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4 associated genes
No signs/symptoms info
PROTEIN INTERACTIONS: 1
6 OMIM references -
5 associated genes
9 signs/symptoms
Pediatric systemic lupus erythematosus
Split hand-split foot malformation

IRAK1 BTRC
PTPN22 FBXW4
SPP1 SHFM1
STAT4 TP63
WNT10B


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
IRAK1
(0.63)
BTRC



Citations in the biomedical literature:


Pediatric systemic lupus erythematosus
IRAK1 PTPN22 SPP1 STAT4
Split hand-split foot malformation
BTRC FBXW4 SHFM1 TP63 WNT10B



Pediatric systemic lupus erythematosus
Split hand-split foot malformation

Synonym(s):
- SLE, pediatric onset

Synonym(s):
- Ectrodactyly
- Lobster-claw deformity
- SHFM
- Split hand foot malformation

Classification (Orphanet):
- Rare neurologic disease
- Rare renal disease
- Rare respiratory disease
- Rare systemic or rheumatologic disease
Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare genetic disease

Classification (ICD10):
- Diseases of the musculoskeletal system and connective tissue -
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -

Epidemiological data:
(no data available)
Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: neonatal/infancy
Average age of death: -
Type of inheritance: autosomal dominant

External references:
No OMIM references
No MeSH references
External references:
6 OMIM references -
No MeSH references

Split hand-split foot malformation

Very frequent
- Autosomal dominant inheritance
- Oligodactyly / ectrodactyly of fingers

Frequent
- Syndactyly of fingers / interdigital palm

Occasional
- Aniridia / iris hypoplasia
- Autosomal recessive inheritance
- Hand agenesis / absence
- Sensorineural deafness / hearing loss
- Trident hand / split hand / abnormal median ray
- X-linked recessive inheritance


Pediatric systemic lupus erythematosus

(no data available)