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Hereditary nonpolyposis colon cancer
7 OMIM references -
12 associated genes
288 connected diseases
No signs/symptoms info
Disease Type of connection
Constitutional mismatch repair deficiency syndrome
Non-polyposis Turcot syndrome
Muir-Torre syndrome
Familial pancreatic carcinoma
Familial thoracic aortic aneurysm and aortic dissection
Noonan syndrome
Juvenile myelomonocytic leukemia
Pilocytic astrocytoma
Costello syndrome
Linear nevus sebaceus syndrome
Generalized juvenile polyposis / juvenile polyposis coli
Cowden syndrome
Loeys-Dietz syndrome type 1
CLOVE syndrome
Cardiofaciocutaneous syndrome
Macrodactyly of fingers, unilateral
Megalencephaly-capillary malformation-polymicrogyria syndrome
Segmental progressive overgrowth syndrome with fibroadipose hyperplasia
Hereditary mixed polyposis syndrome
Intestinal epithelial dysplasia
Juvenile polyposis of infancy
Marfan syndrome type 2
Hereditary breast and ovarian cancer syndrome
Fanconi anemia
Familial prostate cancer
Hereditary breast cancer
Hereditary site-specific ovarian cancer syndrome
Seckel syndrome
Burkitt lymphoma
Precursor T-cell acute lymphoblastic leukemia
Cornelia de Lange syndrome
B-cell chronic lymphocytic leukemia
Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome
Late-onset autosomal recessive medullary cystic kidney disease
Primary peritoneal carcinoma
Brachydactyly type A2
Bloom syndrome
Cystic fibrosis
Heritable pulmonary arterial hypertension
Hereditary hemorrhagic telangiectasia
Li-Fraumeni syndrome
Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus
Estrogen resistance syndrome
Severe combined immunodeficiency due to DNA-PKcs deficiency
Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
Giant cell glioblastoma
Precursor B-cell acute lymphoblastic leukemia
Amyotrophic lateral sclerosis
Familial cerebral saccular aneurysm
Autoimmune lymphoproliferative syndrome
Autosomal agammaglobulinemia
SHORT syndrome
Ataxia-telangiectasia variant
Ataxia-telangiectasia-like disorder
Combined cervical dystonia
Mantle cell lymphoma
Nijmegen breakage syndrome
Nijmegen breakage syndrome-like disorder
Brachydactyly type C
Severe X-linked mitochondrial encephalomyopathy
X-linked Charcot-Marie-Tooth disease type 4
Congenital bilateral absence of vas deferens
Familial cylindromatosis
Familial multiple trichoepithelioma
Hereditary chronic pancreatitis
Idiopathic bronchiectasis
Inherited cancer-predisposing syndrome due to biallelic BRCA2 mutations
Male infertility with normal virilization due to meiosis defect
Williams syndrome
Familial gastric cancer
MUTYH-related attenuated familial adenomatous polyposis
X-linked non-syndromic intellectual deficit
Adrenocortical carcinoma
Essential thrombocythemia
Papilloma of choroid plexus
Autosomal dominant nonsyndromic intellectual deficit
Pseudohypoaldosteronism type 2E
Translocation renal cell carcinoma
Acute myeloid leukemia with t(8;16)(p11;p13) translocation
Rubinstein-Taybi syndrome due to 16p13.3 microdeletion
Rubinstein-Taybi syndrome due to CREBBP mutations
Autosomal dominant hypohidrotic ectodermal dysplasia
Fibrodysplasia ossificans progressiva
Autoimmune polyendocrinopathy type 1
Familial congenital mirror movements
Isolated adermatoglyphia
Aicardi-Goutières syndrome
Chilblain lupus
Idiopathic hypereosinophilic syndrome
Early-onset autosomal dominant Alzheimer disease
Hereditary cerebral hemorrhage with amyloidosis, Arctic type
Hereditary cerebral hemorrhage with amyloidosis, Dutch type
Hereditary cerebral hemorrhage with amyloidosis, Flemish type
Hereditary cerebral hemorrhage with amyloidosis, Iowa type
Hereditary cerebral hemorrhage with amyloidosis, Italian type
Hereditary cerebral hemorrhage with amyloidosis, Piedmont type
Aneurysm - osteoarthritis syndrome
LEOPARD syndrome
Multiple keratoacanthoma, Ferguson-Smith type
Phakomatosis pigmentokeratotica
20p12.3 microdeletion syndrome
Camurati-Engelmann disease
14q22q23 microdeletion syndrome
Acromesomelic dysplasia, Grebe type
Acromesomelic dysplasia, Hunter-Thomson type
Angel-shaped phalango-epiphyseal dysplasia
Brachydactyly type A1
Fibular aplasia - complex brachydactyly
Microphthalmia with brain and digit anomalies
Multiple synostoses syndrome
Proximal symphalangism
Severe combined immunodeficiency due to LCK deficiency
Hereditary pheochromocytoma-paraganglioma
Idiopathic pulmonary arterial hypertension
Pulmonary venoocclusive disease
Catecholaminergic polymorphic ventricular tachycardia
Noonan syndrome-like disorder with juvenile myelomonocytic leukemia
Noonan syndrome-like disorder with loose anagen hair
Peters anomaly
Lethal congenital contracture syndrome type 2
Smith-Magenis syndrome
Autosomal dominant limb-girdle muscular dystrophy type 1E
Autosomal dominant nonsyndromic sensorineural deafness type DFNA
Autosomal recessive limb-girdle muscular dystrophy due to desmin deficiency
Baraitser-Winter syndrome
Familial isolated dilated cardiomyopathy
Scapuloperoneal amyotrophy
Nager syndrome
Colobomatous microphthalmia
Dominant hypophosphatemia with nephrolithiasis or osteoporosis
Follicular lymphoma
Hereditary spherocytosis
Intravascular large B-cell lymphoma
Isolated Klippel-Feil syndrome
Leber congenital amaurosis
Xeroderma pigmentosum variant
Desmoid tumor
Familial multiple nevi flammei
Hepatocellular carcinoma, childhood-onset
Pyogenic bacterial infections due to MyD88 deficiency
Sturge-Weber syndrome
Waldenström macroglobulinemia
Anhidrotic ectodermal dysplasia - immunodeficiency - osteopetrosis - lymphedema
Autosomal recessive nonsyndromic intellectual deficit
Blepharophimosis-intellectual deficit syndrome, MKB type
Charcot-Marie-Tooth disease type 4B2
Charcot-Marie-Tooth disease type 4B3
Coffin-Siris syndrome
Developmental delay with autism spectrum disorder and gait instability
Dubowitz syndrome
FG syndrome type 1
Familial amyloidosis, Finnish type
Familial rhabdoid tumor
Glycogen storage disease due to phosphoglycerate kinase 1 deficiency
Hypohidrotic ectodermal dysplasia with immunodeficiency
Incontinentia pigmenti
Isolated ATP synthase deficiency
Partial chromosome Y deletion
Romano-Ward syndrome
Spinocerebellar ataxia type 12
Treacher-Collins syndrome
X-linked intellectual deficit with marfanoid habitus
X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency
Large congenital melanocytic nevus
X-linked dominant chondrodysplasia, Chassaing-Lacombe type
Rubinstein-Taybi syndrome due to EP300 haploinsufficiency
Ear-patella-short stature syndrome
22q11.2 deletion syndrome
46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency
Acrodysostosis with multiple hormone resistance
Acute neonatal citrullinemia type I
Adenine phosphoribosyltransferase deficiency
Adult-onset citrullinemia type I
Atelosteogenesis type I
Atelosteogenesis type III
Autosomal dominant Larsen syndrome
Autosomal dominant hyper-IgE syndrome
Autosomal dominant limb-girdle muscular dystrophy type 1D
Autosomal dominant neovascular inflammatory vitreoretinopathy
Autosomal dominant secondary polycythemia
Berardinelli-Seip congenital lipodystrophy
Boomerang dysplasia
COFS syndrome
Charcot-Marie-Tooth disease type 4D
Chronic granulomatous disease
Cleidocranial dysplasia
Cockayne syndrome type 1
Cockayne syndrome type 2
Complete androgen insensitivity syndrome
Craniolenticulosutural dysplasia
Dedifferentiated liposarcoma
Diffuse cutaneous systemic sclerosis
Distal 22q11.2 microdeletion syndrome
Distal myopathy with posterior leg and anterior hand involvement
Dyskeratosis congenita
Familial hypospadias
Familial melanoma
Familial visceral myopathy
Gastrointestinal stromal tumor
Genetic hyperferritinemia without iron overload
Glycogen storage disease due to aldolase A deficiency
Hereditary hyperferritinemia with congenital cataracts
Hoyeraal-Hreidarsson syndrome
Hyper-IgM syndrome type 3
Idiopathic aplastic anemia
Idiopathic pulmonary fibrosis
Infantile cerebellar-retinal degeneration
Intermittent hydrarthrosis
Isolated NADH-CoQ reductase deficiency
Kennedy disease
Leigh syndrome with leukodystrophy
Lethal acantholytic epidermolysis bullosa
Limited cutaneous systemic sclerosis
Metaphyseal dysplasia - maxillary hypoplasia - brachydacty
Multiple endocrine neoplasia type 1
Muscle filaminopathy
Myeloid neoplasm associated with PDGFRA rearrangement
Naxos disease
Osteogenesis imperfecta type 3
Papillary or follicular thyroid carcinoma
Partial androgen insensitivity syndrome
Proteus syndrome
Proximal spinal muscular atrophy type 1
Proximal spinal muscular atrophy type 2
Proximal spinal muscular atrophy type 3
Proximal spinal muscular atrophy type 4
Recurrent infections associated with rare immunoglobulin isotypes deficiency
Spinocerebellar ataxia type 26
Split hand-split foot malformation
Spondylocarpotarsal synostosis
TRAPS syndrome
Well-differentiated liposarcoma
X-linked central congenital hypothyroidism with late-onset testicular enlargement
Xeroderma pigmentosum complementation group F
Young adult-onset Parkinsonism
Cerebroretinal vasculopathy
HERNS syndrome
Hereditary vascular retinopathy
West syndrome
Xeroderma pigmentosum complementation group A
Acute promyelocytic leukemia
Autosomal recessive systemic lupus erythematosus
Bilateral striopallidodentate calcinosis
Chronic mucocutaneous candidiasis
Chronic myelomonocytic leukemia
Common variable immunodeficiency
Herpetic encephalitis
Infantile myofibromatosis
Mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency
Myeloid neoplasm associated with PDGFRB rearrangement
Myhre syndrome
Susceptibility to viral and mycobacterial infections
Unclassified chronic myeloproliferative disease
Atypical Werner syndrome
Autosomal codominant severe lipodystrophic laminopathy
Autosomal dominant Emery-Dreifuss muscular dystrophy
Autosomal dominant limb-girdle muscular dystrophy type 1B
Autosomal dominant spastic paraplegia type 13
Autosomal recessive Emery-Dreifuss muscular dystrophy
Blackfan-Diamond anemia
Charcot-Marie-Tooth disease type 2B1
Congenital muscular dystrophy due to LMNA mutation
Dilated cardiomyopathy - hypergonadotropic hypogonadism
Extraskeletal Ewing sarcoma
Familial dilated cardiomyopathy with conduction defect due to LMNA mutation
Familial partial lipodystrophy, Dunnigan type
Familial partial lipodystrophy, Köbberling type
Heart-hand syndrome, Slovenian type
Hutchinson-Gilford progeria syndrome
LMNA-related cardiocutaneous progeria syndrome
Laminopathy type Decaudain-Vigouroux
Left ventricular noncompaction
Lethal restrictive dermopathy
Mandibuloacral dysplasia with type A lipodystrophy
Neuralgic amyotrophy
Pelizaeus-Merzbacher-like due to HSPD1 mutation
Progeria-associated arthropathy
- Familial nonpolyposis colon cancer
- Familial nonpolyposis colorectal cancer
- Hereditary nonpolyposis colorectal cancer
- Lynch syndrome

Classification (Orphanet):
(no data available)
Classification (ICD10):
- Neoplasms -

Epidemiological data:
Class of prevalence: unknown
Average age onset: adulthood
Average age of death: -
Type of inheritance: autosomal dominant
External references:
7 OMIM references -
1 MeSH reference: D003123

No signs/symptoms info available.