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Fibronectin glomerulopathy
2 OMIM references -
1 associated gene
321 connected diseases
10 signs/symptoms
Disease Type of connection
Blackfan-Diamond anemia
Precursor T-cell acute lymphoblastic leukemia
Immunodeficiency due to an early component of complement deficiency
Amyotrophic lateral sclerosis
Autosomal dominant nonsyndromic sensorineural deafness type DFNA
Isolated NADH-CoQ reductase deficiency
Epidermolytic palmoplantar keratoderma
Translocation renal cell carcinoma
Familial afibrinogenemia
Familial dysfibrinogenemia
Familial hypodysfibrinogenemia
Familial hypofibrinogenemia
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
Annular epidermolytic ichthyosis
Epidermolytic ichthyosis
Hypotrichosis simplex
Inflammatory myofibroblastic tumor
Leigh syndrome with leukodystrophy
Familial pancreatic carcinoma
Acute promyelocytic leukemia
Familial isolated dilated cardiomyopathy
Frontotemporal dementia with motor neuron disease
Young adult-onset Parkinsonism
Acute infantile liver failure-multisystemic involvement syndrome
Autosomal agammaglobulinemia
Baraitser-Winter syndrome
Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
Immunodeficiency due to a late component of complements deficiency
Retinitis pigmentosa
Autosomal recessive nonsyndromic sensorineural deafness type DFNB
Autosomal dominant Alport syndrome
Autosomal recessive Alport syndrome
Ehlers-Danlos / osteogenesis imperfecta syndrome
Familial porencephaly
High bone mass osteogenesis imperfecta
Osteogenesis imperfecta type 1
Osteogenesis imperfecta type 2
Osteogenesis imperfecta type 3
Osteogenesis imperfecta type 4
X-linked diffuse leiomyomatosis - Alport syndrome
Chuvash erythrocytosis
Dyssegmental dysplasia, Silverman-Handmaker type
Schwartz-Jampel syndrome
Synpolydactyly type 2
Von Hippel-Lindau disease
Familial amyloidosis, Finnish type
Acral dystrophic epidermolysis bullosa
Centripetalis recessive dystrophic epidermolysis bullosa
Dystrophic epidermolysis bullosa pruriginosa
Dystrophic epidermolysis bullosa, nails only
Epidermolysis bullosa simplex superficialis
Generalized dominant dystrophic epidermolysis bullosa
Granular corneal dystrophy type I
Granular corneal dystrophy type II
Lattice corneal dystrophy type I
Microcystic corneal dystrophy
Pretibial dystrophic epidermolysis bullosa
Recessive dystrophic epidermolysis bullosa inversa
Recessive dystrophic epidermolysis bullosa-generalized other
Reis-Bücklers corneal dystrophy
Severe generalized recessive dystrophic epidermolysis bullosa
Thiel-Behnke corneal dystrophy
Transient bullous dermolysis of the newborn
Congenital atransferrinemia
Diffuse cutaneous systemic sclerosis
Limited cutaneous systemic sclerosis
Autoimmune lymphoproliferative syndrome
Autosomal dominant polycystic kidney disease type 1 with tuberous sclerosis
Congenital factor XIII deficiency
Congenital glaucoma
Familial gestational hyperthyroidism
Familial hyperthyroidism due to mutations in TSH receptor
Hypothyroidism due to TSH receptor mutations
Juvenile glaucoma
Ligneous conjunctivitis
Thyroid hypoplasia
Generalized juvenile polyposis / juvenile polyposis coli
Hereditary hemorrhagic telangiectasia
Myhre syndrome
17p13.3 microduplication syndrome
22q11.2 deletion syndrome
3-phosphoglycerate dehydrogenase deficiency
Acute fatty liver of pregnancy
Acute myeloblastic leukemia with maturation
Acute myeloblastic leukemia without maturation
Acute myelomonocytic leukemia
Apolipoprotein A-I deficiency
Atelosteogenesis type I
Atelosteogenesis type III
Auriculocondylar syndrome
Autosomal dominant Charcot-Marie-Tooth disease type 2B
Autosomal dominant Charcot-Marie-Tooth disease type 2N
Autosomal dominant Larsen syndrome
Autosomal recessive intermediate Charcot-Marie-Tooth disease type B
Autosomal recessive spastic paraplegia type 18
Boomerang dysplasia
Bowen-Conradi syndrome
Burkitt lymphoma
Cap myopathy
Childhood-onset nemaline myopathy
Chronic intestinal pseudoobstruction
Common variable immunodeficiency
Congenital analbuminemia
Congenital dyserythropoietic anemia type II
Congenital fiber-type disproportion myopathy
Congenital reticular ichthyosiform erythroderma
Congenital short bowel syndrome
Congenital valvular dysplasia
D,L-2-hydroxyglutaric aciduria
Distal 17p13.3 microdeletion syndrome
Dowling-Degos disease
Dyskeratosis congenita
Ehlers-Danlos syndrome with periventricular heterotopia
Epidermolysis bullosa simplex with circinate migratory erythema
Epidermolysis bullosa simplex with mottled pigmentation
Epidermolysis bullosa simplex, Dowling-Meara type
Erythrocyte galactose epimerase deficiency
Facioscapulohumeral dystrophy
Familial atrial fibrillation
Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
Familial renal amyloidosis due to Apolipoprotein AI variant
Frontometaphyseal dysplasia
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type
Generalized galactose epimerase deficiency
Giant cell glioblastoma
Glycogen storage disease due to aldolase A deficiency
Glycogen storage disease due to lactate dehydrogenase H-subunit deficiency
Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency
Glycogen storage disease due to phosphoglycerate kinase 1 deficiency
Hereditary cerebral cavernous malformation
Hereditary sensory and autonomic neuropathy with spastic paraplegia
Hyperinsulinism-hyperammonemia syndrome
Ichthyosis hystrix of Curth-Macklin
Intermediate nemaline myopathy
Isolated ATP synthase deficiency
Isolated cytochrome C oxidase deficiency
Juvenile amyotrophic lateral sclerosis
Juvenile primary lateral sclerosis
Keratosis palmoplantaris striata
Leigh syndrome with nephrotic syndrome
Leukocyte adhesion deficiency type III
Localized epidermolysis bullosa simplex
Long chain 3-hydroxyacyl-CoA dehydrogenase deficiency
MELAS syndrome
Mandibulofacial dysostosis-microcephaly syndrome
Maternally-inherited Leigh syndrome
Miller-Dieker syndrome
Mitochondrial trifunctional protein deficiency
Myxoid / round cell liposarcoma
Neuralgic amyotrophy
Osteodysplasty, Melnick-Needles type
Otopalatodigital syndrome type 1
Otopalatodigital syndrome type 2
Papillary or follicular thyroid carcinoma
Periventricular nodular heterotopia
Primary systemic amyloidosis
Pyruvate dehydrogenase E1-beta deficiency
Pyruvate dehydrogenase E3 deficiency
Recessive intellectual disability - motor dysfunction - multiple joint contractures
Spinocerebellar ataxia type 26
Spondylocarpotarsal synostosis
Superficial epidermolytic ichthyosis
Terminal osseous dysplasia - pigmentary defects
Treacher-Collins syndrome
Williams syndrome
X-linked intellectual deficit - cardiomegaly - congestive heart failure
Adenine phosphoribosyltransferase deficiency
Adult-onset autosomal dominant leukodystrophy
Adult-onset distal myopathy due to VCP mutation
Alpha-1-antitrypsin deficiency
Alpha-thalassemia - intellectual deficit syndrome linked to chromosome 16
Atypical Werner syndrome
Atypical hemolytic uremic syndrome with B factor anomaly
Atypical hemolytic uremic syndrome with C3 anomaly
Autosomal codominant severe lipodystrophic laminopathy
Autosomal dominant Charcot-Marie-Tooth disease type 2F
Autosomal dominant Charcot-Marie-Tooth disease type 2M
Autosomal dominant Charcot-Marie-Tooth disease type 2O
Autosomal dominant Emery-Dreifuss muscular dystrophy
Autosomal dominant centronuclear myopathy
Autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures
Autosomal dominant intermediate Charcot-Marie-Tooth disease type B
Autosomal dominant intermediate Charcot-Marie-Tooth disease type C
Autosomal dominant limb-girdle muscular dystrophy type 1B
Autosomal dominant methemoglobinemia
Autosomal dominant nonsyndromic intellectual deficit
Autosomal dominant spastic paraplegia type 13
Autosomal recessive Emery-Dreifuss muscular dystrophy
Autosomal recessive centronuclear myopathy
Autosomal recessive limb-girdle muscular dystrophy type 2D
Autosomal recessive limb-girdle muscular dystrophy type 2J
Autosomal recessive limb-girdle muscular dystrophy type 2Q
B-cell chronic lymphocytic leukemia
Behavioral variant of frontotemporal dementia
Behçet disease
Cerebral sinovenous thrombosis
Charcot-Marie-Tooth disease type 2B1
Combined oxidative phosphorylation defect type 4
Complement component 3 deficiency
Congenital alpha2 antiplasmin deficiency
Congenital factor II deficiency
Congenital isolated thyroxine-binding globulin deficiency
Congenital lactic acidosis, Saguenay-Lac-St. Jean type
Congenital muscular dystrophy due to LMNA mutation
Corticosteroid-binding globulin deficiency
Desmoplastic small round cell tumor
Developmental malformations - deafness - dystonia
Dilated cardiomyopathy - hypergonadotropic hypogonadism
Distal hereditary motor neuropathy type 2
Distal myopathy with posterior leg and anterior hand involvement
Distal myopathy with vocal cord weakness
Distal myopathy, Welander type
Early-onset myopathy with fatal cardiomyopathy
Epidermolysis bullosa simplex with muscular dystrophy
Epidermolysis bullosa simplex with pyloric atresia
Epidermolysis bullosa simplex, Ogna type
Ewing sarcoma
Extraskeletal Ewing sarcoma
Extraskeletal myxoid chondrosarcoma
Familial dilated cardiomyopathy with conduction defect due to LMNA mutation
Familial isolated congenital asplenia
Familial melanoma
Familial partial lipodystrophy, Dunnigan type
Familial partial lipodystrophy, Köbberling type
Familial renal amyloidosis due to fibrinogen A alpha-chain variant
Fetal akinesia-cerebral and retinal hemorrhage syndrome
HSD10 disease, atypical type
HSD10 disease, infantile type
HSD10 disease, neonatal type
Hb Bart's hydrops fetalis
Heart-hand syndrome, Slovenian type
Hemoglobin H disease
Hemorrhagic disease due to alpha-1-antitrypsin Pittsburgh mutation
Hereditary proximal myopathy with early respiratory failure
Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency
Heritable pulmonary arterial hypertension
Hutchinson-Gilford progeria syndrome
Hypomyelination with brain stem and spinal cord involvement and leg spasticity
Joubert syndrome with renal defect
LMNA-related cardiocutaneous progeria syndrome
Laminopathy type Decaudain-Vigouroux
Left ventricular noncompaction
Lethal restrictive dermopathy
Mandibuloacral dysplasia with type A lipodystrophy
Melanoma and neural system tumor syndrome
Melanoma of soft part
Melanoma-pancreatic cancer syndrome
Mosaic variegated aneuploidy syndrome
Muscle filaminopathy
Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality
Pachyonychia congenita
Pelizaeus-Merzbacher-like due to HSPD1 mutation
Precursor B-cell acute lymphoblastic leukemia
Progeria-associated arthropathy
Progressive non-fluent aphasia
Pulverulent cataract
Richieri Costa-Pereira syndrome
Rubinstein-Taybi syndrome due to EP300 haploinsufficiency
Semantic dementia
Severe combined immunodeficiency due to DNA-PKcs deficiency
Spastic paraplegia - Paget disease of bone
Spinocerebellar ataxia type 10
Spinocerebellar ataxia type 7
Systemic-onset juvenile idiopathic arthritis
Tibial muscular dystrophy
Achondrogenesis type 2
Autosomal dominant macrothrombocytopenia
Autosomal dominant rhegmatogenous retinal detachment
Czech dysplasia, metatarsal type
Familial avascular necrosis of femoral head
Fetal and neonatal alloimmune thrombocytopenia
Glanzmann thrombasthenia
Hereditary arterial and articular multiple calcification syndrome
Kniest dysplasia
Legg-Calvé-Perthes disease
Mild spondyloepiphyseal dysplasia due to COL2A1 mutation with early-onset osteoarthritis
Multiple epiphyseal dysplasia, Beighton type
Otospondylomegaepiphyseal dysplasia
Platyspondylic dysplasia, Torrance type
Spondyloepimetaphyseal dysplasia congenita, Strudwick type
Spondyloepiphyseal dysplasia congenita
Spondylometaphyseal dysplasia, 'corner fracture' type
Spondylometaphyseal dysplasia, Schmidt type
Spondyloperipheral dysplasia - short ulna
Stickler syndrome type 1
Autosomal dominant familial hematuria - retinal arteriolar tortuosity - contractures
Bethlem myopathy
Bilateral renal agenesis
CLN10 disease
Caffey disease
Congenital muscular dystrophy, Ullrich type
Congenital nephrotic syndrome-interstitial lung disease-epidermolysis bullosa syndrome
Congenital stromal corneal dystrophy
Dermatofibrosarcoma protuberans
Ehlers-Danlos syndrome type 1
Ehlers-Danlos syndrome type 7A
Ehlers-Danlos syndrome type 7B
Ehlers-Danlos syndrome, cardiac valvular type
Ehlers-Danlos syndrome, vascular-like type
Familial vascular leukoencephalopathy
IRIDA syndrome
Juvenile Paget disease
Metaphyseal anadysplasia
Multiple epiphyseal dysplasia type 1
Walker-Warburg syndrome
X-linked Alport syndrome
X-linked nonsyndromic sensorineural deafness type DFN
- Glomerulopathy with fibronectin deposits

Classification (Orphanet):
- Rare genetic disease
- Rare renal disease

Classification (ICD10):
- Diseases of the genitourinary system -

Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: variable
Average age of death: -
Type of inheritance: autosomal dominant
External references:
2 OMIM references -
No MeSH references

Gene symbol UniProt reference OMIM reference
FN1 P02751135600
Very frequent
- Autosomal dominant inheritance
- Chronic arterial hypertension
- Edema of the legs / lower limbs
- Functional anomalies of the kidney and the urinary tract
- Hematuria / microhematuria
- Nephrotic syndrome
- Proteinuria
- Renal failure
- Renal glomerular defect / glomerulopathy

- Intracranial / cerebral / meningeal hemorrhage