dec_14_19: 265 ALTDFIQEEFQHLKTQAEQLHNHLQPG 291 (292) Q Consensus 265 ~~~~~i~~~l~~l~~~~~~~~~~~~~~ 291 (292) .+.+.++++|..+..++++-..+...| T Consensus 5 hILnKLqeEM~klaeeree~rkkp~~~ 31 (39) T 5b16_B 5 HILSKLQEEMKRLAEEREETRHGGSRG 31 (39) T ss_dssp HHHHHHHHHHHHHHHHHHHHC------ T ss_pred HHHHHHHHHHHHHHHHHHHhccCCCcc Done!
Please cite one of the following articles:
Söding J, Biegert A, Lupas AN (2005) The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res 33 (suppl 2), W244-W248.
Söding J (2005) Protein homology detection by HMM-HMM comparison. Bioinformatics 21: 951-960.
Biegert A, Mayer C, Remmert M, Söding J, Lupas AN (2006) The MPI Bioinformatics Toolkit for protein sequence analysis. Nucleic Acids Res 34 (suppl 2), W335-W339.
Hildebrand A, Remmert A, Biegert A, Söding J (2009) Fast and accurate automatic structure prediction with HHpred. Proteins 77 (S9), 128-132.
Remmert M, Biegert A, Hauser A, Söding J (2012) HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment. Nature Methods 9 (2), 173-175.
Meier A, Söding J (2015) Automatic Prediction of Protein 3D Structures by Probabilistic Multi-template Homology Modeling. PLoS Comput Biol 11 (10), e1004343.
PSIPRED: Jones DT (1999) Protein secondary structure prediction based on position-specific scoring matrices. JMB 292: 195-202.
PDB: Bourne PE et al. (2004) The distribution and query systems of the RCSB Protein Data Bank. NAR 32: D223.