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5 OMIM references -
4 associated genes
11 signs/symptoms
PROTEIN INTERACTIONS: 2
COMMON SIGNS: 1
6 OMIM references -
5 associated genes
9 signs/symptoms
Nephroblastoma
Split hand-split foot malformation

DIS3L2 BTRC
H19 FBXW4
POU6F2 SHFM1
WT1 TP63
WNT10B


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
H19
WT1
(0.63)
(0.55)
TP63
TP63



Citations in the biomedical literature:


Nephroblastoma
DIS3L2 H19 POU6F2 WT1
Split hand-split foot malformation
BTRC FBXW4 SHFM1 TP63 WNT10B



Nephroblastoma
Split hand-split foot malformation

Synonym(s):
- Renal embryonic tumor
- Wilms tumor

Synonym(s):
- Ectrodactyly
- Lobster-claw deformity
- SHFM
- Split hand foot malformation

Classification (Orphanet):
- Rare genetic disease
Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare genetic disease

Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -

Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: childhood
Average age of death: any age
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: neonatal/infancy
Average age of death: -
Type of inheritance: autosomal dominant

External references:
5 OMIM references -
1 MeSH reference: D009396
External references:
6 OMIM references -
No MeSH references


COMMON
SIGNS
- Aniridia / iris hypoplasia


Nephroblastoma
Split hand-split foot malformation

Very frequent
- Acute abdominal pain / colic
- Kidney / renal neoplasm / tumor / carcinoma / cancer
- Neoplasms / tumors

Occasional
- Chronic arterial hypertension
- Fever / chilling
- Hematuria / microhematuria
- Hepatic / liver neoplasm / tumor / carcinoma / cancer
- Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer
- Lymphadenopathy / polyadenopathies
- Weight loss / loss of appetite / break in weight curve / general health alteration


Very frequent
- Autosomal dominant inheritance
- Oligodactyly / ectrodactyly of fingers

Frequent
- Syndactyly of fingers / interdigital palm

Occasional
- Autosomal recessive inheritance
- Hand agenesis / absence
- Sensorineural deafness / hearing loss
- Trident hand / split hand / abnormal median ray
- X-linked recessive inheritance