Cytoscape Web
Click node...


1 OMIM reference -
1 associated gene
23 signs/symptoms
COMMON GENES: 1
COMMON SIGNS: 3
6 OMIM references -
10 associated genes
8 signs/symptoms
Odonto-onycho-dermal dysplasia
Oligodontia

WNT10A AXIN2
EDA
EDARADD
FGFR1
IRF6
LTBP3
MSX1
PAX9
TGFA
WNT10A


COMMON
GENES
WNT10A



Citations in the biomedical literature:


Odonto-onycho-dermal dysplasia
WNT10A
Oligodontia
AXIN2 EDA EDARADD FGFR1 IRF6 LTBP3
MSX1 PAX9 TGFA



Odonto-onycho-dermal dysplasia
Oligodontia

Synonym(s):
- OODD

Synonym(s):
- Selective tooth agenesis

Classification (Orphanet):
- Rare developmental defect during embryogenesis
- Rare genetic disease
- Rare odontologic disease
- Rare skin disease
Classification (Orphanet):
- Rare genetic disease
- Rare odontologic disease

Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Classification (ICD10):
- Diseases of the digestive system -

Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: childhood
Average age of death: normal
Type of inheritance: autosomal recessive
Epidemiological data:
Class of prevalence: unknown
Average age onset: childhood
Average age of death: normal
Type of inheritance: autosomal dominant

External references:
1 OMIM reference -
1 MeSH reference: C537742
External references:
6 OMIM references -
No MeSH references


COMMON
SIGNS
- Anodontia / oligodontia / hypodontia
- Autosomal recessive inheritance
- Tooth shape anomaly


Odonto-onycho-dermal dysplasia
Oligodontia

Very frequent
- Abnormal hair texture / hair dysplasia
- Cutaneous rash
- Decreased body hair / axillar / pubic hairlessness
- Dental malocclusion
- Dysplastic / thick / grooved fingernails
- Dysplastic / thick / grooved toenails
- Erythema / erythematous lesions / erythroderma / polymorphous erythema
- Hyperhidrosis / increased sweating
- Hypotrichosis / atrichia / atrichiasis / scalp hairlessness
- Palmoplantar hyperkeratosis / keratoderma
- Urticaria

Frequent
- Absent / decreased / thin eyebrows
- Acanthosis nigricans
- Anomalies of tongue, gingiva and oral mucosa
- Blepharitis / eyelid inflammation
- Chronic uveitis / blepharitis / episcleritis / scleritis / conjonctivitis / keratitis
- Photophobia
- Skin photosensitivity
- Telangiectasiae of the skin

Occasional
- Skin / cutaneous neoplasm / tumor / carcinoma / cancer (excluding melanoma)


Very frequent
- Complete / partial microdontia
- Face / facial anomalies
- Hypoplastic mandibula / partial absence of the mandibula

Frequent
- Autosomal dominant inheritance
- X-linked recessive inheritance