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Hereditary cerebral hemorrhage with amyloidosis, Piedmont type
1 OMIM reference -
1 associated gene
486 connected diseases
13 signs/symptoms
Disease Type of connection
Early-onset autosomal dominant Alzheimer disease
Hereditary cerebral hemorrhage with amyloidosis, Arctic type
Hereditary cerebral hemorrhage with amyloidosis, Dutch type
Hereditary cerebral hemorrhage with amyloidosis, Flemish type
Hereditary cerebral hemorrhage with amyloidosis, Iowa type
Hereditary cerebral hemorrhage with amyloidosis, Italian type
Familial isolated dilated cardiomyopathy
Young adult-onset Parkinsonism
Isolated NADH-CoQ reductase deficiency
Autosomal dominant nonsyndromic intellectual deficit
Fanconi anemia
Primary ciliary dyskinesia
Retinitis pigmentosa
Behavioral variant of frontotemporal dementia
Progressive non-fluent aphasia
Semantic dementia
Familial thoracic aortic aneurysm and aortic dissection
Amyotrophic lateral sclerosis
Blackfan-Diamond anemia
Familial melanoma
Hereditary persistence of fetal hemoglobin - beta-thalassemia
Leber congenital amaurosis
Leigh syndrome with leukodystrophy
Berardinelli-Seip congenital lipodystrophy
Posterior polar cataract
Early infantile epileptic encephalopathy
Juvenile myelomonocytic leukemia
Noonan syndrome
X-linked diffuse leiomyomatosis - Alport syndrome
Autosomal dominant nonsyndromic sensorineural deafness type DFNA
Acute promyelocytic leukemia
Alport syndrome - intellectual deficit - midface hypoplasia - elliptocytosis
Autosomal dominant centronuclear myopathy
Combined deficiency of factor V and factor VIII
Cree leukoencephalopathy
Dedifferentiated liposarcoma
Ear-patella-short stature syndrome
Ewing sarcoma
Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
Familial prostate cancer
Frontotemporal dementia with motor neuron disease
Hereditary breast and ovarian cancer syndrome
Hereditary nonpolyposis colon cancer
Hereditary persistence of fetal hemoglobin - sickle cell disease
Isolated ATP synthase deficiency
Leigh syndrome with cardiomyopathy
Multiple endocrine neoplasia type 1
Waardenburg syndrome type 2
Well-differentiated liposarcoma
Wolf-Hirschhorn syndrome
X-linked non-syndromic intellectual deficit
Familial porencephaly
HSD10 disease, atypical type
HSD10 disease, infantile type
HSD10 disease, neonatal type
Parkinsonian-pyramidal syndrome
Synpolydactyly type 2
Apolipoprotein A-I deficiency
Familial Alzheimer-like prion disease
Familial renal amyloidosis due to Apolipoprotein AI variant
Fatal familial insomnia
Gerstmann-Straussler-Scheinker syndrome
Huntington disease-like 1
Inherited Creutzfeldt-Jakob disease
Primary systemic amyloidosis
Essential thrombocythemia
Myelofibrosis with myeloid metaplasia
Camurati-Engelmann disease
Cystic fibrosis
CLN10 disease
Fatal infantile hypertonic myofibrillar myopathy
Zonular cataract
Classical progressive supranuclear palsy
Familial amyloidosis, Finnish type
Progressive supranuclear palsy - corticobasal syndrome
Progressive supranuclear palsy - parkinsonism
Progressive supranuclear palsy - progressive non fluent aphasia
Progressive supranuclear palsy - pure akinesia with gait freezing
Alexander disease type I
Alexander disease type II
Autosomal dominant spastic paraplegia type 13
Familial partial lipodystrophy due to AKT2 mutations
Hypoinsulinemic hypoglycemia and body hemihypertrophy
Pelizaeus-Merzbacher-like due to HSPD1 mutation
Peters anomaly
Severe motor and intellectual disabilities-sensorineural deafness-dystonia syndrome
Dehydratase deficiency
17q11 microdeletion syndrome
17q11.2 microduplication syndrome
Leber 'plus' disease
Maternally-inherited Leigh syndrome
Neurofibromatosis type 1 due to NF1mutation or intragenic deletion
Sporadic Leigh syndrome
Watson syndrome
X-linked nonsyndromic sensorineural deafness type DFN
15q13.3 microdeletion syndrome
Neonatal inflammatory skin and bowel disease
Homozygous familial hypercholesterolemia
Chronic myeloid leukemia
Hyperlipidemia type 3
Lipoprotein glomerulopathy
Precursor B-cell acute lymphoblastic leukemia
Precursor T-cell acute lymphoblastic leukemia
Sea-blue histiocytosis
Diffuse cutaneous systemic sclerosis
Heritable pulmonary arterial hypertension
Limited cutaneous systemic sclerosis
Alpha-1-antichymotrypsin deficiency
Autosomal dominant Charcot-Marie-Tooth disease type 2A1
Autosomal dominant Charcot-Marie-Tooth disease type 2E
Baraitser-Winter syndrome
Cerebellar ataxia - hypogonadism
Charcot-Marie-Tooth disease type 1F
Developmental malformations - deafness - dystonia
Early-onset progressive neurodegeneration - blindness - ataxia - spasticity
Familial amyloid polyneuropathy
Hemochromatosis type 4
Severe early-onset axonal neuropathy due to NEFL deficiency
Transthyretin-related familial amyloid cardiomyopathy
Congenital factor XII deficiency
Dyssegmental dysplasia, Silverman-Handmaker type
Hereditary angioedema type 3
Mitochondrial trifunctional protein deficiency
Schwartz-Jampel syndrome
12p12.1 microdeletion syndrome
2q37 microdeletion syndrome
3-hydroxy-3-methylglutaryl-CoA synthase deficiency
3-methylglutaconic aciduria type 3
3-phosphoglycerate dehydrogenase deficiency
Abruzzo-Erickson syndrome
Acrodysostosis with multiple hormone resistance
Acute intermittent porphyria
Acute myeloblastic leukemia with maturation
Acute myeloblastic leukemia without maturation
Acute myelomonocytic leukemia
Acute neonatal citrullinemia type I
Adams-Oliver syndrome
Adenine phosphoribosyltransferase deficiency
Adult-onset autosomal recessive sideroblastic anemia
Adult-onset citrullinemia type I
Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency
Agenesis of the corpus callosum - intellectual deficit - coloboma - micrognathia
Agnathia - holoprosencephaly - situs inversus
Aicardi-Goutières syndrome
Alobar holoprosencephaly
Alpha-N-acetylgalactosaminidase deficiency type 1
Alpha-N-acetylgalactosaminidase deficiency type 2
Alpha-N-acetylgalactosaminidase deficiency type 3
Alveolar soft-part sarcoma
Aneurysm - osteoarthritis syndrome
Angelman syndrome
Antley-Bixler syndrome
Apert syndrome
Arthrogryposis - renal dysfunction - cholestasis
Ataxia with vitamin E deficiency
Atrial septal defect, ostium primum type
Atrial septal defect, ostium secundum type
Atypical Mayer-Rokitansky-Küster-Hauser syndrome
Atypical teratoid tumor
Autism-epilepsy syndrome due to branched chain ketoacid dehydrogenase kinase deficiency
Autoimmune lymphoproliferative syndrome
Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis
Autosomal agammaglobulinemia
Autosomal dominant Charcot-Marie-Tooth disease type 2M
Autosomal dominant hypohidrotic ectodermal dysplasia
Autosomal dominant intermediate Charcot-Marie-Tooth disease type B
Autosomal dominant limb-girdle muscular dystrophy type 1A
Autosomal dominant limb-girdle muscular dystrophy type 1D
Autosomal dominant optic atrophy and cataract
Autosomal dominant optic atrophy plus syndrome
Autosomal dominant optic atrophy, classic type
Autosomal recessive centronuclear myopathy
Autosomal recessive cerebellar ataxia with late-onset spasticity
Autosomal recessive limb-girdle muscular dystrophy type 2C
Autosomal recessive nonsyndromic intellectual deficit
Autosomal recessive nonsyndromic sensorineural deafness type DFNB
Autosomal recessive spastic ataxia with leukoencephalopathy
Autosomal recessive spastic paraplegia type 20
Autosomal recessive spastic paraplegia type 43
Autosomal recessive spastic paraplegia type 46
Autosomal recessive spastic paraplegia type 53
Autosomal recessive spastic paraplegia type 54
Autosomal recessive spastic paraplegia type 55
Autosomal recessive spondylocostal dysostosis
Autosomal recessive systemic lupus erythematosus
Bardet-Biedl syndrome
Becker muscular dystrophy
Beta-propeller protein-associated neurodegeneration
Birt-Hogg-Dube syndrome
Blepharophimosis-intellectual deficit syndrome, MKB type
Bohring-Opitz syndrome
Bothnia retinal dystrophy
Bowen-Conradi syndrome
Brachydactyly type A2
Brachydactyly type C
Brachyolmia type 1, Toledo type
Cabezas syndrome
Capillary malformation - arteriovenous malformation
Cardiofaciocutaneous syndrome
Cerebellar ataxia, Cayman type
Charcot-Marie-Tooth disease type 4G
Chilblain lupus
Chuvash erythrocytosis
Clear cell renal carcinoma
Coats disease
Coffin-Siris syndrome
Combined immunodeficiency due to ZAP70 deficiency
Combined oxidative phosphorylation defect type 15
Combined oxidative phosphorylation defect type 7
Combined oxidative phosphorylation defect type 9
Combined pituitary hormone deficiencies, genetic forms
Common variable immunodeficiency
Cone rod dystrophy
Congenital analbuminemia
Congenital mesoblastic nephroma
Congenital non-communicating hydrocephalus
Congenital sodium diarrhea
Costello syndrome
Cowden syndrome
Crouzon disease
Cutis gyrata - acanthosis nigricans - craniosynostosis
Desmoid tumor
Developmental and speech delay due to SOX5 deficiency
Diffuse panbronchiolitis
Dilated cardiomyopathy with ataxia
Distal monosomy 12p
Distal monosomy 15q
Distal monosomy 3p
Donnai-Barrow syndrome
Duchenne muscular dystrophy
Early-onset spastic ataxia-neuropathy syndrome
Endocrine-cerebro-osteodysplasia syndrome
Erythrocyte galactose epimerase deficiency
Ethylmalonic encephalopathy
Extraskeletal Ewing sarcoma
FG syndrome type 1
FGFR2-related bent bone dysplasia
Familial advanced sleep-phase syndrome
Familial exudative vitreoretinopathy
Familial hemophagocytic lymphohistiocytosis
Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation
Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis
Familial idiopathic steroid-resistant nephrotic syndrome with minimal changes
Familial isolated restrictive cardiomyopathy
Familial lipoprotein lipase deficiency
Familial multiple meningioma
Familial pancreatic carcinoma
Familial partial lipodystrophy associated with PPARG mutations
Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis without severe ocular involvement
Familial rhabdoid tumor
Familial scaphocephaly syndrome, McGillivray type
Familial spontaneous pneumothorax
Familial steroid-resistant nephrotic syndrome with sensorineural deafness
Fatal infantile cytochrome C oxidase deficiency
Fetal akinesia-cerebral and retinal hemorrhage syndrome
Fleck corneal dystrophy
Free sialic acid storage disease, infantile form
Fundus albipunctatus
Galactokinase deficiency
Generalized galactose epimerase deficiency
Geroderma osteodysplastica
Giant cell glioblastoma
Glycogen storage disease due to GLUT2 deficiency
Glycogen storage disease due to muscle and heart glycogen synthase deficiency
Glycogen storage disease due to muscle beta-enolase deficiency
Glycogen storage disease due to phosphoglucomutase deficiency
Griscelli disease type 2
Growth delay due to insulin-like growth factor I resistance
Hamel cerebro-palato-cardiac syndrome
Hemoglobin Lepore - beta-thalassemia
Hemoglobinopathy Toms River
Hemolytic anemia due to adenylate kinase deficiency
Hepatocellular carcinoma, childhood-onset
Hereditary North American Indian childhood cirrhosis
Hereditary fructose intolerance
Hereditary sensory and autonomic neuropathy type 1
Hereditary sensory and autonomic neuropathy type 2
Herpetic encephalitis
Hyper-IgM syndrome type 2
Hyper-IgM syndrome type 5
Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency
Hyperlipoproteinemia type 5
Hyperphosphatasia-intellectual deficiency syndrome
Hyperprolinemia type 2
Hypothalamic insufficiency-secondary microcephaly-visual impairment-urinary anomalies
Idiopathic hypereosinophilic syndrome
Idiopathic pulmonary fibrosis
Immunodeficiency by defective expression of HLA class 1
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
Infantile Bartter syndrome with deafness
Infantile Refsum disease
Infantile autosomal recessive medullary cystic kidney disease
Infantile cerebellar-retinal degeneration
Inflammatory myofibroblastic tumor
Intellectual deficit, X-linked, Siderius type
Intermediate severe Salla disease
Isolated CoQ-cytochrome C reductase deficiency
Isolated Klippel-Feil syndrome
Isolated anophthalmia - microphthalmia
Isolated congenital digital clubbing
Isolated cytochrome C oxidase deficiency
Isolated megalencephaly
Jackson-Weiss syndrome
Junctional epidermolysis bullosa - pyloric atresia
Juvenile autosomal recessive medullary cystic kidney disease
Lacrimo-auriculo-dento-digital syndrome
Laron syndrome with immunodeficiency
Left ventricular noncompaction
Leigh syndrome with nephrotic syndrome
Lennox-Gastaut syndrome
Leukocyte adhesion deficiency type III
Leukonychia totalis
Li-Fraumeni syndrome
Linear nevus sebaceus syndrome
Lissencephaly type 1 due to doublecortin gene mutation
Lobar holoprosencephaly
Loeys-Dietz syndrome type 1
MEGDEL syndrome
MITF-related melanoma and renal cell carcinoma predisposition syndrome
MODY syndrome
Machado-Joseph disease type 1
Machado-Joseph disease type 2
Machado-Joseph disease type 3
Marfan syndrome type 2
McKusick-Kaufman syndrome
Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus
Mesomelia-synostoses syndrome
Methylmalonic acidemia due to methylmalonyl-CoA epimerase deficiency
Micro syndrome
Microcephalic primordial dwarfism, Alazami type
Microcephaly - seizures - developmental delay
Microform holoprosencephaly
Midline interhemispheric variant of holoprosencephaly
Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency
Mosaic variegated aneuploidy syndrome
Mowat-Wilson syndrome due to a point mutation
Mowat-Wilson syndrome due to monosomy 2q22
Mucocutaneous venous malformations
Mucolipidosis type 2
Mucolipidosis type 3
Multiple acyl-CoA dehydrogenation deficiency, mild type
Multiple acyl-CoA dehydrogenation deficiency, severe neonatal type
Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality
Myostatin-related muscle hypertrophy
Myotilin-related myofibrillar myopathy without spheroid body
Nail-patella syndrome
Neonatal adrenoleukodystrophy
Neuralgic amyotrophy
Neurodegeneration with brain iron accumulation due to C19orf12 mutation
Neurofibromatosis type 3
Neurological conditions associated with aminoacylase 1 deficiency
Non-spherocytic hemolytic anemia due to hexokinase deficiency
Noonan syndrome-like disorder with loose anagen hair
Normosmic congenital hypogonadotropic hypogonadism
Norrie disease
Nuclear cataract
Obesity due to pro-opiomelanocortin deficiency
Ocular albinism with congenital sensorineural deafness
Ondine syndrome
Pancreatic insufficiency - anemia - hyperostosis
Papillary or follicular thyroid carcinoma
Papillary renal cell carcinoma
Parkes Weber syndrome
Paroxysmal non-kinesigenic dyskinesia
Pelizaeus-Merzbacher-like due to AIMP1 mutation
Pendred syndrome
Peripheral primitive neuroectodermal tumor
Permanent neonatal diabetes mellitus
Persistent hyperplastic primary vitreous
Peutz-Jeghers syndrome
Pfeiffer syndrome type 1
Pfeiffer syndrome type 2
Pfeiffer syndrome type 3
Phosphoenolpyruvate carboxykinase 1 deficiency
Phosphoenolpyruvate carboxykinase 2 deficiency
Phosphoserine aminotransferase deficiency
Pilocytic astrocytoma
Pontocerebellar hypoplasia type 1
Progressive cone dystrophy
Progressive myoclonic epilepsy type 6
Proteus syndrome
Pseudohypoaldosteronism type 2E
Pulverulent cataract
Punctate palmoplantar keratoderma type 1
Pyridoxal phosphate-responsive seizures
Pyridoxine-dependent epilepsy
Rare isolated myopia
Refsum disease
Retinitis punctata albescens
Retinopathy of prematurity
Romano-Ward syndrome
SERKAL syndrome
Saethre-Chotzen syndrome
Salla disease
Schinzel-Giedion syndrome
Semilobar holoprosencephaly
Septo-optic dysplasia
Septopreoptic holoprosencephaly
Severe early-childhood-onset retinal dystrophy
Severe intellectual deficit and progressive spastic paraplegia
Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia
Short stature-delayed bone age due to thyroid hormone metabolism deficiency
Situs ambiguus
Situs inversus totalis
Spheroid body myopathy
Spinocerebellar ataxia type 14
Spinocerebellar ataxia type 23
Spinocerebellar ataxia type 28
Spinocerebellar ataxia with axonal neuropathy type 2
Spondyloepimetaphyseal dysplasia, Pakistani type
Squamous cell carcinoma of head and neck
Subcortical band heterotopia
Sudden infant death - dysgenesis of the testes
Symptomatic form of muscular dystrophy of Duchenne and Becker in female carriers
Syndactyly type 8
Syndromic microphthalmia type 5
Takayasu arteritis
Thiopurine S-methyltransferase deficiency
Thrombocytopenia - absent radius
Tietz syndrome
Total congenital cataract
Transcobalamin deficiency
Translocation renal cell carcinoma
Triose phosphate-isomerase deficiency
Von Hippel-Lindau disease
WAGR syndrome
Williams syndrome
Wolfram syndrome
X-linked Charcot-Marie-Tooth disease type 1
X-linked Charcot-Marie-Tooth disease type 6
X-linked agammaglobulinemia
X-linked cleft palate and ankyloglossia
X-linked dominant chondrodysplasia punctata
X-linked intellectual deficit with marfanoid habitus
X-linked intellectual deficit, Golabi-Ito-Hall type
X-linked intellectual deficit, Porteous type
X-linked intellectual deficit, Sutherland-Haan type
X-linked osteoporosis with fractures
X-linked progressive cerebellar ataxia
X-linked sideroblastic anemia - ataxia
Xeroderma pigmentosum variant
Zellweger syndrome
Autoimmune lymphoproliferative syndrome with recurrent infections
Autosomal dominant Alport syndrome
Autosomal dominant familial hematuria - retinal arteriolar tortuosity - contractures
Autosomal recessive Alport syndrome
Biliary atresia
Congenital high-molecular-weight kininogen deficiency
Ehlers-Danlos syndrome type 7B
Ehlers-Danlos syndrome, cardiac valvular type
Ehlers-Danlos / osteogenesis imperfecta syndrome
Familial dementia, British type
Familial dementia, Danish type
Familial vascular leukoencephalopathy
Hereditary chronic pancreatitis
High bone mass osteogenesis imperfecta
Osteogenesis imperfecta type 1
Osteogenesis imperfecta type 2
Osteogenesis imperfecta type 3
Osteogenesis imperfecta type 4
Postsynaptic congenital myasthenic syndromes
Walker-Warburg syndrome
X-linked Alport syndrome
Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
Knobloch syndrome
- HCHWA, Piedmont type

Classification (Orphanet):
- Rare genetic disease
- Rare neurologic disease
- Rare systemic or rheumatologic disease

Classification (ICD10):
(no data available)

Epidemiological data:
(no data available)
External references:
1 OMIM reference -
No MeSH references

Gene symbol UniProt reference OMIM reference
APP P05067104760
Very frequent
- Autosomal dominant inheritance
- Intellectual deficit / mental / psychomotor retardation / learning disability
- Intracranial / cerebral / meningeal hemorrhage
- Motor deficit / trouble
- Obnubilation / coma / lethargia / desorientation
- Paresthesia / dysesthesia / hypoesthesia / anesthesia / numbness
- Psychic / psychomotor regression / dementia / intellectual decline
- Sensitive trouble / deficit
- Transient cerebral ischemia / stroke

- Cerebral vascular anomalies
- Facial pain / cephalalgia / migraine
- Psychic / behavioural troubles

- Early death / lethality