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1 OMIM reference -
1 associated gene
No signs/symptoms info
PROTEIN INTERACTIONS: 1
2 OMIM references -
1 associated gene
14 signs/symptoms
Congenital factor II deficiency
Hereditary thrombophilia due to congenital protein S deficiency

F2 PROS1


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
F2
(0.52)
PROS1



Citations in the biomedical literature:


Congenital factor II deficiency
F2
Hereditary thrombophilia due to congenital protein S deficiency
PROS1



Congenital factor II deficiency
Hereditary thrombophilia due to congenital protein S deficiency

Synonym(s):
- Dysprothrombinemia
- Hypoprothrombinemia
- Prothrombin deficiency

Synonym(s):
(no synonyms)

Classification (Orphanet):
- Rare genetic disease
- Rare hematologic disease
Classification (Orphanet):
(no data available)

Classification (ICD10):
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -
Classification (ICD10):
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: variable
Average age of death: any age
Type of inheritance: autosomal recessive
Epidemiological data:
Class of prevalence: 1-9 / 1 000 000
Average age onset: neonatal/infancy
Average age of death: -
Type of inheritance: autosomal recessive

External references:
1 OMIM reference -
No MeSH references
External references:
2 OMIM references -
No MeSH references

Hereditary thrombophilia due to congenital protein S deficiency

Very frequent
- Autosomal dominant inheritance
- Purpura / petichiae

Frequent
- Anomalies of skin, subcutaneous tissue and mucosae
- Retinopathy
- Skin hypoplasia / aplasia / atrophy
- Thin skin
- Venous thrombosis / phlebitis / thrombophlebitis

Occasional
- Abnormal pigmentary skin changes / skin pigmentation anomalies
- Arterial embolism / thrombosis
- Cerebral vascular anomalies
- Chronic skin infection / ulcerations / ulcers / cancrum
- Gangrena / necrosis
- Pulmonary thromboembolism
- Varices / varicous veins / venous insufficiency


Congenital factor II deficiency

(no data available)