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Laron syndrome with immunodeficiency
1 OMIM reference -
1 associated gene
95 connected diseases
No signs/symptoms info
Disease Type of connection
Acute promyelocytic leukemia
Juvenile rheumatoid factor-negative polyarthritis
Oligoarticular juvenile arthritis
Juvenile myelomonocytic leukemia
Distal 22q11.2 microdeletion syndrome
Gastrointestinal stromal tumor
Idiopathic hypereosinophilic syndrome
Budd-Chiari syndrome
Essential thrombocythemia
Familial thrombocytosis
Myelofibrosis with myeloid metaplasia
Polycythemia vera
Glucocorticoid resistance
Giant cell glioblastoma
Hyperinsulinism due to INSR deficiency
Insulin-resistance syndrome type A
Rabson-Mendenhall syndrome
Primary familial polycythemia
LEOPARD syndrome
Noonan syndrome
Laron syndrome
Short stature due to partial GHR deficiency
Autosomal recessive primary microcephaly
Seckel syndrome
T-B+ severe combined immunodeficiency due to CD3delta / CD3epsilon / CD3zeta
Acute myeloblastic leukemia with maturation
Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
Acute myeloid leukemia with t(8;21)(q22;q22) translocation
Aleukemic mast cell leukemia
Bullous diffuse cutaneous mastocytosis
Classic mast cell leukemia
Cutaneous mastocytoma
Granulomatosis with polyangiitis
Isolated bone marrow mastocytosis
Lymphoadenopathic mastocytosis with eosinophilia
Nodular urticaria pigmentosa
Plaque-form urticaria pigmentosa
Pseudoxanthomatous diffuse cutaneous mastocytosis
Rubinstein-Taybi syndrome due to EP300 haploinsufficiency
Smouldering systemic mastocytosis
Systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease
Telangiectasia macularis eruptiva perstans
Typical urticaria pigmentosa
Acute myeloid leukemia with t(8;16)(p11;p13) translocation
Antley-Bixler syndrome
Apert syndrome
Autosomal dominant Charcot-Marie-Tooth disease type 2N
Crouzon disease
Cutis gyrata - acanthosis nigricans - craniosynostosis
Extraskeletal myxoid chondrosarcoma
FGFR2-related bent bone dysplasia
Familial scaphocephaly syndrome, McGillivray type
Hereditary motor and sensory neuropathy, Okinawa type
Idiopathic pulmonary fibrosis
Jackson-Weiss syndrome
Kostmann syndrome
Lacrimo-auriculo-dento-digital syndrome
Papillary or follicular thyroid carcinoma
Pfeiffer syndrome type 1
Pfeiffer syndrome type 2
Pfeiffer syndrome type 3
Rubinstein-Taybi syndrome due to 16p13.3 microdeletion
Rubinstein-Taybi syndrome due to CREBBP mutations
Saethre-Chotzen syndrome
Spastic paraplegia-optic atrophy-neuropathy syndrome
T-B+ severe combined immunodeficiency due to JAK3 deficiency
Amyotrophic lateral sclerosis
Chronic mucocutaneous candidiasis
Mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency
Susceptibility to viral and mycobacterial infections
Autosomal dominant hyper-IgE syndrome
Early-onset autosomal dominant Alzheimer disease
Hereditary cerebral hemorrhage with amyloidosis, Arctic type
Hereditary cerebral hemorrhage with amyloidosis, Dutch type
Hereditary cerebral hemorrhage with amyloidosis, Flemish type
Hereditary cerebral hemorrhage with amyloidosis, Iowa type
Hereditary cerebral hemorrhage with amyloidosis, Italian type
Hereditary cerebral hemorrhage with amyloidosis, Piedmont type
Bilateral striopallidodentate calcinosis
Chronic myelomonocytic leukemia
Immunodeficiency due to CD25 deficiency
Infantile myofibromatosis
Mucocutaneous venous malformations
Myeloid neoplasm associated with PDGFRA rearrangement
Myeloid neoplasm associated with PDGFRB rearrangement
Noonan syndrome-like disorder with juvenile myelomonocytic leukemia
Omenn syndrome
Precursor B-cell acute lymphoblastic leukemia
T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency
Unclassified chronic myeloproliferative disease
WHIM syndrome
- Laron-like syndrome
- Short stature due to STAT5b deficiency

Classification (Orphanet):
- Rare endocrine disease
- Rare genetic disease
- Rare immune disease

Classification (ICD10):
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: -
Average age of death: -
Type of inheritance: autosomal recessive
External references:
1 OMIM reference -
No MeSH references

Gene symbol UniProt reference OMIM reference
STAT5B P51692604260
No signs/symptoms info available.