Cytoscape Web
Click node...


70 OMIM references -
63 associated genes
29 signs/symptoms
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 8
1 OMIM reference -
1 associated gene
43 signs/symptoms
Retinitis pigmentosa
Von Hippel-Lindau disease

ABCA4 VHL
AIPL1
ARL2BP
ARL6
BEST1
C2ORF71
C8ORF37
CA4
CDHR1
CERKL
CLRN1
CNGA1
CNGB1
CRB1
CRX
CYP4V2
DHDDS
EYS
FAM161A
FSCN2
GUCA1B
IDH3B
IMPDH1
IMPG2
KLHL7
LRAT
MAK
MERTK
NEK2
NR2E3
NRL
OFD1
PDE6A
PDE6B
PDE6G
PRCD
PROM1
PRPF3
PRPF31
PRPF6
PRPF8
PRPH2
RBP3
RDH12
RGR
RHO
RLBP1
ROM1
RP1
RP1L1
RP2
RP9
RPE65
RPGR
SAG
SEMA4A
SNRNP200
SPATA7
TOPORS
TTC8
TULP1
USH2A
ZNF513


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
SNRNP200
(0.63)
VHL



Citations in the biomedical literature:


Retinitis pigmentosa
ABCA4 AIPL1 ARL2BP ARL6 BEST1 C2ORF71
C8ORF37 CA4 CDHR1 CERKL CLRN1 CNGA1
CNGB1 CRB1 CRX CYP4V2 DHDDS EYS
FAM161A FSCN2 GUCA1B IDH3B IMPDH1 IMPG2
KLHL7 LRAT MAK MERTK NEK2 NR2E3
NRL OFD1 PDE6A PDE6B PDE6G PRCD
PROM1 PRPF3 PRPF31 PRPF6 PRPF8 PRPH2
RBP3 RDH12 RGR RHO RLBP1 ROM1
RP1 RP1L1 RP2 RP9 RPE65 RPGR
SAG SEMA4A SNRNP200 SPATA7 TOPORS TTC8
TULP1 USH2A ZNF513
Von Hippel-Lindau disease
VHL



Retinitis pigmentosa
Von Hippel-Lindau disease

Synonym(s):
(no synonyms)

Synonym(s):
- Familial cerebelloretinal angiomatosis
- Hippel-Lindau disease
- Lindau disease
- VHL
- Von Hippel-Lindau syndrome

Classification (Orphanet):
- Rare eye disease
- Rare genetic disease
Classification (Orphanet):
- Rare circulatory system disease
- Rare developmental defect during embryogenesis
- Rare endocrine disease
- Rare eye disease
- Rare genetic disease
- Rare neurologic disease
- Rare oncologic disease
- Rare renal disease

Classification (ICD10):
- Diseases of the eye and adnexa -
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -

Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: variable
Average age of death: normal
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: adulthood
Average age of death: elderly
Type of inheritance: autosomal dominant

External references:
70 OMIM references -
1 MeSH reference: D012174
External references:
1 OMIM reference -
1 MeSH reference: D006623


COMMON
SIGNS
- Autosomal dominant inheritance
- Cataract / lens opacification
- Glaucoma
- Mild visual loss / impaired visual acuity
- Nystagmus
- Retinal vascular anomalies / retinal telangiectasia
- Sensorineural deafness / hearing loss
- Visual loss / blindness / amblyopia


Retinitis pigmentosa
Von Hippel-Lindau disease

Very frequent
- Abnormal ERG / electroretinogram / electroretinography
- Abnormal scarring / cheloids / hypertrophic scars
- Anteverted nares / nostrils
- Autosomal recessive inheritance
- Broad nasal root
- Conductive deafness / hearing loss
- Intellectual deficit / mental / psychomotor retardation / learning disability
- Late puberty / hypogonadism / hypogenitalism
- Micropenis / small penis / agenesis
- Night blindness / hemeralopia
- Optic nerve anomaly / optic atrophy / anomaly of the papilla
- Photophobia
- Retinitis pigmentosa / retinal pigmentary changes
- Small / atrophic / hypoplastic testes / monorchism / microorchidism / anorchia
- X-linked recessive inheritance

Frequent
- Generalized obesity
- Hyperinsulinism / hyperinsulinemia
- Keratoconus / keratoglobus
- Ophthalmoplegia / ophthalmoparesis / oculomotor palsy

Occasional
- Hypereflexia
- Insulin-independent / type 2 diabetes


Very frequent
- Arteriovenous malformations / vascular malformations (excluding port-wine stains)
- Cerebellum / cerebellar vermis anomaly / agenesis / hypoplasia
- Cerebral vascular anomalies
- Congenital pancreatic cyst
- Kidney / renal neoplasm / tumor / carcinoma / cancer
- Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia
- Vascular anomalies of skin / mucosae
- Vascular malignancy / tumor
- Visceral angiomatosis (excluding skin)

Frequent
- Abnormal gait
- Ataxia / incoordination / trouble of the equilibrium
- Capillary hemangioma / nevus / naevus flammeus / port-wine stain
- Facial pain / cephalalgia / migraine
- Hemiplegia / diplegia / hemiparesia / limb palsy
- Hydrocephaly
- Motor deficit / trouble
- Multicystic kidney / renal dysplasia
- Nausea / vomiting / regurgitation / merycism / hyperemesis
- Renal / kidney anomalies
- Sensitive trouble / deficit
- Telangiectasiae of the skin

Occasional
- Anomalies of the lymphatic system
- Cardiac rhythm disorder / arrhythmia
- Chronic arterial hypertension
- Cranial hypertension
- Hearing loss / hypoacusia / deafness
- Hyperhidrosis / increased sweating
- Middle ear neoplasm / tumor / carcinoma / cancer
- Neoplasms / tumors
- Neuroendocrine tumor / apudoma / carcinoid
- Pheochromocytoma / paraganglioma
- Polycystic kidneys
- Retinal detachment
- Spermatocele / epididymal / funicular / spermatic / vaginal / albugineal cyst
- Structural anomalies of the pancreas