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1 OMIM reference -
1 associated gene
8 signs/symptoms
PROTEIN INTERACTIONS: 1
7 OMIM references -
8 associated genes
10 signs/symptoms
Huntington disease
Narcolepsy-cataplexy

HTT CTSH
HCRT
HLA-DQB1
HLA-DRB1
MOG
P2RY11
TNFSF4
ZNF365


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
HTT
(0.63)
MOG



Citations in the biomedical literature:


Huntington disease
HTT
Narcolepsy-cataplexy
CTSH HCRT HLA-DQB1 HLA-DRB1 MOG P2RY11
TNFSF4 ZNF365



Huntington disease
Narcolepsy-cataplexy

Synonym(s):
- Huntington chorea

Synonym(s):
- GĂ©lineau disease

Classification (Orphanet):
- Rare genetic disease
- Rare neurologic disease
Classification (Orphanet):
- Rare neurologic disease

Classification (ICD10):
- Diseases of the nervous system -
Classification (ICD10):
- Diseases of the nervous system -

Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: variable
Average age of death: any age
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adolescence / young
Average age of death: normal
Type of inheritance: unknown

External references:
1 OMIM reference -
1 MeSH reference: D006816
External references:
7 OMIM references -
1 MeSH reference: D009290

Huntington disease
Narcolepsy-cataplexy

Frequent
- Abnormal cry / voice / phonation disorder / nasal speech
- Autosomal dominant inheritance
- Cortical atrophy without hydrocephaly / cerebral hemiatrophy / subcortical atrophy
- EEG anomalies
- Hypertonia / spasticity / rigidity / stiffness
- Movement disorder
- Psychic / behavioural troubles
- Psychic / psychomotor regression / dementia / intellectual decline



Very frequent
- Delirium / hallucination
- Muscle weakness / flaccidity
- Sleep and vigilance disorders
- Somnolence / hypersomnia / parasomnia
- Troubles of memory / amnesia / hypermnesia

Frequent
- Abnormal eye movements / oculomotor disorder
- Anomalies of eyes and vision

Occasional
- Collapse / sudden death / cardiac arrest / cardiorespiratory arrest
- Generalized obesity
- Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia