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5 OMIM references -
4 associated genes
11 signs/symptoms
PROTEIN INTERACTIONS: 2
COMMON SIGNS: 1
1 OMIM reference -
1 associated gene
10 signs/symptoms
Nephroblastoma
Papilloma of choroid plexus

DIS3L2 TP53
H19
POU6F2
WT1


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
WT1
H19
(0.86)
(0.63)
TP53
TP53



Citations in the biomedical literature:


Nephroblastoma
DIS3L2 H19 POU6F2 WT1
Papilloma of choroid plexus
TP53



Nephroblastoma
Papilloma of choroid plexus

Synonym(s):
- Renal embryonic tumor
- Wilms tumor

Synonym(s):
(no synonyms)

Classification (Orphanet):
- Rare genetic disease
Classification (Orphanet):
- Rare neurologic disease
- Rare oncologic disease

Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Neoplasms -

Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: childhood
Average age of death: any age
Type of inheritance: autosomal dominant
Epidemiological data:
(no data available)

External references:
5 OMIM references -
1 MeSH reference: D009396
External references:
1 OMIM reference -
1 MeSH reference: D020288


COMMON
SIGNS
- Neoplasms / tumors


Nephroblastoma
Papilloma of choroid plexus

Very frequent
- Acute abdominal pain / colic
- Kidney / renal neoplasm / tumor / carcinoma / cancer

Occasional
- Aniridia / iris hypoplasia
- Chronic arterial hypertension
- Fever / chilling
- Hematuria / microhematuria
- Hepatic / liver neoplasm / tumor / carcinoma / cancer
- Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer
- Lymphadenopathy / polyadenopathies
- Weight loss / loss of appetite / break in weight curve / general health alteration


Very frequent
- Autosomal recessive inheritance
- Central nervous system / peripheral nerves neoplasm / tumor / carcinoma / cancer
- Hydrocephaly
- Structural anomalies of the nervous system

Occasional
- Hemiplegia / diplegia / hemiparesia / limb palsy
- Hypertonia / spasticity / rigidity / stiffness
- Intellectual deficit / mental / psychomotor retardation / learning disability
- Mild visual loss / impaired visual acuity
- Seizures / epilepsy / absences / spasms / status epilepticus