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1 OMIM reference -
14 associated genes
No signs/symptoms info
PROTEIN INTERACTIONS: 1
6 OMIM references -
10 associated genes
8 signs/symptoms
Microform holoprosencephaly
Oligodontia

CDON AXIN2
DISP1 EDA
DLL1 EDARADD
FGF8 FGFR1
FOXH1 IRF6
GAS1 LTBP3
GLI2 MSX1
NODAL PAX9
PTCH1 TGFA
SHH WNT10A
SIX3
TDGF1
TGIF1
ZIC2


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
FGF8
(0.55)
FGFR1



Citations in the biomedical literature:


Microform holoprosencephaly
CDON DISP1 DLL1 FGF8 FOXH1 GAS1
GLI2 NODAL PTCH1 SHH SIX3 TDGF1
TGIF1 ZIC2
Oligodontia
AXIN2 EDA EDARADD FGFR1 IRF6 LTBP3
MSX1 PAX9 TGFA WNT10A



Microform holoprosencephaly
Oligodontia

Synonym(s):
- Microform HPE

Synonym(s):
- Selective tooth agenesis

Classification (Orphanet):
(no data available)
Classification (Orphanet):
- Rare genetic disease
- Rare odontologic disease

Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Classification (ICD10):
- Diseases of the digestive system -

Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: neonatal/infancy
Average age of death: adult
Type of inheritance: multigenic/multifactorial
Epidemiological data:
Class of prevalence: unknown
Average age onset: childhood
Average age of death: normal
Type of inheritance: autosomal dominant

External references:
1 OMIM reference -
No MeSH references
External references:
6 OMIM references -
No MeSH references

Oligodontia

Very frequent
- Anodontia / oligodontia / hypodontia
- Complete / partial microdontia
- Face / facial anomalies
- Hypoplastic mandibula / partial absence of the mandibula
- Tooth shape anomaly

Frequent
- Autosomal dominant inheritance
- Autosomal recessive inheritance
- X-linked recessive inheritance



Microform holoprosencephaly

(no data available)