comparative gene prediction
	3. GENE PREDICTION IS SEPARATED FROM SEQUENCE ALIGNMENT first, the alignment is obtained between two homologous genomic sequences using  some generic sequence alignment program, such as tblastx, sim4 or glass then, gene structures are predicted that are compatible with this alignment, meaning that predicted exons fall in the aligned regions. •  rosseta – batzoglou et al., 2000 •  cem – bafna and huson, 2000 •  sgp-1 – wiehe et al., 2001