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2 OMIM references -
1 associated gene
44 signs/symptoms
PROTEIN INTERACTIONS: 1
1 OMIM reference -
1 associated gene
14 signs/symptoms
Waldenström macroglobulinemia
Combined immunodeficiency due to DOCK8 deficiency

MYD88 DOCK8


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
MYD88
(0.72)
DOCK8



Citations in the biomedical literature:


Waldenström macroglobulinemia
MYD88
Combined immunodeficiency due to DOCK8 deficiency
DOCK8



Waldenström macroglobulinemia
Combined immunodeficiency due to DOCK8 deficiency

Synonym(s):
- Lymphoplasmacytic immunocytoma
- Lymphoplasmacytic lymphoma

Synonym(s):
- CID due to DOCK8 deficiency
- Combined immunodeficiency due to dedicator of cytokinesis 8 protein deficiency
- DOCK8 immunodeficiency syndrome

Classification (Orphanet):
- Rare hematologic disease
- Rare neurologic disease
- Rare oncologic disease
Classification (Orphanet):
- Rare genetic disease
- Rare immune disease

Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

Epidemiological data:
Class of prevalence: unknown
Average age onset: adulthood
Average age of death: elderly
Type of inheritance: multigenic/multifactorial
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: neonatal/infancy
Average age of death: child / adolescent
Type of inheritance: autosomal recessive

External references:
2 OMIM references -
1 MeSH reference: D008258
External references:
1 OMIM reference -
No MeSH references

Waldenström macroglobulinemia
Combined immunodeficiency due to DOCK8 deficiency

Very frequent
- Bone marrow / medullar infiltration
- Hematologic / blood / lymphatic cancer
- Monoclonal immunoglobulins / gammapathy / dysglobulinemia
- Myeloproliferative syndrome / chronic leukemia

Frequent
- Blood hyperviscosity / hypercoagulability
- Dizziness
- Gingivorrhagia / gingival bleeding
- Normocytic anemia
- Pallor
- Polynuclear cells / neutrophils anomalies / neutropenia
- Respiratory distress / dyspnea / respiratory failure / lung volume reduction

Occasional
- Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax
- Anorexia
- Asthenia / fatigue / weakness
- Ataxia / incoordination / trouble of the equilibrium
- Biological inflammatory syndrome / increased erythrocyte sedimentation rate / CRP
- Cranial nerves palsy
- Cryoglobulinemia
- Cutis marmorata / marbled skin / livedo
- Edema of the legs / lower limbs
- Epistaxis / nose bleeding
- Facial pain / cephalalgia / migraine
- Fever / chilling
- Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia
- Hearing loss / hypoacusia / deafness
- Heart / cardiac failure
- Hepatomegaly / liver enlargement (excluding storage disease)
- Immunodeficiency / increased susceptibility to infections / recurrent infections
- Lung / pulmonary infiltrates
- Lymphadenopathy / polyadenopathies
- Malabsorption / chronic diarrhea / steatorrhea
- Motor deficit / trouble
- Obnubilation / coma / lethargia / desorientation
- Palpebral edema / periorbital edema
- Peripheral neuropathy
- Proptosis / exophthalmos
- Purpura / petichiae
- Renal failure
- Retinal vascular anomalies / retinal telangiectasia
- Splenomegaly
- Transient cerebral ischemia / stroke
- Troubles of memory / amnesia / hypermnesia
- Urticaria
- Vascularitis / vasculitides / arteritis


Very frequent
- Agammaglobulinemia / hypogammaglobulinemia / B-cell deficiency
- Asthma / bronchospasm
- Autosomal recessive inheritance
- Chronic skin infection / ulcerations / ulcers / cancrum
- Chronic / relapsing otitis
- Eczema
- Ground-glass / reticular / alveolar / interstitial lung / pulmonary opacity
- Nasal congestion / sinusitis / rhinitis / rhinorrhea
- Repeat respiratory infections
- Severe allergic reaction / atopy
- T-cell deficiency / cellular immunity deficiency
- Warts / papillomas

Occasional
- Neoplasms / tumors
- Skin / cutaneous neoplasm / tumor / carcinoma / cancer (excluding melanoma)