comparative gene prediction
1.  THE GENE PREDICTION IS THE RESULT OF THE SEQUENCE
ALIGNMENT
given two homologous genomic sequences, infer the exonic structure in each
sequence maximizing the score of the alignment of the resulting amino acid
sequences.
This  problem is usually solved through a complex extension of the classical
dynamic programming algorithm for sequence alignment.
 blayo et al., 2002
 pedersen and scharl, 2002