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Dedifferentiated liposarcoma
3 associated genes
393 connected diseases
No signs/symptoms info
Disease Type of connection
Well-differentiated liposarcoma
Familial melanoma
12q14 microdeletion syndrome
Blackfan-Diamond anemia
Amyotrophic lateral sclerosis
Precursor T-cell acute lymphoblastic leukemia
Multiple endocrine neoplasia type 1
Precursor B-cell acute lymphoblastic leukemia
Familial pancreatic carcinoma
Hereditary breast and ovarian cancer syndrome
B-cell chronic lymphocytic leukemia
Acute promyelocytic leukemia
Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
Familial retinoblastoma
Monosomy 13q14
Unilateral retinoblastoma
Papillary or follicular thyroid carcinoma
Young adult-onset Parkinsonism
Familial prostate cancer
Inflammatory myofibroblastic tumor
Familial isolated dilated cardiomyopathy
Cornelia de Lange syndrome
Translocation renal cell carcinoma
Autosomal dominant nonsyndromic sensorineural deafness type DFNA
Li-Fraumeni syndrome
Melanoma and neural system tumor syndrome
Melanoma-pancreatic cancer syndrome
Familial thoracic aortic aneurysm and aortic dissection
Mantle cell lymphoma
Epidermolytic palmoplantar keratoderma
Acute myeloblastic leukemia with maturation
Acute myeloblastic leukemia without maturation
Acute myelomonocytic leukemia
Essential thrombocythemia
Cowden syndrome
Split hand-split foot malformation
Familial advanced sleep-phase syndrome
Annular epidermolytic ichthyosis
Baraitser-Winter syndrome
Epidermolytic ichthyosis
Keratosis palmoplantaris striata
Autosomal dominant progressive external ophthalmoplegia
Geroderma osteodysplastica
Anaplastic ependymoma
Adult-onset distal myopathy due to VCP mutation
Behavioral variant of frontotemporal dementia
Progressive non-fluent aphasia
Semantic dementia
Spastic paraplegia - Paget disease of bone
Autosomal recessive primary microcephaly
Epidermolysis bullosa simplex with mottled pigmentation
Epidermolysis bullosa simplex, Dowling-Meara type
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type
Localized epidermolysis bullosa simplex
Ear-patella-short stature syndrome
Idiopathic pulmonary fibrosis
46,XY partial gonadal dysgenesis
Autosomal dominant macrothrombocytopenia
Cabezas syndrome
Cockayne syndrome type 1
Cockayne syndrome type 2
Cockayne syndrome type 3
Coffin-Siris syndrome
Desmoplastic small round cell tumor
Early-onset progressive neurodegeneration - blindness - ataxia - spasticity
Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis
Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
Frontotemporal dementia with motor neuron disease
Hereditary sensory and autonomic neuropathy with spastic paraplegia
Isolated CoQ-cytochrome C reductase deficiency
Isolated NADH-CoQ reductase deficiency
Left ventricular noncompaction
Leigh syndrome with cardiomyopathy
Leigh syndrome with leukodystrophy
Lethal acantholytic epidermolysis bullosa
Multiple acyl-CoA dehydrogenation deficiency, mild type
Multiple acyl-CoA dehydrogenation deficiency, severe neonatal type
Osteogenesis imperfecta type 3
Perrault syndrome
UV-sensitive syndrome
Aneurysm - osteoarthritis syndrome
Acrodysostosis with multiple hormone resistance
Early-onset autosomal dominant Alzheimer disease
Hereditary cerebral hemorrhage with amyloidosis, Arctic type
Hereditary cerebral hemorrhage with amyloidosis, Dutch type
Hereditary cerebral hemorrhage with amyloidosis, Flemish type
Hereditary cerebral hemorrhage with amyloidosis, Iowa type
Hereditary cerebral hemorrhage with amyloidosis, Italian type
Hereditary cerebral hemorrhage with amyloidosis, Piedmont type
Isolated polycystic liver disease
Multiple myeloma
Adrenocortical carcinoma
Giant cell glioblastoma
Multiple endocrine neoplasia type 4
Papilloma of choroid plexus
Complete androgen insensitivity syndrome
Familial hypospadias
Kennedy disease
Partial androgen insensitivity syndrome
Proteus syndrome
Rubinstein-Taybi syndrome due to EP300 haploinsufficiency
Estrogen resistance syndrome
X-linked dystonia-parkinsonism
Acute myeloid leukemia with CEBPA somatic mutations
Acute myeloid leukemia with t(8;21)(q22;q22) translocation
Autosomal recessive limb-girdle muscular dystrophy type 2G
Growth delay due to insulin-like growth factor I resistance
Inherited acute myeloid leukemia
Hereditary breast cancer
Hereditary site-specific ovarian cancer syndrome
Intellectual deficit, X-linked, Nascimento type
Primary peritoneal carcinoma
Spinocerebellar ataxia type 17
Burkitt lymphoma
Developmental malformations - deafness - dystonia
Ichthyosis hystrix of Curth-Macklin
ADULT syndrome
Ankyloblepharon - ectodermal defects - cleft lip / palate
Bladder exstrophy
Chronic myeloid leukemia
Constitutional megaloblastic anemia with severe neurologic disease
EEC syndrome
Limb-mammary syndrome
Acute myeloid leukemia with t(8;16)(p11;p13) translocation
Familial gastric cancer
Gastric linitis plastica
Rubinstein-Taybi syndrome due to 16p13.3 microdeletion
Rubinstein-Taybi syndrome due to CREBBP mutations
X-linked lymphoproliferative disease
Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
Kearns-Sayre syndrome
Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy
Mitochondrial neurogastrointestinal encephalomyopathy
Catecholaminergic polymorphic ventricular tachycardia
Glucocorticoid resistance
Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality
Nijmegen breakage syndrome
Nijmegen breakage syndrome-like disorder
Retinitis pigmentosa
Autosomal recessive epidermolysis bullosa simplex
Dermatopathia pigmentosa reticularis
Familial amyloidosis, Finnish type
Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency
Naegeli-Franceschetti-Jadassohn syndrome
Agnathia - holoprosencephaly - situs inversus
Combined pituitary hormone deficiencies, genetic forms
Dyskeratosis congenita
Hereditary persistence of fetal hemoglobin - beta-thalassemia
Hoyeraal-Hreidarsson syndrome
Idiopathic aplastic anemia
Isolated anophthalmia - microphthalmia
Microcephalic primordial dwarfism due to ZNF335 deficiency
Septo-optic dysplasia
Syndromic microphthalmia type 5
Alveolar rhabdomyosarcoma
Ataxia-telangiectasia variant
Combined cervical dystonia
Xeroderma pigmentosum complementation group C
Beckwith-Wiedemann syndrome due to CDKN1C mutation
Facial dysmorphism - immunodeficiency - livedo - short stature
Glycogen storage disease due to phosphoglycerate mutase deficiency
IMAGe syndrome
3-phosphoglycerate dehydrogenase deficiency
ALDH18A1-related De Barsy syndrome
Acrokeratosis verruciformis of Hopf
Acute fatty liver of pregnancy
Adult-onset autosomal dominant leukodystrophy
Adult-onset proximal spinal muscular atrophy, autosomal dominant
Alexander disease type I
Alexander disease type II
Ataxia-telangiectasia-like disorder
Atelosteogenesis type I
Atelosteogenesis type III
Atypical Werner syndrome
Autoimmune lymphoproliferative syndrome
Autosomal codominant severe lipodystrophic laminopathy
Autosomal dominant Charcot-Marie-Tooth disease type 2B
Autosomal dominant Charcot-Marie-Tooth disease type 2F
Autosomal dominant Emery-Dreifuss muscular dystrophy
Autosomal dominant Larsen syndrome
Autosomal dominant limb-girdle muscular dystrophy type 1B
Autosomal dominant nonsyndromic intellectual deficit
Autosomal dominant spastic paraplegia type 13
Autosomal recessive Emery-Dreifuss muscular dystrophy
Autosomal recessive cerebellar ataxia - epilepsy - intellectual deficit
Autosomal recessive cutis laxa type 2B
Autosomal recessive intermediate Charcot-Marie-Tooth disease type B
Autosomal recessive limb-girdle muscular dystrophy type 2Q
Autosomal recessive nonsyndromic sensorineural deafness type DFNB
Bifunctional enzyme deficiency
Boomerang dysplasia
CLN1 disease
CLN10 disease
COFS syndrome
Cap myopathy
Cardiofaciocutaneous syndrome
Carney-Stratakis syndrome
Cervical spina bifida aperta
Cervical spina bifida cystica
Cervicothoracic spina bifida aperta
Cervicothoracic spina bifida cystica
Charcot-Marie-Tooth disease type 2B1
Charcot-Marie-Tooth disease type 4G
Childhood-onset nemaline myopathy
Chronic intestinal pseudoobstruction
Cleidocranial dysplasia
Combined oxidative phosphorylation defect type 4
Congenital cataract - hypertrophic cardiomyopathy - mitochondrial myopathy
Congenital fiber-type disproportion myopathy
Congenital lactic acidosis, Saguenay-Lac-St. Jean type
Congenital muscular dystrophy due to LMNA mutation
Congenital reticular ichthyosiform erythroderma
Congenital short bowel syndrome
Congenital valvular dysplasia
D-2-hydroxyglutaric aciduria
Darier disease
Denys-Drash syndrome
Desmoid tumor
Dilated cardiomyopathy - hypergonadotropic hypogonadism
Distal 22q11.2 microdeletion syndrome
Distal hereditary motor neuropathy type 2
Distal myopathy with vocal cord weakness
Dominant hypophosphatemia with nephrolithiasis or osteoporosis
Dowling-Degos disease
Ehlers-Danlos syndrome with periventricular heterotopia
Epidermolysis bullosa simplex with circinate migratory erythema
Epidermolysis bullosa simplex with muscular dystrophy
Epidermolysis bullosa simplex with pyloric atresia
Epidermolysis bullosa simplex, Ogna type
Erythropoietic protoporphyria
Ewing sarcoma
Extraskeletal Ewing sarcoma
Extraskeletal myxoid chondrosarcoma
Familial atrial fibrillation
Familial dilated cardiomyopathy with conduction defect due to LMNA mutation
Familial isolated congenital asplenia
Familial leiomyomatosis
Familial multiple meningioma
Familial partial lipodystrophy, Dunnigan type
Familial partial lipodystrophy, Köbberling type
Familial renal cell carcinoma
Familial rhabdoid tumor
Fraser syndrome
Frasier syndrome
Frontometaphyseal dysplasia
Fumaric aciduria
Gastrointestinal stromal tumor
Glycogen storage disease due to LAMP-2 deficiency
Glycogen storage disease due to aldolase A deficiency
Glycogen storage disease due to phosphoglycerate kinase 1 deficiency
HSD10 disease, atypical type
HSD10 disease, infantile type
HSD10 disease, neonatal type
Heart-hand syndrome, Slovenian type
Hemolytic anemia due to glucophosphate isomerase deficiency
Hepatocellular carcinoma, childhood-onset
Hereditary chronic pancreatitis
Hereditary nonpolyposis colon cancer
Hereditary pheochromocytoma-paraganglioma
Heritable pulmonary arterial hypertension
Hutchinson-Gilford progeria syndrome
Hyperinsulinism due to HNF4A deficiency
Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency
Hyperprolinemia type 2
Hypomyelination with atrophy of basal ganglia and cerebellum
Hypoparathyroidism - deafness - renal disease
Hypotrichosis simplex
Idiopathic central precocious puberty
Immunodeficiency with natural-killer cell deficiency and adrenal insufficiency
Infantile cerebellar-retinal degeneration
Intermediate nemaline myopathy
Intestinal epithelial dysplasia
Isolated 3-methylcrotonyl-CoA carboxylase deficiency
Isolated ATP synthase deficiency
Isolated cytochrome C oxidase deficiency
Jawad syndrome
Juvenile amyotrophic lateral sclerosis
Juvenile myelomonocytic leukemia
Ketoacidosis due to beta-ketothiolase deficiency
Kleefstra syndrome due to 9q34 microdeletion
Kleefstra syndrome due to a point mutation
LMNA-related cardiocutaneous progeria syndrome
Laminopathy type Decaudain-Vigouroux
Large congenital melanocytic nevus
Leigh syndrome with nephrotic syndrome
Lethal congenital contracture syndrome type 2
Lethal restrictive dermopathy
Long chain 3-hydroxyacyl-CoA dehydrogenase deficiency
Lumbosacral spina bifida aperta
Lumbosacral spina bifida cystica
MODY syndrome
Maffucci syndrome
Mandibuloacral dysplasia with type A lipodystrophy
Meacham syndrome
Medium chain acyl-CoA dehydrogenase deficiency
Melanoma of soft part
Metaphyseal dysplasia - maxillary hypoplasia - brachydacty
Mitochondrial trifunctional protein deficiency
Mohr-Tranebjaerg syndrome
Mosaic variegated aneuploidy syndrome
Myelofibrosis with myeloid metaplasia
Myxoid / round cell liposarcoma
Naxos disease
Non-spherocytic hemolytic anemia due to hexokinase deficiency
Noonan syndrome
Oculopharyngeal muscular dystrophy
Osteodysplasty, Melnick-Needles type
Osteogenesis imperfecta type 2
Osteogenesis imperfecta type 4
Otopalatodigital syndrome type 1
Otopalatodigital syndrome type 2
PYCR1-related DeBarsy syndrome
Pachyonychia congenita
Parkinsonian-pyramidal syndrome
Partial chromosome Y deletion
Pelizaeus-Merzbacher-like due to HSPD1 mutation
Periventricular nodular heterotopia
Primary dystonia, DYT4 type
Progeria-associated arthropathy
Pseudohypoaldosteronism type 2E
Pulverulent cataract
Pyogenic bacterial infections due to MyD88 deficiency
Pyruvate carboxylase deficiency, benign type
Pyruvate carboxylase deficiency, infantile type
Pyruvate carboxylase deficiency, severe neonatal type
Pyruvate dehydrogenase E1-beta deficiency
Pyruvate dehydrogenase E2 deficiency
Pyruvate dehydrogenase E3 deficiency
Reticular dysgenesis
Rhizomelic chondrodysplasia punctata type 3
Seckel syndrome
Severe X-linked mitochondrial encephalomyopathy
Severe combined immunodeficiency due to DNA-PKcs deficiency
Skin fragility-woolly hair-palmoplantar keratoderma syndrome
Spinocerebellar ataxia type 26
Spondylocarpotarsal synostosis
Sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis
Succinyl-CoA:3-ketoacid CoA transferase deficiency
Superficial epidermolytic ichthyosis
Syndromic multisystem autoimmune disease due to Itch deficiency
Systemic-onset juvenile idiopathic arthritis
Terminal osseous dysplasia - pigmentary defects
Thoracolumbosacral spina bifida aperta
Thoracolumbosacral spina bifida cystica
Total spina bifida aperta
Total spina bifida cystica
Transaldolase deficiency
Triose phosphate-isomerase deficiency
Upper thoracic spina bifida aperta
Upper thoracic spina bifida cystica
WAGR syndrome
Waardenburg syndrome type 2
Waldenström macroglobulinemia
Williams syndrome
Woolly hair-palmoplantar keratoderma-dilated cardiomyopathy syndrome
X-linked Charcot-Marie-Tooth disease type 4
X-linked distal arthrogryposis multiplex congenita
Xeroderma pigmentosum variant
Acute necrotizing encephalopathy of childhood
Angelman syndrome
Brachydactyly type A2
Brachydactyly type C
Carney complex
Familial acute necrotizing encephalopathy
Familial atrial myxoma
Loeys-Dietz syndrome type 1
Mandibular hypoplasia-deafness-progeroid syndrome
Multiple keratoacanthoma, Ferguson-Smith type
Primary pigmented nodular adrenocortical disease
Acute infantile liver failure-multisystemic involvement syndrome
Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation
Autosomal dominant spastic paraplegia type 10
Beta-propeller protein-associated neurodegeneration
Common variable immunodeficiency
Cystic fibrosis
Prune belly syndrome
Wolf-Hirschhorn syndrome
X-linked non-syndromic intellectual deficit

Classification (Orphanet):
- Rare oncologic disease

Classification (ICD10):
- Neoplasms -

Epidemiological data:
Class of prevalence: unknown
Average age onset: adulthood
Average age of death: adult
Type of inheritance: sporadic
External references:
No OMIM references
No MeSH references

Gene symbol UniProt reference OMIM reference
CDK4 P11802123829
HMGA2 P52926600698
MDM2 Q00987164785
No signs/symptoms info available.