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PROTEIN INTERACTIONS: 1
1 OMIM reference -
20 associated genes
No signs/symptoms info
Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency
Precursor B-cell acute lymphoblastic leukemia

IRF8 ABL1
AFF1
AUTS2
BCR
CDKN2A
ETV6
FLT3
FOXP1
GATA3
HLF
IGH
IKZF1
KMT2A
PAX5
PBX1
PDGFRA
PIP4K2A
RUNX1
TCF3
TP53


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
IRF8
(0.72)
ETV6



Citations in the biomedical literature:


Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency
IRF8
Precursor B-cell acute lymphoblastic leukemia
ABL1 AFF1 AUTS2 BCR CDKN2A ETV6
FLT3 FOXP1 GATA3 HLF IGH IKZF1
KMT2A PAX5 PBX1 PDGFRA PIP4K2A RUNX1
TCF3 TP53



Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency
Precursor B-cell acute lymphoblastic leukemia

Synonym(s):
- MSMD due to partial IRF8 deficiency
- MSMD due to partial interferon regulatory factor 8 deficiency
- Mendelian susceptibility to mycobacterial diseases due to partial interferon regulatory factor 8 deficiency

Synonym(s):
- B-ALL
- Precursor B-cell acute lymphoblastic leukemia/lymphoma
- Precursor B-cell acute lymphocytic leukemia
- Precursor B-cell acute lymphocytic leukemia/lymphoma

Classification (Orphanet):
- Rare genetic disease
- Rare immune disease
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease

Classification (ICD10):
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -
Classification (ICD10):
- Neoplasms -

Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: neonatal/infancy
Average age of death: normal
Type of inheritance: autosomal dominant
Epidemiological data:
(no data available)

External references:
1 OMIM reference -
No MeSH references
External references:
1 OMIM reference -
No MeSH references

Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency

Very frequent
- Autosomal dominant inheritance
- Fever / chilling
- Immunodeficiency / increased susceptibility to infections / recurrent infections
- Lymphadenopathy / polyadenopathies



Precursor B-cell acute lymphoblastic leukemia

(no data available)