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1 OMIM reference -
1 associated gene
34 signs/symptoms
PROTEIN INTERACTIONS: 1
20 associated genes
No signs/symptoms info
Glutaryl-CoA dehydrogenase deficiency
Precursor T-cell acute lymphoblastic leukemia

GCDH ABL1
BCR
CDKN2A
CNOT3
DDX3X
FLT3
HNRNPH1
MLLT10
MYB
MYC
PICALM
STIL
TAL1
TCL1A
TLX1
TLX3
TRA
()
TRB
TRD
TRG
()


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
GCDH
(0.72)
MYC



Citations in the biomedical literature:


Glutaryl-CoA dehydrogenase deficiency
GCDH
Precursor T-cell acute lymphoblastic leukemia
ABL1 BCR CDKN2A CNOT3 DDX3X FLT3
HNRNPH1 MLLT10 MYB MYC PICALM STIL
TAL1 TCL1A TLX1 TLX3 TRA TRB
TRD TRG



Glutaryl-CoA dehydrogenase deficiency
Precursor T-cell acute lymphoblastic leukemia

Synonym(s):
- GA1
- GCDHD
- Glutaric acidemia type 1
- Glutaric aciduria type 1
- Glutaryl-coenzyme A dehydrogenase deficiency

Synonym(s):
- Precursor T-cell acute lymphoblastic leukemia/lymphoma
- Precursor T-cell acute lymphocytic leukemia
- Precursor T-cell acute lymphocytic leukemia/lymphoma
- T-ALL

Classification (Orphanet):
- Inborn errors of metabolism
- Rare genetic disease
- Rare neurologic disease
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease

Classification (ICD10):
- Endocrine, nutritional and metabolic diseases -
Classification (ICD10):
- Neoplasms -

Epidemiological data:
Class of prevalence: unknown
Average age onset: neonatal/infancy
Average age of death: child / adolescent
Type of inheritance: autosomal recessive
Epidemiological data:
(no data available)

External references:
1 OMIM reference -
1 MeSH reference: C536833
External references:
No OMIM references
No MeSH references

Glutaryl-CoA dehydrogenase deficiency

Very frequent
- Autosomal recessive inheritance
- Dystonia / torticollis / writer's cramp / blepharospasms
- Encephalitis
- Hyperkinesia / dyskinesia
- Large fontanelle / delayed fontanelle closure
- Metabolic anomalies
- Nausea / vomiting / regurgitation / merycism / hyperemesis

Frequent
- Chorea / athetosis / choreoathetosis / choreic syndrome
- Extrapyramidal syndrome
- Facial dysmorphism
- Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia
- Frontal bossing / prominent forehead
- Humour troubles / anxiety / depression / apathy / euphoria / irritability
- Hypertonia / spasticity / rigidity / stiffness
- Hypotonia
- Joint / articular deformation
- Macrocephaly / macrocrania / megalocephaly / megacephaly
- Movement disorder
- Structural anomalies of the nervous system

Occasional
- Abnormal eye movements / oculomotor disorder
- Abnormal gait
- Dizziness
- Facial pain / cephalalgia / migraine
- Hemiplegia / diplegia / hemiparesia / limb palsy
- Intellectual deficit / mental / psychomotor retardation / learning disability
- Intracranial / cerebral / meningeal hemorrhage
- Malignant hyperthermia
- Motor deficit / trouble
- Obnubilation / coma / lethargia / desorientation
- Psychic / psychomotor regression / dementia / intellectual decline
- Retinal vascular anomalies / retinal telangiectasia
- Seizures / epilepsy / absences / spasms / status epilepticus
- Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia
- Transient cerebral ischemia / stroke


Precursor T-cell acute lymphoblastic leukemia

(no data available)