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1 OMIM reference -
1 associated gene
No signs/symptoms info
PROTEIN INTERACTIONS: 1
1 OMIM reference -
4 associated genes
14 signs/symptoms
Rubinstein-Taybi syndrome due to CREBBP mutations
Follicular lymphoma

CREBBP BCL2
BCL6
HLA-DRB1
IGH


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
CREBBP
(0.52)
BCL6



Citations in the biomedical literature:


Rubinstein-Taybi syndrome due to CREBBP mutations
CREBBP
Follicular lymphoma
BCL2 BCL6 HLA-DRB1 IGH



Rubinstein-Taybi syndrome due to CREBBP mutations
Follicular lymphoma

Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare endocrine disease
- Rare eye disease
- Rare genetic disease
- Rare neurologic disease
- Rare oncologic disease
- Rare renal disease
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease

Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Classification (ICD10):
- Neoplasms -

Epidemiological data:
(no data available)
Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adulthood
Average age of death: adult
Type of inheritance: multigenic/multifactorial

External references:
1 OMIM reference -
No MeSH references
External references:
1 OMIM reference -
1 MeSH reference: D008224

Follicular lymphoma

Very frequent
- Fever / chilling
- Hematologic / blood / lymphatic cancer
- Hyperhidrosis / increased sweating
- Lymphadenopathy / polyadenopathies
- Weight loss / loss of appetite / break in weight curve / general health alteration

Frequent
- Asthenia / fatigue / weakness
- Mediastinal / hilar adenopathies
- Splenomegaly

Occasional
- Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax
- Anomalies of skin, subcutaneous tissue and mucosae
- Bone marrow / medullar infiltration
- Lymphedema
- Meningitis / meningeal syndrome
- Structural anomaly of the peritoneum


Rubinstein-Taybi syndrome due to CREBBP mutations

(no data available)