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1 OMIM reference -
5 associated genes
13 signs/symptoms
PROTEIN INTERACTIONS: 7
6 OMIM references -
7 associated genes
No signs/symptoms info
Multiple endocrine neoplasia type 1
B-cell chronic lymphocytic leukemia

CDKN1A ARL11
CDKN1B ATM
CDKN2B CCND1
CDKN2C IGHG1
MEN1 IGHV3-21
()
POT1
TP53


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
CDKN1A
CDKN1B
CDKN1A
CDKN2C
CDKN2C
MEN1
MEN1
(0.97)
(0.96)
(0.88)
(0.73)
(0.68)
(0.63)
(0.56)
CCND1
CCND1
TP53
TP53
ATM
IGHV3-21
TP53



Citations in the biomedical literature:


Multiple endocrine neoplasia type 1
CDKN1A CDKN1B CDKN2B CDKN2C MEN1
B-cell chronic lymphocytic leukemia
ARL11 ATM CCND1 IGHG1 IGHV3-21 POT1
TP53



Multiple endocrine neoplasia type 1
B-cell chronic lymphocytic leukemia

Synonym(s):
- MEN 1
- Wermer syndrome

Synonym(s):
- B-CLL
- B-cell chronic lymphoid leukemia
- Lymphoplasmacytic leukemia
- Lymphoplasmacytoid immunocytoma
- Small lymphocytic lymphoma

Classification (Orphanet):
- Rare endocrine disease
- Rare gastroenterologic disease
- Rare genetic disease
- Rare oncologic disease
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease

Classification (ICD10):
- Neoplasms -
Classification (ICD10):
- Neoplasms -

Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: variable
Average age of death: adult
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adulthood
Average age of death: -
Type of inheritance: sporadic

External references:
1 OMIM reference -
1 MeSH reference: D018761
External references:
6 OMIM references -
1 MeSH reference: D015451

Multiple endocrine neoplasia type 1

Very frequent
- Anomalies of the endocrine glands
- Anomaly of pancreatic hormones
- Autosomal dominant inheritance
- Hypercalcemia
- Hyperparathyroidy
- Hypothalamic-hypophyseal axis anomalies / hypothalamus / pituitary anomalies
- Neoplasms / tumors
- Parathyroids anomalies
- Structural anomalies of the pancreas

Frequent
- Cortico-adrenal hyperplasia / hypersecretion
- Epigastralgia / heartburn / gastric / duodenal ulcer / gastritis
- Thyroid anomalies
- Xanthomas / lipomas



B-cell chronic lymphocytic leukemia

(no data available)