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B-cell chronic lymphocytic leukemia
6 OMIM references -
7 associated genes
437 connected diseases
No signs/symptoms info
Disease Type of connection
Mantle cell lymphoma
Familial pancreatic carcinoma
Precursor B-cell acute lymphoblastic leukemia
Giant cell glioblastoma
Gliosarcoma
Li-Fraumeni syndrome
Adrenocortical carcinoma
Ataxia-telangiectasia
Ataxia-telangiectasia variant
Combined cervical dystonia
Essential thrombocythemia
Papilloma of choroid plexus
Multiple myeloma
Hereditary breast and ovarian cancer syndrome
Blackfan-Diamond anemia
Precursor T-cell acute lymphoblastic leukemia
Familial prostate cancer
Multiple endocrine neoplasia type 1
Amyotrophic lateral sclerosis
Hereditary breast cancer
Hereditary site-specific ovarian cancer syndrome
Familial isolated dilated cardiomyopathy
Young adult-onset Parkinsonism
Familial melanoma
Dedifferentiated liposarcoma
Well-differentiated liposarcoma
Fanconi anemia
Coffin-Siris syndrome
Seckel syndrome
3M syndrome
Chronic myeloid leukemia
Constitutional mismatch repair deficiency syndrome
Hereditary nonpolyposis colon cancer
Muir-Torre syndrome
Non-polyposis Turcot syndrome
Primary peritoneal carcinoma
Hypohidrotic ectodermal dysplasia with immunodeficiency
Familial rhabdoid tumor
Acute promyelocytic leukemia
46,XY partial gonadal dysgenesis
Split hand-split foot malformation
Melanoma of soft part
Peripheral resistance to thyroid hormones
Cornelia de Lange syndrome
Distal 22q11.2 microdeletion syndrome
Autosomal dominant progressive external ophthalmoplegia
Retinitis pigmentosa
Acute myeloid leukemia with t(8;16)(p11;p13) translocation
Familial advanced sleep-phase syndrome
17p13.3 microduplication syndrome
Autosomal recessive primary microcephaly
Distal 17p13.3 microdeletion syndrome
Miller-Dieker syndrome
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
Epidermolytic palmoplantar keratoderma
Bloom syndrome
COFS syndrome
Estrogen resistance syndrome
Trichothiodystrophy
Severe combined immunodeficiency due to DNA-PKcs deficiency
X-linked dystonia-parkinsonism
Squamous cell carcinoma of head and neck
Intellectual deficit, X-linked, Turner type
Melanoma and neural system tumor syndrome
Melanoma-pancreatic cancer syndrome
Werner syndrome
Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome
Rubinstein-Taybi syndrome due to EP300 haploinsufficiency
Familial congenital mirror movements
Inherited cancer-predisposing syndrome due to biallelic BRCA2 mutations
Angelman syndrome
Familial retinoblastoma
Generalized resistance to thyroid hormone
Monosomy 13q14
Osteosarcoma
Prader-Willi syndrome due to imprinting mutation
Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
Selective pituitary resistance to thyroid hormone
Unilateral retinoblastoma
Atypical teratoid tumor
Chuvash erythrocytosis
Familial multiple meningioma
Neurofibromatosis type 3
Von Hippel-Lindau disease
Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
Kearns-Sayre syndrome
Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy
Mitochondrial neurogastrointestinal encephalomyopathy
Anhidrotic ectodermal dysplasia - immunodeficiency - osteopetrosis - lymphedema
Incontinentia pigmenti
MODY syndrome
X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency
Cockayne syndrome type 1
Cockayne syndrome type 2
Cockayne syndrome type 3
Complete androgen insensitivity syndrome
Dyskeratosis congenita
Familial hypospadias
Hoyeraal-Hreidarsson syndrome
Kennedy disease
Partial androgen insensitivity syndrome
Rubinstein-Taybi syndrome due to 16p13.3 microdeletion
Rubinstein-Taybi syndrome due to CREBBP mutations
UV-sensitive syndrome
Peutz-Jeghers syndrome
Desmoplastic small round cell tumor
Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis
Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
Familial thoracic aortic aneurysm and aortic dissection
Cerebellar ataxia - hypogonadism
Congenital analbuminemia
Papillary or follicular thyroid carcinoma
Alpha-crystallinopathy
Fatal infantile hypertonic myofibrillar myopathy
Posterior polar cataract
Zonular cataract
Xeroderma pigmentosum complementation group C
Behavioral variant of frontotemporal dementia
Progressive non-fluent aphasia
Semantic dementia
Burkitt lymphoma
Leber congenital amaurosis
Osteogenesis imperfecta type 3
Omenn syndrome
Infantile Refsum disease
Neonatal adrenoleukodystrophy
Oligodontia
Zellweger syndrome
Annular epidermolytic ichthyosis
Baraitser-Winter syndrome
Developmental malformations - deafness - dystonia
Ear-patella-short stature syndrome
Epidermolysis bullosa simplex with mottled pigmentation
Epidermolysis bullosa simplex, Dowling-Meara type
Epidermolytic ichthyosis
Familial cortical myoclonus
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type
Glycogen storage disease due to liver phosphorylase kinase deficiency
Idiopathic aplastic anemia
Localized epidermolysis bullosa simplex
Pachyonychia congenita
Autosomal dominant nonsyndromic intellectual deficit
Common variable immunodeficiency
X-linked hyper-IgM syndrome
Multiple endocrine neoplasia type 4
ADULT syndrome
Ankyloblepharon - ectodermal defects - cleft lip / palate
Bladder exstrophy
EEC syndrome
Limb-mammary syndrome
Acute myeloblastic leukemia with maturation
Acute myeloblastic leukemia without maturation
Acute myelomonocytic leukemia
Branchio-oculo-facial syndrome
Huntington disease
Intellectual deficit, X-linked, Nascimento type
Juvenile Huntington disease
Proximal spinal muscular atrophy type 1
Proximal spinal muscular atrophy type 2
Proximal spinal muscular atrophy type 3
Proximal spinal muscular atrophy type 4
Retinopathy - anemia- central nervous system anomalies
Spinocerebellar ataxia type 17
Autosomal recessive cerebellar ataxia - epilepsy - intellectual deficit
Dystonia 16
Pontocerebellar hypoplasia type 1
Xeroderma pigmentosum complementation group B
Autosomal recessive cutis laxa type 1
Isolated brachycephaly
Isolated scaphocephaly
Lethal arteriopathy syndrome due to FBLN4 deficiency
Neuroblastoma
Nijmegen breakage syndrome
Recurrent infections associated with rare immunoglobulin isotypes deficiency
Saethre-Chotzen syndrome
Spinocerebellar ataxia type 26
Xeroderma pigmentosum complementation group D
Autosomal dominant Charcot-Marie-Tooth disease type 2F
Bannayan-Riley-Ruvalcaba syndrome
Cowden syndrome
Distal hereditary motor neuropathy type 2
Glucocorticoid resistance
Hereditary sensory and autonomic neuropathy with spastic paraplegia
Juvenile polyposis of infancy
Lhermitte-Duclos disease
Macrocephaly-autism syndrome
Proteus syndrome
Proteus-like syndrome
Segmental outgrowth - lipomatosis - arteriovenous malformation - epidermal nevus
Ataxia-telangiectasia-like disorder
Denys-Drash syndrome
Follicular lymphoma
Frasier syndrome
Intravascular large B-cell lymphoma
Meacham syndrome
Nephroblastoma
Sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis
WAGR syndrome
Autosomal dominant hyper-IgE syndrome
Hyperinsulinism due to HNF4A deficiency
Developmental delay with autism spectrum disorder and gait instability
Aneurysm - osteoarthritis syndrome
Lennox-Gastaut syndrome
Spinocerebellar ataxia type 1 with axonal neuropathy
Early-onset progressive neurodegeneration - blindness - ataxia - spasticity
Hypotonia with lactic acidemia and hyperammonemia
Syndromic multisystem autoimmune disease due to Itch deficiency
Ataxia - oculomotor apraxia type 1
Jawad syndrome
Moyamoya disease - short stature - facial dysmorphism - hypergonadotropic hypogonadism
Beckwith-Wiedemann syndrome due to CDKN1C mutation
Constitutional megaloblastic anemia with severe neurologic disease
Hypocalcemic vitamin D-resistant rickets
IMAGe syndrome
Paternal uniparental disomy of chromosome 6
Transient neonatal diabetes mellitus
Adult-onset distal myopathy due to VCP mutation
Autosomal dominant polycystic kidney disease type 1 with tuberous sclerosis
Cerebellar ataxia-deafness-narcolepsy syndrome
Congenital lactic acidosis, Saguenay-Lac-St. Jean type
Keratosis follicularis spinulosa decalvans
Lymphangioleiomyomatosis
Prader-Willi syndrome due to translocation
Purine nucleoside phosphorylase deficiency
Spastic paraplegia - Paget disease of bone
Tuberous sclerosis
Chorioretinopathy, Birdshot type
Endocrine-cerebro-osteodysplasia syndrome
Ethylmalonic encephalopathy
Senior-Loken syndrome
Wilson-Turner syndrome
Autosomal dominant medullary cystic kidney disease with or without hyperuricemia
Severe combined immunodeficiency due to DCLRE1C deficiency
Combined immunodeficiency due to STK4 deficiency
Cabezas syndrome
Desmosterolosis
Hypodontia - dysplasia of nails
Systemic-onset juvenile idiopathic arthritis
1p36 deletion syndrome
22q11.2 deletion syndrome
46,XY complete gonadal dysgenesis
6-pyruvoyl-tetrahydropterin synthase deficiency
Aceruloplasminemia
Adrenomyeloneuropathy
Alpha-thalassemia - X-linked intellectual deficit syndrome
Alpha-thalassemia - myelodysplastic syndrome
Alport syndrome - intellectual deficit - midface hypoplasia - elliptocytosis
Amyotrophic lateral sclerosis-parkinsonism-dementia complex
Apolipoprotein A-I deficiency
Atelosteogenesis type I
Atelosteogenesis type III
Autoimmune lymphoproliferative syndrome
Autoimmune lymphoproliferative syndrome with recurrent infections
Autosomal agammaglobulinemia
Autosomal dominant Larsen syndrome
Autosomal dominant childhood-onset cortical cataract
Autosomal dominant cutis laxa
Autosomal dominant limb-girdle muscular dystrophy type 1D
Autosomal dominant severe congenital neutropenia
Autosomal dominant spastic paraplegia type 13
Autosomal recessive centronuclear myopathy
Autosomal recessive epidermolysis bullosa simplex
Autosomal recessive limb-girdle muscular dystrophy type 2J
Autosomal recessive limb-girdle muscular dystrophy type 2S
Autosomal recessive spastic paraplegia type 45
Autosomal recessive systemic lupus erythematosus
Baller-Gerold syndrome
Boomerang dysplasia
Budd-Chiari syndrome
CADDS
CLN11 disease
Carpenter-Waziri syndrome
Cerebral sinovenous thrombosis
Chudley-Lowry-Hoar syndrome
Cleidocranial dysplasia
Cone rod dystrophy
Congenital atransferrinemia
Congenital communicating hydrocephalus
Congenital factor V deficiency
Congenital fibrosis of extraocular muscles
Congenital reticular ichthyosiform erythroderma
Connective tissue disorder due to lysyl hydroxylase-3 deficiency
Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation
Costello syndrome
Cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies
Dermatopathia pigmentosa reticularis
Disseminated superficial actinic porokeratosis
Dowling-Degos disease
Duchenne muscular dystrophy
Early-onset myopathy with fatal cardiomyopathy
East Texas bleeding disorder
Epidermolysis bullosa simplex with circinate migratory erythema
Ewing sarcoma
Extraskeletal Ewing sarcoma
Extraskeletal myxoid chondrosarcoma
FTH1-related iron overload
Familial afibrinogenemia
Familial amyloid polyneuropathy
Familial dysfibrinogenemia
Familial hypodysfibrinogenemia
Familial hypofibrinogenemia
Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
Familial isolated congenital asplenia
Familial lipoprotein lipase deficiency
Familial renal amyloidosis due to Apolipoprotein AI variant
Familial renal amyloidosis due to fibrinogen A alpha-chain variant
Fatal infantile cytochrome C oxidase deficiency
Fibronectin glomerulopathy
Fructose-1,6-bisphosphatase deficiency
GCS1-CDG
Glycogen storage disease due to lactate dehydrogenase H-subunit deficiency
Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency
Glycogen storage disease due to liver and muscle phosphorylase kinase deficiency
Glycogen storage disease due to phosphoglucomutase deficiency
Growth delay due to insulin-like growth factor I resistance
Guanidinoacetate methyltransferase deficiency
Hartsfield-Bixler-Demyer syndrome
Hereditary cerebral cavernous malformation
Hereditary proximal myopathy with early respiratory failure
Holmes-Gang syndrome
Holocarboxylase synthetase deficiency
Hyperimmunoglobulinemia D with periodic fever
Hyperlipoproteinemia type 5
Hypermethioninemia due to glycine N-methyltransferase deficiency
Hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome
Hypotrichosis simplex
Ichthyosis hystrix of Curth-Macklin
Idiopathic pulmonary fibrosis
Infantile onset spinocerebellar ataxia
Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression
Intellectual disability-hyperkinetic movement-truncal ataxia syndrome
Isolated ATP synthase deficiency
Isolated trigonocephaly
Juberg-Marsidi syndrome
Kallmann syndrome
Keratosis palmoplantaris striata
LIG4 syndrome
Leigh syndrome with cardiomyopathy
Linear nevus sebaceus syndrome
Lissencephaly due to TUBA1A mutation
Lissencephaly type 1 due to doublecortin gene mutation
Metaphyseal dysplasia - maxillary hypoplasia - brachydacty
Mevalonic aciduria
Mitochondrial DNA depletion syndrome, hepatocerebrorenal form
Moyamoya disease
Muscular dystrophy, Selcen type
Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality
Myeloid neoplasm associated with FGFR1 rearrangement
Naegeli-Franceschetti-Jadassohn syndrome
Neurological conditions associated with aminoacylase 1 deficiency
Normosmic congenital hypogonadotropic hypogonadism
Occipital pachygyria and polymicrogyria
Osteoglophonic dwarfism
PGM-CDG
Partial chromosome Y deletion
Pelizaeus-Merzbacher-like due to HSPD1 mutation
Persistent polyclonal B-cell lymphocytosis
Peters anomaly
Pfeiffer syndrome type 1
Phakomatosis pigmentokeratotica
Piebaldism
Pilocytic astrocytoma
Pontocerebellar hypoplasia type 9
Primary systemic amyloidosis
Psychomotor retardation due to S-adenosylhomocysteine hydrolase deficiency
RAPADILINO syndrome
Rare isolated myopia
Renal tubular dysgenesis of genetic origin
Rothmund-Thomson syndrome type 2
Schimke immuno-osseous dysplasia
Sensory ataxic neuropathy - dysarthria - ophthalmoparesis
Septo-optic dysplasia
Severe combined immunodeficiency due to CARD11 deficiency
Severe combined immunodeficiency due to CORO1A deficiency
Severe intellectual disability-short stature-behavioral troubles-facial dysmorphism syndrome
Shprintzen-Goldberg syndrome
Shwachman-Diamond syndrome
Smith-Fineman-Myers syndrome
Solitary fibrous tumor
Spinocerebellar ataxia type 18
Spondylocarpotarsal synostosis
Sterile multifocal osteomyelitis with periostitis and pustulosis
Subcortical band heterotopia
Supravalvular aortic stenosis
Tibial muscular dystrophy
Translocation renal cell carcinoma
Transthyretin-related familial amyloid cardiomyopathy
Triose phosphate-isomerase deficiency
Waardenburg syndrome type 2
Williams syndrome
X-linked cerebral adrenoleukodystrophy
X-linked dominant chondrodysplasia, Chassaing-Lacombe type
X-linked non-syndromic intellectual deficit
Craniopharyngioma
Desmoid tumor
Hepatocellular carcinoma, childhood-onset
Kleefstra syndrome due to 9q34 microdeletion
Kleefstra syndrome due to a point mutation
Pilomatrixoma
Autosomal dominant hypohidrotic ectodermal dysplasia
Familial isolated hyperparathyroidism
Familial parathyroid adenoma
Focal facial dermal dysplasia
Romano-Ward syndrome
Zollinger-Ellison syndrome
Nijmegen breakage syndrome-like disorder
Xeroderma pigmentosum complementation group A
17q21.31 microdeletion syndrome
Acute myeloid leukemia with t(8;21)(q22;q22) translocation
Acute necrotizing encephalopathy of childhood
Aicardi-Goutières syndrome
Anaplastic ependymoma
Catecholaminergic polymorphic ventricular tachycardia
Cerebroretinal vasculopathy
Chilblain lupus
Childhood-onset nemaline myopathy
Congenital fiber-type disproportion myopathy
Congenital myopathy with excess of thin filaments
Familial acute necrotizing encephalopathy
Familial platelet syndrome with predisposition to acute myelogenous leukemia
HERNS syndrome
Hereditary vascular retinopathy
Inflammatory myofibroblastic tumor
Intermediate nemaline myopathy
Isolated delta-storage pool disease
Koolen-De Vries syndrome due to a point mutation
Premature chromosome condensation with microcephaly and intellectual deficit
Pseudohypoaldosteronism type 2E
Severe congenital nemaline myopathy
Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia
Spinocerebellar ataxia type 12
Typical nemaline myopathy
X-linked agammaglobulinemia
Synonym(s):
- B-CLL
- B-cell chronic lymphoid leukemia
- Lymphoplasmacytic leukemia
- Lymphoplasmacytoid immunocytoma
- Small lymphocytic lymphoma

Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease

Classification (ICD10):
- Neoplasms -

Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adulthood
Average age of death: -
Type of inheritance: sporadic
External references:
6 OMIM references -
1 MeSH reference: D015451

No signs/symptoms info available.