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1 OMIM reference -
5 associated genes
13 signs/symptoms
PROTEIN INTERACTIONS: 1
7 OMIM references -
12 associated genes
No signs/symptoms info
Multiple endocrine neoplasia type 1
Hereditary nonpolyposis colon cancer

CDKN1A BMPR1A
CDKN1B EPCAM
CDKN2B KRAS
CDKN2C LRRFIP2
MEN1 MLH1
MLH3
MSH2
MSH6
PIK3CA
PMS1
PMS2
TGFBR2


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
CDKN1A
(0.63)
MSH2



Citations in the biomedical literature:


Multiple endocrine neoplasia type 1
CDKN1A CDKN1B CDKN2B CDKN2C MEN1
Hereditary nonpolyposis colon cancer
BMPR1A EPCAM KRAS LRRFIP2 MLH1 MLH3
MSH2 MSH6 PIK3CA PMS1 PMS2 TGFBR2



Multiple endocrine neoplasia type 1
Hereditary nonpolyposis colon cancer

Synonym(s):
- MEN 1
- Wermer syndrome

Synonym(s):
- Familial nonpolyposis colon cancer
- Familial nonpolyposis colorectal cancer
- HNPCC
- Hereditary nonpolyposis colorectal cancer
- Lynch syndrome

Classification (Orphanet):
- Rare endocrine disease
- Rare gastroenterologic disease
- Rare genetic disease
- Rare oncologic disease
Classification (Orphanet):
(no data available)

Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Neoplasms -

Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: variable
Average age of death: adult
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: unknown
Average age onset: adulthood
Average age of death: -
Type of inheritance: autosomal dominant

External references:
1 OMIM reference -
1 MeSH reference: D018761
External references:
7 OMIM references -
1 MeSH reference: D003123

Multiple endocrine neoplasia type 1

Very frequent
- Anomalies of the endocrine glands
- Anomaly of pancreatic hormones
- Autosomal dominant inheritance
- Hypercalcemia
- Hyperparathyroidy
- Hypothalamic-hypophyseal axis anomalies / hypothalamus / pituitary anomalies
- Neoplasms / tumors
- Parathyroids anomalies
- Structural anomalies of the pancreas

Frequent
- Cortico-adrenal hyperplasia / hypersecretion
- Epigastralgia / heartburn / gastric / duodenal ulcer / gastritis
- Thyroid anomalies
- Xanthomas / lipomas



Hereditary nonpolyposis colon cancer

(no data available)