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Young adult-onset Parkinsonism
14 OMIM references -
13 associated genes
416 connected diseases
No signs/symptoms info
Disease Type of connection
Parkinsonian-pyramidal syndrome
Amyotrophic lateral sclerosis-parkinsonism-dementia complex
Fetal Gaucher disease
Gaucher disease - ophthalmoplegia - cardiovascular calcification
Gaucher disease type 1
Gaucher disease type 2
Gaucher disease type 3
Early-onset progressive neurodegeneration - blindness - ataxia - spasticity
Amyotrophic lateral sclerosis
Precursor B-cell acute lymphoblastic leukemia
Behavioral variant of frontotemporal dementia
Progressive non-fluent aphasia
Semantic dementia
Precursor T-cell acute lymphoblastic leukemia
Inflammatory myofibroblastic tumor
Lissencephaly due to TUBA1A mutation
Early-onset autosomal dominant Alzheimer disease
Familial isolated dilated cardiomyopathy
Childhood-onset nemaline myopathy
Congenital fiber-type disproportion myopathy
Cowden syndrome
Proteus syndrome
Autosomal dominant hypohidrotic ectodermal dysplasia
Translocation renal cell carcinoma
Acute promyelocytic leukemia
Hereditary cerebral hemorrhage with amyloidosis, Arctic type
Hereditary cerebral hemorrhage with amyloidosis, Dutch type
Hereditary cerebral hemorrhage with amyloidosis, Flemish type
Hereditary cerebral hemorrhage with amyloidosis, Iowa type
Hereditary cerebral hemorrhage with amyloidosis, Italian type
Hereditary cerebral hemorrhage with amyloidosis, Piedmont type
Familial pancreatic carcinoma
Intermediate nemaline myopathy
Retinitis pigmentosa
Autosomal dominant nonsyndromic intellectual deficit
Autosomal dominant optic atrophy plus syndrome
Cerebellar ataxia - hypogonadism
Giant cell glioblastoma
Gliosarcoma
B-cell chronic lymphocytic leukemia
Essential thrombocythemia
Pulverulent cataract
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
Typical nemaline myopathy
Isolated NADH-CoQ reductase deficiency
Leigh syndrome with leukodystrophy
Autosomal dominant nonsyndromic sensorineural deafness type DFNA
Baraitser-Winter syndrome
Adrenocortical carcinoma
Li-Fraumeni syndrome
Papilloma of choroid plexus
Distal hereditary motor neuropathy type 2
Classical progressive supranuclear palsy
Progressive supranuclear palsy - corticobasal syndrome
Progressive supranuclear palsy - parkinsonism
Progressive supranuclear palsy - progressive non fluent aphasia
Progressive supranuclear palsy - pure akinesia with gait freezing
Blackfan-Diamond anemia
Congenital myopathy with excess of thin filaments
Dedifferentiated liposarcoma
Left ventricular noncompaction
Severe congenital nemaline myopathy
Well-differentiated liposarcoma
Williams syndrome
Frontotemporal dementia with motor neuron disease
X-linked non-syndromic intellectual deficit
Autosomal dominant optic atrophy, classic type
Chronic myeloid leukemia
Congenital cataract - hypertrophic cardiomyopathy - mitochondrial myopathy
Glycogen storage disease due to LAMP-2 deficiency
Autosomal dominant Charcot-Marie-Tooth disease type 2F
17p13.3 microduplication syndrome
Distal 17p13.3 microdeletion syndrome
Miller-Dieker syndrome
Papillary or follicular thyroid carcinoma
Adult-onset distal myopathy due to VCP mutation
Spastic paraplegia - Paget disease of bone
Developmental malformations - deafness - dystonia
Hereditary breast and ovarian cancer syndrome
Isolated cytochrome C oxidase deficiency
Acute myeloblastic leukemia with maturation
Acute myeloblastic leukemia without maturation
Acute myelomonocytic leukemia
Angelman syndrome
Autosomal dominant macrothrombocytopenia
Autosomal recessive nonsyndromic sensorineural deafness type DFNB
Cap myopathy
Chuvash erythrocytosis
Familial melanoma
Von Hippel-Lindau disease
Leber hereditary optic neuropathy
MELAS syndrome
Maternally-inherited Leigh syndrome
Desmoid tumor
Atypical Gaucher disease due to saposin C deficiency
Encephalopathy due to prosaposin deficiency
Infantile Krabbe disease
Metachromatic leukodystrophy, adult form
Metachromatic leukodystrophy, juvenile form
Metachromatic leukodystrophy, late infantile form
Autoimmune lymphoproliferative syndrome with recurrent infections
Lethal encephalopathy due to mitochondrial and peroxisomal fission defect
Infantile dystonia-parkinsonism
Multiple endocrine neoplasia type 1
Catecholaminergic polymorphic ventricular tachycardia
FADD-related immunodeficiency
Oculootodental syndrome
Acute necrotizing encephalopathy of childhood
Distal 22q11.2 microdeletion syndrome
Familial acute necrotizing encephalopathy
Autosomal dominant progressive external ophthalmoplegia
Severe combined immunodeficiency due to DNA-PKcs deficiency
Bannayan-Riley-Ruvalcaba syndrome
Juvenile polyposis of infancy
Lhermitte-Duclos disease
Macrocephaly-autism syndrome
Proteus-like syndrome
Segmental outgrowth - lipomatosis - arteriovenous malformation - epidermal nevus
Squamous cell carcinoma of head and neck
Autosomal dominant Charcot-Marie-Tooth disease type 2A2
Hereditary motor and sensory neuropathy type 5
Hereditary motor and sensory neuropathy type 6
Severe early-onset axonal neuropathy due to MFN2 deficiency
Posterior polar cataract
Charcot-Marie-Tooth disease type 4G
Non-spherocytic hemolytic anemia due to hexokinase deficiency
X-linked epilepsy - learning disabilities - behavior disorders
Fibronectin glomerulopathy
Leber congenital amaurosis
Congenital fibrosis of extraocular muscles
Proximal spinal muscular atrophy type 1
Proximal spinal muscular atrophy type 2
Proximal spinal muscular atrophy type 3
Proximal spinal muscular atrophy type 4
Adult-onset autosomal dominant leukodystrophy
Atypical Werner syndrome
Autosomal codominant severe lipodystrophic laminopathy
Autosomal dominant Emery-Dreifuss muscular dystrophy
Autosomal dominant limb-girdle muscular dystrophy type 1B
Autosomal recessive Emery-Dreifuss muscular dystrophy
Charcot-Marie-Tooth disease type 2B1
Combined oxidative phosphorylation defect type 4
Congenital muscular dystrophy due to LMNA mutation
D,L-2-hydroxyglutaric aciduria
Dilated cardiomyopathy - hypergonadotropic hypogonadism
Distal myopathy with vocal cord weakness
Familial dilated cardiomyopathy with conduction defect due to LMNA mutation
Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
Familial partial lipodystrophy, Dunnigan type
Familial partial lipodystrophy, Köbberling type
Familial thoracic aortic aneurysm and aortic dissection
Heart-hand syndrome, Slovenian type
Hereditary sensory and autonomic neuropathy with spastic paraplegia
Hutchinson-Gilford progeria syndrome
Isolated ATP synthase deficiency
LMNA-related cardiocutaneous progeria syndrome
Laminopathy type Decaudain-Vigouroux
Lethal restrictive dermopathy
Mandibuloacral dysplasia with type A lipodystrophy
Moyamoya disease
Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality
Prader-Willi syndrome due to imprinting mutation
Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
Progeria-associated arthropathy
Propionic acidemia
Severe X-linked mitochondrial encephalomyopathy
X-linked Charcot-Marie-Tooth disease type 4
X-linked Emery-Dreifuss muscular dystrophy
Genetic recurrent myoglobinuria
APC-related attenuated familial adenomatous polyposis
Familial adenomatous polyposis due to 5q22.2 microdeletion
Gardner syndrome
Turcot syndrome with polyposis
Autosomal dominant spastic paraplegia type 13
Pelizaeus-Merzbacher-like due to HSPD1 mutation
Autosomal dominant Charcot-Marie-Tooth disease type 2O
Autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures
X-linked intellectual deficit, Najm type
X-linked lymphoproliferative disease
MALT lymphoma
Machado-Joseph disease type 1
Machado-Joseph disease type 2
Machado-Joseph disease type 3
Multiple endocrine neoplasia type 4
Alpha-crystallinopathy
Fatal infantile hypertonic myofibrillar myopathy
Zonular cataract
Bardet-Biedl syndrome
Complete androgen insensitivity syndrome
Familial hypospadias
Kennedy disease
Partial androgen insensitivity syndrome
Coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis
Matthew-Wood syndrome
Pachyonychia congenita
Sebocystomatosis
White sponge nevus
Anhidrotic ectodermal dysplasia - immunodeficiency - osteopetrosis - lymphedema
Early-onset generalized limb-onset dystonia
Fructose-1,6-bisphosphatase deficiency
Glycogen storage disease due to lactate dehydrogenase H-subunit deficiency
Hypohidrotic ectodermal dysplasia with immunodeficiency
Hypomyelination with atrophy of basal ganglia and cerebellum
Incontinentia pigmenti
Myoclonus-dystonia syndrome
Primary dystonia, DYT4 type
X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency
West syndrome
Microcephaly - lymphedema - chorioretinopathy
Short rib-polydactyly syndrome, Majewski type
Huntington disease
Juvenile Huntington disease
MMEP syndrome
Senior-Loken syndrome
Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome
Brain dopamine-serotonin vesicular transport disease
HSD10 disease, atypical type
HSD10 disease, infantile type
HSD10 disease, neonatal type
Richieri Costa-Pereira syndrome
Familial advanced sleep-phase syndrome
Coffin-Siris syndrome
Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation
Familial rhabdoid tumor
Follicular lymphoma
Hypotrichosis simplex
Intellectual deficit - sparse hair - brachydactyly
Intravascular large B-cell lymphoma
Autosomal thrombocytopenia with normal platelets
Congenital stationary night blindness
Microcytic anemia with liver iron overload
Oguchi disease
22q11.2 deletion syndrome
2q37 microdeletion syndrome
Acrokeratosis verruciformis of Hopf
Acute myeloid leukemia with t(8;21)(q22;q22) translocation
Adams-Oliver syndrome
Aicardi-Goutières syndrome
Alport syndrome - intellectual deficit - midface hypoplasia - elliptocytosis
Autoimmune lymphoproliferative syndrome
Autoimmune polyendocrinopathy type 1
Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis
Autosomal dominant Charcot-Marie-Tooth disease type 2E
Autosomal recessive ataxia due to ubiquinone deficiency
Autosomal recessive cutis laxa type 2B
Autosomal recessive distal renal tubular acidosis with deafness
Autosomal recessive limb-girdle muscular dystrophy type 2Q
Autosomal recessive primary microcephaly
Autosomal recessive systemic lupus erythematosus
CANDLE syndrome
Cardiomyopathy - hypotonia - lactic acidosis
Carnitine palmitoyl transferase 1A deficiency
Charcot-Marie-Tooth disease type 1F
Chilblain lupus
Citrullinemia type II
Classic maple syrup urine disease
Cold-induced sweating syndrome
Common variable immunodeficiency
Cone rod dystrophy
Congenital analbuminemia
Congenital lactic acidosis, Saguenay-Lac-St. Jean type
Constitutional mismatch repair deficiency syndrome
Cornelia de Lange syndrome
Craniometaphyseal dysplasia
Craniopharyngioma
DPM3-CDG
Darier disease
Dentatorubral pallidoluysian atrophy
Digitotalar dysmorphism
Dyskeratosis congenita
Early infantile epileptic encephalopathy
Early myoclonic encephalopathy
Early-onset spastic ataxia-neuropathy syndrome
Epidermolysis bullosa simplex with muscular dystrophy
Epidermolysis bullosa simplex with pyloric atresia
Epidermolysis bullosa simplex, Ogna type
Epilepsy with myoclonic-astatic seizures
Estrogen resistance syndrome
Ewing sarcoma
Extraskeletal Ewing sarcoma
Facial dysmorphism - immunodeficiency - livedo - short stature
Familial infantile bilateral striatal necrosis
Familial isolated congenital asplenia
Familial partial lipodystrophy due to AKT2 mutations
Familial platelet syndrome with predisposition to acute myelogenous leukemia
Familial visceral myopathy
Fanconi anemia
Fuchs endothelial corneal dystrophy
GCS1-CDG
Geroderma osteodysplastica
Glycerol kinase deficiency, adult form
Glycerol kinase deficiency, infantile form
Glycerol kinase deficiency, juvenile form
Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency
Greenberg dysplasia
Hepatocellular carcinoma, childhood-onset
Hereditary nonpolyposis colon cancer
Hereditary sensory and autonomic neuropathy type 1
Hermansky-Pudlak syndrome with neutropenia
Herpetic encephalitis
Hoyeraal-Hreidarsson syndrome
Hypoinsulinemic hypoglycemia and body hemihypertrophy
Hypoplastic left heart syndrome
Hypotonia with lactic acidemia and hyperammonemia
Hypoxanthine guanine phosphoribosyltransferase partial deficiency
Intermediate maple syrup urine disease
Intermittent maple syrup urine disease
Isolated 3-methylcrotonyl-CoA carboxylase deficiency
Isolated CoQ-cytochrome C reductase deficiency
Isolated Klippel-Feil syndrome
Isolated delta-storage pool disease
Isolated polycystic liver disease
JMP syndrome
Jawad syndrome
Juvenile amyotrophic lateral sclerosis
Juvenile myelomonocytic leukemia
Kostmann syndrome
Lennox-Gastaut syndrome
Lesch-Nyhan syndrome
Lethal ataxia with deafness and optic atrophy
Male infertility associated with large-headed multiflagellar polyploid spermatozoa
Malignant migrating partial seizures of infancy
Mandibular hypoplasia-deafness-progeroid syndrome
Mandibulofacial dysostosis-microcephaly syndrome
Melanoma and neural system tumor syndrome
Melanoma-pancreatic cancer syndrome
Mendelian susceptibility to mycobacterial diseases due to complete ISG15 deficiency
Mitochondrial trifunctional protein deficiency
Mosaic variegated aneuploidy syndrome
Muir-Torre syndrome
Muscular dystrophy, Selcen type
Myelofibrosis with myeloid metaplasia
Myxofibrosarcoma
Myxoid / round cell liposarcoma
Nakajo-Nishimura syndrome
Neonatal intrahepatic cholestasis due to citrin deficiency
Non-polyposis Turcot syndrome
Noonan syndrome-like disorder with juvenile myelomonocytic leukemia
Oculodentodigital dysplasia
PYCR1-related DeBarsy syndrome
Pallister-Hall syndrome
Partial acquired lipodystrophy
Pediatric systemic lupus erythematosus
Pelizaeus-Merzbacher-like due to AIMP1 mutation
Peripheral primitive neuroectodermal tumor
Phosphoenolpyruvate carboxykinase 1 deficiency
Phosphoribosylpyrophosphate synthetase superactivity
Pilomatrixoma
Pitt-Hopkins syndrome
Polymicrogyria due to TUBB2B mutation
Prader-Willi syndrome due to translocation
Primary hyperoxaluria type 3
Primary sclerosing cholangitis
Progressive sensorineural hearing loss - hypertrophic cardiomyopathy
Pseudohypoaldosteronism type 2E
Recessive hereditary methemoglobinemia type 1
Recessive hereditary methemoglobinemia type 2
Recurrent infections associated with rare immunoglobulin isotypes deficiency
Retinopathy - anemia- central nervous system anomalies
Reynolds syndrome
Rhizomelic chondrodysplasia punctata type 3
Rubinstein-Taybi syndrome due to EP300 haploinsufficiency
SSR4-CDG
Seckel syndrome
Severe early-onset axonal neuropathy due to NEFL deficiency
Sheldon-Hall syndrome
Spinocerebellar ataxia type 2
Spinocerebellar ataxia type 26
Spinocerebellar ataxia type 28
Syndactyly type 3
Syndromic multisystem autoimmune disease due to Itch deficiency
Thiamine-responsive maple syrup urine disease
Thrombocytopenia - absent radius
Trismus - pseudocamptodactyly
Wiskott-Aldrich syndrome
X-linked Charcot-Marie-Tooth disease type 5
X-linked intellectual deficit with marfanoid habitus
X-linked non progressive cerebellar ataxia
X-linked nonsyndromic sensorineural deafness type DFN
Autosomal dominant Charcot-Marie-Tooth disease type 2L
Benign adult familial myoclonic epilepsy
Berardinelli-Seip congenital lipodystrophy
Diffuse cutaneous systemic sclerosis
Heritable pulmonary arterial hypertension
Limited cutaneous systemic sclerosis
Autosomal recessive dopa-responsive dystonia
Acral self-healing collodion baby
Bathing suit ichthyosis
Beckwith-Wiedemann syndrome due to CDKN1C mutation
Cataract-glaucoma
Congenital non-bullous ichthyosiform erythroderma
Familial ocular anterior segment mesenchymal dysgenesis
IMAGe syndrome
Intermittent hydrarthrosis
Lamellar ichthyosis
Self-healing collodion baby
TRAPS syndrome
Arthrogryposis - renal dysfunction - cholestasis
Bifunctional enzyme deficiency
Burkitt lymphoma
Familial prostate cancer
Genetic hyperferritinemia without iron overload
Hereditary breast cancer
Hereditary hyperferritinemia with congenital cataracts
Hereditary site-specific ovarian cancer syndrome
Mitochondrial nonsyndromic sensorineural deafness
Mitochondrial nonsyndromic sensorineural deafness with susceptibility to aminoglycoside exposure
Neuroferritinopathy
Perrault syndrome
Primary peritoneal carcinoma
Transaldolase deficiency
Autosomal dominant Charcot-Marie-Tooth disease type 2A1
Synonym(s):
- Early-onset Parkinson disease
- Familial Parkinson disease
- Hereditary Parkinson disease
- Young-onset Parkinson disease

Classification (Orphanet):
- Rare genetic disease
- Rare neurologic disease

Classification (ICD10):
- Diseases of the nervous system -

Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adulthood
Average age of death: elderly
Type of inheritance: autosomal dominant
External references:
14 OMIM references -
No MeSH references

No signs/symptoms info available.