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1 OMIM reference -
5 associated genes
13 signs/symptoms
PROTEIN INTERACTIONS: 1
11 OMIM references -
12 associated genes
No signs/symptoms info
Multiple endocrine neoplasia type 1
Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis

CDKN1A ACTN4
CDKN1B ADCK4
CDKN2B ARHGAP24
CDKN2C CD2AP
MEN1 INF2
MYO1E
NPHS1
NPHS2
PLCE1
PTPRO
TRPC6
WT1


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
MEN1
(0.63)
WT1



Citations in the biomedical literature:


Multiple endocrine neoplasia type 1
CDKN1A CDKN1B CDKN2B CDKN2C MEN1
Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
ACTN4 ADCK4 ARHGAP24 CD2AP INF2 MYO1E
NPHS1 NPHS2 PLCE1 PTPRO TRPC6 WT1



Multiple endocrine neoplasia type 1
Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis

Synonym(s):
- MEN 1
- Wermer syndrome

Synonym(s):
- Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental glomerulosclerosis

Classification (Orphanet):
- Rare endocrine disease
- Rare gastroenterologic disease
- Rare genetic disease
- Rare oncologic disease
Classification (Orphanet):
- Rare genetic disease
- Rare renal disease

Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Diseases of the genitourinary system -

Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: variable
Average age of death: adult
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: -
Average age onset: -
Average age of death: -
Type of inheritance: autosomal dominant

External references:
1 OMIM reference -
1 MeSH reference: D018761
External references:
11 OMIM references -
No MeSH references

Multiple endocrine neoplasia type 1

Very frequent
- Anomalies of the endocrine glands
- Anomaly of pancreatic hormones
- Autosomal dominant inheritance
- Hypercalcemia
- Hyperparathyroidy
- Hypothalamic-hypophyseal axis anomalies / hypothalamus / pituitary anomalies
- Neoplasms / tumors
- Parathyroids anomalies
- Structural anomalies of the pancreas

Frequent
- Cortico-adrenal hyperplasia / hypersecretion
- Epigastralgia / heartburn / gastric / duodenal ulcer / gastritis
- Thyroid anomalies
- Xanthomas / lipomas



Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis

(no data available)