The interactive interface for assessing the tree similarity is not available as Adobe Flash Player got discontinued. While we recruit the resources for re-doing that part using another technology, only a static graphical representation of the two mirroring trees is shown, together with the tree similarity score (correlation value).
Due to technical problems, only the "(B) From multiple alignments" and "(C) From trees" sections of the input form work right now. Do NOT use the "(A) From sequences" entry point.
From sequences
Provide the sequence of a member of each one of the two families (in FASTA format (example)). The system will look for orthologs in different species and generate the multiple sequence alignments and phylogenetic trees. The protocol implemented in the server is not intended to work with protein domains. You have to use whole-length sequences as input for the server. More info...
From multiple alignments - Advanced Users
Provide multiple sequence alignmets of ORTHOLOGS for the two families in "multiple fasta" format (example)). IDs should be in a swissprot-like format ">XXX_YYY". If XXX and/or YYY are not valid Uniprot and NCBI TaxID identifiers the system will work but some features will be disabled. More info...
From trees - Advanced Users
Provide phylogenetic trees of ORTHOLOGS for the two families in "newick" format. Bootstrap values (or "0.0" if not available) should be between squared brackets "[]" (example). IDs should be in a swissprot-like format "XXX_YYY". If XXX and/or YYY are not valid Uniprot and NCBI TaxID identifiers the system will work but some features will be disabled. More info...