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5 OMIM references -
4 associated genes
11 signs/symptoms
PROTEIN INTERACTIONS: 2
3 OMIM references -
5 associated genes
17 signs/symptoms
Nephroblastoma
Essential thrombocythemia

DIS3L2 CALR
H19 JAK2
POU6F2 MPL
WT1 TET2
TP53


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
WT1
H19
(0.86)
(0.63)
TP53
TP53



Citations in the biomedical literature:


Nephroblastoma
DIS3L2 H19 POU6F2 WT1
Essential thrombocythemia
CALR JAK2 MPL TET2 TP53



Nephroblastoma
Essential thrombocythemia

Synonym(s):
- Renal embryonic tumor
- Wilms tumor

Synonym(s):
- ET
- Essential thrombocytosis

Classification (Orphanet):
- Rare genetic disease
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease

Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Neoplasms -

Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: childhood
Average age of death: any age
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adulthood
Average age of death: normal
Type of inheritance: sporadic

External references:
5 OMIM references -
1 MeSH reference: D009396
External references:
3 OMIM references -
1 MeSH reference: D013920

Nephroblastoma
Essential thrombocythemia

Very frequent
- Acute abdominal pain / colic
- Kidney / renal neoplasm / tumor / carcinoma / cancer
- Neoplasms / tumors

Occasional
- Aniridia / iris hypoplasia
- Chronic arterial hypertension
- Fever / chilling
- Hematuria / microhematuria
- Hepatic / liver neoplasm / tumor / carcinoma / cancer
- Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer
- Lymphadenopathy / polyadenopathies
- Weight loss / loss of appetite / break in weight curve / general health alteration


Very frequent
- Acute ischemic syndrome
- Angor pectoris / myocardial infarction
- Arterial embolism / thrombosis
- Bone marrow anomalies
- Cerebral vascular anomalies
- Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding
- Paresthesia / dysesthesia / hypoesthesia / anesthesia / numbness
- Platelet disorders / thrombopathies
- Platelets shape anomalies
- Thoracic / chest pain
- Transient amaurosis / acute visual trouble
- Transient cerebral ischemia / stroke
- Venous thrombosis / phlebitis / thrombophlebitis

Frequent
- Splenomegaly

Occasional
- Acute leukemia
- Myelodysplastic syndrome
- Myeloproliferative syndrome / chronic leukemia