>gi|1173139|sp|P46969|RPE_YEAST  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (RPE)
Length=238

 Score =  340 bits (874),  Expect = 2e-93, Method: Composition-based stats.
 Identities = 238/238 (100%), Positives = 238/238 (100%), Gaps = 0/238 (0%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV
Sbjct  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
            PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS
Sbjct  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180
            KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL
Sbjct  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLLD  238
            NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLLD
Sbjct  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLLD  238


>gi|51701877|sp|Q6FL81|RPE_CANGA  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (RPE)
Length=246

 Score =  330 bits (846),  Expect = 3e-90, Method: Composition-based stats.
 Identities = 202/240 (84%), Positives = 217/240 (90%), Gaps = 3/240 (1%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            MVKPIIAPSILASDFANLGCECH+VIN+GA+WLHIDVMDGHFVPNITLGQPIVTSLRR+V
Sbjct  1    MVKPIIAPSILASDFANLGCECHRVINSGAEWLHIDVMDGHFVPNITLGQPIVTSLRRAV  60

Query  61   PRPGD---ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKL  117
            PR  +   AS    +PTAFFDCHMMVE PEKWV DFAK GADQFTFHYEAT+DPL LVKL
Sbjct  61   PRSQEEEKASGEVARPTAFFDCHMMVEEPEKWVADFAKAGADQFTFHYEATKDPLSLVKL  120

Query  118  IKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF  177
            IK  GIKAACAIKPGT VDVLFELAP+LDMALVMTVEPGFGGQKFM DMMPKVE LR KF
Sbjct  121  IKENGIKAACAIKPGTPVDVLFELAPYLDMALVMTVEPGFGGQKFMPDMMPKVEALRTKF  180

Query  178  PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLL  237
            PH+NIQVDGGLGKETI  AAKAGANVIVAGTSVFTA+DPH+VISFMKEEV KEL+++ +L
Sbjct  181  PHMNIQVDGGLGKETIGVAAKAGANVIVAGTSVFTASDPHEVISFMKEEVRKELKAKHIL  240


>gi|51701884|sp|Q755M2|RPE_ASHGO  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (RPE)
Length=239

 Score =  315 bits (809),  Expect = 7e-86, Method: Composition-based stats.
 Identities = 192/238 (80%), Positives = 205/238 (86%), Gaps = 2/238 (0%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            MVKPIIAPSILASDFANL C CH+VINAGA+WLHIDVMDGHFVPNITLG PIV SLR++V
Sbjct  1    MVKPIIAPSILASDFANLECGCHRVINAGAEWLHIDVMDGHFVPNITLGPPIVKSLRKAV  60

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
            PR GD      KP AFFDCHMMV  PEKWVD F + GADQFTFHYEAT++PL LVKLIKS
Sbjct  61   PRVGDKE--SDKPKAFFDCHMMVAEPEKWVDVFVENGADQFTFHYEATKNPLELVKLIKS  118

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180
            +GI+AACAIKP T VDVLFELAP+LDMALVMTVEPGFGGQKFM DMMPKV  LR KFP L
Sbjct  119  RGIRAACAIKPDTPVDVLFELAPYLDMALVMTVEPGFGGQKFMPDMMPKVAALREKFPQL  178

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLLD  238
            +IQVDGGLGKETIP AAKAGANVIVAGTSVF AAD  DVIS+MK+ V  ELRSR LLD
Sbjct  179  DIQVDGGLGKETIPHAAKAGANVIVAGTSVFAAADQKDVISYMKDNVRDELRSRGLLD  236


>gi|11387063|sp|P57603|RPE_BUCAI  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  305 bits (781),  Expect = 1e-82, Method: Composition-based stats.
 Identities = 90/240 (37%), Positives = 132/240 (55%), Gaps = 17/240 (7%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K  +APSIL++DFA LG +  KVI+AG+D +H DVMD H+VPN+++G  I+ SLR   
Sbjct  1    MNKFFLAPSILSADFARLGEDIKKVIDAGSDLIHFDVMDNHYVPNLSMGPMILESLR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                         TA  D H+MV+  +  +  FAK GA   TFH EAT      + LIK 
Sbjct  58   ---------NYNITAPIDVHLMVKPVDNLIPQFAKAGATFITFHPEATLHIERTLNLIKE  108

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--  178
             G KA  A  P T ++ L  +   LD+ L+M+V PGFG Q F+     K+  +R      
Sbjct  109  NGCKAGLAFNPATPLNFLDYILEKLDLILLMSVNPGFGNQSFLPSTFNKLREVRKIIDAN  168

Query  179  --HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDL  236
               + ++VDGG+  + I   A AGANV V G+ +F  ++   VI  +++++ +   SR +
Sbjct  169  FSDILLEVDGGVKLDNIADIACAGANVFVMGSGLFKYSNYKLVIEKIRKKL-EYAHSRSI  227


>gi|25091192|sp|Q8K940|RPE_BUCAP  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  301 bits (772),  Expect = 1e-81, Method: Composition-based stats.
 Identities = 86/220 (39%), Positives = 124/220 (56%), Gaps = 16/220 (7%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K  +A SIL++DFA LG +  K I+AG+DW+H DVMD H+VPN+T+G  I+ +LR   
Sbjct  1    MKKFFLASSILSADFARLGEDTKKAIDAGSDWIHFDVMDNHYVPNLTMGPMILKALR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                         T   D H+MV+  +  +  FA+ GAD  TFH E+T      + LIK 
Sbjct  58   ---------NYNITVPIDVHLMVKPVDNLIPQFAEAGADFITFHPESTDHIDRTLNLIKE  108

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--  178
             G KA  A+ P TS++ L  +   LD+ L+M+V PGFG Q F+     K+  +R K    
Sbjct  109  CGCKAGLALNPATSLNFLDYVMEKLDLILLMSVNPGFGNQSFLPTSFNKLREVRKKIELN  168

Query  179  --HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADP  216
              ++ ++VDGG+  E I + A +GANV V G+ +F   D 
Sbjct  169  SSNILLEVDGGVKLENISEVAFSGANVFVIGSGIFGYTDY  208


>gi|84028110|sp|P0AG09|RPE_ECO57  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
 gi|84028150|sp|P0AG08|RPE_ECOL6  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
 gi|84028157|sp|P0AG07|RPE_ECOLI  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
 gi|84028158|sp|P0AG10|RPE_SHIFL  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=225

 Score =  300 bits (769),  Expect = 3e-81, Method: Composition-based stats.
 Identities = 90/234 (38%), Positives = 133/234 (56%), Gaps = 16/234 (6%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M + +IAPSIL++DFA LG +  K + AGAD +H DVMD H+VPN+T+G  ++ SLR   
Sbjct  1    MKQYLIAPSILSADFARLGEDTAKALAAGADVVHFDVMDNHYVPNLTIGPMVLKSLR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                         TA  D H+MV+  ++ V DFA  GA   TFH EA++     ++LIK 
Sbjct  58   ---------NYGITAPIDVHLMVKPVDRIVPDFAAAGASIITFHPEASEHVDRTLQLIKE  108

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--  178
             G KA     P T +  L  +   LD+ L+M+V PGFGGQ F+   + K+  +R +    
Sbjct  109  NGCKAGLVFNPATPLSYLDYVMDKLDVILLMSVNPGFGGQSFIPQTLDKLREVRRRIDES  168

Query  179  --HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
               + ++VDGG+    I + A AGA++ VAG+++F   D   VI  M+ E++K 
Sbjct  169  GFDIRLEVDGGVKVNNIGEIAAAGADMFVAGSAIFDQPDYKKVIDEMRSELAKV  222


>gi|34924986|sp|Q96AT9|RPE_HUMAN  Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase)
Length=228

 Score =  300 bits (769),  Expect = 3e-81, Method: Composition-based stats.
 Identities = 126/231 (54%), Positives = 164/231 (70%), Gaps = 11/231 (4%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            I PSIL SD ANLG EC +++++GAD+LH+DVMDGHFVPNIT G P+V SLR+ +     
Sbjct  7    IGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFVPNITFGHPVVESLRKQL-----  61

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                      FFD HMMV  PE+WV   A  GA+Q+TFH EAT++P  L+K I+  G+K 
Sbjct  62   ------GQDPFFDMHMMVSKPEQWVKPMAVAGANQYTFHLEATENPGALIKDIRENGMKV  115

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVD  185
              AIKPGTSV+ L   A  +DMALVMTVEPGFGGQKFMEDMMPKV  LR +FP L+I+VD
Sbjct  116  GLAIKPGTSVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKVHWLRTQFPSLDIEVD  175

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDL  236
            GG+G +T+ K A+AGAN+IV+G+++  + DP  VI+ ++   S+  + R L
Sbjct  176  GGVGPDTVHKCAEAGANMIVSGSAIMRSEDPRSVINLLRNVCSEAAQKRSL  226


>gi|34924979|sp|Q8VEE0|RPE_MOUSE  Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-epimerase)
Length=228

 Score =  300 bits (768),  Expect = 3e-81, Method: Composition-based stats.
 Identities = 125/231 (54%), Positives = 164/231 (70%), Gaps = 11/231 (4%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            I PSIL SD ANLG EC +++++GAD+LH+DVMDGHFVPNIT G P+V SLR+ +     
Sbjct  7    IGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFVPNITFGHPVVESLRKQL-----  61

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                      FFD HMMV  PE+WV   A  GA+Q+TFH EAT++P  L+K I+  G+K 
Sbjct  62   ------GQDPFFDMHMMVSRPEQWVKPMAVAGANQYTFHLEATENPGALIKDIRENGMKV  115

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVD  185
              AIKPGT+V+ L   A  +DMALVMTVEPGFGGQKFMEDMMPKV  LR +FP L+I+VD
Sbjct  116  GLAIKPGTTVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKVHWLRTQFPTLDIEVD  175

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDL  236
            GG+G +T+ K A+AGAN+IV+G+++  + DP  VI+ ++   S+  + R L
Sbjct  176  GGVGPDTVQKCAEAGANMIVSGSAIMRSDDPRAVINLLRNVCSEAAQKRSL  226


>gi|2829613|sp|P74061|RPE_SYNY3  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=230

 Score =  299 bits (767),  Expect = 5e-81, Method: Composition-based stats.
 Identities = 95/239 (39%), Positives = 135/239 (56%), Gaps = 20/239 (8%)

Query  1    MVKPII-APSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
            M K I+ APSIL++DF+ LG E   V  AGADW+H+DVMDG FVPNIT+G  IV ++R  
Sbjct  1    MSKNIVVAPSILSADFSRLGEEIKAVDEAGADWIHVDVMDGRFVPNITIGPLIVDAIRPL  60

Query  60   VPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYE--ATQDPLHLVKL  117
              +               D H+M+  PEK+V+DFAK GAD  + H E  A+      +  
Sbjct  61   TKKT-------------LDVHLMIVEPEKYVEDFAKAGADIISVHVEHNASPHLHRTLCQ  107

Query  118  IKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAK-  176
            I+  G KA   + P T +D L  + P  D+ L+M+V PGFGGQ F+ +++PK+  LR   
Sbjct  108  IRELGKKAGAVLNPSTPLDFLEYVLPVCDLILIMSVNPGFGGQSFIPEVLPKIRALRQMC  167

Query  177  ---FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELR  232
                    I+VDGGL      +  +AGAN IVAG++VF A +  + I+ ++     E +
Sbjct  168  DERGLDPWIEVDGGLKPNNTWQVLEAGANAIVAGSAVFNAPNYAEAIAGVRNSKRPEPQ  226


>gi|1169388|sp|P44756|RPE_HAEIN  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=224

 Score =  298 bits (764),  Expect = 1e-80, Method: Composition-based stats.
 Identities = 81/231 (35%), Positives = 130/231 (56%), Gaps = 16/231 (6%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M   +IAPSIL++D A LG +   V+NAGAD +H DVMD H+VPN+T G  +  +LR   
Sbjct  1    MKPYLIAPSILSADLARLGDDVQNVLNAGADVIHFDVMDNHYVPNLTFGPAVCQALR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                     +   TA  D H+MV+  ++ + DFAK GA+  TFH E+++     ++LI+ 
Sbjct  58   ---------DYGITAPIDVHLMVKPVDRIIPDFAKAGANYITFHPESSEHIDRSLQLIRD  108

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--  178
             G K+     P   +  L  +   +D+ L+M+V PGFGGQ F+   + K++  R      
Sbjct  109  CGCKSGLVFNPAMPLSYLDYVLDKVDVVLLMSVNPGFGGQSFIPATLKKLQQARKIIDES  168

Query  179  --HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
               + ++VDGG+  + I + A AGA++ VAG+++F   D   VI  ++ ++
Sbjct  169  GYDIRLEVDGGVKVDNIAEIAAAGADMFVAGSAIFGKPDYKQVIDQIRTQL  219


>gi|75061668|sp|Q5R5Y2|RPE_PONPY  Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase)
Length=228

 Score =  297 bits (760),  Expect = 4e-80, Method: Composition-based stats.
 Identities = 125/231 (54%), Positives = 163/231 (70%), Gaps = 11/231 (4%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            I PSIL SD ANLG EC +++++GAD+LH+DVMDGHFVPNIT G P+V SLR+ +     
Sbjct  7    IGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFVPNITFGHPVVESLRKQL-----  61

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                      FFD HMMV  PE+WV   A  GA+Q+ FH EAT++P  L+K I+  G+K 
Sbjct  62   ------GQDPFFDMHMMVSKPEQWVKPMAVAGANQYAFHLEATENPGALIKDIRENGMKV  115

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVD  185
              AIKPGTSV+ L   A  +DMALVMTVEPGFGGQKFMEDMMPKV  LR +FP L+I+VD
Sbjct  116  GLAIKPGTSVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKVHWLRTQFPSLDIEVD  175

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDL  236
            GG+G +T+ K A+AGAN+IV+G+++  + DP  VI+ ++   S+  + R L
Sbjct  176  GGVGPDTVHKCAEAGANMIVSGSAIMRSEDPRSVINLLRNVCSEAAQKRSL  226


>gi|1169389|sp|P45455|RPE_SERMA  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=210

 Score =  293 bits (750),  Expect = 4e-79, Method: Composition-based stats.
 Identities = 83/222 (37%), Positives = 124/222 (55%), Gaps = 16/222 (7%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K +IAPSIL++DFA LG +   V+ AG D +H DVMD H+VPN+T+G  +  +LR   
Sbjct  1    MKKFLIAPSILSADFARLGEDTANVLAAGGDVVHFDVMDNHYVPNLTIGPMVCEALR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                         TA  D H+MV+  ++ V DFAK GA   +FH EA++     ++LIK 
Sbjct  58   ---------NYGITAPIDVHLMVKPVDRIVPDFAKAGASYISFHPEASEHVDRTIQLIKE  108

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--  178
             G KA     P T +  L  +   +D+ L+M+V PGFGGQ F+   + K+  +R      
Sbjct  109  HGCKAGLVFNPATPLSYLDYVMDKIDVILLMSVNPGFGGQSFIHGTLDKLRQVRKLIDDS  168

Query  179  --HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
               + ++VDGG+  + I + A AGA++ VAG+++F   D   
Sbjct  169  GRDIRLEVDGGVKVDNIAEIAAAGADMFVAGSAIFGQPDYRK  210


>gi|2499728|sp|Q43843|RPE_SOLTU  Ribulose-phosphate 3-epimerase, chloroplast precursor (Pentose-5-phosphate 
3-epimerase) (PPE) (RPE) (R5P3E)
Length=280

 Score =  292 bits (749),  Expect = 7e-79, Method: Composition-based stats.
 Identities = 88/233 (37%), Positives = 128/233 (54%), Gaps = 19/233 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
            I++PSIL+++F+ LG +   +  AG DW+H+DVMDG FVPNIT+G  +V SLR     P 
Sbjct  58   IVSPSILSANFSKLGEQVKAIEQAGCDWIHVDVMDGRFVPNITIGPLVVDSLRPITDLP-  116

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ--DPLHLVKLIKSKG  122
                         D H+M+  P++ V DF K GAD  + H E +        +  IKS G
Sbjct  117  ------------LDVHLMIVEPDQRVPDFIKAGADIVSVHCEQSSTIHLHRTINQIKSLG  164

Query  123  IKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAK----FP  178
             KA   + PGT +  +  +   +D+ L+M+V PGFGGQ F+E  + K+  LR        
Sbjct  165  AKAGVVLNPGTPLTAIEYVLDAVDLVLIMSVNPGFGGQSFIESQVKKISDLRKICAERGL  224

Query  179  HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
            +  I+VDGG+G +   K  +AGAN +VAG++VF A D  + I  +K     E 
Sbjct  225  NPWIEVDGGVGPKNAYKVIEAGANALVAGSAVFGAPDYAEAIKGIKTSKRPEA  277


>gi|2833386|sp|Q43157|RPE_SPIOL  Ribulose-phosphate 3-epimerase, chloroplast precursor (Pentose-5-phosphate 
3-epimerase) (PPE) (RPE) (R5P3E)
Length=285

 Score =  291 bits (746),  Expect = 1e-78, Method: Composition-based stats.
 Identities = 91/233 (39%), Positives = 127/233 (54%), Gaps = 19/233 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
            I++PSIL+++FA LG +   V  AG DW+H+DVMDG FVPNIT+G  +V +LR     P 
Sbjct  63   IVSPSILSANFAKLGEQVKAVELAGCDWIHVDVMDGRFVPNITIGPLVVDALRPVTDLP-  121

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYE--ATQDPLHLVKLIKSKG  122
                         D H+M+  PE+ V DF K GAD  + H E  +T      V  IKS G
Sbjct  122  ------------LDVHLMIVEPEQRVPDFIKAGADIVSVHCELASTIHLHRTVNQIKSLG  169

Query  123  IKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAK----FP  178
             KA   + PGT +  +  +   +D+ L+M+V PGFGGQ F+E  + K+  LR        
Sbjct  170  AKAGVVLNPGTPLSTIEYVLDVVDLVLIMSVNPGFGGQSFIESQVKKISDLRKMCVEKGV  229

Query  179  HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
            +  I+VDGG+      K  +AGAN +VAG++VF A D  + I  +K     E 
Sbjct  230  NPWIEVDGGVTPANAYKVIEAGANALVAGSAVFGAKDYAEAIKGIKASKRPEP  282


>gi|6647758|sp|O34557|RPE_BACSU  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=217

 Score =  286 bits (733),  Expect = 4e-77, Method: Composition-based stats.
 Identities = 97/229 (42%), Positives = 139/229 (60%), Gaps = 20/229 (8%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M+K  +APSIL++DFA LG E   V   GAD +HIDVMDGHFVPNIT+G  IV ++R   
Sbjct  1    MIK--VAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNITIGPLIVEAVRPVT  58

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
              P              D H+M+E P++++  FAK GAD  + H EA       ++LIK 
Sbjct  59   DLP-------------LDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQLIKE  105

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--  178
            +G+KA   + P T V V+  +   LD+ L+MTV PGFGGQKF+  ++PK++ ++      
Sbjct  106  QGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKRMADEK  165

Query  179  ---HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMK  224
                L I+VDGG+ KET P   +AGAN++VAG++V+  +D    IS ++
Sbjct  166  GKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIR  214


>gi|51701874|sp|O14105|RPE_SCHPO  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (RPE)
Length=228

 Score =  285 bits (730),  Expect = 1e-76, Method: Composition-based stats.
 Identities = 115/234 (49%), Positives = 151/234 (64%), Gaps = 10/234 (4%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            MV+  IAPS+LA DFANL  E  +++  G+DWLH+DVMD  FVPN+T+G  +V ++R   
Sbjct  1    MVQAKIAPSLLAGDFANLEKEVGRMLKYGSDWLHVDVMDAQFVPNLTIGPIVVKAMRNH-  59

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                       K  AFFDCH+MV  PE+++D  A  GA  F FHYEAT+    ++     
Sbjct  60   ---------YTKEEAFFDCHLMVIEPERYIDQLADAGASLFCFHYEATEKHEEIISRAHE  110

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180
            KG+   CA+KP T V+V+      LDM LVMTVEPG GGQ FM + +PKVE LR K+P L
Sbjct  111  KGMLVGCALKPKTPVEVILPFVEKLDMVLVMTVEPGKGGQSFMPECLPKVEFLRKKYPTL  170

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            N++VDGGL  +T+  AA AGANVIVAGT+VF A  P +VIS ++  V K   ++
Sbjct  171  NVEVDGGLSLKTVDAAADAGANVIVAGTAVFHAQSPEEVISGLRNSVMKAQETK  224


>gi|109940150|sp|Q9ZTP5|RPE_ORYSA  Ribulose-phosphate 3-epimerase, chloroplast precursor (Pentose-5-phosphate 
3-epimerase) (PPE) (RPE) (R5P3E)
Length=274

 Score =  280 bits (717),  Expect = 3e-75, Method: Composition-based stats.
 Identities = 90/233 (38%), Positives = 127/233 (54%), Gaps = 19/233 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
            I++PSIL+++F+ LG +   V  AG DW+H+DVMDG FVPNIT+G  +V +LR     P 
Sbjct  52   IVSPSILSANFSKLGEQVKAVEVAGCDWIHVDVMDGRFVPNITIGPLVVDALRPVTDLP-  110

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ--DPLHLVKLIKSKG  122
                         D H+M+  PE+ V DF K GAD  + H E +        V  IKS G
Sbjct  111  ------------LDVHLMIVEPEQRVPDFIKAGADIVSVHCEQSSTIHLHRTVNQIKSLG  158

Query  123  IKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRA----KFP  178
             KA   + P T +  +  +   +D+ L+M+V PGFGGQ F+E  + K+  LR     K  
Sbjct  159  AKAGVVLNPATPLTAIDYVLDVVDLVLIMSVNPGFGGQSFIESQVKKIAELRRLCAEKGV  218

Query  179  HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
            +  I+VDGG+G +   K  +AGAN IVAG++VF A D  + I  +K       
Sbjct  219  NPWIEVDGGVGPKNAYKVIEAGANAIVAGSAVFGAPDYAEAIKGIKTSQKPVA  271


>gi|729235|sp|P40117|RPEC_RALEH  Ribulose-phosphate 3-epimerase, chromosomal (Pentose-5-phosphate 
3-epimerase) (PPE) (R5P3E)
Length=241

 Score =  279 bits (714),  Expect = 6e-75, Method: Composition-based stats.
 Identities = 82/235 (34%), Positives = 124/235 (52%), Gaps = 21/235 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
             +APSIL++DFA LG E   +   GAD +H DVMD H+VPN+T+G  +  ++R  V  P 
Sbjct  17   RLAPSILSADFARLGEEVCAIEAGGADLVHFDVMDNHYVPNLTIGPLVCEAIRPLVSIP-  75

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIK  124
                         D H+MVE  +  +  FAK GA+  +FH EA++     + LI+  G K
Sbjct  76   ------------IDVHLMVEPVDALIPLFAKAGANIISFHPEASRHVDRTIGLIRDHGCK  123

Query  125  AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH-----  179
            A   + P T +  L      LD+ L+M+V PGFGGQ F+  ++ KV   RA+        
Sbjct  124  AGLVLNPATPLGWLDHTLDQLDLVLLMSVNPGFGGQAFIPGVLDKVRQARARIDRQVDAG  183

Query  180  ---LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
               + +++DGG+  + I   A+AGA+  VAG++VF A D     S +   + +  
Sbjct  184  GRPVWLEIDGGVKADNIAAIARAGADTFVAGSAVFGAPDADGGYSSILYRLREAA  238


>gi|729236|sp|Q04539|RPEP_RALEH  Ribulose-phosphate 3-epimerase, plasmid (Pentose-5-phosphate 
3-epimerase) (PPE) (R5P3E)
Length=241

 Score =  277 bits (709),  Expect = 3e-74, Method: Composition-based stats.
 Identities = 80/235 (34%), Positives = 123/235 (52%), Gaps = 21/235 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
             +APSIL++DFA LG E   +   GAD +H DVMD H+V N+T+G  +  ++R  V  P 
Sbjct  17   RLAPSILSADFARLGEEVCAIEAGGADLVHFDVMDNHYVSNLTIGPLVCEAIRPLVSIP-  75

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIK  124
                         D H+MVE  +  +  FAK GA+  +FH EA++     + LI+  G K
Sbjct  76   ------------IDVHLMVEPVDALIPMFAKAGANLISFHPEASRHVDRTIGLIRDHGCK  123

Query  125  AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH-----  179
            A   + P T +  L      LD+ L+M+V PGFGGQ F+  ++ KV   RA+        
Sbjct  124  AGLVLNPATPLSWLDHTLDKLDLVLLMSVNPGFGGQAFIPGVLDKVRQARARIDRQVAAG  183

Query  180  ---LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
               + +++DGG+  + I + A+AGA+  VAG++VF A D       +   + +  
Sbjct  184  GRPVWLEIDGGVKADNITEIARAGADTFVAGSAVFGAPDADGGYRGILHRLREAA  238


>gi|60390595|sp|Q9SE42|RPE1_ORYSA  Ribulose-phosphate 3-epimerase, cytoplasmic isoform (Ribulose-5-phosphate-epimerase) 
(Cyt-RPEase) (RPEcyt) (Pentose-5-phosphate 
3-epimerase) (PPE)
Length=228

 Score =  275 bits (704),  Expect = 9e-74, Method: Composition-based stats.
 Identities = 115/234 (49%), Positives = 161/234 (68%), Gaps = 18/234 (7%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            IAPS+L+SDFANL  E  +++  GADWLH+D+MDGHFVPN+T+G P++ SLR+       
Sbjct  9    IAPSMLSSDFANLAAEADRMVRLGADWLHMDIMDGHFVPNLTIGAPVIQSLRKHT-----  63

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPL-HLVKLIKSKGIK  124
                     A+ DCH+MV NP  +V+  AK GA  FTFH E ++D    L++ IK+KG++
Sbjct  64   --------KAYLDCHLMVTNPSDYVEPLAKAGASGFTFHIEVSRDNWQELIQSIKAKGMR  115

Query  125  AACAIKPGTSVDVLFELAPH---LDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLN  181
               +++PGT V+ +F L      +++ LVMTVEPGFGGQKFM +MM KV  LR K+P L+
Sbjct  116  PGVSLRPGTPVEEVFPLVEAENPVELVLVMTVEPGFGGQKFMPEMMEKVRALRKKYPSLD  175

Query  182  IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRD  235
            I+VDGGLG  TI  AA AGAN IVAG+S+F AA+P +VIS +++ V +  +++ 
Sbjct  176  IEVDGGLGPSTIDVAASAGANCIVAGSSIFGAAEPGEVISALRKSV-EGSQNKS  228


>gi|18203210|sp|Q9L0Z5|RPE_STRCO  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  272 bits (697),  Expect = 6e-73, Method: Composition-based stats.
 Identities = 100/229 (43%), Positives = 141/229 (61%), Gaps = 19/229 (8%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            I PSIL++DFA L  E   V   GADWLH+DVMD HFVPN+TLG P+V SL R+   P  
Sbjct  5    INPSILSADFARLADEAKAVE--GADWLHVDVMDNHFVPNLTLGVPVVESLARATDTP--  60

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                        DCH+M+E P++W   + + GA   TFH EA   P+ L + I++KG +A
Sbjct  61   -----------LDCHLMIEAPDRWAPQYVEAGAGSVTFHAEAAAAPVRLAREIRAKGARA  109

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVE----TLRAKFPHLN  181
            + A+KP T V+   +L P LDM L+MTVEPGFGGQ F++ M+PK+      ++     L 
Sbjct  110  SMALKPATPVEPYEDLLPELDMLLIMTVEPGFGGQAFLDIMLPKIRRTRELIKKHGLELW  169

Query  182  IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            +QVDGG+   TI + A AGA+V VAG++V+ A+DP + +  ++ +    
Sbjct  170  LQVDGGVSAATIERCADAGADVFVAGSAVYGASDPAEAVRALRTQADAA  218


>gi|6226024|sp|O67098|RPE_AQUAE  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=222

 Score =  271 bits (694),  Expect = 2e-72, Method: Composition-based stats.
 Identities = 82/226 (36%), Positives = 123/226 (54%), Gaps = 17/226 (7%)

Query  4    PIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRP  63
             ++APSILA D+  +G +    I  GAD LH DVMDGHFVPNIT G  I++ +R+    P
Sbjct  2    KLLAPSILAGDWWCIGEQIQATIRGGADILHYDVMDGHFVPNITAGYEILSHIRKRASLP  61

Query  64   GDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGI  123
                          D H+M+ENP+K++  F + GA+  + H E        ++LIK  G 
Sbjct  62   -------------IDAHLMIENPDKYIPKFVEAGANWISVHIENNYHIHRTLQLIKELGA  108

Query  124  KAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAK----FPH  179
            KA   + PGTS+  + E   + D  L+M+V PGF GQKF+E  + ++  L+       P 
Sbjct  109  KAGVVVNPGTSLSAIEEALYYADYVLLMSVNPGFSGQKFIERSIERLRILKEMRDRINPS  168

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
              I++DGG+ +  I +  +AGA+V+V G+ +F A D       +K 
Sbjct  169  CLIEIDGGIKENNIAEVVRAGADVVVVGSGIFGAKDIEAQTRKLKS  214


>gi|46396626|sp|Q89A59|RPE_BUCBP  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  269 bits (689),  Expect = 6e-72, Method: Composition-based stats.
 Identities = 72/232 (31%), Positives = 126/232 (54%), Gaps = 14/232 (6%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K +++ S+L+++F+ LG +   V+ +G+D +H DVMD H+V N+T G  ++ SLR   
Sbjct  1    MKKFLLSSSVLSANFSRLGEDIFDVLKSGSDMIHYDVMDNHYVKNLTFGPIVLESLR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                   + EK  +   D H+M    +  +  FAK   +  +FH E+T +    +KLIKS
Sbjct  58   -------SVEKIKSMVIDVHLMTCPVDDLIIKFAKLDVNIISFHPESTNNVEKTIKLIKS  110

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--  178
             G K   A+ P T + VL  +   +D+ L+M+V PGF GQKF+  ++ K+  +R      
Sbjct  111  YGCKVGLALNPLTPLCVLDNVLDKIDLILLMSVNPGFPGQKFIPSILNKIRIVRELIDKS  170

Query  179  --HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
              ++ ++VDGG+    I K A  G ++ V G+++F + +    I   ++ + 
Sbjct  171  KKNILLEVDGGINLSNIFKIASFGTDIFVIGSAIFNSINYDLTIRSFRDVLK  222


>gi|6226025|sp|Q9Z8Z9|RPE_CHLPN  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=229

 Score =  259 bits (662),  Expect = 8e-69, Method: Composition-based stats.
 Identities = 76/226 (33%), Positives = 123/226 (54%), Gaps = 22/226 (9%)

Query  1    MVKP---IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLR  57
            M K    ++ PSI+ +D   LG E  K+  AG+D++HID+MDGHFVPN+T G  I+ ++ 
Sbjct  1    MKKQESVLVGPSIMGADLTCLGVEAKKLEQAGSDFIHIDIMDGHFVPNLTFGPGIIAAIN  60

Query  58   RSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKL  117
            RS                F + H M+ NP ++++ F + GAD+   H+EA++D   L+  
Sbjct  61   RSTDL-------------FLEVHAMIYNPFEFIESFVRSGADRIIVHFEASEDIKELLSY  107

Query  118  IKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF  177
            IK  G++A  A  P TS++ L    P  D+ ++M+V PGF GQ F+ + + K+   R   
Sbjct  108  IKKCGVQAGLAFSPDTSIEFLPSFLPFCDVVVLMSVYPGFTGQSFLPNTIEKIAFARHAI  167

Query  178  ------PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPH  217
                      I+VDGG+ +++ P    AGA+++V  + +F A    
Sbjct  168  KTLGLKDSCLIEVDGGIDQQSAPLCRDAGADILVTASYLFEADSLA  213


>gi|54039256|sp|P65761|RPE_MYCBO  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
 gi|54041952|sp|P65760|RPE_MYCTU  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=229

 Score =  259 bits (662),  Expect = 8e-69, Method: Composition-based stats.
 Identities = 96/231 (41%), Positives = 145/231 (62%), Gaps = 19/231 (8%)

Query  4    PIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRP  63
            P+IAPSILA+DFA L  E   V   GADWLH+DVMDGHFVPN+T+G P+V SL      P
Sbjct  8    PLIAPSILAADFARLADEAAAV--NGADWLHVDVMDGHFVPNLTIGLPVVESLLAVTDIP  65

Query  64   GDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGI  123
                          DCH+M++NP++W   +A+ GA   TFH EAT +P+ + + I++ G 
Sbjct  66   -------------MDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPVGVARDIRAAGA  112

Query  124  KAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP----H  179
            KA  ++KPGT ++   ++ PH D  LVM+VEPGFGGQ+F+ +++ KV  +R         
Sbjct  113  KAGISVKPGTPLEPYLDILPHFDTLLVMSVEPGFGGQRFIPEVLSKVRAVRKMVDAGELT  172

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            + +++DGG+  +TI +AA+AG +  VAG++V+ A DP   ++ ++ +    
Sbjct  173  ILVEIDGGINDDTIEQAAEAGVDCFVAGSAVYGADDPAAAVAALRRQAGAA  223


>gi|14195180|sp|Q9PKR7|RPE_CHLMU  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  258 bits (659),  Expect = 2e-68, Method: Composition-based stats.
 Identities = 82/236 (34%), Positives = 127/236 (53%), Gaps = 26/236 (11%)

Query  1    MVKP--IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRR  58
            M K   +IAPSI+ +D A LG     +  +GA+ +HIDVMDGHFVPNIT G  I+ ++ R
Sbjct  1    MKKQGVLIAPSIMGADLACLGDAARNIEESGANLIHIDVMDGHFVPNITFGPGIIAAINR  60

Query  59   SVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLI  118
            S                F + H M+  P ++V+ F K GAD+   H+EA ++   ++  I
Sbjct  61   STDL-------------FLEVHAMIYTPFEFVEAFVKAGADRIIVHFEAAENLKEILDYI  107

Query  119  KSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF-  177
            +  G++A  A  P TS++ +    P  D+ L+M+V+PGF GQKF+ D + K+  +R    
Sbjct  108  RKCGVQAGIAFSPETSIEFISAFIPLCDVILLMSVQPGFCGQKFIPDTIEKIRFVRQAIQ  167

Query  178  -----PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
                     I+VDGG+ +E+     +AGA+++VA +  F           MKE+V 
Sbjct  168  TLGKEGSCLIEVDGGIDEESARACREAGADILVAASYFFKKDSI-----NMKEKVL  218


>gi|6226026|sp|O84123|RPE_CHLTR  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=233

 Score =  256 bits (655),  Expect = 5e-68, Method: Composition-based stats.
 Identities = 81/236 (34%), Positives = 128/236 (54%), Gaps = 26/236 (11%)

Query  1    MVKP--IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRR  58
            M K   ++APSI+ +D A +G E   +  +GAD +HIDVMDGHFVPNIT G  +V ++ R
Sbjct  6    MKKQGVLVAPSIMGADLACIGREARNIEESGADLIHIDVMDGHFVPNITFGPGVVAAINR  65

Query  59   SVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLI  118
            S                F + H M+  P ++V+ F K GAD+   H+EA ++   ++  I
Sbjct  66   STEL-------------FLEVHAMIYTPFEFVEAFVKAGADRIIVHFEAAENIKEIISYI  112

Query  119  KSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF-  177
            +  G++A  A  P TS++ +    P  D+ L+M+V PGF GQKF+ D + +++ ++    
Sbjct  113  QKCGVQAGVAFSPETSIEFVTSFIPLCDVILLMSVHPGFCGQKFIPDTIERIQFVKQAIQ  172

Query  178  -----PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
                     I+VDGG+ KE+     +AGA+++VA +  F           MKE+V 
Sbjct  173  VLGREGSCLIEVDGGIDKESARACREAGADILVAASYFFEKDSI-----NMKEKVL  223


>gi|17380276|sp|Q9CCP9|RPE_MYCLE  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=224

 Score =  252 bits (645),  Expect = 7e-67, Method: Composition-based stats.
 Identities = 93/213 (43%), Positives = 136/213 (63%), Gaps = 19/213 (8%)

Query  4    PIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRP  63
            P+IAPSILA+DFA L  E   V  A ADWLH+DVMDGHFVPN+T+G P+V SL  +   P
Sbjct  3    PLIAPSILAADFARLTDEAAVV--ASADWLHVDVMDGHFVPNLTIGLPVVQSLLAASDIP  60

Query  64   GDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGI  123
                          DCH+M++NP++W   +A+ GA   TFH EAT +P+ +   I++ G 
Sbjct  61   -------------MDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPVGVAHDIRTAGA  107

Query  124  KAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP----H  179
            KA   +KPGT ++   ++ PH D  L+M+VEPGFGGQ F+ +++ KV T+R         
Sbjct  108  KAGIGVKPGTPLNPYLDILPHFDTLLIMSVEPGFGGQAFIPEVLSKVRTVRKMVDAGELT  167

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT  212
            + +++DGG+  +TI +AA+AG +  VAG++V+ 
Sbjct  168  ILVEIDGGINADTIEQAAEAGVDCFVAGSAVYG  200


>gi|2851605|sp|P51013|RPE_RHORU  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=225

 Score =  251 bits (643),  Expect = 1e-66, Method: Composition-based stats.
 Identities = 77/229 (33%), Positives = 119/229 (51%), Gaps = 16/229 (6%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
             IAPS+L++DFA     C      GAD LH DVMD H+VPN+T+G  +  +LR     P 
Sbjct  6    RIAPSLLSADFAISRPRCPSDGRTGADILHFDVMDNHYVPNLTVGPLVCAALRPHTSLP-  64

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIK  124
                         D H+M    +  +D FA+ GAD  TFH EA+      V++I+ +G+K
Sbjct  65   ------------IDVHLMTRPVDPLIDSFAEAGADMITFHPEASDHVHRSVQMIRKRGLK  112

Query  125  AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLR--AKFPHLNI  182
            A  A+ P + + +L  +   LD+ L+M+V PGFGGQ F+   +PK+  L    +      
Sbjct  113  AGVALNPASPLSLLDHILEDLDLVLIMSVNPGFGGQSFIPSALPKIAALANGRRRACRGD  172

Query  183  QVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
            +VDGG+        A+ GA+++V   ++F A+D    I+ ++      L
Sbjct  173  RVDGGVNPADARALARPGADILVR-LAIFGASDRAKAIASIRGAAESGL  220


>gi|6647759|sp|O66107|RPE_TREPA  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=218

 Score =  250 bits (640),  Expect = 3e-66, Method: Composition-based stats.
 Identities = 83/213 (38%), Positives = 118/213 (55%), Gaps = 17/213 (7%)

Query  4    PIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRP  63
              +APS+L++DF+ L      +   GA W+H+DVMDGHFVPN+T G P++  LR     P
Sbjct  5    FTLAPSLLSADFSALDRALVYLEAHGAQWVHLDVMDGHFVPNLTFGAPVLRCLRSKTHLP  64

Query  64   GDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGI  123
                         FD H+MV  P   ++DF + GAD  TFH EA      L+  I+ +G+
Sbjct  65   -------------FDVHLMVSRPADLIEDFVQAGADFLTFHIEAEVHAHRLIHAIRGRGV  111

Query  124  KAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAK----FPH  179
            K   ++ P T V  L E+ P +D+ LVMTV PGF GQ+ +   + KV  L          
Sbjct  112  KVGISLVPSTPVAALSEVLPFVDLVLVMTVNPGFSGQQMIAHCLSKVSALVQMRTERGYS  171

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT  212
              I VDGG+   T+P+A  AGA+VIV+G++ F+
Sbjct  172  YMISVDGGIDCRTLPQALDAGADVIVSGSAFFS  204


>gi|6094119|sp|P51012|RPE_RHOCA  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  250 bits (639),  Expect = 4e-66, Method: Composition-based stats.
 Identities = 86/213 (40%), Positives = 119/213 (55%), Gaps = 16/213 (7%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            IAPSIL++DFA+ G E   +   GADW+H+DVMDGHFVPN+T G P V + R+       
Sbjct  9    IAPSILSADFADFGREIQAIEAQGADWVHVDVMDGHFVPNLTFGPPAVAAFRKH------  62

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                        D H+M+   + ++D +A+ GAD  T H EA       ++ I++ G+K+
Sbjct  63   -------VKTVMDVHLMISPVDAYIDAYAQAGADVLTAHVEAGPHIHRTLQAIRAAGMKS  115

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLN--IQ  183
              AI PGT  + +  +    D+  VMTV PGFGGQK++ DM  KV  LRA        I+
Sbjct  116  GVAINPGTPAEAIEHVLDIADVVCVMTVNPGFGGQKYI-DMTAKVRKLRAMIGDRPVHIE  174

Query  184  VDGGLGKETIPKAAKAGANVIVAGTSVFTAADP  216
            +DGG+   T P  A AGA+V VAG+ VF     
Sbjct  175  IDGGMDPVTAPLMAAAGADVFVAGSGVFKGGSV  207


>gi|2833527|sp|Q58093|RPE_METJA  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=234

 Score =  247 bits (632),  Expect = 2e-65, Method: Composition-based stats.
 Identities = 89/241 (36%), Positives = 132/241 (54%), Gaps = 22/241 (9%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M+K  I  SIL++DF +L  E  K   AG D+ H+D+MDGHFVPNI++G  I   +++  
Sbjct  1    MIK--IGASILSADFGHLREEIKKAEEAGVDFFHVDMMDGHFVPNISMGIGIAKHVKKLT  58

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
              P              + H+MVEN + +V++F +   D  TFH EA + P  ++  IKS
Sbjct  59   ELP-------------VEVHLMVENVDLFVNEFEE--MDYITFHIEAVKFPFRIINRIKS  103

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF---  177
             G K   A+ P T +D +  +   +   LVMTVEPGF GQKF+  M  K+  L++     
Sbjct  104  IGAKPIVALNPATPLDAIEYILGDVYAVLVMTVEPGFSGQKFIPVMTKKIRKLKSMIVEN  163

Query  178  -PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDL  236
                 I VDGG+  ET P A KAGA+V+VA +++F   D    +  ++E   + L ++D 
Sbjct  164  GYDTKIFVDGGINVETAPLAVKAGADVLVAASAIFGKDDVKTAVKNLREAALEAL-NKDF  222

Query  237  L  237
            L
Sbjct  223  L  223


>gi|6647760|sp|Q9ZJ75|RPE_HELPJ  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=217

 Score =  246 bits (630),  Expect = 4e-65, Method: Composition-based stats.
 Identities = 75/224 (33%), Positives = 124/224 (55%), Gaps = 19/224 (8%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            +APS+L++DF +L  E   V N  AD+LH+DVMDGH+VPN+T+G  I+ ++ +    P  
Sbjct  3    VAPSLLSADFMHLAKEIESVSN--ADFLHVDVMDGHYVPNLTMGPVILENVTQMSQVP--  58

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                        D H+MVEN   +V+ FA       + H E  + P  +++LIKS GI  
Sbjct  59   -----------LDVHLMVENASFFVELFAPLNPQIISIHAENEKHPHRVLQLIKSSGITP  107

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKV----ETLRAKFPHLN  181
               + P T  + +  L   + + L+M+V PGFGGQKF++ ++ K     E ++   P   
Sbjct  108  GIVLNPHTHEESIKYLLESVGLVLLMSVNPGFGGQKFLDLVLEKCLKVKELIKRYNPSCL  167

Query  182  IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
            ++VDGG+  + I +  +AG +V+V+G+ +F + D    I  ++ 
Sbjct  168  LEVDGGVNDKNIFELQQAGVDVVVSGSYIFESKDRKLAIEGLQN  211


>gi|2829457|sp|P56188|RPE_HELPY  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=217

 Score =  244 bits (623),  Expect = 2e-64, Method: Composition-based stats.
 Identities = 72/224 (32%), Positives = 123/224 (54%), Gaps = 19/224 (8%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            +APS+L++DF +L  E   V N  AD+LH+DVMDGH+VPN+T+G  ++ ++ +    P  
Sbjct  3    VAPSLLSADFMHLAKEIESVSN--ADFLHVDVMDGHYVPNLTMGPVVLENVTQMSQVP--  58

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                        D H+MVEN   + + FA       + H E  + P  +++LIK+ GI  
Sbjct  59   -----------LDVHLMVENASFFAELFAPLKPQIISIHAENEKHPHRVLQLIKNLGITP  107

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKV----ETLRAKFPHLN  181
               + P T  + +  L   + + L+M+V PGFGGQKF++ ++ K     E ++   P   
Sbjct  108  GIVLNPHTHEESIKYLLESVGLVLLMSVNPGFGGQKFLDLVLEKCLKVKELIKRYNPSCL  167

Query  182  IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
            ++VDGG+  + I +  +AG +V+V+G+ +F + D    I  ++ 
Sbjct  168  LEVDGGVNDKNIFELQQAGVDVVVSGSYIFKSKDRKLAIEGLQN  211


>gi|418563|sp|P32719|ALSE_ECOLI  D-allulose-6-phosphate 3-epimerase
Length=231

 Score =  240 bits (613),  Expect = 4e-63, Method: Composition-based stats.
 Identities = 70/232 (30%), Positives = 112/232 (48%), Gaps = 21/232 (9%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            I+PS++  D      +  + I++ AD+ HID+MDGHFVPN+TL    V+ +++   +P  
Sbjct  3    ISPSLMCMDLLKFKEQI-EFIDSHADYFHIDIMDGHFVPNLTLSPFFVSQVKKLATKP--  59

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIK  124
                        DCH+MV  P+ ++   A+ GAD  T H E        L+  I+   +K
Sbjct  60   -----------LDCHLMVTRPQDYIAQLARAGADFITLHPETINGQAFRLIDEIRRHDMK  108

Query  125  AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAK----FPHL  180
                + P T V+ +       D   VMTV+PGF GQ F+ +M+ K+  L+A         
Sbjct  109  VGLILNPETPVEAMKYYIHKADKITVMTVDPGFAGQPFIPEMLDKLAELKAWREREGLEY  168

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAG-TSVFT-AADPHDVISFMKEEVSKE  230
             I+VDG   + T  K   AGA+V + G + +F  A +  +    M  ++   
Sbjct  169  EIEVDGSCNQATYEKLMAAGADVFIVGTSGLFNHAENIDEAWRIMTAQILAA  220


>gi|51701892|sp|Q8SRP6|RPE_ENCCU  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (RPE)
Length=217

 Score =  220 bits (562),  Expect = 3e-57, Method: Composition-based stats.
 Identities = 68/226 (30%), Positives = 100/226 (44%), Gaps = 21/226 (9%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M+K  I  SIL  +F NL  E  ++   G   +H+DVMD  FV NIT G  I+  +    
Sbjct  5    MLKKRIGISILDCNFGNLEEELGELKRNGVTNIHLDVMDTTFVKNITFGPCIINRILEH-  63

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                            FD HMMVE+P   +           T H E       + + ++ 
Sbjct  64   -------------DFVFDVHMMVESPLDIIMQIDLERVSLVTIHSEVCDKA-GVAEYLRK  109

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180
            + +    A+ P T VD         D  L+M+V+PGFGGQKF E+ + KVE +R     +
Sbjct  110  RNVLFGIALNPETQVDDAE--MRSADFVLIMSVKPGFGGQKFQEECLAKVEEVRRYGKMV  167

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
             I  DGG+    I +    GA+  V G+  F + D    +  + +E
Sbjct  168  GI--DGGIEMSNIGRI--TGADYAVVGSGYFRSGDRKKFLRDITDE  209


>gi|732069|sp|P39362|SGCE_ECOLI  Protein sgcE
Length=210

 Score =  212 bits (541),  Expect = 8e-55, Method: Composition-based stats.
 Identities = 61/219 (27%), Positives = 98/219 (44%), Gaps = 13/219 (5%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
            I+ PS+ +++  + G E   + N     LH+D+ D  F+ NIT G   V ++ R  P P 
Sbjct  2    ILHPSLASANPLHYGRELTALDNLDFGSLHLDIEDSSFINNITFGMKTVQAVARQTPHP-  60

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIK  124
                           H M+  P++W +  A+        H E    P   +  I+  G +
Sbjct  61   ------------LSFHFMLARPQRWFNALAEIRPAWIFVHAETLDYPSETLTEIRHTGAR  108

Query  125  AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQV  184
            A     P T +D    LA  LD  +VMT EP   GQ+F+  M  K++ +R  FP      
Sbjct  109  AGLVFNPATPIDAWRYLASELDGVMVMTSEPDGQGQRFIPSMCEKIQKVRTAFPQTECWA  168

Query  185  DGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            DGG+      + A AGA  +V G ++F+++D    ++  
Sbjct  169  DGGITLAAAQQLAAAGAQHMVIGRALFSSSDYRATLAQF  207


>gi|2499727|sp|P75522|RPE_MYCPN  Probable ribulose-phosphate 3-epimerase (Pentose-5-phosphate 
3-epimerase) (PPE) (R5P3E)
Length=215

 Score =  164 bits (417),  Expect = 2e-40, Method: Composition-based stats.
 Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 21/187 (11%)

Query  29   GADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEK  88
            G   +H DVMD HFV N                  G+  +  ++     + H+MV+  E+
Sbjct  33   GLRLIHYDVMD-HFVDNTVF--------------QGEHLDELQQIGFQVNVHLMVQALEQ  77

Query  89   WVDDFAKCGA-DQFTFHYEATQDP--LHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
             +  +    A  + +FH E    P   H +  IK  G +   A K  T +     L   L
Sbjct  78   ILPVYLHHQAVKRISFHVEPFDIPTIKHFIAQIKQAGKQVGLAFKFTTPLVNYERLVQQL  137

Query  146  DMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIV  205
            D   +M+V PG GGQ F   +   ++   A   H +I++DGG+  + I +  +   N IV
Sbjct  138  DFVTLMSVPPGKGGQAFNSAVFNNLKQ--AHKYHCSIEIDGGIKLDNIHQ-IQDDVNFIV  194

Query  206  AGTSVFT  212
             G+    
Sbjct  195  MGSGFIK  201


>gi|81649887|sp|Q6GBR7|HPS_STAAS  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
 gi|81651682|sp|Q6GJ99|HPS_STAAR  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
 gi|81762794|sp|Q8NXX1|HPS_STAAW  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score =  161 bits (408),  Expect = 2e-39, Method: Composition-based stats.
 Identities = 39/221 (17%), Positives = 79/221 (35%), Gaps = 20/221 (9%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   +  ++ N   D          +V  + +G PI+      +P     ++  
Sbjct  5    LAIDLLN-KEDAAELANKVKD----------YVDIVEIGTPII--YNEGLPAVKHMADNI  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  +M +  +  V    K GAD  T    A        ++       +    +
Sbjct  52   SNVKVLADMKIM-DAADYEVSQAIKFGADVITILGVAEDASIKAAIEEAHKNNKQ---LL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   +  +  + T+++   +  + V GG
Sbjct  108  VDMIAVQDLEKRAKELDEMGADYIAVHTGYDLQAEGQSPLESLRTVKSVIKNSKVAVAGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +  +TI +      ++++ G  +  A DP +     +  + 
Sbjct  168  IKPDTIKEIVAESPDLVIVGGGIANADDPVEAAKQCRAAIE  208


>gi|119370767|sp|Q2YS94|HPS_STAAB  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score =  161 bits (408),  Expect = 2e-39, Method: Composition-based stats.
 Identities = 39/221 (17%), Positives = 79/221 (35%), Gaps = 20/221 (9%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   +  ++ N   D          +V  + +G PI+      +P     ++  
Sbjct  5    LAIDLLN-KEDAAELANKVKD----------YVDIVEIGTPII--YNEGLPAVKHMADNI  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  +M +  +  V    K GAD  T    A        ++       +    +
Sbjct  52   SNVKVLADMKIM-DAADYEVSQAIKFGADVITILGVAEDASIKTAIEEAHKNNKQ---LL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   +  +  + T+++   +  + V GG
Sbjct  108  VDMIAVQDLEKRAKELDEMGADYIAVHTGYDLQAEGQSPLESLRTVKSVIKNSKVAVAGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +  +TI +      ++++ G  +  A DP +     +  + 
Sbjct  168  IKPDTIKEIVAESPDLVIVGGGIANADDPVEAAKQCRAAIE  208


>gi|119370763|sp|Q49WT0|HPS2_STAS1  3-hexulose-6-phosphate synthase 2 (HPS 2) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase 2)
Length=213

 Score =  161 bits (407),  Expect = 3e-39, Method: Composition-based stats.
 Identities = 44/226 (19%), Positives = 83/226 (36%), Gaps = 20/226 (8%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   +  ++ N   D  H+D+        + +G PIV  +   +P     ++  
Sbjct  5    LAIDLLN-KEDAAELANKVKD--HVDI--------VEIGTPIV--INEGLPAVQHLNDNV  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  +M +  +  V    K GAD  T    A        V      G +    +
Sbjct  52   DGVKVLADLKIM-DAADYEVSQAVKFGADIVTILGVAEDASIKAAVDEAHKHGKQ---LL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   +  +  +  +++   +  + V GG
Sbjct  108  VDMIAVQDLEKRAKDLDDLGADYIAVHTGYDLQAEGQSPLESLRKVKSVISNSKVAVAGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRS  233
            +  +TI        ++I+ G  +  A DP +     ++ V    ++
Sbjct  168  IKPDTIKDIVAENPDLIIVGGGIANADDPVEAAKQCRDIVDAHTKA  213


>gi|81695133|sp|Q5HIA5|HPS_STAAC  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
 gi|81706157|sp|Q7A774|HPS_STAAN  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
 gi|81782064|sp|Q99W39|HPS_STAAM  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
 gi|119370766|sp|Q2G0K7|HPS_STAA8  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score =  160 bits (406),  Expect = 3e-39, Method: Composition-based stats.
 Identities = 39/221 (17%), Positives = 78/221 (35%), Gaps = 20/221 (9%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   +  ++ N   D          +V  + +G PI+      +P     ++  
Sbjct  5    LAIDLLN-KEDAAELANKVKD----------YVDIVEIGTPII--YNEGLPAVKHMADNI  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  +M +  +  V    K GAD  T    A        ++       +    +
Sbjct  52   SNVKVLADMKIM-DAADYEVSQAIKFGADVITILGVAEDASIKAAIEEAHKNNKQ---LL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   +  +  + T+++   +  + V GG
Sbjct  108  VDMIAVQDLEKRAKELDEMGADYIAVHTGYDLQAEGQSPLESLRTVKSVIKNSKVAVAGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +  +TI        ++++ G  +  A DP +     +  + 
Sbjct  168  IKPDTIKDIVAESPDLVIVGGGIANADDPVEAAKQCRAAIE  208


>gi|119370764|sp|Q49VB7|HPS3_STAS1  3-hexulose-6-phosphate synthase 3 (HPS 3) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase 3)
Length=210

 Score =  160 bits (405),  Expect = 5e-39, Method: Composition-based stats.
 Identities = 45/221 (20%), Positives = 80/221 (36%), Gaps = 20/221 (9%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   E  ++ N   D          +V  + +G PIV  +   +P     ++  
Sbjct  5    LAIDLLN-KEEAAELANKVKD----------YVDIVEIGTPIV--INEGLPAVQYLNDNI  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  +M +  +  V    K GAD  T    A        V+     G +    +
Sbjct  52   DGVKVLADLKIM-DAADYEVSQAVKFGADVVTILGVAEDASIKGAVEEAHKNGKE---LL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   E  +  +  +++   +  + V GG
Sbjct  108  VDMIAVQDLQKRAKELDELGADYIAVHTGYDLQAEGESPLESLRQVKSVINNSKVAVIGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +  +TI +      +++V G  +  A DP       K+ + 
Sbjct  168  IKPDTIKEVVAEEPDLVVVGGGIANADDPVAAAKACKDAIE  208


>gi|119370762|sp|Q49WT7|HPS1_STAS1  3-hexulose-6-phosphate synthase 1 (HPS 1) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase 1)
Length=210

 Score =  159 bits (404),  Expect = 6e-39, Method: Composition-based stats.
 Identities = 43/221 (19%), Positives = 79/221 (35%), Gaps = 20/221 (9%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   E   + N   D+++I          + +G PIV  +   +P     ++  
Sbjct  5    LAIDLLN-KEEATILANKVKDYINI----------VEIGTPIV--INEGLPAVQHLNDNI  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  +M +  +  V    K GAD  T    A        V      G +    +
Sbjct  52   DGVKVLADLKIM-DAADYEVSQAVKFGADIVTILGVAEDASIKAAVDEAHKHGKQ---LL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   +  +  +  +++   +  + V GG
Sbjct  108  VDMIAVQDLEKRAKDLDDLGADYIAVHTGYDLQAEGQSPLESLRKVKSVISNSKVAVAGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +  +TI        ++I+ G  +  A DP +     +  + 
Sbjct  168  IKPDTIKDIVAENPDLIIVGGGIANADDPVEAAKQCRAAIE  208


>gi|119370765|sp|Q2FJ70|HPS_STAA3  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score =  158 bits (400),  Expect = 2e-38, Method: Composition-based stats.
 Identities = 38/221 (17%), Positives = 78/221 (35%), Gaps = 20/221 (9%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   +  ++ N   D          +V  + +G PI+      +P     ++  
Sbjct  5    LAIDLLN-KEDAAELANKVKD----------YVDIVEIGTPII--YNEGLPAVKHMADNI  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  + ++  +  V    K GAD  T    A        ++       +    +
Sbjct  52   SNVKVLADMKI-IDAADYEVSQAIKFGADVITILGVAEDASIKAAIEEAHKNNKQ---LL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   +  +  + T+++   +  + V GG
Sbjct  108  VDMIAVQDLEKRAKELDEMGADYIAVHTGYDLQAEGQSPLESLRTVKSVIKNSKVAVAGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +  +TI        ++++ G  +  A DP +     +  + 
Sbjct  168  IKPDTIKDIVAESPDLVIVGGGIANADDPVEAAKQCRAAIE  208


>gi|119370768|sp|Q4L3P8|HPS_STAHJ  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score =  157 bits (399),  Expect = 2e-38, Method: Composition-based stats.
 Identities = 40/221 (18%), Positives = 77/221 (34%), Gaps = 20/221 (9%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   E  ++     +          +V  + +G PIV  +   +P         
Sbjct  5    LAIDLLN-KEEAAELAKKVEE----------YVDIVEIGTPIV--INEGLPAVQHLDENI  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  +M +  +  V    K GAD  T    A        V+       +    +
Sbjct  52   SNAKVLADLKIM-DAADYEVSQAIKFGADVVTILGVAEDASIKAAVEEAHKHDKQ---LL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   +  +  + T+++   +  + V GG
Sbjct  108  VDMIAVQDLEKRAKELDEMGADYIAVHTGYDLQAEGQSPLDSLRTVKSVIKNSKVAVAGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +  +TI        ++++ G  +  A DP +     ++ + 
Sbjct  168  IKPDTIKDIVAEQPDLVIVGGGIANADDPVEAAKQCRDAIE  208


>gi|81675362|sp|Q5HRH7|HPS_STAEQ  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score =  157 bits (397),  Expect = 4e-38, Method: Composition-based stats.
 Identities = 42/221 (19%), Positives = 77/221 (34%), Gaps = 20/221 (9%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   E  K+     +          +V  + +G PIV  +   +P     +   
Sbjct  5    LAIDLLN-KEEAAKLAQKVEE----------YVDIVEIGTPIV--INEGLPAVQHLNENI  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  +M +  +  V    K GAD  T    A        V+     G      +
Sbjct  52   NNAKVLADLKIM-DAADYEVSQAVKYGADIVTILGVAEDASIKAAVEEAHKHGK---ALL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   +  +  + T+++   +  + V GG
Sbjct  108  VDMIAVQNLEQRAKELDEMGADYIAVHTGYDLQAEGKSPLDSLRTVKSVIKNSKVAVAGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +  +TI        ++++ G  +  A DP +     +  + 
Sbjct  168  IKPDTIKDIVAEDPDLVIVGGGIANADDPVEAAKQCRAAIE  208


>gi|1351490|sp|P47358|RPE_MYCGE  Probable ribulose-phosphate 3-epimerase (Pentose-5-phosphate 
3-epimerase) (PPE) (R5P3E)
Length=209

 Score =  156 bits (396),  Expect = 5e-38, Method: Composition-based stats.
 Identities = 46/187 (24%), Positives = 78/187 (41%), Gaps = 21/187 (11%)

Query  29   GADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEK  88
            G   +H DVMD  FV N       +  L+                    + H+MVE    
Sbjct  28   GLRLIHYDVMD-QFVHNTAFKGEYLDELK--------------TIGFDVNVHLMVEQIIP  72

Query  89   WVDDF-AKCGADQFTFHYEAT--QDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
             ++ + ++    + +FH E         L++L+K  G +   A K  T++ +       +
Sbjct  73   QINFYLSQPNVKRISFHVEPFSFAKIKELIQLVKENGKEVGLAFKFTTNLQLYQPFFTTI  132

Query  146  DMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIV  205
            D   +M+V PG GGQ F E +   ++   A   +L I++DGG+    I +  KA  + IV
Sbjct  133  DFITLMSVPPGKGGQAFNEAVFTNLKI--ANHYNLKIEIDGGIKVNNIDQ-IKAFVDFIV  189

Query  206  AGTSVFT  212
             G+    
Sbjct  190  MGSGFIK  196


>gi|81843092|sp|Q8CQ69|HPS_STAES  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score =  155 bits (393),  Expect = 1e-37, Method: Composition-based stats.
 Identities = 42/221 (19%), Positives = 77/221 (34%), Gaps = 20/221 (9%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   E  K+     +          +V  + +G PIV  +   +P     +   
Sbjct  5    LAIDLLN-KEEAAKLAQKVEE----------YVDIVEIGTPIV--INEGLPAVQHLNENI  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  +M +  +  V    K GAD  T    A        V+     G      +
Sbjct  52   NNAKVLADLKIM-DAADYEVSQAVKYGADIVTILGVAEDASIKAAVEEAHKHGK---ALL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   +  +  + T+++   +  + V GG
Sbjct  108  VDMIAVQNLEQRAKELDEMGADYIAVHTGYDLQAEGKSPLDSLRTVKSVIKNSKVAVAGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +  +TI        ++++ G  +  A DP +     +  + 
Sbjct  168  IKPDTIKDIVAEDPDLVIVGGGIANADDPVEAAKQCRVAIE  208


>gi|73622033|sp|Q82WI1|TRPA_NITEU  Tryptophan synthase alpha chain
Length=275

 Score =  142 bits (358),  Expect = 1e-33, Method: Composition-based stats.
 Identities = 39/235 (16%), Positives = 82/235 (34%), Gaps = 27/235 (11%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
            H++  AG D + + V    F   +  G  I  S  R++       +       F      
Sbjct  38   HRLTQAGVDLIELGV---PFSDPMADGPTIQRSSERALKHHISLKDVFSMVAEFRKTNQS  94

Query  77   FDCHMM-VENPE------KWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP        +V      G D         ++    V+ +K + I     +
Sbjct  95   TPVVLMGYANPIEAMGYKDFVQTAGHAGVDGVLVVDYPPEECTEWVRYLKEQNIDPIFLL  154

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME--DMMPKVETLRAKFPHLNIQVDG  186
             P T    +  +A         ++++ G  G   ++  ++  K+  LR+   ++ I V  
Sbjct  155  SPTTPESRIRRVAELARGYVYYVSLK-GVTGASHLDLHEVGDKLSQLRSYI-NIPIGVGF  212

Query  187  GLGKETIPKAAKAGANVIVAGTSVFT------AADPHDVISFMKEEVSKELRSRD  235
            G+  E   +     A+ +V G+ +        AAD    +  + E + + + ++ 
Sbjct  213  GIRDEQTARRIAEQADAVVIGSRIVEEIEHSPAADLLANVGALVESLRRAIDAKS  267


>gi|28380194|sp|Q8TYA2|TRPA_METKA  Tryptophan synthase alpha chain
Length=275

 Score =  139 bits (350),  Expect = 1e-32, Method: Composition-based stats.
 Identities = 36/225 (16%), Positives = 79/225 (35%), Gaps = 19/225 (8%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPI---VTSLRRSVPRPGDASNTEKKPTAFFD  78
               + + G D L + V    F   I  G  I   V    R+   P D     ++ + F  
Sbjct  39   ARALRDGGVDILELGV---PFSEPIADGPTIQKAVDEALRAGTTPWDCLEVAEEVSEFVP  95

Query  79   CHMMVE-------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
              ++           E+++   A+ G           ++   +  + +   I     + P
Sbjct  96   VVLLCYYNTLHANGFERYLSAAAEAGVSGIIVADMPVEESDEVHSVARDLEIDVIYLVAP  155

Query  132  GTSVDVLFELAPHL-DMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQVDGGL  188
             T+ + L ++         V++   G  G +    ED +  V  +R     + + V  G+
Sbjct  156  STTDERLKKIGERASGFVYVISRY-GVTGARRDLSEDTLELVRWVRDHVD-VPVAVGFGI  213

Query  189  GKE-TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELR  232
             +   + +   AGA+  + G++        + I+  +E V +  +
Sbjct  214  SERWHVEEVIAAGADGAIVGSAFIKEIHRSEDIAEAEERVRELAK  258


>gi|73622054|sp|Q5N324|TRPA_SYNP6  Tryptophan synthase alpha chain
Length=266

 Score =  130 bits (327),  Expect = 5e-30, Method: Composition-based stats.
 Identities = 38/243 (15%), Positives = 82/243 (33%), Gaps = 25/243 (10%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPI-------VTSLRRSVPRPGDA  66
            D          +   GAD + + V    +   +  G  I       + +  R        
Sbjct  29   DLETTRQALLALDREGADLIELGV---PYSDPLADGPVIQAAATRALQAGTRLDDVLALL  85

Query  67   SNTEKKPTAFFDCHMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
             +   +  A         NP      E ++D  A  GA+         ++   L ++   
Sbjct  86   KDVRSQIKAPI-VLFTYCNPILNRGFEAFLDQIAAAGANGLVVPDLPLEESQRLSEVAAE  144

Query  121  KGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGG--QKFMEDMMPKVETLRAKF  177
            +GI     I P +S D +  ++        +++V  G  G  Q     +   ++ +R   
Sbjct  145  RGIDLILLIAPTSSADRIAAISKQARGFIYLVSV-TGVTGMRQGMQSRVADLLQEIRQ-G  202

Query  178  PHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFT--AADPHDVISFMKEEVSKELRSR  234
                I V  G+ G E   +    GA+ ++ G++          + ++ +  E+ + +  +
Sbjct  203  TDKPIGVGFGISGAEQARQVRDWGADGVIVGSAFVNRLQEQGVEGVATLCRELRQAIDRQ  262

Query  235  DLL  237
             +L
Sbjct  263  PVL  265


>gi|3041689|sp|P42405|HPS_BACSU  3-hexulose-6-phosphate synthase (HPS) (HUMPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score =  125 bits (314),  Expect = 1e-28, Method: Composition-based stats.
 Identities = 30/190 (15%), Positives = 74/190 (38%), Gaps = 9/190 (4%)

Query  41   HFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQ  100
             ++  + +G P+V  +   +    +      +     D  +M +     +   ++ GAD 
Sbjct  24   QYIDVVEIGTPVV--INEGLRAVKEIKEAFPQLKVLADLKIM-DAGGYEIMKASEAGADI  80

Query  101  FTFHYEATQ-DPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD--MALVMTVEPGF  157
             T             V+  K +  K    +    +V  +   A  +D      + V  G+
Sbjct  81   ITVLGATDDATIKGAVEEAKKQKKK---ILVDMINVKDIESRAKEIDALGVDYICVHTGY  137

Query  158  GGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPH  217
              Q   ++   ++ T++    +    + GG+  +T+P+  +   ++++ G  + +AAD  
Sbjct  138  DLQAEGKNSFEELTTIKNTVKNAKTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKA  197

Query  218  DVISFMKEEV  227
            +  S MK+ +
Sbjct  198  ETASKMKQLI  207


>gi|97051922|sp|Q46DA4|HPS_METBF  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=413

 Score =  118 bits (296),  Expect = 2e-26, Method: Composition-based stats.
 Identities = 40/211 (18%), Positives = 79/211 (37%), Gaps = 27/211 (12%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNI-TLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCH  80
              + I  GADW+ I        P I + G   + ++R++ P     ++ +   T   +  
Sbjct  8    AKEAIAGGADWIEIG------TPLIKSEGMDAIRTMRKAFPDRTILADMKTVDTGAIEVE  61

Query  81   MMVENPEKWVDDFAKCGADQFTFHYEATQDPL-HLVKLIKSKGIK--AACAIKPGTSVDV  137
            M            AK GAD       A    L   ++     G++  A     P    D 
Sbjct  62   M-----------AAKAGADVVIVLGSADDSTLLDALRSSHKYGVRLMADLISAP----DP  106

Query  138  LFELAP-HLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKA  196
            +  +          + V  G   Q   +D +  +  +  +  ++ + V GGL   +  +A
Sbjct  107  VKRVVELEALGVDYVNVHIGIDQQMMGKDPIALLREISQRV-NVQLAVAGGLDANSAVQA  165

Query  197  AKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
             KAGA V++ G ++  + +  +    +++ V
Sbjct  166  VKAGAKVVIVGGNITHSDNVTEAARKIRQSV  196


>gi|51316365|sp|Q7VRI8|METE_BLOFL  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=769

 Score =  117 bits (293),  Expect = 5e-26, Method: Composition-based stats.
 Identities = 34/198 (17%), Positives = 68/198 (34%), Gaps = 34/198 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              +  E   +  +G   + ID       P +  G P+  S      +        + +  
Sbjct  589  LAIRDEVMDLEKSGIGVIQID------EPALREGLPLKKSEQSYYLKWAINTFKITVSSV  642

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM      + +DD  K   D  +   E+++  L L++ IK+ G K       
Sbjct  643  KDNTQIHTHMCYSEFNEIIDDILKLDVDVISI--ESSRSDLQLLQFIKTAGKK-------  693

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
               ++ +      +              Q  + ++M K++ L    P   L I  D GL 
Sbjct  694  ---LNEIGPGIYDIHSI----------HQPSINEIMDKLKKLLQYIPKDRLWINPDCGLK  740

Query  190  KETIPKAAKAGANVIVAG  207
              +  +  ++  N+++A 
Sbjct  741  TRSWNEIRESLNNMVIAA  758


>gi|20139851|sp|Q9UZ35|PYRF_PYRAB  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=208

 Score =  105 bits (262),  Expect = 2e-22, Method: Composition-based stats.
 Identities = 35/191 (18%), Positives = 64/191 (33%), Gaps = 30/191 (15%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFA-KCGADQFTFHYEA  107
            G  I+  L+        A                + N  K +     + GAD    H   
Sbjct  39   GLDIIRKLKDRTGLKIIADLKLAD----------IPNTNKLIARKVYEAGADYIIVHPFV  88

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTS--VDVLFELAPHLDMALVMTVEPGFGGQKFMED  165
             +D +  V  +          ++      ++ +  L     + L   VEP FG       
Sbjct  89   GRDSVEAVNELGEI----ILVVEMSHPGALEFINPLTDKF-IELANDVEP-FGVIAPGTR  142

Query  166  MMPKVETLRA------KFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDV  219
               +V+ +R       K     I   GG       +A +AGA+ ++ G S++ A +P + 
Sbjct  143  P-ERVKYIRERLKEGVKILTPGIGAQGG----KAKEAIEAGADYVIVGRSIYNAPNPREA  197

Query  220  ISFMKEEVSKE  230
               + +E+  E
Sbjct  198  AREIYDEIRGE  208


>gi|73913711|sp|Q5JDB0|PYRF_PYRKO  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=213

 Score =  104 bits (259),  Expect = 3e-22, Method: Composition-based stats.
 Identities = 37/190 (19%), Positives = 69/190 (36%), Gaps = 28/190 (14%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFA-KCGADQFTFHYEA  107
            G  I+T L++    P  A                + N  + +     + GAD    H   
Sbjct  43   GLKIITELKQVTGLPIIADLKLAD----------IPNTNRLIASKVFEAGADYIIAHGFV  92

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMM  167
             +D +  V  +    I    +  PG   + +  +   L + L   +EP FG         
Sbjct  93   GRDSVEAVMELGKTIIVVEMS-HPGAK-EFIQPVTDKL-IELANELEP-FGVIA--PATR  146

Query  168  P-KVETLRAK------FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVI  220
            P +V  +R++           +   GG        A KAGA+ ++ G S++ + +P +  
Sbjct  147  PERVSYIRSRLERGIRILTPGVGAQGG----KASDAIKAGADYVIVGRSIYGSNNPREAA  202

Query  221  SFMKEEVSKE  230
              + EE+ + 
Sbjct  203  RRLYEEILEV  212


>gi|28380179|sp|Q8KX32|TRPA_SYNP2  Tryptophan synthase alpha chain
Length=264

 Score =  104 bits (259),  Expect = 4e-22, Method: Composition-based stats.
 Identities = 34/241 (14%), Positives = 74/241 (30%), Gaps = 29/241 (12%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D          +  AGAD++ + V    +   +  G  I  +  R++ R           
Sbjct  29   DLETTEQALKILDAAGADFIELGV---PYSDPLADGPTIQAAATRALSRGVTLEQVLAIV  85

Query  74   -------TAFFDCHMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                   TA         NP      + ++   A  G           ++   ++    S
Sbjct  86   QRVHGQLTAPI-ILFTYYNPIFYRGIDAFMAQVAAAGVKGLVIPDLPLEESQMVLDAATS  144

Query  121  KGIKAACAIKPGTSVDVLFELAP-HLDMALVMTVEPGFGGQ--KFMEDMMPKVETLRAKF  177
             G+     + P +  + +  +A        +++V  G  G        +   +  LR   
Sbjct  145  HGLDLILLVAPTSPTERIEAIAKASQGFIYLVSV-TGVTGARTSVASRVGELLPKLRQVT  203

Query  178  PHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFT---AADPHD---VISFMKEEVSKE  230
                I V  G+       +  + GA+ ++ G++V        P +    +    E + + 
Sbjct  204  DKP-IGVGFGVSDPAQARQLKEWGADGVIVGSAVVKRLATGTPAEGLAAVKEFCESLKEA  262

Query  231  L  231
            +
Sbjct  263  I  263


>gi|3043366|sp|Q48907|HPS_METAM  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=209

 Score =  103 bits (258),  Expect = 5e-22, Method: Composition-based stats.
 Identities = 36/174 (20%), Positives = 58/174 (33%), Gaps = 7/174 (4%)

Query  41   HFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQ  100
              V  + +G P +      +                 D   M +      + F K GAD 
Sbjct  25   PHVDILEIGTPCIKH--NGIKLLETLRAKFPNNKILVDLKTM-DAGFYEAEPFYKAGADI  81

Query  101  FTFHYEA-TQDPLHLVKLIKSKGIKAAC-AIKPGTSVDVLFELAPHLDMALVMTVEPGFG  158
             T    A       ++      G KA    I  G       E+A     A ++ V  G  
Sbjct  82   TTVLGVADLGTIKGVIDAANKYGKKAQIDLINVGDKAARTKEVAKL--GAHIIGVHTGLD  139

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT  212
             Q   +     + T+      L + V GG+   T+ +   AGA +IVAG +++ 
Sbjct  140  QQAAGQTPFADLATVTGLNLGLEVSVAGGVKPATVAQVKDAGATIIVAGAAIYG  193


>gi|21759371|sp|Q8U1U1|PYRF_PYRFU  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=211

 Score =  103 bits (257),  Expect = 7e-22, Method: Composition-based stats.
 Identities = 38/189 (20%), Positives = 70/189 (37%), Gaps = 28/189 (14%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFA-KCGADQFTFHYEA  107
            G  +++ L++    P  A                + N  + +       GAD    H   
Sbjct  39   GLGVISELKKKTGLPIIADLKLAD----------IPNTNRLIAKKVYDAGADYIILHSFV  88

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPH-LDMALVMTVEPGFGGQKFMEDM  166
             +D +  VK +    +    +  PG +++ +  L    +DMA    ++P FG        
Sbjct  89   GRDSVKAVKELGEIIMIVEMS-HPG-ALEFINPLTDKFIDMA--NEIKP-FGVIAPGTRP  143

Query  167  MPKVETLRA------KFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVI  220
              ++  +R       K     I   GG       +A KAGA+ I+ G +++ A  P +  
Sbjct  144  -ERIRYIRERLSKDIKVLTPGIGAQGGSPV----EALKAGADYIIIGRAIYNAERPREAA  198

Query  221  SFMKEEVSK  229
              + EEV +
Sbjct  199  KKIFEEVKE  207


>gi|73622039|sp|Q7TV26|TRPA_PROMM  Tryptophan synthase alpha chain
Length=275

 Score =  100 bits (251),  Expect = 3e-21, Method: Composition-based stats.
 Identities = 38/235 (16%), Positives = 81/235 (34%), Gaps = 24/235 (10%)

Query  8    PSILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS-----V  60
            P ++A D            +  +GAD + + +    +   +  G  I  +  R+      
Sbjct  32   PFLMAGDPDLETTAEVLLSLEQSGADMIELGI---PYSDPLADGPVIQAAASRALASGTT  88

Query  61   PRPGDASNTEKKPTAFFDCHM-MVENP------EKWVDDFAKCGADQFTFHYEATQDPLH  113
            P        + +        +    NP      E++ D+ A+ G           ++   
Sbjct  89   PARVLQMLIDLRGKLSIPVILFTYTNPLFNRGMERFCDEAAEAGVAGLVVPDLPLEEAER  148

Query  114  LVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQ-KFMEDMMPKVE  171
            L  L  ++G+     + P T  + +  +A        +++V  G  G+   MED +  + 
Sbjct  149  LSPLASARGLDLVLLVAPTTPAERMARIAESSRGFTYLVSV-TGVTGERSVMEDRVQSLV  207

Query  172  TLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSV---FTAADPHDVISF  222
                      + V  G+ G + + +    GA+  + G+++     AA P  V   
Sbjct  208  QQLKLSGSNPVAVGFGISGPQQVRQVRSWGADGAIVGSALVKRMAAAAPGLVAQE  262


>gi|2501410|sp|P77960|TRPA_SYNY3  Tryptophan synthase alpha chain
Length=264

 Score =  100 bits (251),  Expect = 3e-21, Method: Composition-based stats.
 Identities = 34/216 (15%), Positives = 73/216 (33%), Gaps = 29/216 (13%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D A        +  AGAD + + V    +   +  G  I  +  R++ +     +     
Sbjct  29   DLATTAEALRILDRAGADLIELGV---PYSDPLADGPVIQAAATRALQKGVKLDDVLAIV  85

Query  74   TAFFDCH---------MMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLI  118
                + H             NP      E ++D     G           ++   L++  
Sbjct  86   R---EVHQDIAAPIILFTYYNPIFYQGVEVFLDKIKAAGVKGLVVPDLPLEESDRLLEAT  142

Query  119  KSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFMEDMMPKVETLR---  174
              +G++    + P +S +    +A        +++V  G  G +   ++  +VE L    
Sbjct  143  AERGLELILLVAPTSSPERQTAIAKKSQGFVYLVSV-TGVTGVR--TEVGSRVEALLAGM  199

Query  175  AKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTS  209
             +     I V  G+   E   +    GA+ ++ G++
Sbjct  200  RQVTDKPIGVGFGISQPEQAEQVKAWGADAVIVGSA  235


>gi|23822009|sp|Q8PV88|PYRF_METMA  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=220

 Score = 99.8 bits (248),  Expect = 7e-21, Method: Composition-based stats.
 Identities = 46/233 (19%), Positives = 81/233 (34%), Gaps = 28/233 (12%)

Query  10   ILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNT  69
            ILA D      E  K+     ++  +D +   +   +  G  I+  L R  P   D    
Sbjct  8    ILALDVTE-REEALKIAENVREF--VDAIKVGYPLILATGLDIIRELARFAPVIADFKVA  64

Query  70   EKKPTAFFDCHMMVENPEKWV-DDFAKCGADQFTFHYEATQDPLHL-VKLIKSKGIKAAC  127
            +            + N  + + +   K GAD         +D L   +++    G     
Sbjct  65   D------------IPNTNRLICEQVFKAGADAVIVQGFTGRDSLDACIEVASKYGKDVFV  112

Query  128  AIKPGTS--VDVLFELAPHLDMALVMTVEPG-FGGQKFMEDMMP-KVETLRAKFPHLNIQ  183
              +       + L   A  +     M VE G FG         P +V+ +R         
Sbjct  113  VSEMSHPGGAEFLQSAAEAIAK---MAVEAGAFGLVA--PATRPERVKEIRKIIGDRLTI  167

Query  184  VDGGLGKE--TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            +  G+G +         AGA+ ++ G S++ A  P +    + EE+  ELR +
Sbjct  168  ISPGVGAQGGKASDVISAGADWVIVGRSIYKAESPKEAACEIAEEIQAELRGK  220


>gi|73622026|sp|Q5ZVY3|TRPA_LEGPH  Tryptophan synthase alpha chain
Length=272

 Score = 99.0 bits (246),  Expect = 1e-20, Method: Composition-based stats.
 Identities = 40/260 (15%), Positives = 91/260 (35%), Gaps = 37/260 (14%)

Query  3    KPIIAPSILASDFANLGCEC-----HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLR  57
            K +++P I A D      E      H+++ +GAD L + +    F   +  G  I  ++ 
Sbjct  16   KKMLSPYITAGDPY---PELTVSLMHQLVKSGADVLELGI---PFSDPMAEGPVIQRAME  69

Query  58   RSVPRPGDASNTEKKPTAF------FDCHMM-VENP------EKWVDDFAKCGADQFTFH  104
            R++       +       F          +M   NP      + +     + G D     
Sbjct  70   RALAHSIHCDDVLNMVRQFRKTDTETPVILMGYLNPIEQYGYDLFAQQAVEAGVDGTILV  129

Query  105  YEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFM  163
                ++   + ++ +  G+ +     P TS + +  +  H       ++++ G  G   +
Sbjct  130  DLPPEEADGVSRVWQKHGLYSIYLCSPTTSAERMNYINQHANGYLYYVSLK-GVTGSDAL  188

Query  164  EDMMPKVETL-RAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTA--------  213
            +    K + L R     L + V  G+   E   + A+  A+ ++ G ++           
Sbjct  189  KLPELKAQYLQRKAQSKLPLMVGFGIKTPEMAAQVAE-FADGVIVGAALINEIIEAYEAK  247

Query  214  ADPHDVISFMKEEVSKELRS  233
             DP      +   + + + +
Sbjct  248  KDPLQASGALLSSMRQAIDN  267


>gi|73622025|sp|Q5X5Q1|TRPA_LEGPA  Tryptophan synthase alpha chain
Length=272

 Score = 97.9 bits (243),  Expect = 3e-20, Method: Composition-based stats.
 Identities = 41/260 (15%), Positives = 92/260 (35%), Gaps = 37/260 (14%)

Query  3    KPIIAPSILASDFANLGCEC-----HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLR  57
            K +++P I A D      E      H+++ +GAD L + +    F   +  G  I  ++ 
Sbjct  16   KKMLSPYITAGDPY---PELTVSLMHQLVKSGADVLELGI---PFSDPMAEGPVIQRAME  69

Query  58   RSVPRPGDASNTEKKPTAF------FDCHMM-VENP------EKWVDDFAKCGADQFTFH  104
            R++       +       F          +M   NP      + +     + GAD     
Sbjct  70   RALAHSIHCDDVLNMVRQFRKTDTETPVILMGYLNPIEQYGYDLFAQQAVEAGADGTILV  129

Query  105  YEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFM  163
                ++   + ++ +  G+ +     P TS + +  +  H       ++++ G  G   +
Sbjct  130  DLPPEEADGVSRVWQKHGLYSIYLCSPTTSAERMNFINQHANGYLYYVSLK-GVTGSDAL  188

Query  164  EDMMPKVETL-RAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTA--------  213
            +    K + L R     L + V  G+   E   + A+  A+ ++ G ++           
Sbjct  189  KLPELKAQYLQRKAQSKLPLMVGFGIKTPEMAAQVAE-FADGVIVGAALINEIIEAYEAK  247

Query  214  ADPHDVISFMKEEVSKELRS  233
             DP      +   + + + +
Sbjct  248  KDPLQASGALLSSMRQAIDN  267


>gi|73622027|sp|Q5WX31|TRPA_LEGPL  Tryptophan synthase alpha chain
Length=272

 Score = 96.3 bits (239),  Expect = 8e-20, Method: Composition-based stats.
 Identities = 40/260 (15%), Positives = 91/260 (35%), Gaps = 37/260 (14%)

Query  3    KPIIAPSILASDFANLGCEC-----HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLR  57
            K +++P I A D      E      H+++ +GAD L + +    F   +  G  I  ++ 
Sbjct  16   KKMLSPYITAGDPY---PELTVSLMHQLVKSGADVLELGI---PFSDPMAEGPVIQRAME  69

Query  58   RSVPRPGDASNTEKKPTAF------FDCHMM-VENP------EKWVDDFAKCGADQFTFH  104
            R++       +       F          +M   NP      + +     + G D     
Sbjct  70   RALAHSIHCDDVLNMVRQFRKTDTETPVILMGYLNPIEQYGYDLFAQQAVEAGVDGTILV  129

Query  105  YEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFM  163
                ++   + ++ +  G+ +     P TS + +  +  H       ++++ G  G   +
Sbjct  130  DLPPEEADGVSRVWQKHGLYSIYLCSPTTSAERMNFINQHANGYLYYVSLK-GVTGSDAL  188

Query  164  EDMMPKVETL-RAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTA--------  213
            +    K + L R     L + V  G+   E   + A+  A+ ++ G ++           
Sbjct  189  KLPELKAQYLQRKAQSKLPLMVGFGIKTPEMAAQVAE-FADGVIVGAALINEIIEAYEAK  247

Query  214  ADPHDVISFMKEEVSKELRS  233
             DP      +   + + + +
Sbjct  248  KDPLQASGALLSSMRQAIDN  267


>gi|20140828|sp|Q9K0D4|TRPA_NEIMB  Tryptophan synthase alpha chain
Length=261

 Score = 95.9 bits (238),  Expect = 1e-19, Method: Composition-based stats.
 Identities = 40/233 (17%), Positives = 81/233 (34%), Gaps = 30/233 (12%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP------TAF  76
            H ++  GAD L + V    F   +  G  I  +  R++       +              
Sbjct  36   HGMVANGADILELGV---PFSDPMADGPVIQRAAERALANGISLRDVLDVVRKFRETDTQ  92

Query  77   FDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP       ++  + AK G D         +    L + +K  G+     I
Sbjct  93   TPVVLMGYLNPVHKMGYREFAQEAAKAGVDGVLTVDSPVETIDPLYRELKDNGVDCIFLI  152

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFM--EDMMPKVETLRAKFPHLNIQVDG  186
             P T+ D +  +A         ++++ G  G   +  +++  K+E L      + I V  
Sbjct  153  APTTTEDRIKTIAELAGGFVYYVSLK-GVTGAASLDTDEVSRKIEYLHQYID-IPIGVGF  210

Query  187  GLGKETIPKAAKAG--ANVIVAGTSVF-----TAADPHDVISFMKEEVSKELR  232
            G+       A K G  A+ ++ G+ +         +    +  + +E+   +R
Sbjct  211  GI--SNAESARKIGRVADAVIVGSRIVKEIENNTGNEAAAVGALVKELKDAVR  261


>gi|73622032|sp|Q5F9Y6|TRPA_NEIG1  Tryptophan synthase alpha chain
Length=261

 Score = 95.6 bits (237),  Expect = 1e-19, Method: Composition-based stats.
 Identities = 42/233 (18%), Positives = 82/233 (35%), Gaps = 30/233 (12%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP------TAF  76
            H ++ +GAD L + V    F   +  G  I  +  R++       +              
Sbjct  36   HGMVASGADILELGV---PFSDPMADGPVIQRAAERALANGISLRDVLDVVRKFRETDTQ  92

Query  77   FDCHMM-VENPE------KWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP       ++  + AK G D         +    L + +K   +     I
Sbjct  93   TPVVLMGYLNPIHKMGYREFAQEAAKAGVDGVLTVDSPIETIDSLYRELKDNEVDCIFLI  152

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFM--EDMMPKVETLRAKFPHLNIQVDG  186
             P T+ D +  +A         ++++ G  G   +  +++  K+E LR     + I V  
Sbjct  153  APTTTEDRIKTIAELAGGFVYYVSLK-GVTGAASLDTDEVSRKIEYLRQYID-IPIGVGF  210

Query  187  GLGKETIPKAAKAG--ANVIVAGTSVF-----TAADPHDVISFMKEEVSKELR  232
            G+       A K G  A  I+ G+ +       A +    +  + +E+   +R
Sbjct  211  GI--SNAESARKIGRVAAAIIVGSRIVKEIENNAGNEAAAVGALVKELKDAVR  261


>gi|24638310|sp|Q8U092|TRPF_PYRFU  N-(5'-phosphoribosyl)anthranilate isomerase (PRAI)
Length=208

 Score = 95.6 bits (237),  Expect = 2e-19, Method: Composition-based stats.
 Identities = 39/193 (20%), Positives = 67/193 (34%), Gaps = 25/193 (12%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEAT  108
            G  + ++ +R +P        E      F    MV    +W     + GA     H  A 
Sbjct  25   GVVVNSNSKRRIPLEKAREIIENSAIPVFLVSTMV-GFSEWAMAIERTGAQYIQVHSNAL  83

Query  109  QDPLHLVKLIKSKGIKAACAIKPGT----SVDVLFELAPHL-----DMALVMTVEPGFGG  159
               +  +K  K  G+    A +  T      +    L   +     DM L+ T   G G 
Sbjct  84   PQTIDTLK--KEFGVFVMKAFRVPTISKNPEEDANRLLSEISRYNADMVLLDT---GAGS  138

Query  160  QKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKA----GANVIVAGTSVFTAAD  215
             K  +  +  +  +  K P   + V GGL  E + +  K     G + + +G   +   D
Sbjct  139  GKLHDLRVSSL--VARKIP---VIVAGGLNAENVEEVIKVVKPYGVD-VSSGVEKYGIKD  192

Query  216  PHDVISFMKEEVS  228
            P  V  F++   +
Sbjct  193  PKLVEEFVRRAKN  205


>gi|23822016|sp|Q8TS37|PYRF_METAC  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=221

 Score = 95.2 bits (236),  Expect = 2e-19, Method: Composition-based stats.
 Identities = 43/232 (18%), Positives = 77/232 (33%), Gaps = 28/232 (12%)

Query  10   ILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNT  69
            ILA D  +         +    W  +D +   +   +  G  I+  L    P   D    
Sbjct  8    ILALDVTDREEALKIAEDV---WEFVDAIKVGYPLILATGLGIIRELAEFAPVIADFKVA  64

Query  70   EKKPTAFFDCHMMVENPEKWV-DDFAKCGADQFTFHYEATQDPLHL-VKLIKSKGIKAAC  127
            +            + N  + + D   + GAD         +D L   +++          
Sbjct  65   D------------IPNTNRLICDQVFEAGADAVIAQGFTGRDSLDACIEIASEYRKDVFV  112

Query  128  AIKPGTS--VDVLFELAPHLDMALVMTVEPG-FGGQKFMEDMMPK-VETLRAKFPHLNIQ  183
              +       D +  +A  +     M +E G FG         PK V+ +R         
Sbjct  113  VSEMSHPGGADFMQPVAEAIAK---MALEAGAFGLVA--PATRPKRVKKIRRIIGDKLTI  167

Query  184  VDGGLGKE--TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRS  233
            +  G+G +         AGA+ ++ G S++ A  P +    + EE+  ELR 
Sbjct  168  ISPGVGAQGGKASDVIAAGADWVIVGRSIYKAESPKEAARQIAEEIQAELRG  219


>gi|73622019|sp|Q74AI3|TRPA_GEOSL  Tryptophan synthase alpha chain
Length=264

 Score = 95.2 bits (236),  Expect = 2e-19, Method: Composition-based stats.
 Identities = 37/242 (15%), Positives = 78/242 (32%), Gaps = 28/242 (11%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNT  69
            D A        +  +GAD + + V    F   +  G  I      +L      P      
Sbjct  29   DLAATEALIPLLAESGADIVELGV---PFSDPMADGPTIQLSSERALAAGTTLPKILDMV  85

Query  70   EKKPTA-FFDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK  121
             +  T       +M   NP      E++  D +  G D         ++           
Sbjct  86   RRVRTRCQVPIVLMGYYNPILIHGLERFAADASAAGVDGVLLVDLPPEEAAEFKACADRH  145

Query  122  GIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFM--EDMMPKVETLRAKFP  178
            G+     + P +    + ++A         ++V  G  G +      +   V  +R    
Sbjct  146  GLDVIFLLTPTSDEGRIRKVARQARGFVYYVSV-TGVTGARSGVEASVSSNVAAIREAI-  203

Query  179  HLNIQVDGGL-GKETIPKAAKAGANVIVAGTSV------FTAADPHDVISFMKEEVSKEL  231
             + + V  G+   +   +   A A+ +V G+++      FTAA+    ++     + + +
Sbjct  204  TVPVVVGFGISTPDQAAQV-AASADGVVVGSAIVKLFERFTAAELGREVATFVSALREAI  262

Query  232  RS  233
             +
Sbjct  263  GN  264


>gi|20140823|sp|Q9JVE0|TRPA_NEIMA  Tryptophan synthase alpha chain
Length=261

 Score = 95.2 bits (236),  Expect = 2e-19, Method: Composition-based stats.
 Identities = 42/233 (18%), Positives = 82/233 (35%), Gaps = 30/233 (12%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP------TAF  76
            H ++  GAD L + V    F   +  G  I  +  R++       +              
Sbjct  36   HGMVANGADILELGV---PFSDPMADGPVIQRAAERALANGISLRDVLDVVRKFRETDTQ  92

Query  77   FDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP       ++  + AK G D         +    L + +K  G+     I
Sbjct  93   TPVVLMGYLNPVHKMGYREFAQEAAKAGVDGVLTVDSPVETIDPLYRELKDNGVDCIFLI  152

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFM--EDMMPKVETLRAKFPHLNIQVDG  186
             P T+ D +  +A         ++++ G  G   +  +++  K+E L      + I V  
Sbjct  153  APTTTEDRIKTIAELAGGFVYYVSLK-GVTGAASLDTDEVSRKIEYLHQYID-IPIGVGF  210

Query  187  GLGKETIPKAAKAG--ANVIVAGTSVF-----TAADPHDVISFMKEEVSKELR  232
            G+       A K G  A  ++ G+ +       A +   V+  + +E+   +R
Sbjct  211  GI--SNAESARKIGRVAEAVIVGSRIVKEIENNAGNEAAVVGALVKELKDAVR  261


>gi|20139591|sp|Q977X5|PYRF_METTE  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=215

 Score = 94.8 bits (235),  Expect = 2e-19, Method: Composition-based stats.
 Identities = 42/232 (18%), Positives = 75/232 (32%), Gaps = 28/232 (12%)

Query  10   ILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNT  69
            ILA D  +         +    W  +D +   +   +T G  I+  L    P   D    
Sbjct  2    ILALDVTDRDEALKIAEDV---WEFVDAIKVGYPLILTTGLGIIRELAEFAPVIADFKVA  58

Query  70   EKKPTAFFDCHMMVENPEKWV-DDFAKCGADQFTFHYEATQDPLHL-VKLIKSKGIKAAC  127
            +            + N  + + D   + GAD         +D L   +++          
Sbjct  59   D------------IPNTNRLICDQVFEAGADAVIVQGFTGRDSLDACIEIASEYRKDVFV  106

Query  128  AIKPGTS--VDVLFELAPHLDMALVMTVEPG-FGGQKFMEDMMP-KVETLRAKFPHLNIQ  183
              +       + L   A  +     M +E G FG         P +V  +R         
Sbjct  107  VSEMSHPGGAEFLQPAAESIAK---MALEAGAFGLVA--PATRPERVRKIRRIIGDKLTI  161

Query  184  VDGGLGKE--TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRS  233
            +  G+G +         AG + ++ G S++ A  P +    + EE+  ELR 
Sbjct  162  ISPGVGAQGGKASDVIAAGTDWVIVGRSIYKAESPKEAAREIAEEIQAELRG  213


>gi|73622020|sp|Q7NHC5|TRPA_GLOVI  Tryptophan synthase alpha chain
Length=276

 Score = 94.4 bits (234),  Expect = 3e-19, Method: Composition-based stats.
 Identities = 34/212 (16%), Positives = 70/212 (33%), Gaps = 21/212 (9%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV---PRPGDASNTE  70
            D          +   GAD L + +    +   +  G  I  +  R++     PG   +  
Sbjct  35   DLETTAEALLTLDRNGADLLELGL---PYSDPLADGPTIQAAATRALARGTTPGAVLDLV  91

Query  71   KKPTAFFDCHMMV---------ENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK  121
             + T      ++V            E +V+  A  GA          ++   L      +
Sbjct  92   ARLTPELRAPLIVFTYFNLILAVGIEAFVERLAASGASGLLVPDLPVEEGDALQTAANVQ  151

Query  122  GIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFM--EDMMPKVETLRAKFP  178
            G+     + P +  + L  +A        +++   G  G +      +   +  LRA   
Sbjct  152  GLDVIWLVAPTSPPERLRRIAERTTGFVYLVS-TTGVTGARTQVASSVRTSLAQLRALT-  209

Query  179  HLNIQVDGGL-GKETIPKAAKAGANVIVAGTS  209
               + V  G+   E   + A  GA+ ++ G++
Sbjct  210  TRPVAVGFGISTPEQAHEVASLGADGVIVGSA  241


>gi|136373|sp|P00931|TRP_YEAST  Tryptophan synthase
Length=707

 Score = 94.4 bits (234),  Expect = 3e-19, Method: Composition-based stats.
 Identities = 36/204 (17%), Positives = 72/204 (35%), Gaps = 18/204 (8%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK--KPTA  75
                 + G D + + +    F   I  G  I      +L+  V  P       +      
Sbjct  38   LKGFQDGGVDIIELGM---PFSDPIADGPTIQLSNTVALQNGVTLPQTLEMVSQARNEGV  94

Query  76   FFDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M   NP      E+++ D AK GA+ F       ++ L +   I   G+     
Sbjct  95   TVPIILMGYYNPILNYGEERFIQDAAKAGANGFIIVDLPPEEALKVRNYINDNGLSLIPL  154

Query  129  IKPGTSVDVLFELAPHLD-MALVMTVEPGFGGQKFMEDMMPK-VETLRAKFPHLNIQVDG  186
            + P T+ + L  L+   D    V++     G Q  +   + + +  +R       + V  
Sbjct  155  VAPSTTDERLELLSHIADSFVYVVSRMGTTGVQSSVASDLDELISRVRKYTKDTPLAVGF  214

Query  187  GLGKETIPKAAKAGANVIVAGTSV  210
            G+      ++  + A+ +V G+ +
Sbjct  215  GVSTREHFQSVGSVADGVVIGSKI  238


>gi|41018348|sp|Q8DHK2|THIE_SYNEL  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=351

 Score = 92.1 bits (228),  Expect = 2e-18, Method: Composition-based stats.
 Identities = 29/148 (19%), Positives = 47/148 (31%), Gaps = 17/148 (11%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFE-LAPH  144
                VD      AD    H      P+ L + I  +        +  T+   L   +A  
Sbjct  209  VNDRVDIALGANADG--VHLGQMDIPMELARQILGRDRLVG---RSTTNAQELERAIAEG  263

Query  145  LDMALVMTV-----EPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKA  199
             D   V  +     +PG     F       ++  R   P     + GG+    I +  KA
Sbjct  264  ADYVGVGPIFATPTKPGKAAVGF-----DYLQYARKHAPMPQFAI-GGIDLSNIEEVIKA  317

Query  200  GANVIVAGTSVFTAADPHDVISFMKEEV  227
            GA  +    ++  AADP      +   +
Sbjct  318  GATQVAVVRAIMAAADPEATTRELLRRL  345


>gi|1717756|sp|P51382|TRPA_PORPU  Tryptophan synthase alpha chain
Length=273

 Score = 92.1 bits (228),  Expect = 2e-18, Method: Composition-based stats.
 Identities = 32/232 (13%), Positives = 80/232 (34%), Gaps = 26/232 (11%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D  +       +   GAD + + +    +   +  G  I  +  R++ +  + +N     
Sbjct  37   DLVSTSKALKILDQHGADIIELGL---PYSDPLADGPIIQAASSRALKQSINLNNILDMV  93

Query  74   T-------AFFDCHMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                    A         NP        ++   ++ G           ++  +++ + K 
Sbjct  94   NITSSNIVAPI-VLFTYYNPVLNLGINNFISAISRAGIKGLLIPDLPIEESDYIISVCKL  152

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180
              I+    + P +S++ + ++       + +    G  GQK   ++  K++ L      +
Sbjct  153  FNIELIFLLSPTSSIERINKIVEQAPGCIYLVSTTGVTGQK--PELTGKLKRLTETIKKM  210

Query  181  ---NIQVDGGL-GKETIPKAAKAGANVIVAGTSVFT---AADPHDVISFMKE  225
                I +  G+   E I +      N IV G++      +  P + +  +K+
Sbjct  211  TQKPIILGFGISTAEQIKEIKGWNINGIVIGSAFVKRLSSDFPEEGLRKIKD  262


>gi|97049455|sp|Q46DY5|FAEHP_METBF  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=392

 Score = 90.6 bits (224),  Expect = 4e-18, Method: Composition-based stats.
 Identities = 30/182 (16%), Positives = 66/182 (36%), Gaps = 15/182 (8%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEAT  108
            G  +++ +R   P     ++ +   T   +  M+ +            G           
Sbjct  213  GMDVISRIREVRPDAFIVADLKTLDTGNLEARMVADA----------AGDAIVVSALAPI  262

Query  109  QDPLHLVKLIKSKGIKAAC-AIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMM  167
                 L++     GI A    +     + VL +L   + M  V+ +  G   +   E   
Sbjct  263  STIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQL--KV-MPDVIELHRGIDIEA-TEHAW  318

Query  168  PKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
              +  ++   P + + V GG+  + +P A   GA+++V G ++  + D  +V       +
Sbjct  319  GNIAEIKKIAPKILVAVAGGVRLDKVPVALGQGADILVVGRAITNSKDVREVAEQFINSL  378

Query  228  SK  229
            +K
Sbjct  379  NK  380


>gi|73920965|sp|P42390|TRPA_MAIZE  Indole-3-glycerol phosphate lyase, chloroplast precursor (Indole 
synthase) (Tryptophan synthase alpha chain) (Benzoxazineless 
1)
Length=347

 Score = 90.6 bits (224),  Expect = 5e-18, Method: Composition-based stats.
 Identities = 31/231 (13%), Positives = 72/231 (31%), Gaps = 21/231 (9%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D A        +   GAD + + V           G  I  S+ R++          +  
Sbjct  115  DLATTAEALRLLDGCGADVIELGV---PCSDPYIDGPIIQASVARALASGTTMDAVLEML  171

Query  74   TAFFD------CHMMVENP--EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                         +    P   + + +  + G                L    K+  ++ 
Sbjct  172  REVTPELSCPVVLLSYYKPIMSRSLAEMKEAGVHGLIVPDLPYVAAHSLWSEAKNNNLEL  231

Query  126  ACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNI  182
                 P    D + E+         +++V  G  G +      +   ++ ++    +  +
Sbjct  232  VLLTTPAIPEDRMKEITKASEGFVYLVSVN-GVTGPRANVNPRVESLIQEVKK-VTNKPV  289

Query  183  QVDGGL-GKETIPKAAKAGANVIVAGTSVFT----AADPHDVISFMKEEVS  228
             V  G+   E + + A+ GA+ ++ G+++      AA P   +  ++E   
Sbjct  290  AVGFGISKPEHVKQIAQWGADGVIIGSAMVRQLGEAASPKQGLRRLEEYAR  340


>gi|34222869|sp|Q8DLN9|TRPA_SYNEL  Tryptophan synthase alpha chain
Length=266

 Score = 90.6 bits (224),  Expect = 5e-18, Method: Composition-based stats.
 Identities = 38/242 (15%), Positives = 79/242 (32%), Gaps = 29/242 (11%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D          + + GAD + + +    +   +  G  I  +  R++ R        +  
Sbjct  31   DLETTVAALKILDDHGADLIELGM---PYSDPLADGPVIQAAATRALQRGTRLEAVLEMT  87

Query  74   TAFFDCH---------MMVENPEK------WVDDFAKCGADQFTFHYEATQDPLHLVKLI  118
            T   D H             NP        ++   A+ G           ++   ++   
Sbjct  88   T---DLHQQLTAPLILFSYYNPIYHRGVSSFLKAVAQAGIKGLVIPDLPLEEAEPVLAET  144

Query  119  KSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGG--QKFMEDMMPKVETLRAK  176
             + G++    I P TS + +  +A      + +    G  G  Q+    +   + TLR  
Sbjct  145  ANLGLELTLLIAPTTSPERMRAIATASQGFIYLVSTTGVTGMRQEMASRVQELLHTLRQI  204

Query  177  FPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTA-ADPH---DVISFMKEEVSKEL  231
             P   I V  G+   E   +    GA+  + G++     A+P      ++   + +   L
Sbjct  205  TPKP-IGVGFGIASPEHARQVRDWGADAAIVGSAFVKRLAEPDQGLAAVAEFCQSLRTAL  263

Query  232  RS  233
             +
Sbjct  264  DT  265


>gi|38258736|sp|Q88B60|TRPA_PSESM  Tryptophan synthase alpha chain
Length=270

 Score = 89.0 bits (220),  Expect = 1e-17, Method: Composition-based stats.
 Identities = 41/222 (18%), Positives = 69/222 (31%), Gaps = 25/222 (11%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----  76
               +  AGAD + + +    F   +  G  I  +  R++        T +  + F     
Sbjct  37   LKGLPAAGADVIELGM---PFTDPMADGVAIQLATLRALDAGQTLLKTLQMVSEFRVDDQ  93

Query  77   -FDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M   NP      E +V    + G D         +    L    ++ GI     
Sbjct  94   TTPIVLMGYYNPIHRFGVEAFVAQAKEAGVDGLIIVDLPPEHDAELATPAQASGIDFIRL  153

Query  129  IKPGTSVDVLFELAPH-LDMALVMTVEPGFGGQ--KFMEDMMPKVETLRAKFPHLNIQVD  185
              P T    L  +          ++V  G  G      E +   +  LR     L I V 
Sbjct  154  TTPTTDDARLPRVLERSSGFVYYVSV-AGVTGAGSATTEHVTEAIARLRRHT-SLPISVG  211

Query  186  GGLGKETIPKAAKAGANVIVAGTS----VFTAADPHDVISFM  223
             G+       A    A+ +V G++    + TA  P   I  +
Sbjct  212  FGIRTPEQAAAIARLADGVVVGSAFVDKIATAESPEQAIDGV  253


>gi|73622040|sp|Q7TUC8|TRPA_PROMP  Tryptophan synthase alpha chain
Length=279

 Score = 89.0 bits (220),  Expect = 1e-17, Method: Composition-based stats.
 Identities = 44/253 (17%), Positives = 94/253 (37%), Gaps = 27/253 (10%)

Query  3    KPIIAPSILASDF--ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            K  + P I+A D           K+   GAD + + +    +   +  G  I  S  R++
Sbjct  30   KLALMPFIMAGDPNIETTSEILLKLQEKGADLIELGI---PYSDPLADGPIIQLSASRAL  86

Query  61   PRPGDASNTEKKPTAFFD-CHM-----MVENP------EKWVDDFAKCGADQFTFHYEAT  108
                   N  +   +  D  H+        NP      E + +  +K G           
Sbjct  87   KSGTTLKNVIQLLESLKDKLHIPIILFTYFNPVLNFGLENFCELASKVGVSGLIIPDLPL  146

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQK-FMEDM  166
            ++     ++I S  I     + P T  + +  ++ +      +++V  G  G++  ME+ 
Sbjct  147  EEAYKFSEIISSYSIDLILLVAPTTPSERMKIISNNTKGFTYLVSV-TGVTGERNKMENR  205

Query  167  MPKVETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFT---AADPHDVISF  222
            +  + T   +     + V  G+   E + K  K GA+ ++ G++       ++  +V++ 
Sbjct  206  VENLITKLQEISINPVAVGFGISSPEHVNKVRKWGADGVIIGSAFVKRISNSNEKEVVNQ  265

Query  223  MK---EEVSKELR  232
            +    EE+ K   
Sbjct  266  IGKFCEEMRKAAD  278


>gi|20141660|sp|O58462|PYRF_PYRHO  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=208

 Score = 89.0 bits (220),  Expect = 1e-17, Method: Composition-based stats.
 Identities = 37/217 (17%), Positives = 76/217 (35%), Gaps = 28/217 (12%)

Query  19   GCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFD  78
            G    K+  +  D++ +  ++   +  +  G  I+  L+        A            
Sbjct  11   GERAIKIAKSVKDYISMIKVNWPLI--LGSGVDIIRRLKEETGVEIIADLKLAD------  62

Query  79   CHMMVENPEKWVDDFA-KCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDV  137
                + N  + +       GAD    H    +D +  VK +    +    +  PG +++ 
Sbjct  63   ----IPNTNRLIARKVFGAGADYVIVHTFVGRDSVMAVKELGEIIMVVEMS-HPG-ALEF  116

Query  138  LFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRA------KFPHLNIQVDGGLGKE  191
            +  L     + +   +EP FG          ++  +R       K     I   GG    
Sbjct  117  INPLTDRF-IEVANEIEP-FGVIAPGTRP-ERIGYIRDRLKEGIKILAPGIGAQGG----  169

Query  192  TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
                A KAGA+ I+ G +++ A +P +    + +E+ 
Sbjct  170  KAKDAVKAGADYIIVGRAIYNAPNPREAAKAIYDEIR  206


>gi|73622041|sp|Q8XXY2|TRPA_RALSO  Tryptophan synthase alpha chain
Length=265

 Score = 88.6 bits (219),  Expect = 2e-17, Method: Composition-based stats.
 Identities = 32/233 (13%), Positives = 80/233 (34%), Gaps = 27/233 (11%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
            H ++  GA+ + + V    F   +  G  I  +  R++ +            AF      
Sbjct  38   HALVKGGANVIELGV---PFSDPMADGPVIQRASERALAKKIGLRTVLDYVRAFRATDKT  94

Query  77   FDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP      + +    ++ G D         ++     K +++ GI     +
Sbjct  95   TPVVLMGYANPIERMGIDAFAKAASEAGVDGVLVVDYPPEECEAFAKTMRAAGIDPIFLL  154

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKF--MEDMMPKVETLRAKFPHLNIQVDG  186
             P ++   + ++A         ++++ G  G     ++ +  ++  +R     L + V  
Sbjct  155  APTSTEARMAQIARVASGYIYYVSLK-GVTGAATLDLDSVAARIPQIRQHA-RLPVGVGF  212

Query  187  GLGKETIPKAAKAGANVIVAGTSVF---TAADPHDVIS---FMKEEVSKELRS  233
            G+      +A    A+ +V G+ +      A     +        ++ + L +
Sbjct  213  GIRDAATARAIGGVADAVVIGSRIVQLLEEASREQAVQCLTDFIADIRQALDA  265


>gi|73621987|sp|Q5P1I9|TRPA_AZOSE  Tryptophan synthase alpha chain
Length=271

 Score = 88.2 bits (218),  Expect = 2e-17, Method: Composition-based stats.
 Identities = 30/230 (13%), Positives = 75/230 (32%), Gaps = 31/230 (13%)

Query  24   KVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------F  77
             ++  GAD + + V    F   +  G  I  +  R++               F       
Sbjct  39   ALVEGGADIIELGV---PFSDPMADGPTIQRASERALANGMTLRRVLDTVREFRTGNAET  95

Query  78   DCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIK  130
               +M   NP      E++V    +   D         ++     +  K  G+     + 
Sbjct  96   PVVLMGYANPIEAMGVERFVSAAREAQVDGVLIVDYPPEECESFARAAKDAGLDPIFLLA  155

Query  131  PGTSVDVLFELAP-HLDMALVMTVEPGFGGQKFME--DMMPKVETLRAKFPHLNIQVDGG  187
            P ++     ++A         ++++ G  G   ++  ++  ++  +RA+     + V  G
Sbjct  156  PTSTEQRFRDVARVGSGYIYYVSLK-GVTGSATLDFDEVAARIPQIRAQVGMP-VGVGFG  213

Query  188  LGKETIPKAAKAGANVIVAGTSVFT----------AADPHDVISFMKEEV  227
            +      +     A+ +V G+ +            AA+    +  ++  +
Sbjct  214  IRDAESARRIGEVADAVVIGSRIIEEIERSPRDRLAANVTAFLREVRTAL  263


>gi|74527158|sp|Q8THA9|FAEHP_METAC  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=392

 Score = 88.2 bits (218),  Expect = 2e-17, Method: Composition-based stats.
 Identities = 32/182 (17%), Positives = 66/182 (36%), Gaps = 15/182 (8%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEAT  108
            G  +++ +R+  P     ++ +   T   +  M+ +            G           
Sbjct  213  GVDVISKIRQVRPDAFIVADLKTLDTGNLEARMVADA----------AGDAIVVSALAPI  262

Query  109  QDPLHLVKLIKSKGIKAAC-AIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMM  167
                 L++     GI A    +     + VL +L   + M  V+ +  G   +   E   
Sbjct  263  STIDKLIEEAHKTGIYAVMDTLNQHDPISVLKQL--KV-MPDVIELHRGIDIEG-TEHAW  318

Query  168  PKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
              +  ++   P   I V GG+  + +P A   GA+++V G ++  A D  +V       +
Sbjct  319  GNIGEIKKIAPKALIAVAGGVRLDKVPVALGQGADILVVGRAITNAKDVREVAEQFINAL  378

Query  228  SK  229
            +K
Sbjct  379  NK  380


>gi|7674396|sp|Q9YGA9|TRPA_PYRKO  Tryptophan synthase alpha chain
Length=251

 Score = 87.9 bits (217),  Expect = 3e-17, Method: Composition-based stats.
 Identities = 35/217 (16%), Positives = 79/217 (36%), Gaps = 22/217 (10%)

Query  30   ADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----FDCHMM-V  83
            A  + + +    F   +  G+ I  S  R++       +T +    F         +M  
Sbjct  32   AGLIELGI---PFSDPMADGKTIQESHYRALRNGFKLDDTFRILREFRRHSSTPVILMTY  88

Query  84   ENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDV  137
             NP      +K++ +    GAD               +   K +G+K      P T  + 
Sbjct  89   YNPVFRTGVKKFLGEAKASGADGILVVDLPVSHAGEFLDAAKEEGLKTVFLAAPNTPDER  148

Query  138  LFELAPHL--DMALVMTVEPGFGGQKFMEDM-MPKVETLRAKFPHLNIQVDGGL-GKETI  193
            L E+          ++++    G +  + +     V   R    +  + V  G+  +E +
Sbjct  149  LREI-DKASTGFVYLISLYGTTGARDRLPETAFEFVRRARKICNN-KLAVGFGVSRREQV  206

Query  194  PKAAKAGANVIVAGTSVFTAADPHDV-ISFMKEEVSK  229
             +  KAGA+ +V G+++       +  +  ++ +V++
Sbjct  207  EELLKAGADGVVVGSALIELISRSENPVEELRRKVAE  243


>gi|109892905|sp|Q46GE2|PYRF_METBF  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=221

 Score = 87.1 bits (215),  Expect = 6e-17, Method: Composition-based stats.
 Identities = 38/229 (16%), Positives = 77/229 (33%), Gaps = 28/229 (12%)

Query  10   ILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNT  69
            ILA D ++   E  K+    +++  +D +   +   +  G  I+  L    P   D    
Sbjct  8    ILALDVSD-REEALKIAEDVSEF--VDAIKVGYPLILATGLGIIRELAEFAPIIADFKVA  64

Query  70   EKKPTAFFDCHMMVENPEKWVDDFA-KCGADQFTFHYEATQDPLHL-VKLIKSKGIKAAC  127
            +            + N  + + +   + G D         +D L   +++    G     
Sbjct  65   D------------IPNTNRLICEHVFEAGTDAVIVQGFTGRDSLDACIEIASEYGKDVFV  112

Query  128  AIKPGTS--VDVLFELAPHLDMALVMTVEPG-FGGQKFMEDMMP-KVETLRAKFPHLNIQ  183
              +       + L  +         M  E G FG         P +V T+R    +    
Sbjct  113  VSEMSHPGGAEFLQPVGE---AIARMAAEAGAFGLVA--PATRPERVTTIRKIIGNKLTI  167

Query  184  VDGGLGKE--TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            +  G+G +         AGA+ ++ G +++ A  P +    +  E+  E
Sbjct  168  ISPGVGAQGGKASDVIAAGADWVIVGRAIYKAESPREAARKIAAEIEAE  216


>gi|73621990|sp|Q81GG4|TRPA_BACCR  Tryptophan synthase alpha chain
Length=258

 Score = 86.7 bits (214),  Expect = 7e-17, Method: Composition-based stats.
 Identities = 41/249 (16%), Positives = 90/249 (36%), Gaps = 36/249 (14%)

Query  2    VKPIIAPSILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
             K  I P ++  D     L      +  AGA  + I +    F   +  G  I  + +R+
Sbjct  14   KKAFI-PYVMGGDGGLEKLKERIRFLDEAGASIVEIGI---PFSDPVADGPTIQRAGKRA  69

Query  60   VP-------RPGDASNTEKKPTAFFDCHMMVENP------EKWVDDFAKCGADQFTFHYE  106
            +             +   K+    F   M   NP      E+++++  + G D       
Sbjct  70   LDSGVTLKGIFQALAEVRKEVQMPF-VLMTYLNPVLAFGKERFIENCIEAGVDGIIVPDL  128

Query  107  ATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGG--QKFM  163
              ++   +  L++   I     +   + ++ + ++          +TV  G  G  Q F 
Sbjct  129  PYEEQNIIAPLLREVNIALIPLVTVTSPIERIEKITSESEGFVYAVTV-AGVTGVRQNFK  187

Query  164  EDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
            E++   +E +++   +L +    G+  KE + +      + +V G+          VI  
Sbjct  188  EEIHSYLEKVKSHV-NLPVVAGFGISTKEHVEEMVTI-CDGVVVGS---------KVIEL  236

Query  223  MKEEVSKEL  231
            ++ E  +E+
Sbjct  237  LENEKREEI  245


>gi|73621989|sp|Q73BQ6|TRPA_BACC1  Tryptophan synthase alpha chain
Length=258

 Score = 86.3 bits (213),  Expect = 9e-17, Method: Composition-based stats.
 Identities = 41/248 (16%), Positives = 92/248 (37%), Gaps = 34/248 (13%)

Query  2    VKPIIAPSILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
             K  I P ++  D     L      +  AGA  + I +    F   +  G  I  + +R+
Sbjct  14   KKAFI-PYVMGGDGGLEKLKERIRFLDEAGASIVEIGI---PFSDPVADGPTIQRAGKRA  69

Query  60   VP-----RPGDASNTEKKPTAFFDCHMMVE-NP------EKWVDDFAKCGADQFTFHYEA  107
            +      +    +  E +        +M   NP      E+++++  + G D        
Sbjct  70   LDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKEQFIENCIEAGVDGIIVPDLP  129

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGG--QKFME  164
             ++   +  L+++  I     +   + ++ + ++          +TV  G  G  Q F E
Sbjct  130  YEEQDIIAPLLRTANIALIPLVTVTSPIERIEKITSESEGFVYAVTV-AGVTGVRQNFKE  188

Query  165  DMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            ++   +E +++   HL +    G+  KE + +      + +V G+          VI  +
Sbjct  189  EIHSYLEKVKSHT-HLPVVAGFGISTKEHVEEMITI-CDGVVVGS---------KVIELL  237

Query  224  KEEVSKEL  231
            + E  +E+
Sbjct  238  ENEKREEI  245


>gi|74525136|sp|Q8PXE1|FAEHP_METMA  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=392

 Score = 85.9 bits (212),  Expect = 1e-16, Method: Composition-based stats.
 Identities = 30/182 (16%), Positives = 66/182 (36%), Gaps = 15/182 (8%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEAT  108
            G  +++ +R+  P     ++ +   T   +  M+ +            G           
Sbjct  213  GTDVISKIRQVRPDAFIVADLKTLDTGNLEARMVADA----------AGDAIVVSALAPI  262

Query  109  QDPLHLVKLIKSKGIKAAC-AIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMM  167
                 L++     GI A    +     + VL +L   + M  V+ +  G   +   E   
Sbjct  263  STIDKLIEEAHKTGIYAVMDTLNQQDPISVLKQL--KV-MPDVIELHRGIDIEG-TEHAW  318

Query  168  PKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
              +  ++   P   + V GG+  + +P A   GA+++V G ++  A D  ++       +
Sbjct  319  GNIGEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRAITNAKDVREMAEQFINSL  378

Query  228  SK  229
            +K
Sbjct  379  NK  380


>gi|73622038|sp|Q7VD15|TRPA_PROMA  Tryptophan synthase alpha chain
Length=267

 Score = 85.9 bits (212),  Expect = 1e-16, Method: Composition-based stats.
 Identities = 38/234 (16%), Positives = 80/234 (34%), Gaps = 31/234 (13%)

Query  2    VKPIIA--PSILASDF-ANLGCECH-KVINAGADWLHIDVMDGHFVPNITLGQPIVTSLR  57
             +  IA  P I+A D   N   E    +   GAD + + +    +   +  G  I  +  
Sbjct  15   KEGRIALMPFIMAGDPDVNTSAEILIMLEKKGADIIELGI---PYSDPLADGPIIQKAAS  71

Query  58   RSV---PRPGDASNTEKKPTAFFDC---HMMVENP------EKWVDDFAKCGADQFTFHY  105
            R++     P                        NP      E++  D +K GA       
Sbjct  72   RALNSGTSPKSVLEMLSTLKTKLSVPIILFTYSNPLLNYGMEEFCIDASKAGAAGLVVPD  131

Query  106  EATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME  164
               ++   L  +  SK +     + P T  + + +++        +++V  G  G++   
Sbjct  132  LPLEETEKLSSIALSKNLDLVLLVAPTTPKERMRKISQRSNGFTYLVSV-TGVTGER---  187

Query  165  DMMPK-----VETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFT  212
              +       +  LR  F    + V  G+   + + +  + GA+  + G+++  
Sbjct  188  SALENRVQLLINELRG-FSSTPVAVGFGISDTKHVIQVKRWGADGAIIGSALVK  240


>gi|73622029|sp|Q604P4|TRPA_METCA  Tryptophan synthase alpha chain
Length=267

 Score = 85.5 bits (211),  Expect = 2e-16, Method: Composition-based stats.
 Identities = 38/235 (16%), Positives = 82/235 (34%), Gaps = 29/235 (12%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
            H ++ AGAD + + V    F   +  G  I  +  R++        T      F      
Sbjct  38   HAMVEAGADVIELGV---PFSDPMADGPVIQKASERALVHHMSLGKTLDLVAEFRRADRT  94

Query  77   FDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP      +++VD     G D         ++    V ++   G+     +
Sbjct  95   TPIVLMGYLNPVECMGYQRFVDRAKDAGVDGVLTVDMPPEEAGEFVPMLHRAGLDPIFLL  154

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME--DMMPKVETLRAKFPHLNIQVDG  186
             P +S   +  +A         ++++ G  G   ++  ++  ++  +R+    L I V  
Sbjct  155  APNSSDARVQRMAALGRGYLYYVSLK-GVTGASHLDLAEVESRIAHIRSLTD-LPIGVGF  212

Query  187  GLGKETIPKAAKAGANVIVAGTS----VFTAADPHDVISF----MKEEVSKELRS  233
            G+       A    A+ +V G++    +  A D  +        +   + + L +
Sbjct  213  GVKNAETAAAIGRFADAVVVGSALVEKIAAAQDRPEQARKDIVDLLAVMRRALDA  267


>gi|73621991|sp|Q63EC6|TRPA_BACCZ  Tryptophan synthase alpha chain
Length=258

 Score = 85.2 bits (210),  Expect = 2e-16, Method: Composition-based stats.
 Identities = 40/248 (16%), Positives = 91/248 (36%), Gaps = 34/248 (13%)

Query  2    VKPIIAPSILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
             K  I P ++  D     L      +  AGA  + I +    F   +  G  I  + +R+
Sbjct  14   KKAFI-PYVMGGDGGLEILKERIRFLDEAGASIVEIGI---PFSDPVADGPTIQRAGKRA  69

Query  60   VP-----RPGDASNTEKKPTAFFDCHMMVE-NP------EKWVDDFAKCGADQFTFHYEA  107
            +      +    +  E +        +M   NP      E+++++  + G D        
Sbjct  70   LDSGVTVKGIFQALIEARKEVQIPFVLMTYLNPVLAFGKERFIENCMEAGVDGIIVPDLP  129

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGG--QKFME  164
             ++   +  L++   I     +   + ++ + ++          +TV  G  G  Q F +
Sbjct  130  YEEQDIIAPLLREANIALIPLVTVTSPIERIKKITSESEGFVYAVTV-AGVTGVRQNFKD  188

Query  165  DMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            ++   +E +++   HL +    G+  KE + +      + +V G+          VI  +
Sbjct  189  EIHSYLEKVKSHT-HLPVVAGFGISTKEHVEEMVTI-CDGVVVGS---------KVIELL  237

Query  224  KEEVSKEL  231
            + E  +E+
Sbjct  238  ENEKREEI  245


>gi|73621988|sp|Q81TL7|TRPA_BACAN  Tryptophan synthase alpha chain
Length=258

 Score = 84.8 bits (209),  Expect = 2e-16, Method: Composition-based stats.
 Identities = 40/248 (16%), Positives = 91/248 (36%), Gaps = 34/248 (13%)

Query  2    VKPIIAPSILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
             K  I P ++  D     L      +  AGA  + I +    F   +  G  I  + +R+
Sbjct  14   KKAFI-PYVMGGDGGLEILKERIRFLDEAGASIVEIGI---PFSDPVADGPTIQRAGKRA  69

Query  60   VP-----RPGDASNTEKKPTAFFDCHMMVE-NP------EKWVDDFAKCGADQFTFHYEA  107
            +      +    +  E +        +M   NP      E+++++  + G D        
Sbjct  70   LDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKERFIENCMEAGVDGIIVPDLP  129

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGG--QKFME  164
             ++   +  L++   I     +   + ++ + ++          +TV  G  G  Q F +
Sbjct  130  YEEQDIIAPLLREANIALIPLVTVTSPIERIKKITSESEGFVYAVTV-AGVTGVRQNFKD  188

Query  165  DMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            ++   +E +++   HL +    G+  KE + +      + +V G+          VI  +
Sbjct  189  EIHSYLEKVKSHT-HLPVVAGFGISTKEHVEEMVTI-CDGVVVGS---------KVIELL  237

Query  224  KEEVSKEL  231
            + E  +E+
Sbjct  238  ENEKREEI  245


>gi|73621994|sp|Q6HLU3|TRPA_BACHK  Tryptophan synthase alpha chain
Length=258

 Score = 84.8 bits (209),  Expect = 2e-16, Method: Composition-based stats.
 Identities = 40/248 (16%), Positives = 91/248 (36%), Gaps = 34/248 (13%)

Query  2    VKPIIAPSILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
             K  I P ++  D     L      +  AGA  + I +    F   +  G  I  + +R+
Sbjct  14   KKAFI-PYVMGGDGGLEILKERIRFLDEAGASIVEIGI---PFSDPVADGPTIQRAGKRA  69

Query  60   VP-----RPGDASNTEKKPTAFFDCHMMVE-NP------EKWVDDFAKCGADQFTFHYEA  107
            +      +    +  E +        +M   NP      E+++++  + G D        
Sbjct  70   LDSGVTVKGIFQALIEVREEVQIPFVLMTYLNPVLAFGKERFIENCMEAGVDGIIVPDLP  129

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGG--QKFME  164
             ++   +  L++   I     +   + ++ + ++          +TV  G  G  Q F +
Sbjct  130  YEEQDIIAPLLREANIALIPLVTVTSPIERIKKITSESEGFVYAVTV-AGVTGVRQNFKD  188

Query  165  DMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            ++   +E +++   HL +    G+  KE + +      + +V G+          VI  +
Sbjct  189  EIHSYLEKVKSHT-HLPVVAGFGISTKEHVEEMVTI-CDGVVVGS---------KVIELL  237

Query  224  KEEVSKEL  231
            + E  +E+
Sbjct  238  ENEKREEI  245


>gi|3334388|sp|O28673|TRPA_ARCFU  Tryptophan synthase alpha chain
Length=248

 Score = 84.8 bits (209),  Expect = 3e-16, Method: Composition-based stats.
 Identities = 35/226 (15%), Positives = 74/226 (32%), Gaps = 24/226 (10%)

Query  25   VINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV-----PRPGDASNTEKKPTAFFDC  79
               +GAD + + V    F   +  G+ I  S  R++      R  + +   +  +     
Sbjct  27   AAESGADVIELGV---PFSDPVADGKTIQESYVRALRNFRVERVFEIAKAFRAESDKPLV  83

Query  80   HMMVENPEK------WVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGT  133
             M   NP        +V+     G D          +    V++    G+K      P T
Sbjct  84   LMSYYNPIYRRGVESFVEKAYSSGIDAMLVVDLPYDEAGDFVEVCSRTGMKNVFLAAPNT  143

Query  134  SVDVLFELAPHLDMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQVDGGL-GK  190
              D L  +        +++   G  G++          ++  +       + V  G+   
Sbjct  144  PEDRLRAMDELSAFVYLVSTY-GVTGERDRISPLAFEALKRAKGIC-RKPVAVGFGVSKA  201

Query  191  ETIPKAAKAGANVIVAGTSVFTAADPH-----DVISFMKEEVSKEL  231
            + + +   AGA+ +V G++     +       + I  + E +   L
Sbjct  202  DHVRQLISAGADGVVVGSAFVRLINEKGERATEDIRALTENLRSGL  247


>gi|14423983|sp|Q9V1G9|TRPA_PYRAB  Tryptophan synthase alpha chain
Length=248

 Score = 84.8 bits (209),  Expect = 3e-16, Method: Composition-based stats.
 Identities = 32/214 (14%), Positives = 74/214 (34%), Gaps = 21/214 (9%)

Query  33   LHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----FDCHMM-VENP  86
            + + +    F   I  G+ I  S  R++       +       F         +M   NP
Sbjct  35   IELGI---PFSDPIADGKTIQQSHFRALKGGFKLEHAFNIVREFRKHSDVPIVLMTYYNP  91

Query  87   ------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFE  140
                   +++      G D               +++ + +GIK      P T  + L E
Sbjct  92   VFRVGLREFIGKAKDSGVDGMLIVDLPVMHASEFLEVAREEGIKTVFLAAPNTPDERLKE  151

Query  141  LAP-HLDMALVMTVEPGFGGQKFMEDM-MPKVETLRAKFPHLNIQVDGGL-GKETIPKAA  197
            +         ++++    G +  + +     ++  +    +  + V  G+  +E +    
Sbjct  152  IDKASTGFVYLISLYGTTGARDKIPETAFNLLKRAKRICKN-KVAVGFGVSKREHVEMLL  210

Query  198  KAGANVIVAGTSVFT--AADPHDVISFMKEEVSK  229
             AGAN +V G+++    A    +    ++E+V +
Sbjct  211  NAGANGVVVGSALINIIAEHGENAEEKLREKVRE  244


>gi|7676173|sp|Q60180|TRPA_METJA  Tryptophan synthase alpha chain
Length=281

 Score = 83.6 bits (206),  Expect = 5e-16, Method: Composition-based stats.
 Identities = 32/214 (14%), Positives = 69/214 (32%), Gaps = 27/214 (12%)

Query  18   LGCECHKVINAGADWLHIDVMDGHFVPNITLGQPI----VTSLR------RSVPRPGDAS  67
            +  +  +VI   AD + I +    F   +  G  I    V +L       ++       +
Sbjct  33   ISEKALEVICKHADIVEIGI---PFSDPVADGITIQKADVRALNSGMNPLKAFELAKKLN  89

Query  68   NTEKKPTAFFDCHMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK  121
                     F   +   N       E++V    + G           ++   L    K  
Sbjct  90   EKAPNVPKVF---LTYYNIIFKMGEEEFVKKCKEAGVSGIIVPDLPIEEADSLYNYCKKY  146

Query  122  GIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKF--MEDMMPKVETLRAKFP  178
            G+     + P T  + L ++         V++V  G  G +    E+    ++ ++  F 
Sbjct  147  GVDLIFLVAPTTPDERLKKILEKCSGFVYVVSV-TGITGAREKVAEETKELIKRVKK-FS  204

Query  179  HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT  212
             +   V  G+ K    +     A+  + G+++  
Sbjct  205  KIPACVGFGISKREHVEEITEIADGAIVGSAIVK  238


>gi|73621986|sp|Q6FEE6|TRPA_ACIAD  Tryptophan synthase alpha chain
Length=267

 Score = 83.6 bits (206),  Expect = 6e-16, Method: Composition-based stats.
 Identities = 35/231 (15%), Positives = 80/231 (34%), Gaps = 25/231 (10%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----  76
             HK++ AG D + + +    F   +  G  I  +  R++    +  +       F     
Sbjct  37   LHKMVEAGVDVIELGL---PFSDPMADGPVIALAAERALAAGTNTLDALNMVKEFRQNDS  93

Query  77   -FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M       V   EK+V     CG D         ++      ++K   +     
Sbjct  94   ETPVVLMGYLNPVEVIGYEKFVSHAKACGVDGVLLVDLPPEEAKEFDVVLKQHDMDQIFL  153

Query  129  IKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME--DMMPKVETLRAKFPHLNIQVD  185
            + P ++   +  +          ++++ G  G   ++  +   ++  ++ K   + + V 
Sbjct  154  LAPTSTDQRIEHVVKQASGFIYYVSLK-GVTGAATLDVTEAAERIAKIKTKT-SVPVGVG  211

Query  186  GGLGKETIPKAAKAGANVIVAGTSV---FTAADPHDVISFMKEEVSKELRS  233
             G+      KA    A+ ++ G++    F        +     +V KELR+
Sbjct  212  FGISDAASAKAMGQVADAVIVGSAFVKPFATLAIDQAVEQTVNKV-KELRA  261


>gi|12230945|sp|P07344|TRPA_PSEAE  Tryptophan synthase alpha chain
Length=268

 Score = 82.8 bits (204),  Expect = 9e-16, Method: Composition-based stats.
 Identities = 38/230 (16%), Positives = 73/230 (31%), Gaps = 25/230 (10%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D+A+       +  AGAD + + +    F   +  G  I  +  R++      + T +  
Sbjct  29   DYASSLEILKGLPAAGADVIELGM---PFTDPMADGPAIQLANIRALDGGQTLARTLQMV  85

Query  74   TAF------FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
              F          +M           E+++ +  + G D         +    L    ++
Sbjct  86   REFRSGDSETPLVLMGYFNPIHHYGVERFIAEAKEVGVDGLIVVDLPPEHNEDLCHPAQA  145

Query  121  KGIKAACAIKPGTSVDVLFELAP-HLDMALVMTVEPGFGG--QKFMEDMMPKVETLRAKF  177
             GI       P T    L  +          ++V  G  G     +E +   V  LR   
Sbjct  146  AGIDFIRLTTPTTGDQRLPTVLEGSSGFVYYVSV-AGVTGANAATLEHVEEAVARLRRHT  204

Query  178  PHLNIQVDGGLGKETIPKAAKAGANVIVAGTS----VFTAADPHDVISFM  223
              L I +  G+       A    A+ +V G++    +  A D    +  +
Sbjct  205  D-LPIGIGFGIRSAEHAAAVARLADGVVVGSALIDRIAKARDNAQAVKDV  253


>gi|24638311|sp|Q8U094|TRPA_PYRFU  Tryptophan synthase alpha chain
Length=248

 Score = 82.1 bits (202),  Expect = 1e-15, Method: Composition-based stats.
 Identities = 34/220 (15%), Positives = 73/220 (33%), Gaps = 23/220 (10%)

Query  30   ADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----FDCHMM-V  83
            A  + + +    F   I  G+ I  S  R++               F         +M  
Sbjct  32   AGAIELGI---PFSDPIADGKTIQESHYRALKNGFKLREAFWIVKEFRRHSSTPIVLMTY  88

Query  84   ENPEKWV---DDFAKC---GADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDV  137
             NP       +  A+    G D                ++ + +GIK      P T  + 
Sbjct  89   YNPIYRAGVRNFLAEAKASGVDGILVVDLPVFHAKEFTEIAREEGIKTVFLAAPNTPDER  148

Query  138  LFELAPHL--DMALVMTVEPGFGGQKFMEDMM-PKVETLRAKFPHLNIQVDGGL-GKETI  193
            L  +   +      ++++    G ++ +       +   +    +  + V  G+  +E +
Sbjct  149  LK-VIDDMTTGFVYLVSLYGTTGAREEIPKTAYDLLRRAKRICRN-KVAVGFGVSKREHV  206

Query  194  PKAAKAGANVIVAGTSVFTA--ADPHDVISFMKEEVSKEL  231
                K GAN +V G+++         +   F+K++V + L
Sbjct  207  VSLLKEGANGVVVGSALVKIIGEKGREATEFLKKKVEELL  246


>gi|28380182|sp|Q8PT96|TRPA_METMA  Tryptophan synthase alpha chain
Length=271

 Score = 82.1 bits (202),  Expect = 2e-15, Method: Composition-based stats.
 Identities = 38/239 (15%), Positives = 84/239 (35%), Gaps = 21/239 (8%)

Query  10   ILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRP  63
            ++A D  F         +   GAD + +      F   +  G  I      +L   +   
Sbjct  33   VMAGDPTFEASSEVVKALAKGGADIIELGF---PFSDPVADGPTIQVAGQRALAEGMDIE  89

Query  64   GDASNTEKKPTAFFDCHMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKL  117
               +             M   NP      EK+V++ A+ G           ++   L   
Sbjct  90   RYFAFARALEVDVPLVCMTYYNPVFRYGVEKFVENAAEAGISGLIIPDIPVEEAADLKTG  149

Query  118  IKSKGIKAACAIKPGTSVDVLFELAPH-LDMALVMTVEPGFGGQKFMEDMMPKVETLRAK  176
              + G+     + P T+   + ++         +++   G  G +  +D+    + L ++
Sbjct  150  CDAHGLDLIFLVAPTTTEARIRKILQRGSGFIYLVSR-LGVTGAR--DDVAGSTKELLSR  206

Query  177  FP-HLNIQVDGGLGK-ETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRS  233
                +   V  G+   E   +  KAGA+ ++ G++     +    ++   E +++EL+S
Sbjct  207  VNTDIPKAVGFGISTGEQAAEVRKAGADGVIVGSAFVRIIEEGTDVNERLETLARELKS  265


>gi|73622000|sp|Q7W5G9|TRPA_BORPA  Tryptophan synthase alpha chain
Length=285

 Score = 82.1 bits (202),  Expect = 2e-15, Method: Composition-based stats.
 Identities = 29/202 (14%), Positives = 71/202 (35%), Gaps = 21/202 (10%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS------VPRPGDASNTEKKPTAF  76
            H ++ AGAD + + V    F   +  G  +  +  R+      + R  +     ++  + 
Sbjct  42   HALVRAGADLVELGV---PFSDPMADGPVVQRAAERAIAQGVGLRRVLELVADFRRDDSV  98

Query  77   FDCHMM-VENPEKWV------DDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP + +            G D         ++      ++   G+     +
Sbjct  99   TPVVLMGYANPIERMGQRAFAQAAQAAGVDGVLVVDYPPEEVDEFAAMLAEAGVAPIFLL  158

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME--DMMPKVETLRAKFPHLNIQVDG  186
             P ++   +  +          ++++ G  G   ++  D+  K+  +R    H+ + V  
Sbjct  159  APTSTEARIEAIGRVARGYVYYVSLK-GVTGAGSLDTDDVARKLALIRRHV-HIPVGVGF  216

Query  187  GLGKETIPKAAKAGANVIVAGT  208
            G+      +   A A+ +V G+
Sbjct  217  GIRDAASAQRIAAHADAVVIGS  238


>gi|32172413|sp|O22018|TRPA_CYAME  Tryptophan synthase alpha chain
Length=243

 Score = 81.7 bits (201),  Expect = 2e-15, Method: Composition-based stats.
 Identities = 34/212 (16%), Positives = 67/212 (31%), Gaps = 18/212 (8%)

Query  12   ASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRR------SVPRPGD  65
            A D         K+   GAD + I V    +   +  G  +  + ++       +    +
Sbjct  10   APDINTTKEAVMKLAKKGADVIEIGV---PYSDALADGAILQKASKQALMNGFHLDHLWN  66

Query  66   ASNTEKKPTAFFDCHMMVEN------PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIK  119
              +   +        +   N       EKWV                  ++   L ++  
Sbjct  67   LLSEVNEIEVPL-VILAYYNQIWHYGVEKWVKKLVAHNVKGLIVPDLPYEESKTLRQICD  125

Query  120  SKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP  178
              G+     I P T+     ELA    D   V++     G +   +  +PK+     K  
Sbjct  126  RYGLNIIWLISPTTNKTRAQELARACKDWIYVISRTGVTGLETEFDKQIPKLIGELKKVT  185

Query  179  HLNIQVDGGL-GKETIPKAAKAGANVIVAGTS  209
               I +  G+   E +      GA+ ++ G++
Sbjct  186  KAPIALGFGISKSEQVKLVKSWGADGVIIGSA  217


>gi|73622035|sp|Q8ESU5|TRPA_OCEIH  Tryptophan synthase alpha chain
Length=262

 Score = 81.7 bits (201),  Expect = 2e-15, Method: Composition-based stats.
 Identities = 40/247 (16%), Positives = 83/247 (33%), Gaps = 23/247 (9%)

Query  2    VKPIIAPSILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
             KPI  P I+A D    NL      +  AGA  + + +    F   +  G  I  + +R+
Sbjct  17   KKPIFVPYIMAGDGGIDNLNKRIQFLEEAGASAVELGI---PFSDPVADGPVIQDAGQRA  73

Query  60   VPRPGDASNTEK-----KPTAFFDCHMMVE-------NPEKWVDDFAKCGADQFTFHYEA  107
            +       +  +     K        +M           E++  D ++ G D        
Sbjct  74   LANKTTIGSVLEALESEKSQRNIPVVLMTYINPVWKYGFEQFARDCSQAGVDGIIIPDIP  133

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMED--  165
             ++   +   +    I         ++ D L  +A   +  L      G  G++   +  
Sbjct  134  MEEEDDVASSLTQHDIAFIRLAAMTSTEDRLERIAKRSEGFLYAVSVTGTTGERAQHEND  193

Query  166  MMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSV---FTAADPHDVISF  222
                +E L+    H+ +    G+      +   A  + +V G+ +   F   D   + S 
Sbjct  194  AFHFLEKLKQ-ISHVPVLAGFGISTAERARELSAACDGVVVGSKIVQLFEQGDEDGIHSL  252

Query  223  MKEEVSK  229
            ++E + +
Sbjct  253  IRESIGE  259


>gi|73621999|sp|Q7WD05|TRPA_BORBR  Tryptophan synthase alpha chain
Length=285

 Score = 81.7 bits (201),  Expect = 2e-15, Method: Composition-based stats.
 Identities = 29/202 (14%), Positives = 71/202 (35%), Gaps = 21/202 (10%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS------VPRPGDASNTEKKPTAF  76
            H ++ AGAD + + V    F   +  G  +  +  R+      + R  +     ++  + 
Sbjct  42   HALVRAGADLVELGV---PFSDPMADGPVVQRAAERAIAQGVGLRRVLELVADFRRDDSV  98

Query  77   FDCHMM-VENPEKWV------DDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP + +            G D         ++      ++   G+     +
Sbjct  99   TPVVLMGYANPIERMGQRAFAQAAQAAGVDGVLVVDYPPEEVDEFAAMLAEAGVAPIFLL  158

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME--DMMPKVETLRAKFPHLNIQVDG  186
             P ++   +  +          ++++ G  G   ++  D+  K+  +R    H+ + V  
Sbjct  159  APTSTEARIEAIGRVARGYVYYVSLK-GVTGAGSLDTDDVARKLALIRRHV-HIPVGVGF  216

Query  187  GLGKETIPKAAKAGANVIVAGT  208
            G+      +   A A+ +V G+
Sbjct  217  GIRDAASAQRIAAHADAVVIGS  238


>gi|12230284|sp|Q9KRD8|METE_VIBCH  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=761

 Score = 81.3 bits (200),  Expect = 3e-15, Method: Composition-based stats.
 Identities = 34/201 (16%), Positives = 62/201 (30%), Gaps = 35/201 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              L  E   + +AG + + ID       P I  G P+      +      +    S    
Sbjct  584  LALRDEVADLQDAGINIIQID------EPAIREGLPLKKRDHQTYLDWAVQAFKISAGSA  637

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +P      HM      + ++  A   AD  T   E ++  + L+K  +            
Sbjct  638  RPETQIHTHMCYSEFNEIIESVAALDADVITI--ETSRSNMELLKAFEE--------FNY  687

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +         P    Q ++E     +     K P   L +  D GL 
Sbjct  688  P---NEIGPGVYDIHS-------PNIPAQAWIE---DLLRKAAEKIPAQRLWVNPDCGLK  734

Query  190  KETIPKAAKAGANVIVAGTSV  210
                P+   A  N++ A  ++
Sbjct  735  TRNWPEVEAALTNMVNAAKAL  755


>gi|136261|sp|P26920|TRPA_METTM  Tryptophan synthase alpha chain
Length=265

 Score = 80.9 bits (199),  Expect = 3e-15, Method: Composition-based stats.
 Identities = 36/236 (15%), Positives = 75/236 (31%), Gaps = 24/236 (10%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS-----VPRPGDASN  68
            D          +++AGAD L I      F   I  G  +  +  R+              
Sbjct  25   DMETSVEIIRTLVDAGADALEIGF---PFSDPIADGTSVQEADLRALNSGMTTDDCFRLI  81

Query  69   TEKKPTAFFDCHMMVE-------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK  121
               +        ++V          +++    A+ G           ++    ++  +  
Sbjct  82   ERIREFTSVPVGLLVYYNLIYRMGADEFYRRAAEAGVTGILAADLPPEEAGDALRAAERY  141

Query  122  GIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPH  179
            GI     + P T    L  ++        +    G  G +    E  +  +E ++     
Sbjct  142  GIDQIFIVAPTTDNQRLKMISEVSSGFHYLVSVMGVTGARSRVEESTLELIERVKGAG-S  200

Query  180  LNIQVDGGLG-KETIPKAAKAGANVIVAGTSVF-----TAADPHDVISFMKEEVSK  229
            L + V  G+   E +   A AGA+ ++ G+++         D   ++  + E V K
Sbjct  201  LPVMVGFGVSQPEHVRMLADAGADGVIVGSAIIDLISKNLDDRERMLQEIYEMVRK  256


>gi|30173100|sp|Q8ZAL3|METE_YERPE  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=758

 Score = 80.9 bits (199),  Expect = 3e-15, Method: Composition-based stats.
 Identities = 32/198 (16%), Positives = 62/198 (31%), Gaps = 35/198 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P +  G P+      +  +        +    
Sbjct  582  LALRDEVEDLEKAGIGIIQID------EPALREGLPLRRADWQAYLQWAVDAFKLNAAVA  635

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +       HM        +D  A   AD  T   E ++  + L++           + + 
Sbjct  636  QNDTQIHTHMCYCEFNDIMDSIAALDADVITI--ETSRSDMELLE-----------SFED  682

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V +VE       ++E     +     + P   L +  D GL 
Sbjct  683  FAYPNEIGPGVYDIHSPNVPSVE-------WIEA---LLRKAAQRIPAERLWVNPDCGLK  732

Query  190  KETIPKAAKAGANVIVAG  207
                P+  +A AN+++A 
Sbjct  733  TRGWPETRQALANMVLAA  750


>gi|20140676|sp|Q92TC8|TRPA_RHIME  Tryptophan synthase alpha chain
Length=279

 Score = 80.9 bits (199),  Expect = 4e-15, Method: Composition-based stats.
 Identities = 39/227 (17%), Positives = 79/227 (34%), Gaps = 30/227 (13%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
              +  AGAD + + V    F   +  G  I  + +R++      + T +    F      
Sbjct  39   KALRQAGADIIELGV---PFSDPMADGPAIQLAGQRALKAGQSLAKTLELARLFRAEDQR  95

Query  77   FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M       +   E+++ D  + G D         +    L      KGI      
Sbjct  96   TPIVLMGYYNPIYIYGVERFLADALEAGVDGLIVVDLPPEMDDELCIPALEKGISFIRLA  155

Query  130  KPGTSVDVLFELAP-HLDMALVMTVEPGFGGQKFMEDMM--PKVETLRAKFPHLNIQVDG  186
             P T    L ++          +++  G  G    +  +    V  ++A  P L + V  
Sbjct  156  TPTTDDRRLPKVLENTSGFVYYVSM-TGITGSALPDPSLIAGAVARIKAHTP-LPVCVGF  213

Query  187  GLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRS  233
            G+      +A  A A+ +V GT++         ++ +   +++E R+
Sbjct  214  GVKTADHARAIGASADGVVVGTAI---------VNQIASSLTEEGRA  251


>gi|73622030|sp|Q6LYI9|TRPA_METMP  Tryptophan synthase alpha chain
Length=258

 Score = 80.5 bits (198),  Expect = 4e-15, Method: Composition-based stats.
 Identities = 42/255 (16%), Positives = 89/255 (34%), Gaps = 33/255 (12%)

Query  1    MVKPIIAPSILASDF---ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLR  57
            M KP++   +++ D    A L     K ++  +  + + +    F   +  G  I  +  
Sbjct  1    MNKPVLVSFLVSGDPNPDATLK--FMKTLDKYSGVIELGI---PFSDPVADGPTIQAADV  55

Query  58   RSVPRPGDASNTEKKPTAF-----FDCHMM-VENP------EKWVDDFAKCGADQFTFHY  105
            RS+      + + +    F         +M   NP      E +V    + GA+      
Sbjct  56   RSLSNNFKIAKSFEVLKEFRKESDTPVILMTYYNPVYKRGIENFVIQAKEAGANGLIIVD  115

Query  106  EATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL--DMALVMTVEPGFGGQK--  161
               Q+     K+ K   +       P T  + L  ++     +   +++   G  G +  
Sbjct  116  LPLQEATEYRKICKKHEMGTVFLAAPNTPEERLK-ISDEASTEFLYLIS-TFGITGARDT  173

Query  162  FMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVF----TAADP  216
            F +     ++  R       I V  G+          + GA+ ++ G++         D 
Sbjct  174  FEQMTFDFIKRARTTCKG-KICVGFGISKGSHAESLIEQGADGVIVGSAFVDIIKNYGDS  232

Query  217  HDVISFMKEEVSKEL  231
             + +  + EE++KEL
Sbjct  233  KEALVKL-EELAKEL  246


>gi|73622001|sp|Q7VTF0|TRPA_BORPE  Tryptophan synthase alpha chain
Length=285

 Score = 80.5 bits (198),  Expect = 4e-15, Method: Composition-based stats.
 Identities = 29/202 (14%), Positives = 71/202 (35%), Gaps = 21/202 (10%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS------VPRPGDASNTEKKPTAF  76
            H ++ AGAD + + V    F   +  G  +  +  R+      + R  +     ++  + 
Sbjct  42   HALVRAGADLVELGV---PFSDPMADGPVVQRAAERAIAQGVGLRRVLELVADFRRDDSV  98

Query  77   FDCHMM-VENPEKWV------DDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP + +            G D         ++      ++   G+     +
Sbjct  99   TPVVLMGYANPIERMGQRAFAQAAQAAGVDGVLVVDYPPEEVDEFAVMLAEAGVAPIFLL  158

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME--DMMPKVETLRAKFPHLNIQVDG  186
             P ++   +  +          ++++ G  G   ++  D+  K+  +R    H+ + V  
Sbjct  159  APTSTEARIEAIGRVARGYVYYVSLK-GVTGAGSLDTDDVARKLALIRRHV-HIPVGVGF  216

Query  187  GLGKETIPKAAKAGANVIVAGT  208
            G+      +   A A+ +V G+
Sbjct  217  GIRDAASAQRIAAHADAVVIGS  238


>gi|38258744|sp|Q88RP7|TRPA_PSEPK  Tryptophan synthase alpha chain
Length=269

 Score = 80.2 bits (197),  Expect = 5e-15, Method: Composition-based stats.
 Identities = 38/224 (16%), Positives = 67/224 (29%), Gaps = 23/224 (10%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----  76
               +  AGAD + + +    F   +  G  I  +  R++        T +    F     
Sbjct  37   LKGLPAAGADVIELGM---PFTDPMADGVAIQLATLRALEAGQTLVKTLQMVREFRVDNQ  93

Query  77   -FDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M   NP      + +V    + G D         +    L    ++ GI     
Sbjct  94   TTPIVLMGYYNPIHRFGVDTFVTQAKEAGVDGLIIVDLPPEHDAELATPAQAAGIDFIRL  153

Query  129  IKPGTSVDVLFELAPH-LDMALVMTVEPGFGGQ--KFMEDMMPKVETLRAKFPHLNIQVD  185
              P T    L  +          ++V  G  G      E +   +  LR     L I V 
Sbjct  154  TTPTTDDARLPRVLERSSGFVYYVSV-AGVTGAGSATTEHVTEAIARLRRHTD-LPISVG  211

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
             G+   E     A+  A+ +V G+++               +V 
Sbjct  212  FGIRTPEQAANIAR-LADGVVVGSALVDKIAQAKSADQAVTDVL  254


>gi|73622009|sp|Q7NUD9|TRPA_CHRVO  Tryptophan synthase alpha chain
Length=262

 Score = 80.2 bits (197),  Expect = 6e-15, Method: Composition-based stats.
 Identities = 44/230 (19%), Positives = 83/230 (36%), Gaps = 25/230 (10%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
            H +++ GAD + + V    F   +  G  I  +  R++       +  +    F      
Sbjct  36   HGLVDGGADIIELGV---PFSDPMADGPVIQRASERALKHKVGLRHVLEMVAEFRRDNAT  92

Query  77   FDCHMM-VENPE------KWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP       ++       G D         ++   L   + + G+     +
Sbjct  93   TPVVLMGYLNPLCAMGYTEFASRAKAAGVDGVLTVDCPPEEAAELESALDAHGLDTVFLV  152

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKF--MEDMMPKVETLRAKFPHLNIQVDG  186
             P T    + E+A         ++++ G  G     +ED+  K+  LR + P L I V  
Sbjct  153  APTTPPSRVAEIAKLARGYVYYVSLK-GVTGAGHLDIEDVARKIAALRQQLP-LPIGVGF  210

Query  187  GLGKETIPKAAKAGANVIVAGTSV---FTAADPHDVISFMKEEVSKELRS  233
            G+      KA  A A+ +V G+ +     AA P +        +  EL++
Sbjct  211  GIRDAATAKAIAAAADAVVVGSRLVQEIEAATP-ETAREQLTRLVAELKA  259


>gi|38258595|sp|Q8FXY6|TRPA_BRUSU  Tryptophan synthase alpha chain
Length=279

 Score = 80.2 bits (197),  Expect = 6e-15, Method: Composition-based stats.
 Identities = 40/240 (16%), Positives = 72/240 (30%), Gaps = 35/240 (14%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
              +  AGAD + + +    F   +  G  I  +  R++      + T      F      
Sbjct  39   KALPKAGADVIELGM---PFSDPMADGPAIQAAGLRALNAGQTLAKTLYMAAEFRKEDDT  95

Query  77   FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                MM       V   E+++ D    G D        ++    L       GI      
Sbjct  96   TPIVMMGYYNPIYVYGVERFLTDAKASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLT  155

Query  130  KPGTSVDVLFELAP-HLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP---HLNIQVD  185
             P T    L ++          +++  G  G    +    KV            L I V 
Sbjct  156  TPTTDDKRLPKVLHNSSGFVYYVSMN-GITGAAIADT--AKVGEAVRHIKKSTDLPICVG  212

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTA------------ADPHDVISFMKEEVSKELRS  233
             G+       A    A+ +V GT++  A             DP    + +   +++ +R+
Sbjct  213  FGVKTPEQAAAIATHADGVVVGTAIVNAIAGELDEKGKVKGDPVAAATRLVHALAESVRA  272


>gi|136264|sp|P11081|TRPA_PSEPU  Tryptophan synthase alpha chain
Length=269

 Score = 80.2 bits (197),  Expect = 7e-15, Method: Composition-based stats.
 Identities = 41/206 (19%), Positives = 70/206 (33%), Gaps = 23/206 (11%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-FDCH  80
               +  AGAD + + +    F   +  G  I  +  R++      + T +    F  D H
Sbjct  37   LKGLPAAGADVIELGM---PFTDPMADGVAIQLATLRALEAGQTLAKTLQMVREFRVDNH  93

Query  81   -----MM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M   NP      EK+V +  + G D         +    L    ++ GI     
Sbjct  94   TTPIVLMGYYNPIHRFGVEKFVAEAKQAGVDGLIIVDLPPEHDAELATPAQAAGIDFIRL  153

Query  129  IKPGTSVDVLFELAPH-LDMALVMTVEPGFGGQ--KFMEDMMPKVETLRAKFPHLNIQVD  185
              P T    L  +          ++V  G  G      E +   +  LR     L I V 
Sbjct  154  TTPTTDDARLPRVLERSSGFVYYVSV-AGVTGAGSATTEHVTEAIARLRRHTD-LPISVG  211

Query  186  GGL-GKETIPKAAKAGANVIVAGTSV  210
             G+   E     A+  A+ +V G+++
Sbjct  212  FGIRTPEQAANIAR-LADGVVVGSAL  236


>gi|28380199|sp|Q8YE59|TRPA_BRUME  Tryptophan synthase alpha chain
Length=279

 Score = 79.8 bits (196),  Expect = 7e-15, Method: Composition-based stats.
 Identities = 39/240 (16%), Positives = 72/240 (30%), Gaps = 35/240 (14%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
              +  AGAD + + +    F   +  G  I  +  R++      + T      F      
Sbjct  39   KALPKAGADVIELGM---PFSDPMADGPAIQAAGLRALNAGQTLAKTLYMAAEFRKEDDT  95

Query  77   FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                MM       +   E+++ D    G D        ++    L       GI      
Sbjct  96   TPIVMMGYYNLIYIYGVERFLTDAKASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLT  155

Query  130  KPGTSVDVLFELAP-HLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP---HLNIQVD  185
             P T    L ++          +++  G  G    +    KV            L I V 
Sbjct  156  TPTTDDKRLPKVLHNSSGFVYYVSMN-GITGAAIADT--AKVGEAVRHIKKSTDLPICVG  212

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTA------------ADPHDVISFMKEEVSKELRS  233
             G+       A    A+ +V GT++  A             DP    + +   +++ +R+
Sbjct  213  FGVKTPEQAAAIATHADGVVVGTAIVNAIAGELDEKGKAKGDPVAAATRLVHALAESVRA  272


>gi|464911|sp|P34816|TRPA_PSESY  Tryptophan synthase alpha chain
Length=269

 Score = 79.8 bits (196),  Expect = 7e-15, Method: Composition-based stats.
 Identities = 41/238 (17%), Positives = 77/238 (32%), Gaps = 28/238 (11%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----  76
               +  AGAD + + +    F   +  G  I  +  R++    +   T +    F     
Sbjct  37   LKGLPAAGADVIELGM---PFTDPMADGPAIQLANIRALEAKQNLLKTLQMVREFRKGNN  93

Query  77   -FDCHMM-VENPE------KWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M   NP       K++ D  + G D         +    L    ++ GI     
Sbjct  94   DTPLVLMGYFNPIHKYGVPKFIADAKEAGVDGLIVVDMPPEHNGELCDPAQAAGIDFIRL  153

Query  129  IKPGTSVDVLFELAP-HLDMALVMTVEPGFG--GQKFMEDMMPKVETLRAKFPHLNIQVD  185
              P T    L  +          ++V  G    G   +E +   V  LR     L I + 
Sbjct  154  TTPTTDDVRLPTVLNGSSGFVYYVSV-AGVTGAGAATLEHVEEAVARLRRHTD-LPISIG  211

Query  186  GGLGKETIPKAAKAGANVIVAGTS----VFTAADPHDVISFMK---EEVSKELRSRDL  236
             G+       A    A+ +V G++    +  A +    I  +      +S+ +R+  +
Sbjct  212  FGIRTPEQAAAIARLADGVVVGSALIDHIANAKNDQQAIDGVLGLCAALSEGVRNASV  269


>gi|28380191|sp|Q8TLP4|TRPA_METAC  Tryptophan synthase alpha chain
Length=272

 Score = 79.8 bits (196),  Expect = 8e-15, Method: Composition-based stats.
 Identities = 33/226 (14%), Positives = 76/226 (33%), Gaps = 21/226 (9%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV----PRPGDASNTEKKPTAFF  77
               ++N GAD + +      F   +  G  I  + +R++                     
Sbjct  48   VKALVNGGADIIELGF---PFSDPVADGPTIQAAGQRALAAGMDIEHYFELVRGLGVEVP  104

Query  78   DCHMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
               M   NP      +K+V+  A  G           ++   L    +  G+     + P
Sbjct  105  LVCMTYYNPVFRYGVDKFVEHAADAGISGLIIPDIPVEEAADLKSSCEKYGLDLIFLVAP  164

Query  132  GTSVDVLFELAPH-LDMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQVDGGL  188
             T+   + ++         +++   G  G +          +  ++   P     V  G+
Sbjct  165  TTTDARIRKILERGSGFIYLVSR-LGVTGARADVSGSTKELLSRVKTDIPK---AVGFGI  220

Query  189  GK-ETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRS  233
               +   +  KAGA+ ++ G+      +  + ++   E +++EL+S
Sbjct  221  STGKQAAEVRKAGADAVIVGSVFVRIIEEGNGVNEKLEALARELKS  266


>gi|20140887|sp|Q9PDK3|TRPA_XYLFA  Tryptophan synthase alpha chain
Length=268

 Score = 79.8 bits (196),  Expect = 8e-15, Method: Composition-based stats.
 Identities = 45/256 (17%), Positives = 83/256 (32%), Gaps = 31/256 (12%)

Query  3    KPIIAPSILASDFANLGCEC---HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
            K +I P I A D + L       H ++ AGAD + + V    F   +  G  I  S  R+
Sbjct  17   KALI-PFITAGDPS-LEAAVPVMHALVRAGADVIELGV---PFSDPMADGPVIQHSSERA  71

Query  60   VPRPGDASNTEKKPTAF------FDCHMM-------VENPEKWVDDFAKCGADQFTFHYE  106
            + R    +   +    F          +M       +    ++      CG D       
Sbjct  72   LQRGVGLAYVLQTVDVFRQSDAVTPVVLMGYLNPLEIYGIARFTQHAVACGVDGVLLVDL  131

Query  107  ATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFME--  164
              ++   +  +  + G+       P TS   L  L+      L      G  G   ++  
Sbjct  132  PPEEADEIRPIFSAAGLALIVLASPTTSASRLARLSGVAQGYLYYVSFSGVTGADRLDAQ  191

Query  165  DMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT----AADPHDV-  219
                ++  LRA+   + + V  G+            A+ +V G+++ T    A D     
Sbjct  192  SAGDRLRGLRAQT-QVPVVVGFGIRDAASAAVMAVDADGVVVGSALVTALSDAPDVDTAC  250

Query  220  --ISFMKEEVSKELRS  233
                     + + L +
Sbjct  251  RRADAFLAPLRQALDA  266


>gi|73622013|sp|Q9RVT0|TRPA_DEIRA  Tryptophan synthase alpha chain
Length=270

 Score = 79.8 bits (196),  Expect = 8e-15, Method: Composition-based stats.
 Identities = 33/233 (14%), Positives = 76/233 (32%), Gaps = 18/233 (7%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV-----PRPGDASN  68
            D A  G     ++ A AD + + +    +   +  G  I  +  +++      R      
Sbjct  41   DAARFGEVAGDLL-ARADIMEVGI---PYSDPLGDGPTIQRASEQALAGGTSTRRTLELV  96

Query  69   TEKKPTAFFDCHMMVE-------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK  121
             E +        +M          P +++    + G D            L +  L    
Sbjct  97   RELRQKDDTPIVIMTYINPIYAVGPAEFMRLAQEAGVDGLILPDLPPDQDLEIADLAAQH  156

Query  122  GIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDM--MPKVETLRAKFPH  179
            G+     I P ++ + +  +A      L      G  G +    +  +P++  L  ++  
Sbjct  157  GLAVTFLIAPTSTPERVKLVAEACTGFLYAVSVTGVTGAREGAALGEVPRMLDLARQYAQ  216

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELR  232
              + V  G+      +     A+ +V G++   A      +  + +E++   R
Sbjct  217  RPVVVGFGVKDAATAQQVAQVADGVVVGSAFINAVAAGRDVGALADELAAGCR  269


>gi|116256441|sp|Q1XDA5|TRPA_PORYE  Tryptophan synthase alpha chain
Length=263

 Score = 79.4 bits (195),  Expect = 1e-14, Method: Composition-based stats.
 Identities = 27/214 (12%), Positives = 70/214 (32%), Gaps = 19/214 (8%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKK-  72
            D  + G     + + GAD + + +    +   +  G  I  +  R++ +  + +      
Sbjct  27   DLVSTGKALQILDSYGADIIELGL---PYSDPLADGPIIQEASNRALKQGINLNKILSMV  83

Query  73   ------PTAFFDCHMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                    A         NP        ++   +  G           ++  +++ +   
Sbjct  84   KTVNMTIKAPI-VLFTYYNPVLHLGINNFIYAISNAGIRGLLIPDLPIEESEYVISVCNL  142

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKF-MEDMMPKVETLRAKFPH  179
              I+    + P +S + + ++       + +    G  GQK  +   + ++        +
Sbjct  143  FNIELILLLAPTSSRERISKIIKRAPGCIYLVSTTGVTGQKSQLTSQLKELTETVKTMTN  202

Query  180  LNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFT  212
             +I +  G+   E I +      N IV G++   
Sbjct  203  KSIILGFGISTTEQIKEIKGWNINGIVIGSAFVK  236


>gi|2822116|sp|P16578|TRP_COPCI  Tryptophan synthase
Length=702

 Score = 79.0 bits (194),  Expect = 1e-14, Method: Composition-based stats.
 Identities = 36/210 (17%), Positives = 77/210 (36%), Gaps = 21/210 (10%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----  76
               +   GAD + + +    F   I  G  I  +   ++    D      +         
Sbjct  34   LLALQAGGADIIELGI---PFSDPIADGPVIQEANTVALKNDIDYPTVLGQIREARQQGL  90

Query  77   -FDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M   NP      +K + D A+ GA+ F       ++ +   +   +  +     
Sbjct  91   TAPVLLMGYYNPMLAYGEDKAIQDAAEAGANGFIMVDLPPEEAIAFRQKCAASNLSYVPL  150

Query  129  IKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF---PHLNIQVD  185
            I P T++  +  LA   D  + +  + G  G      +  ++ T+ ++     H+ + V+
Sbjct  151  IAPSTTLKRIQFLASIADSFIYVVSKMGTTGSSANVAVNEELPTILSRIREYTHVPLAVE  210

Query  186  GGL-GKETIPKAAKAGANVIVA-GTSVFTA  213
             G+  ++     A AGA+ +V  G+ +  A
Sbjct  211  FGVATRDQFNYVADAGADGVVVIGSRIVNA  240


>gi|136262|sp|P14637|TRPA_METVO  Tryptophan synthase alpha chain
Length=284

 Score = 78.6 bits (193),  Expect = 2e-14, Method: Composition-based stats.
 Identities = 33/226 (14%), Positives = 67/226 (29%), Gaps = 22/226 (9%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----F  77
               ++     + + +    F   I  G  I  +  RS+        +      F      
Sbjct  44   MNALDEYCGVIELGI---PFSDPIADGSTIQEANVRSLSNGYKIHQSFDVLREFRKFSDT  100

Query  78   DCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIK  130
               +M   NP      E +V    + GA+          +      + K   +     + 
Sbjct  101  PVVLMTYYNPIYKRGIENFVIQAKEAGANGLIIVDLPLDEAEQYRAICKKHDMGTVFLVA  160

Query  131  PGTSVDVLFELAPHLDMALVMTVEPGFGGQ--KFMEDMMPKVETLRAKFPHLNIQVDGGL  188
            P T  + L        + L +    G  G    F +     +   +       + V  G+
Sbjct  161  PNTPDERLMYSDEASTLFLYVISTFGITGARGSFEKMTFEFIARAKNLCDKNKLYVGFGI  220

Query  189  -GKETIPKAAKAGANVIVAGTSVF----TAADPHDVISFMKEEVSK  229
               E   K  + GA+ ++ G++         D ++ I  +KE   +
Sbjct  221  SNGEHAEKIIENGADGVIVGSAFVDIIKEYGDSNETIYKLKELARE  266


>gi|73622055|sp|Q7TTU8|TRPA_SYNPX  Tryptophan synthase alpha chain
Length=269

 Score = 78.6 bits (193),  Expect = 2e-14, Method: Composition-based stats.
 Identities = 37/254 (14%), Positives = 83/254 (32%), Gaps = 27/254 (10%)

Query  2    VKPIIAPSILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
             +  + P ++A D   A        + N+GAD + + +    +   +  G  I  +  R+
Sbjct  20   KRLALMPFLMAGDPDLATTSEVLLSLQNSGADMVELGM---PYSDPLADGPVIQAAAARA  76

Query  60   V---PRPGDASNTEKKPTAF--FDCHM-MVENP------EKWVDDFAKCGADQFTFHYEA  107
            +     PG                  +    NP      E + +  A  GA         
Sbjct  77   LAAGTTPGKVLEMLTSLKGQLTIPVILFTYSNPLLNVGMEAFCERAAAAGAAGLVVPDLP  136

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKF-MED  165
             ++   L  L + +G+     + P T  D +  +         +++V  G  G++  ME 
Sbjct  137  LEEAERLSPLAEQQGLDLVLLVAPTTPADRMVRIGQRSRGFTYLVSV-TGVTGERAQMET  195

Query  166  MMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSV------FTAADPHD  218
             +  +     +   + + V  G+ G + + +    GA+  + G+++             +
Sbjct  196  RVEGLVEELKQSSAVPVAVGFGISGADQVRQVRSWGADGAIVGSALVKRMAAAGEGQIAE  255

Query  219  VISFMKEEVSKELR  232
                   E+     
Sbjct  256  EAGQFCRELRNAAD  269


>gi|32130277|sp|Q87DR8|TRPA_XYLFT  Tryptophan synthase alpha chain
Length=268

 Score = 78.6 bits (193),  Expect = 2e-14, Method: Composition-based stats.
 Identities = 44/256 (17%), Positives = 82/256 (32%), Gaps = 31/256 (12%)

Query  3    KPIIAPSILASDFANLGCEC---HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
            K +I P I A D + L       H ++ AGAD + + V    F   +  G  I  S  R+
Sbjct  17   KALI-PFITAGDPS-LEAAVPVMHALVRAGADVIELGV---PFSDPMADGPVIQHSSERA  71

Query  60   VPRPGDASNTEKKPTAF------FDCHMM-------VENPEKWVDDFAKCGADQFTFHYE  106
            + R    +   +    F          +M       +    ++       G D       
Sbjct  72   LQRGVGLAYVLQTVDVFRQSDAVTPVVLMGYLNPLEIYGIARFTQQALASGVDGVLLVDL  131

Query  107  ATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFME--  164
              ++   +  +  + G+       P TS   L  L+      L      G  G   ++  
Sbjct  132  PPEEADEIRAIFSAAGLALIVLASPTTSASRLATLSGVAQGYLYYVSFAGVTGADRLDAQ  191

Query  165  DMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT----AADPHDV-  219
                ++  LRA+   + + V  G+            A+ +V G+++ T    A D     
Sbjct  192  SAGDRLRGLRAQT-QVPVVVGFGIRDAASAVVMAVDADGVVVGSALVTALSDAPDVDTAC  250

Query  220  --ISFMKEEVSKELRS  233
                     + + L +
Sbjct  251  RRADAFLAPLRQALDA  266


>gi|73622021|sp|Q5FRN3|TRPA_GLUOX  Tryptophan synthase alpha chain
Length=270

 Score = 78.6 bits (193),  Expect = 2e-14, Method: Composition-based stats.
 Identities = 35/211 (16%), Positives = 66/211 (31%), Gaps = 29/211 (13%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----  76
               +  AGAD + I V    F      G  I  +  R +          +   AF     
Sbjct  37   LRAMPAAGADLIEIGV---PFSDPSADGPTIQAAALRGLKAGATLGRVLEMVRAFRETDN  93

Query  77   -FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M          P ++  D A+ G D        T++   L    +   +     
Sbjct  94   ETPIVLMGYLNPIDSYGPAEFCFDAAQAGVDGIIVVDMPTEEADLLDAHAREADLDIISL  153

Query  129  IKPGTSVDVLFELAPHL-DMALVMTVEPGFGG-----QKFMEDMMPKVETLRAKFPHLNI  182
            + P TS   LF +          +++  G  G        +E  +P++         L +
Sbjct  154  VAPTTSNSRLFHVLREASGFVYYVSI-TGITGTNSASAADLEKALPRIREAT----SLPV  208

Query  183  QVDGGL-GKETIPKAAKAGANVIVAGTSVFT  212
             +  G+   E    A++ G +  V  +++  
Sbjct  209  AIGFGISTPEQARTASRIG-DAAVVASALIK  238


>gi|73622003|sp|Q57AF2|TRPA_BRUAB  Tryptophan synthase alpha chain
Length=279

 Score = 78.6 bits (193),  Expect = 2e-14, Method: Composition-based stats.
 Identities = 40/240 (16%), Positives = 72/240 (30%), Gaps = 35/240 (14%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
              +  AGAD + + +    F   +  G  I  +  R++      + T      F      
Sbjct  39   KALPKAGADVIELGM---PFSDPMADGPAIQAAGLRALNAGQTLAKTLYMAAEFRKEDDT  95

Query  77   FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                MM       V   E+++ D    G D        ++    L       GI      
Sbjct  96   TPIVMMGYYNPIYVYGVERFLTDAKASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLT  155

Query  130  KPGTSVDVLFELAP-HLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP---HLNIQVD  185
             P T    L ++          +++  G  G    +    KV            L I V 
Sbjct  156  TPTTDDKRLPKVLHNSSGFVYYVSMN-GITGAAIADT--AKVGEAVRHIKKSTDLPICVG  212

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTA------------ADPHDVISFMKEEVSKELRS  233
             G+       A    A+ +V GT++  A             DP    + +   +++ +R+
Sbjct  213  FGVKTPEQAAAIATHADSVVVGTAIVNAIAGELDEKGKVKGDPVAAATRLVHALAESVRA  272


>gi|73622018|sp|Q5KXV2|TRPA_GEOKA  Tryptophan synthase alpha chain
Length=268

 Score = 78.2 bits (192),  Expect = 2e-14, Method: Composition-based stats.
 Identities = 33/225 (14%), Positives = 71/225 (31%), Gaps = 22/225 (9%)

Query  3    KPIIAPSILASDFA--NLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
             P+  P I+A D A          +  AGAD L + V    +   +  G  I  +  R++
Sbjct  7    PPLFIPFIVAGDPAPDVTIDLALALEEAGADILELGV---PYSDPLADGPTIQRAAARAL  63

Query  61   P----RPGDASNTEKKPTAFFDC---HMMVENP------EKWVDDFAKCGADQFTFHYEA  107
                  P       +      +         NP      E +     + GAD        
Sbjct  64   DGGMTLPKAIQLIGEMRKKGVNIPIILFTYYNPVLQLGEESFFALARENGADGVLIPDLP  123

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKF-MEDM  166
             ++    ++ +  +      ++   TS   +  +A      L      G  G +  + + 
Sbjct  124  FEES-GPLRELGERFGLPLISLVAPTSKQRIERIASAAQGFLYCVSSLGVTGVRETLPET  182

Query  167  M-PKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSV  210
            +   +  ++     + + V  G+         K   + +V G+++
Sbjct  183  LGDFLREVKRH-SRVPVAVGFGISAPEQVAMLKEVCDGVVVGSAL  226


>gi|73622053|sp|Q67PJ3|TRPA_SYMTH  Tryptophan synthase alpha chain
Length=279

 Score = 77.8 bits (191),  Expect = 3e-14, Method: Composition-based stats.
 Identities = 27/212 (12%), Positives = 61/212 (28%), Gaps = 21/212 (9%)

Query  15   FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS------VPRPGDASN  68
             A      H +  AG D + + +    F   +  G  I  + +R+           +   
Sbjct  30   LATTRRLVHALAEAGVDMVELGL---PFSDPLADGPVIQAASQRALAAGANTDNVLELVA  86

Query  69   TEKKPTAFFDCHMMVE-------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK  121
              +         +M           E +    A  G D         ++   +     + 
Sbjct  87   ALRADGLQIPLLIMTYYNLVLRPGVENFCHRAAAAGVDGLILPDVPVEESDEIRAAAGAV  146

Query  122  GIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQ--KFMEDMMPKVETLRAKFPH  179
            G+     + P +  + +   A      +      G  G   +    +   VE ++A    
Sbjct  147  GLDLIQFVAPTSPPERIRRAAELARGFIYAVSSTGVTGVRDRLPPQLTAMVEAVKAVTDT  206

Query  180  LNIQVDGGL-GKETIPKAAKAGANVIVAGTSV  210
              + V  G+   E + +     A+  + G++ 
Sbjct  207  -PVAVGFGISRPEQVRQVTAV-ADAAIVGSAF  236


>gi|136258|sp|P18284|TRPA_HALVO  Tryptophan synthase alpha chain
Length=277

 Score = 77.8 bits (191),  Expect = 3e-14, Method: Composition-based stats.
 Identities = 37/242 (15%), Positives = 74/242 (30%), Gaps = 32/242 (13%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRR-----SVPRPGDASN  68
            D+ +       +   GAD + + +    F   I  G  I  ++ R       P       
Sbjct  23   DYESSLEYVEALERGGADVIELGL---PFSEPIAEGPTIQNAVVRSLEGGMTPTRFFEFV  79

Query  69   TEKKPTAFFDCHMMVEN----------PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLI  118
             +   +    C M   N          P  +V+  A+ G + F       ++   L +  
Sbjct  80   EDLDVSVPLVC-MRYYNLIYRYGDEPGPRPFVEKAAEVGIEGFVVPDLPAEEAGPLREAC  138

Query  119  KSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFMEDMMPK-VETLRAK  176
               G+     + P T  + L  +   +     V       G Q  + D     +E L   
Sbjct  139  DEFGLDLVFIVAPTTRGERLDRIMEQVSGYVYVQARLGTTGAQSSVSDQTDSSLERLTDY  198

Query  177  FPHLNIQVDGGLGK-ETIPKAAKAGANVIVAGTSVF--------TAADPHDVISFMKEEV  227
               +   V  G+   +   +   +GA+ I+ G+++            D   V   ++   
Sbjct  199  --DVPKAVGFGISDGDHAERIVASGADGIIVGSALVDIVAEGHENGDDAETVADRLETLA  256

Query  228  SK  229
             +
Sbjct  257  RE  258


>gi|51316415|sp|Q83IW0|METE_SHIFL  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=753

 Score = 77.5 bits (190),  Expect = 3e-14, Method: Composition-based stats.
 Identities = 35/195 (17%), Positives = 61/195 (31%), Gaps = 35/195 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P +  G P+  S      +        +    
Sbjct  579  LALRDEVADLEAAGIGIIQID------EPALREGLPLRRSDWDAYLQWGVEAFRINAAVA  632

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM        +D  A   AD  T   E ++  + L++  +           P
Sbjct  633  KDDTQIHTHMCYCEFNDIMDSIAALDADVITI--ETSRSDMELLESFEEFD-------YP  683

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V +VE       ++E ++ K      + P   L +  D GL 
Sbjct  684  ----NEIGPGVYDIHSPNVPSVE-------WIEALLKK---AAKRIPAERLWVNPDCGLK  729

Query  190  KETIPKAAKAGANVI  204
                P+   A AN++
Sbjct  730  TRGWPETRAALANMV  744


>gi|68053105|sp|Q6B8L2|TRPA_GRATL  Tryptophan synthase alpha chain
Length=268

 Score = 77.5 bits (190),  Expect = 4e-14, Method: Composition-based stats.
 Identities = 29/207 (14%), Positives = 72/207 (34%), Gaps = 21/207 (10%)

Query  20   CECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFF-D  78
                 +   GAD + + +    +   +  G  I  + + ++ +           T    D
Sbjct  33   KALKVLDREGADLIELGI---PYSDALADGPIIQEASQAALKQGIYIEQVLSILTKVIPD  89

Query  79   CH-----MMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAAC  127
             H         NP      +K++ + ++ GA          ++  ++++L     I+   
Sbjct  90   LHAPIIIFTYYNPVLVRGVDKFICEISQAGAKGLIIPDLPLEEVDYILELCNLYSIELIL  149

Query  128  AIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP---HLNIQV  184
             + P +S   +  +A      + +    G  G +   D+  K++ L        +  I +
Sbjct  150  FVAPTSSQSRIQLIASKSPGCIYLVSSCGVTGLRDNFDV--KIQHLANNIKSTTNKLIML  207

Query  185  DGGLG-KETIPKAAKAGANVIVAGTSV  210
              G+   + I +      + IV G+++
Sbjct  208  GFGINNPDQISQIINWNIDGIVVGSAI  234


>gi|30173093|sp|Q8X8L5|METE_ECO57  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=753

 Score = 77.5 bits (190),  Expect = 4e-14, Method: Composition-based stats.
 Identities = 35/195 (17%), Positives = 61/195 (31%), Gaps = 35/195 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P +  G P+  S      +        +    
Sbjct  579  LALRDEVADLEAAGIGIIQID------EPALREGLPLRRSDWDAYLQWGVEAFRINAAVA  632

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM        +D  A   AD  T   E ++  + L++  +           P
Sbjct  633  KDDTQIHTHMCYCEFNDIMDSIAALDADVITI--ETSRSDMELLESFEEFD-------YP  683

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V +VE       ++E ++ K      + P   L +  D GL 
Sbjct  684  ----NEIGPGVYDIHSPNVPSVE-------WIEALLKK---AAKRIPAERLWVNPDCGLK  729

Query  190  KETIPKAAKAGANVI  204
                P+   A AN++
Sbjct  730  TRGWPETRAALANMV  744


>gi|30173061|sp|Q8FBM1|METE_ECOL6  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=753

 Score = 77.1 bits (189),  Expect = 5e-14, Method: Composition-based stats.
 Identities = 35/195 (17%), Positives = 61/195 (31%), Gaps = 35/195 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P +  G P+  S      +        +    
Sbjct  579  LALRDEVADLEAAGIGIIQID------EPALREGLPLRRSDWDAYLQWGVEAFRINAAVA  632

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM        +D  A   AD  T   E ++  + L++  +           P
Sbjct  633  KDDTQIHTHMCYCEFNDIMDSIAALDADVITI--ETSRSDMELLESFEEFD-------YP  683

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V +VE       ++E ++ K      + P   L +  D GL 
Sbjct  684  ----NEIGPGVYDIHSPNVPSVE-------WIEALLKK---AAKRIPAERLWVNPDCGLK  729

Query  190  KETIPKAAKAGANVI  204
                P+   A AN++
Sbjct  730  TRGWPETRAALANMV  744


>gi|2851502|sp|P25665|METE_ECOLI  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=753

 Score = 77.1 bits (189),  Expect = 5e-14, Method: Composition-based stats.
 Identities = 35/195 (17%), Positives = 61/195 (31%), Gaps = 35/195 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P +  G P+  S      +        +    
Sbjct  579  LALRDEVADLEAAGIGIIQID------EPALREGLPLRRSDWDAYLQWGVEAFRINAAVA  632

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM        +D  A   AD  T   E ++  + L++  +           P
Sbjct  633  KDDTQIHTHMCYCEFNDIMDSIAALDADVITI--ETSRSDMELLESFEEFD-------YP  683

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V +VE       ++E ++ K      + P   L +  D GL 
Sbjct  684  ----NEIGPGVYDIHSPNVPSVE-------WIEALLKK---AAKRIPAERLWVNPDCGLK  729

Query  190  KETIPKAAKAGANVI  204
                P+   A AN++
Sbjct  730  TRGWPETRAALANMV  744


>gi|54039758|sp|P66983|TRPA_STAAN  Tryptophan synthase alpha chain
 gi|54042262|sp|P66982|TRPA_STAAM  Tryptophan synthase alpha chain
Length=242

 Score = 77.1 bits (189),  Expect = 5e-14, Method: Composition-based stats.
 Identities = 38/252 (15%), Positives = 89/252 (35%), Gaps = 29/252 (11%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K  I P I+ +   +L      +   GAD + I V    F   +  G  I+ + ++++
Sbjct  1    MTKLFI-PYIMGNK--DLIENATLLSENGADIIEIGV---PFSDPVADGPVIMEAGQQAI  54

Query  61   PRPGDASNTEKKPTAFFD------CHMMVENP------EKWVDDFAKCGADQFTFHYEAT  108
             +         +     D        M   N       + + +     G           
Sbjct  55   KQGITIDYIFNQLEKHGDQIKCNYVLMTYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPY  114

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALV---MTVEPGFGGQKFMED  165
            +    L +     G+K    +   T    + ++  H +  +    M    G  G  F  +
Sbjct  115  ELSQRLKQQFSHYGVKIISLVAMTTDDKRIKDIVSHAEGFIYTVTMNATTGQNG-AFHPE  173

Query  166  MMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSV---FTAADPHDVIS  221
            +  K+E+++A   ++ +    G+   + +    +  A+ IV G+ +   F +    ++I 
Sbjct  174  LKRKIESIKA-IANVPVVAGFGIRTPQHVADIKEV-ADGIVIGSEIVKRFKSNTREEIIR  231

Query  222  FMKEEVSKELRS  233
            ++ + + + L +
Sbjct  232  YL-QSIQQTLNN  242


>gi|30173098|sp|Q8Z3B6|METE_SALTI  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=754

 Score = 76.7 bits (188),  Expect = 7e-14, Method: Composition-based stats.
 Identities = 36/205 (17%), Positives = 64/205 (31%), Gaps = 35/205 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P +  G P+  S               +    
Sbjct  579  LALRDEVADLEAAGIGIIQID------EPALREGLPLRRSDWDAYLEWGVEAFRINAAVA  632

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM        +D  A   AD  T   E ++  + L++           + + 
Sbjct  633  KDETQIHTHMCYCEFNDIMDSIAALDADVITI--ETSRSDMELLE-----------SFEA  679

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V +VE       ++E ++ K      + P   L +  D GL 
Sbjct  680  FDYPNEIGPGVYDIHSPNVPSVE-------WIEALLKK---AAQRIPAQRLWVNPDCGLK  729

Query  190  KETIPKAAKAGANVIVAGTSVFTAA  214
                P+   A AN++ A  ++  A 
Sbjct  730  TRGWPETRAALANMVKAAHNLRQAK  754


>gi|12230290|sp|Q9L6N1|METE_SALTY  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=754

 Score = 76.7 bits (188),  Expect = 7e-14, Method: Composition-based stats.
 Identities = 36/205 (17%), Positives = 64/205 (31%), Gaps = 35/205 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P +  G P+  S               +    
Sbjct  579  LALRDEVADLEAAGIGIIQID------EPALREGLPLRRSDWDAYLEWGVEAFRINAAVA  632

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM        +D  A   AD  T   E ++  + L++           + + 
Sbjct  633  KDETQIHTHMCYCEFNDIMDSIAALDADVITI--ETSRSDMELLE-----------SFEA  679

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V +VE       ++E ++ K      + P   L +  D GL 
Sbjct  680  FDYPNEIGPGVYDIHSPNVPSVE-------WIEALLKK---AAQRIPAQRLWVNPDCGLK  729

Query  190  KETIPKAAKAGANVIVAGTSVFTAA  214
                P+   A AN++ A  ++  A 
Sbjct  730  TRGWPETRAALANMVKAAHNLRQAK  754


>gi|38258804|sp|Q8NWU1|TRPA_STAAW  Tryptophan synthase alpha chain
 gi|56749712|sp|Q6G9I6|TRPA_STAAS  Tryptophan synthase alpha chain
 gi|71153358|sp|Q5HG46|TRPA_STAAC  Tryptophan synthase alpha chain
Length=242

 Score = 76.3 bits (187),  Expect = 9e-14, Method: Composition-based stats.
 Identities = 38/252 (15%), Positives = 89/252 (35%), Gaps = 29/252 (11%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K  I P I+ +   +L      +   GAD + I V    F   +  G  I+ + ++++
Sbjct  1    MTKLFI-PYIMGNK--DLIENATLLSENGADIIEIGV---PFSDPVADGPVIMEAGQQAI  54

Query  61   PRPGDASNTEKKPTAFFD------CHMMVENP------EKWVDDFAKCGADQFTFHYEAT  108
             +         +     D        M   N       + + +     G           
Sbjct  55   KQGITIDYIFNQLEKHGDQIKCNYVLMTYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPY  114

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALV---MTVEPGFGGQKFMED  165
            +    L +     G+K    +   T    + ++  H +  +    M    G  G  F  +
Sbjct  115  ELSQRLKQQFSHYGVKIISLVAMTTDDKRIKDIVSHAEGFIYTVTMNATTGQNG-AFHPE  173

Query  166  MMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSV---FTAADPHDVIS  221
            +  K+E+++A   ++ +    G+   + +    +  A+ IV G+ +   F +    ++I 
Sbjct  174  LKRKIESIKA-IANVPVVAGFGIRTPQHVADIKEV-ADGIVIGSEIVKRFKSNTREEIIK  231

Query  222  FMKEEVSKELRS  233
            ++ + + + L +
Sbjct  232  YL-QSIQQTLNN  242


>gi|73622059|sp|Q5GXR6|TRPA_XANOR  Tryptophan synthase alpha chain
Length=268

 Score = 76.3 bits (187),  Expect = 1e-13, Method: Composition-based stats.
 Identities = 36/233 (15%), Positives = 67/233 (28%), Gaps = 27/233 (11%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
            H ++ AGAD + + V    F   +  G  I  S  R++ R    +   +    F      
Sbjct  38   HALVRAGADVIELGV---PFSDPMADGPTIQRSSERALGRGAGLAYVLEAVHEFRREDAA  94

Query  77   FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M       +    ++ +     G D         ++      +    G+      
Sbjct  95   TPVVLMGYLNPIEIHGTRRFAEAAVAAGVDGLLLVDLPPEEADETRAIFTEVGLALIALA  154

Query  130  KPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDM---MPKVETLRAKFPHLNIQVDG  186
             P TS   L  L       L      G  G   + D      ++  LR +     +    
Sbjct  155  SPTTSEQRLDMLCSTAQGYLYYVSFAGVTGASNLLDTHAASDRLRQLRQRAG-APVVAGF  213

Query  187  GLGKETIPKAAKAGANVIVAGT----SVFTAADPHDV---ISFMKEEVSKELR  232
            G+       A    A+ +V G+    ++  A D              + + L 
Sbjct  214  GIKDAASAAAMAVDADGVVVGSALVAALAEADDVRSARERAEAFLAPLRQALD  266


>gi|20140722|sp|Q98CN6|TRPA_RHILO  Tryptophan synthase alpha chain
Length=279

 Score = 76.3 bits (187),  Expect = 1e-13, Method: Composition-based stats.
 Identities = 38/240 (15%), Positives = 77/240 (32%), Gaps = 35/240 (14%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
              +  AG+D + + +    F   +  G  I  +  R++        T K  + F      
Sbjct  39   KALPGAGSDIIELGM---PFSDPMADGPAIQAAGLRALKGGQTLVKTLKMASEFRAGDNE  95

Query  77   FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M       +   ++++ D    G D         +    L       GI      
Sbjct  96   TPIVLMGYYNPIYIYGVDRFLKDALASGIDGLIVVDLPPEMDEELCIPALKAGINFIRLA  155

Query  130  KPGTSVDVLFELAP-HLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP---HLNIQVD  185
             P T    L ++          +++  G  G    +    KV     +      L + V 
Sbjct  156  TPTTDDKRLPKVLQNTSGFVYYVSM-TGITGSALADT--GKVAAAVNRIKGHTDLPVCVG  212

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTA------------ADPHDVISFMKEEVSKELRS  233
             G+      +   A A+ +V GT++  A            ADP + ++ +   +++ +RS
Sbjct  213  FGVKTAEQARVIGANADGVVVGTAIVNAVANVLGPKGEKTADPAEAVATLVSGLAQGVRS  272


>gi|30173084|sp|Q8KRG6|METE_VIBHA  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=760

 Score = 75.9 bits (186),  Expect = 1e-13, Method: Composition-based stats.
 Identities = 35/218 (16%), Positives = 65/218 (29%), Gaps = 48/218 (22%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVT----SLRRSVPRPGDASNTEK  71
              L  E   +  AG + + ID       P I  G P+      +  +        +    
Sbjct  584  LALRDEVSDLQQAGINIIQID------EPAIREGLPLKKRDHKAYLQWAVDAFKIAAASA  637

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            KP      HM      + +D  A   AD  T   E ++  + L+K           A + 
Sbjct  638  KPETQIHTHMCYSEFNEIIDSVAALDADVITI--ETSRSNMELLK-----------AFED  684

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +         P    ++++E     ++    K P   L +  D GL 
Sbjct  685  FNYPNEIGPGVYDIHS-------PNIPSEEWIE---ELIKKAAEKIPAQRLWVNPDCGLK  734

Query  190  KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
                 +   A AN++                  ++ E+
Sbjct  735  TRNWSETEAALANLV-------------SAAKKLRAEL  759


>gi|7676165|sp|O27697|TRPA_METTH  Tryptophan synthase alpha chain
Length=270

 Score = 75.5 bits (185),  Expect = 1e-13, Method: Composition-based stats.
 Identities = 30/212 (14%), Positives = 72/212 (33%), Gaps = 19/212 (8%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPI----VTSLRRSVPRPGDASNT  69
            D          +++AGAD L +      F   I  G  +    + +LR  +         
Sbjct  31   DMETSLEIIRTLVDAGADALEVGF---PFSDPIADGTSVQGADLRALRAGMTTEKCFQLI  87

Query  70   EKKPTAF-FDCHMMVE-------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK  121
            E+          ++V          +++    A+ G           ++    ++  +  
Sbjct  88   ERVREFTSIPIGLLVYYNLIYRMGVDEFYRRAAEAGVTGILAADLPPEEASDALRAAEKY  147

Query  122  GIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQ--KFMEDMMPKVETLRAKFPH  179
             I     + P T  + L  ++        +    G  G   +  +  +  ++ ++A+   
Sbjct  148  DIDQIFIVAPTTGSERLKRISEVSSGFHYLVSVMGVTGARSRVEDATIELIKRVKAEG-S  206

Query  180  LNIQVDGGL-GKETIPKAAKAGANVIVAGTSV  210
            L + V  G+   E +     AGA+ ++ G+++
Sbjct  207  LPVMVGFGVSRPEHVRMLRDAGADGVIVGSAI  238


>gi|56749741|sp|Q6GH32|TRPA_STAAR  Tryptophan synthase alpha chain
Length=242

 Score = 75.1 bits (184),  Expect = 2e-13, Method: Composition-based stats.
 Identities = 36/252 (14%), Positives = 90/252 (35%), Gaps = 29/252 (11%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K  I P I+ +   +L      +   GAD + I V    F   +  G  I+ + ++++
Sbjct  1    MTKLFI-PYIMGNK--DLIENATLLSENGADIIEIGV---PFSDPVADGPVIMEAGQQAI  54

Query  61   PRPGDASNTEKKPTAFFD------CHMMVENP------EKWVDDFAKCGADQFTFHYEAT  108
             +        ++     +        M   N       + + +     G           
Sbjct  55   KQGITIDYIFEQLEKHGNQIKCQYVLMTYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPF  114

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALV---MTVEPGFGGQKFMED  165
            +    L +     G+K    +   T    + ++  + +  +    M    G  G  F  +
Sbjct  115  ELSQRLKQQFSHYGVKIISLVAMTTDDKRIKDIVSYAEGFIYTVTMNATTGQNG-AFHPE  173

Query  166  MMPKVETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSV---FTAADPHDVIS  221
            +  K+E+++A   ++ +    G+   + +    +  A+ IV G+ +   F +    ++I 
Sbjct  174  LKRKIESIKA-IANVPVVAGFGIRSPQHVADIKEV-ADGIVIGSEIVKRFKSNTREEIIK  231

Query  222  FMKEEVSKELRS  233
            ++ + + + L +
Sbjct  232  YL-QSIQQTLNN  242


>gi|13633984|sp|Q9UZQ5|THIE_PYRAB  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=207

 Score = 75.1 bits (184),  Expect = 2e-13, Method: Composition-based stats.
 Identities = 31/218 (14%), Positives = 62/218 (28%), Gaps = 30/218 (13%)

Query  17   NLGCECHKVINA---GADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
             L  E   V  A   GA  + + + D        +G      +RR           E   
Sbjct  16   RLKPEVKSVRQALEGGATSIQLRIKDASTKEMYEVG----KEIRRLTQ--------EYDA  63

Query  74   TAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGT  133
              F D           +D      AD      E        +++ +             +
Sbjct  64   LFFVD---------DRIDVALAVNADGVQLGPEDMP-----IEVAREIAPNLIIGASVYS  109

Query  134  SVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETI  193
              + L       D     +V P    +      +  +  +      + +   GG+  E +
Sbjct  110  LEEALEAEKKGADYLGAGSVFPTKTKRDVRVIRIEGLREIVEAV-SIPVVAIGGINVENV  168

Query  194  PKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
             +   AG + I   ++V  A+D       +++ + + L
Sbjct  169  KQVLSAGVDGIAVVSAVMGASDVKKATEELRKIIEEVL  206


>gi|73622024|sp|Q5QX79|TRPA_IDILO  Tryptophan synthase alpha chain
Length=269

 Score = 75.1 bits (184),  Expect = 2e-13, Method: Composition-based stats.
 Identities = 32/206 (15%), Positives = 67/206 (32%), Gaps = 22/206 (10%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV------PRPGDASNTEKKPTA  75
               +I+ GAD L + +    F   +  G  I  +  R++          +     +  + 
Sbjct  37   IKALIDGGADALELGL---PFSDPVADGPMIQRANLRALESGTTFKHILEILKEIRDYSP  93

Query  76   FFDCHMMVEN-------PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 ++V            +       G D        T++      + K  GI+A   
Sbjct  94   QIPIGLLVYANLIYAKGVRNFYQQMKDAGVDSVLIADVPTKEAKRFADIAKEIGIEAVFI  153

Query  129  IKPGTSVDVLFELAPHL-DMALVMTVE--PGFGGQKFMEDMMPKVETLRAKFPHLNIQVD  185
              P  S  +L ++A        +++     G   Q         +  L+         + 
Sbjct  154  APPDASDALLIDIAKQCAGYVYLLSRSGVTGADTQMQAPAS-ELINKLKEAGA-PPTLLG  211

Query  186  GGLG-KETIPKAAKAGANVIVAGTSV  210
             G+   E + +A  AGA+  ++G++V
Sbjct  212  FGISQPEHVQRALAAGADGAISGSAV  237


>gi|31340219|sp|Q87NA1|METE_VIBPA  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=760

 Score = 75.1 bits (184),  Expect = 2e-13, Method: Composition-based stats.
 Identities = 35/218 (16%), Positives = 64/218 (29%), Gaps = 48/218 (22%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVT----SLRRSVPRPGDASNTEK  71
              L  E   + +AG + + ID       P I  G P+      +           S    
Sbjct  584  LALRDEVSDLQDAGINIIQID------EPAIREGLPLKKRDHKAYLEWAVNAFKISAASA  637

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            KP      HM      + +D  A   AD  T   E ++  + L+K  +            
Sbjct  638  KPETQIHTHMCYSEFNEIIDSVAALDADVITI--ETSRSNMELLKAFEE--------FNY  687

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +         P    ++++E     ++    K P   L +  D GL 
Sbjct  688  P---NEIGPGVYDIHS-------PNIPTEEWIEG---LIKKAAEKIPVQRLWVNPDCGLK  734

Query  190  KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
                 +   A AN++                  ++ E+
Sbjct  735  TRNWAETEAALANLV-------------SAAKKLRAEL  759


>gi|73621996|sp|Q5WGS0|TRPA_BACSK  Tryptophan synthase alpha chain
Length=269

 Score = 75.1 bits (184),  Expect = 2e-13, Method: Composition-based stats.
 Identities = 30/235 (12%), Positives = 75/235 (31%), Gaps = 35/235 (14%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV----PRPGDASNTEKKPTA--  75
               +  +GAD L + +    +   +  G  I  + +R++          +   +      
Sbjct  33   ALSLQRSGADVLELGI---PYSDPLADGPVIQNASKRALAGGMTLAKAMALVPEMRKEGL  89

Query  76   FFDC-HMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                      NP      E++ +     G D         ++   L    + +G  A  +
Sbjct  90   TIPVIVFTYANPLLQFGFERFCETACDYGIDGLLVPDLPFEESETLANECEKQG-LALIS  148

Query  129  IKPGTSVDVLFELAPHLDMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQVDG  186
            +   TS   +  +A      L      G  G +      +   ++ ++   P +   V  
Sbjct  149  LVAPTSQQRIKAIASRAQGFLYCVSSLGVTGARKTLHPQVEAFLKLVKEASP-VPFVVGF  207

Query  187  GLGKETIPKAAKAG--ANVIVAGTSVFT-----------AADPHDVISFMKEEVS  228
            G+   +  +  + G  A+ +V G+++             A    + +  +++ V+
Sbjct  208  GI--SSYEQVEEMGRHADGVVIGSAIVEQIGLRCEALKQAESRDEAVKEIEQYVN  260


>gi|24212493|sp|Q8YA44|THIE_LISMO  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=214

 Score = 74.8 bits (183),  Expect = 2e-13, Method: Composition-based stats.
 Identities = 30/143 (20%), Positives = 51/143 (35%), Gaps = 10/143 (6%)

Query  87   EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD  146
               V    + GAD    H   T + +  V    S  +K   ++    SV    E A  L 
Sbjct  73   NDDVALALEIGADGI--HVGQTDEAIRQVIASCSGKMKIGLSVH---SVSEAKE-AERLG  126

Query  147  MALVMTVEPGFGGQKFME----DMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGAN  202
                + V P F      +         +E +R     + I   GG+ +    +   AGA+
Sbjct  127  AVDYIGVGPIFPTISKADAEPVSGTAILEEIRRAGITIPIVGIGGINETNSAEVLTAGAD  186

Query  203  VIVAGTSVFTAADPHDVISFMKE  225
             +   +++  + D H VI  +K 
Sbjct  187  GVSVISAITQSDDCHSVIKQLKN  209


>gi|97049518|sp|O27518|FAEHP_METTH  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=406

 Score = 74.8 bits (183),  Expect = 3e-13, Method: Composition-based stats.
 Identities = 27/189 (14%), Positives = 57/189 (30%), Gaps = 24/189 (12%)

Query  48   LGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEA  107
             G  +V  +R         ++ +       +  M     ++  D  A  G          
Sbjct  212  FGVGVVRRIRELRRDAFIIADLKTLDVGRIEVKM---AADETADAVAISG-------LGT  261

Query  108  TQDPLHLVKLIKSKGIKAACAI-KPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDM  166
             +     +   + +GI +   +      VD L  L    D+ L+         +    + 
Sbjct  262  VESIEKAIHEAQKQGIYSILDMMNVENFVDKLRGLKYKPDIVLL---HRNVDLETLRAER  318

Query  167  MP---------KVETLRAK-FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADP  216
                        +  ++    P   + V GG+    + +A  +GA++IV G  +  + D 
Sbjct  319  GEELGEMSEWGNIREIKEILGPRGLVAVAGGITPSKMQEALDSGADIIVVGRYIIGSRDV  378

Query  217  HDVISFMKE  225
                    E
Sbjct  379  RRAAEDFLE  387


>gi|73621995|sp|Q65I36|TRPA_BACLD  Tryptophan synthase alpha chain
Length=267

 Score = 74.8 bits (183),  Expect = 3e-13, Method: Composition-based stats.
 Identities = 31/221 (14%), Positives = 73/221 (33%), Gaps = 26/221 (11%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPR------PGDASNTEKKPTA  75
               +  AGA  L + V    +   +  G  I  + +R++                KK   
Sbjct  31   AKSLQEAGASALELGV---PYSDPLADGPVIQRASKRALDNDMNIVKAIRLGGEMKKNGV  87

Query  76   FFDCHM-MVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +    NP      + +     +   D         ++ ++L +  K  GI     
Sbjct  88   HIPIILFTYYNPVLQLDTDHFFALLRQNQLDGLLVPDLPFEESVYLQQQCKKHGITYISL  147

Query  129  IKPGTSVDVLFELAPHLDMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQVDG  186
            + P TS   + ++    +  +      G  G +  F + +   + +++     + + V  
Sbjct  148  VAP-TSESRIQKITQQAEGFVYCVSSLGVTGVRNEFEDSVSSFIRSVKGM-SSVPVAVGF  205

Query  187  GLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            G+      +     A+ +V G+++         I  +K+E+
Sbjct  206  GISSSKQVEMMNELADGVVVGSALVRK------IEELKDEL  240


>gi|24212487|sp|Q8U192|THIE_PYRFU  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=207

 Score = 74.4 bits (182),  Expect = 3e-13, Method: Composition-based stats.
 Identities = 26/148 (17%), Positives = 48/148 (32%), Gaps = 10/148 (6%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
             +  VD      AD      E        +++ K             +  + L       
Sbjct  67   VDDRVDVALAVDADGVQLGPEDMP-----IEVAKEIAPNLIIGASVYSLEEALEAEKKGA  121

Query  146  DMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQV--DGGLGKETIPKAAKAGANV  203
            D     +V P    +   +  +  +E LR     + I V   GG+ K+   +  K G + 
Sbjct  122  DYLGAGSVFPTKTKE---DARVIGLEGLRKIVESVKIPVVAIGGINKDNAREVLKTGVDG  178

Query  204  IVAGTSVFTAADPHDVISFMKEEVSKEL  231
            I   ++V  A D       +++ V + L
Sbjct  179  IAVISAVMGAEDVRKATEELRKIVEEVL  206


>gi|30173118|sp|Q9AMV8|METE_BRAJA  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=781

 Score = 74.4 bits (182),  Expect = 3e-13, Method: Composition-based stats.
 Identities = 32/207 (15%), Positives = 60/207 (28%), Gaps = 35/207 (16%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              +  E   + NAGA  + ID         +  G P+  S                ++  
Sbjct  601  LAMRDEVRDLENAGAAMIQID------EAALREGLPLRRSDWKAYLDWAGDCFRICSSGV  654

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
                    HM        +   A   AD  +   E ++  + L+   +            
Sbjct  655  TDQTQIHTHMCYSEFNDIIGAIAAMDADVISI--ETSRSKMELLDAFRRY----------  702

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH--LNIQVDGGLG  189
                +   ++ P +       V          ++M   +   R +     L +  D GL 
Sbjct  703  ----EYPNQIGPGVYDIHSPRV-------PETDEMKELIVLARTRLQDSQLWVNPDCGLK  751

Query  190  KETIPKAAKAGANVIVAGTSVFTAADP  216
                 +   A AN++ A   +  A+DP
Sbjct  752  TRKWEEVRPALANMVAAARELRAASDP  778


>gi|28380181|sp|Q8PJ29|TRPA_XANAC  Tryptophan synthase alpha chain
Length=268

 Score = 74.4 bits (182),  Expect = 3e-13, Method: Composition-based stats.
 Identities = 36/233 (15%), Positives = 67/233 (28%), Gaps = 27/233 (11%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
            H ++ AGAD + + V    F   +  G  I  S  R++ R    +   +    F      
Sbjct  38   HALVRAGADVIELGV---PFSDPMADGPTIQRSSERALARGAGLAYVLEAVHEFRREDAT  94

Query  77   FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M       +    ++ +     G D         ++      +    G+      
Sbjct  95   TPVVLMGYLNPIEIHGTRRFAEAAVAAGVDGVLLVDLPPEEAGETRTIFTEVGLALIALA  154

Query  130  KPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDM---MPKVETLRAKFPHLNIQVDG  186
             P TS   L  L       L      G  G   + D      ++  LR +     +    
Sbjct  155  SPTTSEQRLDMLCSTAQGYLYYVSFAGVTGASNLLDTHAASDRLRQLRRRAG-APVVAGF  213

Query  187  GLGKETIPKAAKAGANVIVAGTSVFTA----ADPHDV---ISFMKEEVSKELR  232
            G+       A    A+ +V G+++  A     D              + + L 
Sbjct  214  GIKDAASAAAMAVDADGVVVGSALVAALAEVNDVRSARERAEAFLAPLRQALD  266


>gi|31076767|sp|Q89B24|METE_BUCBP  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=756

 Score = 74.0 bits (181),  Expect = 5e-13, Method: Composition-based stats.
 Identities = 32/231 (13%), Positives = 65/231 (28%), Gaps = 52/231 (22%)

Query  3    KPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLR----R  58
            K II+  I  +    L  E   +  +G   + ID       P +  G P+  SLR     
Sbjct  572  KKIISRQIALA----LRDEVLDLEQSGVKIIQID------EPALREGLPLRLSLRNEYLS  621

Query  59   SVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLI  118
                    S++          HM        ++      AD  T   E ++  + L++  
Sbjct  622  WAVDSFKLSSSGVCDETQIHTHMCYCEFNDIMNAIVLLDADVITI--ETSRSDMELLEFF  679

Query  119  KSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP  178
            K                + +      +                 +E +M  +       P
Sbjct  680  KEF-KYP----------NDIGPGVYDIHS----------PNIPSIEWIMTLLRQAMHYIP  718

Query  179  --HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
               L +  D GL   T  +             + ++  +       +++++
Sbjct  719  VKRLWVNPDCGLKTRTWDE-------------TYYSLENMVRAAKILRKKL  756


>gi|30173122|sp|Q9F187|METE_RALEU  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=792

 Score = 73.6 bits (180),  Expect = 5e-13, Method: Composition-based stats.
 Identities = 31/206 (15%), Positives = 52/206 (25%), Gaps = 45/206 (21%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              +  E   +  AG   + ID       P +  G P+      +           S +  
Sbjct  580  LAIRDEVCDLEQAGIRVIQID------EPALREGLPLRRADWDAYLDWAVTAFRLSASGV  633

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVK------LIKSKGIKA  125
            +       HM        +   A   AD  T   E ++  + L++           G   
Sbjct  634  QDQTQIHTHMCYAEFNDILPAIAAMDADVITI--ETSRSAMELLEGFGDFDYPNEIGPGV  691

Query  126  ACAIKPGTS-VDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQV  184
                 P    V  +  L           V P                        L +  
Sbjct  692  YDIHSPRVPSVQAMERLLDRACEV----VPP----------------------QRLWVNP  725

Query  185  DGGLGKETIPKAAKAGANVIVAGTSV  210
            D GL      +   A AN++ A  ++
Sbjct  726  DCGLKTRGWEETEAALANMVSAARAL  751


>gi|73621992|sp|Q5LBZ2|TRPA_BACFN  Tryptophan synthase alpha chain
 gi|73621993|sp|Q64SX3|TRPA_BACFR  Tryptophan synthase alpha chain
Length=263

 Score = 73.6 bits (180),  Expect = 5e-13, Method: Composition-based stats.
 Identities = 36/233 (15%), Positives = 71/233 (30%), Gaps = 32/233 (13%)

Query  20   CECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP-----T  74
                 +   G + + I +    F   +  G  I  +  +++          ++       
Sbjct  32   EVIRTLEKHGVNMIEIGI---PFSDPMADGMVIQNAATQALRNGMSLRLLFEQLHDIRRD  88

Query  75   AFFDCHMMVE-------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK-GIKAA  126
                  +M           + +    A+CG D         +D     + I  +  +K  
Sbjct  89   VKIPLILMGYLNPIMQFGFDNFCRQCAECGIDGVIIPDLPFKDYQEHFRTIAERYDVKVI  148

Query  127  CAIKPGTSVDVLFELAPHLDMALVM---TVEPG----FGGQKFMEDMMPKVETLRAKFPH  179
              I P TS + + E+  H D  + M       G    F GQK         + +      
Sbjct  149  MLITPETSEERVREIDEHTDGFIYMVSSAATTGAQQDFDGQK-----RAYFKKIEKMNLR  203

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVF----TAADPHDVISFMKEEVS  228
                V  G+  E   +AA   A+  + G+          +P   I+ +K  ++
Sbjct  204  NPRMVGFGISNEATFRAACENASGAIIGSRFVTLLHEEKNPEKAITRLKAILN  256


>gi|30173017|sp|Q8CWK1|METE_VIBVU  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=778

 Score = 73.2 bits (179),  Expect = 7e-13, Method: Composition-based stats.
 Identities = 34/224 (15%), Positives = 63/224 (28%), Gaps = 46/224 (20%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              L  E   + +AG + + ID       P I  G P+      +           S    
Sbjct  584  LALRDEVSDLQDAGINIIQID------EPAIREGLPLKKRDHQNYLDWAVEAFRISAASA  637

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +P      HM      + ++  A   AD  T   E ++  + L+K  +            
Sbjct  638  RPETQIHTHMCYSEFNEIIESVAALDADVITI--ETSRSNMELLKAFEE--------FNY  687

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMED---MMPKVETLRAKFP--HLNIQVDG  186
                + +      +                 +     ++  V+    K P   L +  D 
Sbjct  688  P---NEIGPGVYDIHS-------------PNIPSEEWIVDLVKKAAQKIPVERLWVNPDC  731

Query  187  GLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            GL     P+   A AN++ A   +       +         S+ 
Sbjct  732  GLKTRNWPETEAALANLVSAAKRL-----RKEFAKETTAVNSEA  770


>gi|51316309|sp|Q7MJM6|METE_VIBVY  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=778

 Score = 73.2 bits (179),  Expect = 7e-13, Method: Composition-based stats.
 Identities = 35/225 (15%), Positives = 63/225 (28%), Gaps = 46/225 (20%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              L  E   + +AG + + ID       P I  G P+      +           S    
Sbjct  584  LALRDEVSDLQDAGINIIQID------EPAIREGLPLKKRDHQNYLDWALEAFRISAASA  637

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +P      HM      + ++  A   AD  T   E ++  + L+K  +            
Sbjct  638  RPETQIHTHMCYSEFNEIIESVAALDADVITI--ETSRSNMELLKAFEE--------FNY  687

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMED---MMPKVETLRAKFP--HLNIQVDG  186
                + +      +                 +     ++  V+    K P   L +  D 
Sbjct  688  P---NEIGPGVYDIHS-------------PNIPSEEWIVDLVKKAAQKIPVERLWVNPDC  731

Query  187  GLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
            GL     P+   A AN++ A   +       +         S  L
Sbjct  732  GLKTRNWPETEAALANLVSAAKRL-----RKEFAKETTAVNSDAL  771


>gi|28380178|sp|Q8KEZ7|TRPA_CHLTE  Tryptophan synthase alpha chain
Length=267

 Score = 73.2 bits (179),  Expect = 8e-13, Method: Composition-based stats.
 Identities = 32/229 (13%), Positives = 70/229 (30%), Gaps = 35/229 (15%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP--------  73
               +  +G D + + +    +   I  G  I  +  +++       +  +          
Sbjct  35   LEALQESGVDLIELGM---PYSDPIGDGSVIQDAAHKAISHGVHVGSIFELVRRARNGEG  91

Query  74   --TAFFDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIK  124
                     +M   NP      + ++ D  K G D         ++    ++  K  G+ 
Sbjct  92   CKKITTPILLMGYCNPLIAYGGDCFMADAVKAGVDGLLIPDLPPEESEDFLERAKHFGLS  151

Query  125  AACAIKPGTS---VDVLFELAPHLDMALVMTVEPGFG---GQKFMEDMMPKVETLRAKFP  178
                I P T    ++++  ++      L +    G G        E +   ++ +R    
Sbjct  152  VIYLISPVTPPDRIELIDSMSTDFSYCLAVNATTGTGKLDVAGMDEKIAEYLKRVRQHTK  211

Query  179  HLNIQVDGGLGKETIPKAAK--AGANVIVAGTS----VFTAADPHDVIS  221
                 V  G+      +  K    A+  V G++    V TA  P +   
Sbjct  212  K-KFVVGFGIKDR--ERVRKMWELADGAVVGSALLQHVATAKTPEETAE  257


>gi|51316315|sp|Q7MZ74|METE_PHOLL  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=758

 Score = 73.2 bits (179),  Expect = 8e-13, Method: Composition-based stats.
 Identities = 32/219 (14%), Positives = 59/219 (26%), Gaps = 48/219 (21%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P +  G P+      S           +    
Sbjct  582  LALRDEVDDLQEAGIGIIQID------EPALREGLPLRREEWQSYLDWAVEAFKLNAAIA  635

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM        +   A   AD  T   E ++  + L+   +            
Sbjct  636  KDDTQIHTHMCYCEFNDIMPSIAALDADVITI--ETSRSDMELLDSFE----------NF  683

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V +VE       ++E     +     + P   L +  D GL 
Sbjct  684  SYP-NEIGPGVYDIHSPNVPSVE-------WIEA---LLRKAADRIPVERLWVNPDCGLK  732

Query  190  KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
                 +  ++ AN++                  ++E V 
Sbjct  733  TRGWTETRQSLANMV-------------QAAKRLRESVK  758


>gi|73622004|sp|Q62AJ6|TRPA_BURMA  Tryptophan synthase alpha chain
Length=271

 Score = 72.8 bits (178),  Expect = 1e-12, Method: Composition-based stats.
 Identities = 35/245 (14%), Positives = 82/245 (33%), Gaps = 31/245 (12%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D A      H +   GAD + + V    F   +  G  I  S  R++ +     +     
Sbjct  29   DPAKTVELMHALAEGGADVIELGV---PFSDPMADGPVIQRSSERALAKGVTLHSVLDDV  85

Query  74   TAF------FDCHMM-VENPEKWV------DDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
              F          +M   NP + +            G D         ++       +++
Sbjct  86   KRFRARDQKTPVVLMGYANPIERMGADAFAAAARDAGVDGVLVVDYPPEESHDFAAKMRA  145

Query  121  KGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME--DMMPKVETLRAKF  177
             GI     + P ++ D +  +          ++++ G  G   ++   +  K+  ++++ 
Sbjct  146  AGIDPIFLLAPTSTDDRIAAVGQVASGYVYYVSLK-GVTGAANLDVSSIAGKIPAIKSRV  204

Query  178  PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT----------AADPHDVISFMKEEV  227
            P L + V  G+      +A    A+ +V G+ +            AA+    ++ ++  +
Sbjct  205  P-LPVGVGFGIRDAATARAVAEVADAVVIGSRLVQLLEQAVPERAAAELAGFVAELRAAI  263

Query  228  SKELR  232
                +
Sbjct  264  DGAAK  268


>gi|20140838|sp|Q9KCA9|TRPA_BACHD  Tryptophan synthase alpha chain
Length=265

 Score = 72.8 bits (178),  Expect = 1e-12, Method: Composition-based stats.
 Identities = 30/229 (13%), Positives = 72/229 (31%), Gaps = 24/229 (10%)

Query  2    VKPIIAPSILASDF--ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
             K +  P I A D            +  AGAD L + +    +   +  G  I  + +R+
Sbjct  11   KKNLFIPFITAGDPNPEVTIELALTLEEAGADILELGI---PYSDPLADGPVIQAASKRA  67

Query  60   VPRPGDASNTEKKP------TAFFDC-HMMVENP------EKWVDDFAKCGADQFTFHYE  106
            +                               NP      E++V   A    D       
Sbjct  68   LKHEMTLEKALSLVPKMRAQGLTIPVIVFTYVNPLLQYGEEQFVKRAADYQVDGILVPDM  127

Query  107  ATQDPLHLVKLI-KSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQK--FM  163
              ++   +++   +   +     + P ++   + ++A      +      G  G +    
Sbjct  128  PFEE-GEVLQAACQEHNLSLISLVAPTSN-KRIEKIAARAQGFVYCVSSLGVTGLRDELD  185

Query  164  EDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT  212
              +   ++T++     + + V  G+ +    +A    A+ +V G+++  
Sbjct  186  PRVHEFLQTVKTHA-SVPVVVGFGISRREQVEALAENADGVVVGSAIVK  233


>gi|73622047|sp|Q5LV87|TRPA_SILPO  Tryptophan synthase alpha chain
Length=263

 Score = 72.8 bits (178),  Expect = 1e-12, Method: Composition-based stats.
 Identities = 38/215 (17%), Positives = 72/215 (33%), Gaps = 21/215 (9%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            DF         +  AG D + + +    F   +  G  I  + +R++        T    
Sbjct  29   DFDTSLELVKGLPGAGVDIIELGL---PFTDPMADGPTIQLAGQRALDGGMTLQRTLDLA  85

Query  74   TAF------FDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
            T F          MM   NP      ++++ D    G D         ++   L    ++
Sbjct  86   TEFRKTDNTTPIVMMGYYNPIYSRGVDRFLADAKAAGIDGLIVVDLPPEEDSELCLPAQA  145

Query  121  KGIKAACAIKPGTSVDVLFELAP-HLDMALVMTVEPGFGGQKFME--DMMPKVETLRAKF  177
             G+       P T    L  +          +++  G  G    E  D+ P+V  ++A  
Sbjct  146  AGLNFIRLATPTTDDKRLPRVLQNTSGFVYYVSI-TGITGSAEAEATDVGPEVARIKAAT  204

Query  178  PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT  212
              L + V  G+      +A  + A+  V G+++  
Sbjct  205  D-LPVIVGFGINTPEKSRAIASVADGAVVGSAIVG  238


>gi|136253|sp|P19867|TRPA_BACST  Tryptophan synthase alpha chain
Length=269

 Score = 72.4 bits (177),  Expect = 1e-12, Method: Composition-based stats.
 Identities = 33/225 (14%), Positives = 73/225 (32%), Gaps = 22/225 (9%)

Query  3    KPIIAPSILASDFA--NLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS-  59
             P+  P I+A D +          +  AGAD L + V    +   +  G  I  +  R+ 
Sbjct  8    PPLFIPFIVAGDPSPEVTVDLALALEEAGADLLELGV---PYSDPLADGPTIQRAAARAL  64

Query  60   -----VPRPGDASNTEKKPTAFFDCHM-MVENP------EKWVDDFAKCGADQFTFHYEA  107
                 +P+        +K        +    NP      E +     + GA+        
Sbjct  65   AGNMTLPKAIHLVAEMRKKGVTIPIILFTYYNPVLQLGEESFFALARENGANGVLIPDLP  124

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKF-MEDM  166
             ++    ++ +  +      ++   TS   +  +A      L      G  G +  + + 
Sbjct  125  FEES-GPLRELGERFDLPLISLVAPTSKQRIERIASVAQGFLYCVSSLGVTGMRETLPES  183

Query  167  M-PKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSV  210
            +   V  ++     + + V  G+         K   + +V G+++
Sbjct  184  LGDFVSEVKRH-SRVPVAVGFGISTPEQVAMLKEVCDGVVIGSAL  227


>gi|47606774|sp|P16608|TRPA_THET2  Tryptophan synthase alpha chain
Length=271

 Score = 72.4 bits (177),  Expect = 1e-12, Method: Composition-based stats.
 Identities = 39/218 (17%), Positives = 84/218 (38%), Gaps = 21/218 (9%)

Query  30   ADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNT-EKKPTAFFDCHMMVE  84
            AD L I +    +   +  G  I  +    LR+ +   G      E +        +M  
Sbjct  43   ADLLEIGL---PYSDPLGDGPVIQRASELALRKGMSVQGALELVREVRALTEKPLFLMTY  99

Query  85   -------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDV  137
                    PE++   F + GA           +   LV+L +  G++    + P ++   
Sbjct  100  LNPVLAWGPERFFGLFKQAGATGVILPDLPPDEDPGLVRLAQEIGLETVFLLAPTSTDAR  159

Query  138  LFELAPHL-DMALVMTVEPGFGG--QKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIP  194
            +  +  H       ++V  G  G  ++  E++   V  ++A+   L + V  G+      
Sbjct  160  IATVVRHATGFVYAVSV-TGVTGMRERLPEEVKDLVRRIKARTA-LPVAVGFGVS-GKAT  216

Query  195  KAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELR  232
             A  A A+ +V G+++  A +    ++ + +E+ + L+
Sbjct  217  AAQAAVADGVVVGSALVRALEEGRSLAPLLQEIRQGLQ  254


>gi|51316235|sp|Q6N765|METE_RHOPA  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=788

 Score = 72.4 bits (177),  Expect = 1e-12, Method: Composition-based stats.
 Identities = 30/216 (13%), Positives = 60/216 (27%), Gaps = 48/216 (22%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              +  E   +  AGA  + ID         +  G P+  S                ++  
Sbjct  611  LAIRDEVGDLEQAGATMIQID------EAALREGLPLRRSEWKGYLDWAVECFRLCSSGV  664

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM        +D  A   AD  +   E ++  + L+   K+           
Sbjct  665  KDETQIHTHMCYSEFNDIIDAIAAMDADVISI--ETSRSKMELLDAFKTY-KYP------  715

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH--LNIQVDGGLG  189
                + +      +    V +VE          +M   ++  R +     L +  D GL 
Sbjct  716  ----NEIGPGVYDIHSPRVPSVE----------EMTTLLQLARQRLSDGQLWVNPDCGLK  761

Query  190  KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
                 +   A  N++             +    +++
Sbjct  762  TRGWDEVQGALVNMV-------------EAARQIRQ  784


>gi|73621997|sp|Q8AAD8|TRPA_BACTN  Tryptophan synthase alpha chain
Length=256

 Score = 72.4 bits (177),  Expect = 1e-12, Method: Composition-based stats.
 Identities = 37/229 (16%), Positives = 71/229 (31%), Gaps = 28/229 (12%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKK-----PTAF  76
               +   G   + + +    F   +  G  I  +  +++          ++         
Sbjct  34   IRTLEKHGVSMIEVGI---PFSDPMADGIVIQNAATQALRNGMSLKILFEQLRNIRQEVS  90

Query  77   FDCHMM-VENPEKWVDDF---------AKCGADQFTFHYEATQDPLHLVKLIKSK-GIKA  125
                 M   NP   +  F          +CG D         +D     ++I  + GIK 
Sbjct  91   IPLVFMGYLNP---IMQFGFENFCRKCVECGIDGVIIPDLPFRDYQDHYRIIAERYGIKV  147

Query  126  ACAIKPGTSVDVLFELAPHLDMALVM--TVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQ  183
               I P TS + + E+  H D  + M  +       Q F E      + +        + 
Sbjct  148  IMLITPETSEERVREIDAHTDGFIYMVSSAATTGAQQDFNEQKRAYFKKIEDMNLRNPLM  207

Query  184  VDGGLGKETIPKAAKAGANVIVAGTSVF----TAADPHDVISFMKEEVS  228
            V  G+  +   +AA   A+  + G+          DP   I  +K+ + 
Sbjct  208  VGFGISNKATFQAACEHASGAIIGSRFVTLLEEEKDPEKAILKLKDALK  256


>gi|73622056|sp|Q5SJC0|TRPA_THET8  Tryptophan synthase alpha chain
Length=271

 Score = 72.4 bits (177),  Expect = 1e-12, Method: Composition-based stats.
 Identities = 39/218 (17%), Positives = 84/218 (38%), Gaps = 21/218 (9%)

Query  30   ADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNT-EKKPTAFFDCHMMVE  84
            AD L I +    +   +  G  I  +    LR+ +   G      E +        +M  
Sbjct  43   ADLLEIGL---PYSDPLGDGPVIQRASELALRKGMSVQGALELVREVRALTEKPLFLMTY  99

Query  85   -------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDV  137
                    PE++   F + GA           +   LV+L +  G++    + P ++   
Sbjct  100  LNPVLAWGPERFFGLFKQAGATGVILPDLPPDEDPGLVRLAQEIGLETVFLLAPTSTDAR  159

Query  138  LFELAPHL-DMALVMTVEPGFGG--QKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIP  194
            +  +  H       ++V  G  G  ++  E++   V  ++A+   L + V  G+      
Sbjct  160  IATVVRHATGFVYAVSV-TGVTGMRERLPEEVKDLVRRIKARTA-LPVAVGFGVS-GKAT  216

Query  195  KAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELR  232
             A  A A+ +V G+++  A +    ++ + +E+ + L+
Sbjct  217  AAQAAVADGVVVGSALVRALEEGRSLAPLLQEIRQGLQ  254


>gi|41018354|sp|Q8E5W9|THIE_STRA3  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=223

 Score = 72.4 bits (177),  Expect = 1e-12, Method: Composition-based stats.
 Identities = 23/149 (15%), Positives = 48/149 (32%), Gaps = 6/149 (4%)

Query  87   EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD  146
            +  +D      AD    H      P   V   + +       +   T  +        +D
Sbjct  72   DDDIDLVELIDADGL--HIGQNDLP---VDEARRRLPDKIIGLSVSTMAEYQKSQLSVVD  126

Query  147  MALVMTVEPGFGGQKFMEDMMPKV-ETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIV  205
               +    P          +  +  + +R     + I   GG+  + +    ++GA+ I 
Sbjct  127  YIGIGPFNPTQSKADAKPAVGNRTTKAVREINQDIPIVAIGGITSDFVHDIIESGADGIA  186

Query  206  AGTSVFTAADPHDVISFMKEEVSKELRSR  234
              +++  A    D    ++ EV K L +R
Sbjct  187  VISAISKANHIVDATRQLRYEVEKALVNR  215


>gi|24212501|sp|Q92EW5|THIE_LISIN  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=214

 Score = 72.1 bits (176),  Expect = 2e-12, Method: Composition-based stats.
 Identities = 25/142 (17%), Positives = 49/142 (34%), Gaps = 8/142 (5%)

Query  87   EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK--GIKAACAIKPGTSVDVLFELAPH  144
               V    + GAD    H     + +   ++I S    +K   ++   +  +    L   
Sbjct  73   NDDVALALEIGADGI--HVGQNDEEIR--QVIASCAGKMKIGLSVHSVSEAEEAERLGS-  127

Query  145  LDMALVMTVEPGFGGQKFME-DMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANV  203
            +D   V  + P               +E +R     L I   GG+ +    +   AGA+ 
Sbjct  128  VDYIGVGPIFPTISKADAEPVSGTAILEEIRRAGIKLPIVGIGGINETNSAEVLTAGADG  187

Query  204  IVAGTSVFTAADPHDVISFMKE  225
            +   +++  + D   VI  +K 
Sbjct  188  VSVISAITRSEDCQSVIKQLKN  209


>gi|24212488|sp|Q8UAS8|THIE_AGRT5  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=220

 Score = 72.1 bits (176),  Expect = 2e-12, Method: Composition-based stats.
 Identities = 29/155 (18%), Positives = 50/155 (32%), Gaps = 13/155 (8%)

Query  87   EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD  146
               VD     GAD    H  A        + I   G KA   +      D     +   D
Sbjct  70   NDRVDVALASGADG--VHLGADDMDAKTARRI--LGEKAIIGLTVKNRADAERAASMPAD  125

Query  147  MALVMTV-------EPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKA  199
             A +  V        P           +     L+   P + +    G+  + +P    A
Sbjct  126  YACIGGVFETVSKVNPDKPVGIEGFTTLR--ALLKEWQPDMPVGAIAGIDLDRVPAVIAA  183

Query  200  GANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            GA+ +   +++F AA+     S  +  +   L++R
Sbjct  184  GADGVAVISAIFRAANIASATSDFRSAIDAALKAR  218


>gi|51316332|sp|Q7NS23|METE_CHRVO  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=760

 Score = 72.1 bits (176),  Expect = 2e-12, Method: Composition-based stats.
 Identities = 32/201 (15%), Positives = 53/201 (26%), Gaps = 35/201 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLR----RSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P I  G P+  + R             S+   
Sbjct  581  LALNDEVLDLEAAGIRVIQID------EPAIREGLPLKRAGRDVYLAWAGEAFRLSSRGV  634

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
                    HM        +   A   AD  T   E ++  + L+               P
Sbjct  635  DDATQIHTHMCYSEFGDILPAIAALDADVITI--ETSRSDMALL-------ADFGRFRYP  685

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +         P       +  ++ K        P   L +  D GL 
Sbjct  686  ----NAIGPGVYDIHS-------PRVPSAAEIRALLDK---ALRVIPAERLWVNPDCGLK  731

Query  190  KETIPKAAKAGANVIVAGTSV  210
                P+   A A ++  G  +
Sbjct  732  TRGWPEVEAALAAMVAVGREL  752


>gi|41018352|sp|Q8E092|THIE_STRA5  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=223

 Score = 71.7 bits (175),  Expect = 2e-12, Method: Composition-based stats.
 Identities = 23/149 (15%), Positives = 48/149 (32%), Gaps = 6/149 (4%)

Query  87   EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD  146
            +  +D      AD    H      P   V   + +       +   T  +        +D
Sbjct  72   DDDIDLVELIDADGL--HIGQNDLP---VDEARRRLPDKIIGLSVSTMDEYQKSQLSVVD  126

Query  147  MALVMTVEPGFGGQKFMEDMMPKV-ETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIV  205
               +    P          +  +  + +R     + I   GG+  + +    ++GA+ I 
Sbjct  127  YIGIGPFNPTQSKADAKPAVGNRTTKAVREINQDIPIVAIGGITSDFVHDIIESGADGIA  186

Query  206  AGTSVFTAADPHDVISFMKEEVSKELRSR  234
              +++  A    D    ++ EV K L +R
Sbjct  187  VISAISKANHIVDATRQLRYEVEKALVNR  215


>gi|732341|sp|P39594|THIE_BACSU  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=222

 Score = 71.7 bits (175),  Expect = 2e-12, Method: Composition-based stats.
 Identities = 22/146 (15%), Positives = 46/146 (31%), Gaps = 10/146 (6%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
                V+      AD    H           K +++        +   T  +V        
Sbjct  78   VNDDVELALNLKADGI--HIGQED---ANAKEVRAAIGDMILGVSAHTMSEVKQAEEDGA  132

Query  146  DMALVMTVEP---GFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGAN  202
            D   +  + P       +      +  +E +R +   + I   GG+  +      +AGA+
Sbjct  133  DYVGLGPIYPTETKKDTRAVQGVSL--IEAVRRQGISIPIVGIGGITIDNAAPVIQAGAD  190

Query  203  VIVAGTSVFTAADPHDVISFMKEEVS  228
             +   +++  A DP       +EE+ 
Sbjct  191  GVSMISAISQAEDPESAARKFREEIQ  216


>gi|136372|sp|P13228|TRP_NEUCR  Tryptophan synthase
Length=708

 Score = 71.3 bits (174),  Expect = 3e-12, Method: Composition-based stats.
 Identities = 39/232 (16%), Positives = 73/232 (31%), Gaps = 24/232 (10%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP------TA  75
               +   GAD + + V    F   I  G  I T+   ++       +T +          
Sbjct  37   LLAMEKGGADVIELGV---PFTDPIADGPTIQTANTIALQHGVTLQSTLQMVRDARQRGL  93

Query  76   FFDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M   NP      E+ ++D  + G + F       ++ +   +L    G+     
Sbjct  94   KAPVMLMGYYNPLLSYGEERLLNDCKEAGVNGFIIVDLPPEEAVSFRQLCTRGGLSYVPL  153

Query  129  IKPGTSVDVLFELAPHLD-MALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQVD  185
            I P TS   +  L    D    V++ + G  G       ++   +  ++    +    V 
Sbjct  154  IAPATSDARMRVLCQLADSFIYVVSRQ-GVTGASGTLNANLPELLARVKKYSGNKPAAVG  212

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLL  237
             G+          A A+ +V G+ + T            EEV         L
Sbjct  213  FGVSTHDHFTQVGAIADGVVVGSMIIT--TIQKAAKG--EEVKAVQEYCSYL  260


>gi|73622005|sp|Q63JM0|TRPA_BURPS  Tryptophan synthase alpha chain
Length=271

 Score = 71.3 bits (174),  Expect = 3e-12, Method: Composition-based stats.
 Identities = 29/194 (14%), Positives = 64/194 (32%), Gaps = 21/194 (10%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D A      H +   GAD + + V    F   +  G  I  S  R++ +     +     
Sbjct  29   DPAKTVELMHALAEGGADVIELGV---PFSDPMADGPVIQRSSERALAKGVTLHSVLDDV  85

Query  74   TAF------FDCHMM-VENPEKWV------DDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
              F          +M   NP + +            G D         ++       +++
Sbjct  86   KRFRARDQKTPVVLMGYANPIERMGADAFAAAARDAGVDGVLVVDYPPEESHDFAAKMRA  145

Query  121  KGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME--DMMPKVETLRAKF  177
             GI     + P ++ D +  +          ++++ G  G   ++   +  K+  ++++ 
Sbjct  146  AGIDPIFLLAPTSTDDRIAAVGQVASGYVYYVSLK-GVTGAANLDVSSIAGKIPAIKSRV  204

Query  178  PHLNIQVDGGLGKE  191
            P L + V  G+   
Sbjct  205  P-LPVGVGFGIRDA  217


>gi|67461983|sp|Q723Y9|THIE_LISMF  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=214

 Score = 71.3 bits (174),  Expect = 3e-12, Method: Composition-based stats.
 Identities = 25/142 (17%), Positives = 50/142 (35%), Gaps = 8/142 (5%)

Query  87   EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK--GIKAACAIKPGTSVDVLFELAPH  144
               V    + GAD    H     + +   ++I S    +K   ++   +  +    L   
Sbjct  73   NDDVALALEIGADGI--HVGQNDEEIR--QVIASCAGKMKIGLSVHSVSEAEEAERLG-A  127

Query  145  LDMALVMTVEPGFG-GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANV  203
            +D   V  + P               +E +R     L I   GG+ +    +   AGA+ 
Sbjct  128  VDYIGVGPIFPTISKADAESVSGTAILEEIRRAGIKLPIVGIGGINETNSAEVLTAGADG  187

Query  204  IVAGTSVFTAADPHDVISFMKE  225
            +   +++  + D + VI  +K 
Sbjct  188  VSVISAITRSDDCYSVIKQLKN  209


>gi|41018273|sp|Q7NNK8|THIE_GLOVI  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=341

 Score = 70.5 bits (172),  Expect = 5e-12, Method: Composition-based stats.
 Identities = 32/186 (17%), Positives = 55/186 (29%), Gaps = 6/186 (3%)

Query  44   PNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTF  103
              + +G P+V    +  P         +        H  +      VD    CGAD    
Sbjct  161  HALAVGLPLVQLREKEAPARAVLDIALRLRDVTLR-HGALFIVNDRVDLALACGADG--V  217

Query  104  HYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFM  163
            H      PL   + +   G +           +    +A   D   V  V      Q   
Sbjct  218  HLGQEDLPLARARALM--GPRLLIGQSTHAPAEAQQAVADGADYLGVGPVYATPTKQGRT  275

Query  164  EDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
               +  V   R         + GG+ +  +     AGA  I    ++  A DP    ++ 
Sbjct  276  PVGLEYVRHCRESIERPGFAI-GGIDRSNLEAVIAAGAERIAVVRAIMAAEDPGRTTAWF  334

Query  224  KEEVSK  229
             E +++
Sbjct  335  LERLNR  340


>gi|28380195|sp|Q8UJA9|TRPA_AGRT5  Tryptophan synthase alpha chain
Length=279

 Score = 70.5 bits (172),  Expect = 5e-12, Method: Composition-based stats.
 Identities = 37/206 (17%), Positives = 67/206 (32%), Gaps = 21/206 (10%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
              +  AGAD + + +    F   +  G  I  + +R++        T      F      
Sbjct  39   KALPEAGADVIELGM---PFSDPMADGPAIQLAGQRALKGGQTLKTTLDLAREFRKQDNA  95

Query  77   FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                MM       +   EK++DD    G D         +    L     ++GI      
Sbjct  96   TPIVMMGYYNPIYIYGVEKFLDDAIASGIDGLIVVDLPPEMDDELCIPALARGINFIRLA  155

Query  130  KPGTSVDVLFELAP-HLDMALVMTVEPGFGGQKFMEDMMPK--VETLRAKFPHLNIQVDG  186
             P T    L  +          +++  G  G    +  +    V  ++A    L + V  
Sbjct  156  TPTTDGKRLPAVLKNTSGFVYYVSMN-GITGSALPDPSLISGAVGRIKAHT-ELPVCVGF  213

Query  187  GLGKETIPKAAKAGANVIVAGTSVFT  212
            G+      KA  A A+ +V G+++  
Sbjct  214  GVKTADHAKAIGAVADGVVVGSAIVN  239


>gi|59799055|sp|Q72U04|TRPA_LEPIC  Tryptophan synthase alpha chain
 gi|59799065|sp|Q8F150|TRPA_LEPIN  Tryptophan synthase alpha chain
Length=264

 Score = 70.5 bits (172),  Expect = 5e-12, Method: Composition-based stats.
 Identities = 31/207 (14%), Positives = 64/207 (30%), Gaps = 23/207 (11%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCH-  80
               +I  GA  L + +    F   +  G  I  + +RS+  P       +  +     H 
Sbjct  33   ADALIRGGAGILELGI---PFTDPVADGPVIQKAFKRSLAHPFSMDKILEVTSEIHKLHP  89

Query  81   ------MMVENP------EKWVDDFAKCGADQFTFHYEATQDP--LHLVKLIKSKGIKAA  126
                  +   NP      E + +     G             P        ++ K I   
Sbjct  90   QIPLVYLTYFNPLFSMGLESFTERAKNSGIQGLIIPDLPFDTPEAEEFFSQLERKRIDFI  149

Query  127  CAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQK-FMEDMM-PKVETLRAKFPHLNIQ  183
              + P T+ D +  +          +T   G  G++  +   +  ++  +R     L + 
Sbjct  150  HLVTPATTEDRIRSMKSLASGFIYYVTSY-GVTGERGSIASGLEDRIRMVRKIVG-LPVC  207

Query  184  VDGGLGKETIPKAAKAGANVIVAGTSV  210
               G+      K     A+ ++ G++V
Sbjct  208  AGFGISTSDQSKVISTYADGVIIGSAV  234


>gi|73622042|sp|Q7URN0|TRPA_RHOBA  Tryptophan synthase alpha chain
Length=278

 Score = 70.1 bits (171),  Expect = 7e-12, Method: Composition-based stats.
 Identities = 41/224 (18%), Positives = 74/224 (33%), Gaps = 27/224 (12%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNT--------EKKP  73
                  AGAD   + V    +   I  G  I  S +R++       +         E   
Sbjct  37   IAAARQAGADLCEVGV---PYSDPIADGPVIQASYQRALDAGFKLQHVWDLGQRLTENPK  93

Query  74   TAFFDCHMMVE-------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAA  126
                    MV           K+VD   + G           ++   L K+ + KG    
Sbjct  94   VKAMPRVTMVSYSIIYRIGMAKYVDQAMQAGYCGAIVPDLLVEEAEDLSKICREKGFDLI  153

Query  127  CAIKPGTSVDVLFELAPH-LDMALVMTVEPGFGGQ--KFMEDMMPKVETLRAKFPHLNIQ  183
              + P T+ D    +A         ++V  G  G+      +++  V  LR +   L I 
Sbjct  154  QLVTPTTTRDRQCRIAELSSGFLYYVSV-TGITGERTALPTNLVDNVGWLREQT-ELPIC  211

Query  184  VDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
            +  G+ G ET  + A   ++ ++ G+++       D +   K  
Sbjct  212  IGFGISGPETAAQLAPV-SDGLIVGSAIVR--RVADAVEKAKSS  252


>gi|73622012|sp|Q83CG2|TRPA_COXBU  Tryptophan synthase alpha chain
Length=267

 Score = 69.8 bits (170),  Expect = 7e-12, Method: Composition-based stats.
 Identities = 37/221 (16%), Positives = 70/221 (31%), Gaps = 19/221 (8%)

Query  15   FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPT  74
                      +   G + L + V    F   +  G  I  +  R++ +     +     T
Sbjct  25   LERSLESLLALAKGGVNILEVGV---PFSDPVADGPVIQEASIRALAQGTTLHDVLTLIT  81

Query  75   AF-----FDCHMMVE-NP-----EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGI  123
            +F         +    NP     +K        G D         ++    +   K+  I
Sbjct  82   SFRQHSEIPIILFTYFNPLLAAGDKIYQQMKSAGVDGCLVVDLPVEEAAPHLTACKTAKI  141

Query  124  KAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKF-MEDMMP-KVETLRAKFPHLN  181
                 I P T+ + L ++  H +  L     PG  G +  + +  P K+  +++    L 
Sbjct  142  APILLISPSTTQERLKKINEHGEGMLYYVCRPGTTGVRATLPENFPAKMNQIKSMT-SLP  200

Query  182  IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
            I    G+    +   A   A+  V G+    A    + IS 
Sbjct  201  IVTGFGIANRKMAAQALQYADGFVIGSLFVKA--IAEGISK  239


>gi|32130302|sp|Q8KZ93|TRPA_BACNA  Tryptophan synthase alpha chain
Length=267

 Score = 69.8 bits (170),  Expect = 8e-12, Method: Composition-based stats.
 Identities = 37/233 (15%), Positives = 78/233 (33%), Gaps = 31/233 (13%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVP------RPGDASNTEKKPTA  75
               +  AGA  L + V    +   +  G  I  + +R++       +  +     KK   
Sbjct  31   AKSLQKAGATALELGVA---YSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGV  87

Query  76   FFDCHM-MVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +    NP      E +     +   D         ++   L +  KS  +     
Sbjct  88   NIPIILFTYYNPVLQLNKEYFFALLQENHIDGLLVPDLPLEESNSLQEECKSHEVTYISL  147

Query  129  IKPGTSVDVLFELAPHLDMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQVDG  186
            + P TS   L  +    +  +      G  G +  F   + P + T++     + + V  
Sbjct  148  VAP-TSESRLKTIIEQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNL-STVPVAVGF  205

Query  187  GLGKETIPKAAKAG--ANVIVAGTSVFTAADPHDVISFMKEE-VSKELRSRDL  236
            G+      +  K    ++ +V G+++         I  +K+  +S E R++ L
Sbjct  206  GI--SNREQVIKMNEISDGVVVGSALVRK------IEELKDRLISAETRNQAL  250


>gi|20141803|sp|Q57700|PYRF_METJA  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=213

 Score = 69.4 bits (169),  Expect = 1e-11, Method: Composition-based stats.
 Identities = 31/203 (15%), Positives = 63/203 (31%), Gaps = 20/203 (9%)

Query  36   DVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFF-DCHMM-VENPEKWVDDF  93
            DV D  +V  I +G P+V S              +        D  +  +    + +   
Sbjct  22   DVKD--YVDAIKVGYPLVLS----TGTEIIKEIKKLCNKEVIADFKVADIPATNEKIAKI  75

Query  94   AKCGADQFTFHYEATQDPLHLVK-LIKSKGIKAACAIKPGTS--VDVLFELAPHLDMALV  150
                AD    H    +D +  V+ + K    K     +      V  L  +A  L     
Sbjct  76   TLKYADGIIVHGFVGEDSVKAVQDVAKKLNKKVIMVTEMSHPGAVQFLQPIADKLS---E  132

Query  151  MTVEPGFGGQKFMEDMMPKVETLRAK----FPHLNIQVDGGLGKETIPKAAKAGANVIVA  206
            M  +              +++ ++           +   GG   E I        + ++ 
Sbjct  133  MAKKLKVDAIVAPSTRPERLKEIKEIAELPVITPGVGAQGG-KIEDILNILDE-NDYVIV  190

Query  207  GTSVFTAADPHDVISFMKEEVSK  229
            G +++ + +P +     KE ++K
Sbjct  191  GRAIYQSQNPKEEAKKYKEMLNK  213


>gi|30173040|sp|Q8DJY0|METE_SYNEL  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=758

 Score = 69.4 bits (169),  Expect = 1e-11, Method: Composition-based stats.
 Identities = 30/222 (13%), Positives = 57/222 (25%), Gaps = 54/222 (24%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +  AGA  + ID       P +  G P+                  +    
Sbjct  576  LALRDEVADLEAAGAKMIQID------EPALREGLPLKAERWNEYLSWAVDAFRLAAGVA  629

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            KP      HM        ++   +  AD  +   E ++     +  I   G +       
Sbjct  630  KPETQIHTHMCYSEFGDIIEHIERLDADVLSI--ENSRSNNETLFQITDAGYRHQV----  683

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH-----LNIQVDG  186
                              V  V         +  +   V+ LR    +     + +  D 
Sbjct  684  ---------------GVGVYDVHS-----PAVPSVEQLVQQLRTSVANLAPEQIWVNPDC  723

Query  187  GLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            GL      +   +  N++             +    +++EV 
Sbjct  724  GLKTRHWEEVIPSLKNMV-------------EATKTIRQEVM  752


>gi|136254|sp|P07601|TRPA_BACSU  Tryptophan synthase alpha chain
Length=267

 Score = 69.4 bits (169),  Expect = 1e-11, Method: Composition-based stats.
 Identities = 37/233 (15%), Positives = 78/233 (33%), Gaps = 31/233 (13%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVP------RPGDASNTEKKPTA  75
               +  AGA  L + V    +   +  G  I  + +R++       +  +     KK   
Sbjct  31   AKSLQKAGATALELGVA---YSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGV  87

Query  76   FFDCHM-MVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +    NP      E +     +   D         ++   L +  KS  +     
Sbjct  88   NIPIILFTYYNPVLQLNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISL  147

Query  129  IKPGTSVDVLFELAPHLDMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQVDG  186
            + P TS   L  +    +  +      G  G +  F   + P + T++     + + V  
Sbjct  148  VAP-TSESRLKTIIEQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNL-STVPVAVGF  205

Query  187  GLGKETIPKAAKAG--ANVIVAGTSVFTAADPHDVISFMKEE-VSKELRSRDL  236
            G+      +  K    ++ +V G+++         I  +K+  +S E R++ L
Sbjct  206  GI--SNREQVIKMNEISDGVVVGSALVRK------IEELKDRLISAETRNQAL  250


>gi|20141970|sp|Q9HSB9|TRPA_HALSA  Tryptophan synthase alpha chain
Length=276

 Score = 69.0 bits (168),  Expect = 1e-11, Method: Composition-based stats.
 Identities = 34/243 (13%), Positives = 79/243 (32%), Gaps = 29/243 (11%)

Query  15   FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPR---PGDASNTEK  71
             A        +++ G D + + +    F   +  G  I  +++R++     P    +   
Sbjct  27   PAATAEYIDALVDGGTDVIELGL---PFSEPVAEGTTIQNAIKRALDAGMTPDAYLDLVA  83

Query  72   KPTAFFDCHMMVE-----------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
            +  A      M              P  +V   A+ G   F        +   L +  ++
Sbjct  84   RIDADVPVVCMTYYNLLFQYGDRAGPAAFVSAAAEAGVSGFVVPDLPVDESGPLREACRA  143

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKF--MEDMMPKVETLRAKFP  178
             G+     + P T+ D    +       + +    G  G +          +  L+    
Sbjct  144  HGLDLVFVVAPTTTADRRERMLDLTTGFVYVQGRVGTTGAREEVSAATPDALAALQHT--  201

Query  179  HLNIQVDGGLGK-ETIPKAAKAGANVIVAGTSVFTA-------ADPHDVISFMKEEVSKE  230
             +   V  G+   E   +   +GA+ ++ G++            DP  V++    +++ E
Sbjct  202  DIPKAVGFGVSSGEQAREITASGADGVIVGSAYVDTVADGVADDDPPSVVADRLRDLAAE  261

Query  231  LRS  233
            L++
Sbjct  262  LKA  264


>gi|74512837|sp|O28964|FAEHP_ARCFU  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=394

 Score = 68.6 bits (167),  Expect = 2e-11, Method: Composition-based stats.
 Identities = 32/180 (17%), Positives = 59/180 (32%), Gaps = 21/180 (11%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEAT  108
            G  ++  LR   P      + +       +  M            A   A+       A 
Sbjct  214  GCEVILKLREVKPDAFYILDLKTLDVGNLEARM-----------AADATANAVVISGLAP  262

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALV----MTVEPGFGGQ-KFM  163
                 +VK I+        +     +VD   +    +  A V    + +      + K  
Sbjct  263  TST--IVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKAGVLPNVVELHRAIDSEDKEP  320

Query  164  EDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
              M+     ++ KF  + + V GG+  E + +   AGA++IV G +V  A D    +   
Sbjct  321  PWMLA--GKIKEKF-SVLVAVAGGIRPENVEEVIAAGADIIVVGRAVTKARDVEGAVRKF  377


>gi|11133452|sp|P57142|METE_BUCAI  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=758

 Score = 68.6 bits (167),  Expect = 2e-11, Method: Composition-based stats.
 Identities = 30/217 (13%), Positives = 61/217 (28%), Gaps = 48/217 (22%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +     + + ID       P +  G P+  S               S +  
Sbjct  577  LALYDEVLDLEKEKIEIIQID------EPALREGLPLRKSSWHEYLSWAVDVFRLSASGV  630

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K T     HM        +D  A   AD  T   EA +  + L++  K            
Sbjct  631  KNTTQIHTHMCYCEFNDIMDSIALLDADVITI--EAARSDMELLESFKKF-KYP------  681

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +   A  +  + + +V          + ++  +       P   + +  D GL 
Sbjct  682  ----NEVGPGAYDIHSSNIPSV----------QSIISLLNKAMKYIPLKRIWVNPDCGLK  727

Query  190  KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
                 +   +  N++             +    ++E+
Sbjct  728  TRNWNETILSLKNMV-------------EATKILREK  751


>gi|51316403|sp|Q82UP6|METE_NITEU  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=758

 Score = 68.6 bits (167),  Expect = 2e-11, Method: Composition-based stats.
 Identities = 27/186 (14%), Positives = 50/186 (26%), Gaps = 35/186 (18%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVT----SLRRSVPRPGDASNTEK  71
              +  E   + NAG   + ID       P    G P+      S      +    +++  
Sbjct  581  LAIRDEVADLENAGIGMIQID------EPAFREGLPLRKQDWKSYLDWAVKAFRVASSGV  634

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM        +   A+  AD  T   E ++  + L+             +K 
Sbjct  635  KDETQIHTHMCYSEFHDILPAIAELDADVITI--ETSRSRMELLDAF----------VKF  682

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH--LNIQVDGGLG  189
                + +      +    V              +M   ++          L +  D GL 
Sbjct  683  SYP-NEIGPGVYDIHSPRV----------PDASEMFELLKKASRYIDPTLLWVNPDCGLK  731

Query  190  KETIPK  195
                P+
Sbjct  732  TRNWPE  737


>gi|97049499|sp|Q2NE86|FAEHP_METST  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=406

 Score = 68.6 bits (167),  Expect = 2e-11, Method: Composition-based stats.
 Identities = 29/184 (15%), Positives = 60/184 (32%), Gaps = 21/184 (11%)

Query  48   LGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEA  107
             G  I++ +R   P     ++ +       +  M  +             AD        
Sbjct  215  FGVEIISKIREERPGAFIIADLKTLDVGRVEVKMAADET-----------ADAVAISGLG  263

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL----DMALV---MTVEPGFGGQ  160
            T + +   K I     +   +I    +V  +      L    ++ L+   +  E      
Sbjct  264  TNESIE--KAIHECSKQGIYSILDMMNVSDIPSKLEELKLKPNIVLLHRNIDSETMRDND  321

Query  161  KFMEDMMPKVETLRAK-FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDV  219
               +     ++ +++K      I V GG+  E +  A   GAN+I+AG  +  ++D    
Sbjct  322  GEQQSEWGNIKDIKSKLGKRGLIAVAGGVTPEKVDTALANGANIIIAGRYIIGSSDVRRA  381

Query  220  ISFM  223
                
Sbjct  382  AEDF  385


>gi|12230241|sp|P57703|METE_PSEAE  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=766

 Score = 68.6 bits (167),  Expect = 2e-11, Method: Composition-based stats.
 Identities = 28/201 (13%), Positives = 58/201 (28%), Gaps = 35/201 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              +  E   +  AG   + ID  +  F      G P+  +                 +  
Sbjct  588  LAIRDEVVDLEAAGIRIVQID--EAAF----REGLPLRRNAWPHYLEWATEAFRLCASGV  641

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +       HM        ++  A   AD  T   E ++  + L++           A + 
Sbjct  642  RDETQIHTHMCYSEFNDVIESIAAMDADVITI--ETSRSDMELLE-----------AFEQ  688

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V + E          +++  +     + P   L +  D GL 
Sbjct  689  FDYPNEIGPGVYDIHSPRVPSRE----------EIVALLRKAARRIPAERLWVNPDCGLK  738

Query  190  KETIPKAAKAGANVIVAGTSV  210
                P+   A  N++ A   +
Sbjct  739  TRAWPETEAALVNMVAAAREL  759


>gi|61217178|sp|Q5MI53|TRPA_LEPBI  Tryptophan synthase alpha chain
Length=266

 Score = 68.2 bits (166),  Expect = 2e-11, Method: Composition-based stats.
 Identities = 35/236 (14%), Positives = 79/236 (33%), Gaps = 38/236 (16%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCH--  80
              +++ GAD L + +    F   +  G  I  ++ RS+           + T     H  
Sbjct  36   KTILDGGADILELGI---PFSDPVADGPVIQRAVARSLKNKFSFDEIF-RVTKQIHLHKQ  91

Query  81   ------MMVENPEK------WVDDFAKCGADQFTFHYEATQDPLH--LVKLIKSKGIKAA  126
                  +   NP        ++D+    G                  L + ++ + +   
Sbjct  92   ETPLVYLTYFNPIYHCGITKFLDNAKDSGVVGLVIPDLPFDTIESETLFQELRLRDMDLI  151

Query  127  CAIKPGTSVDVLFELAP-HLDMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQ  183
              + P ++   +  L          +T   G  G++  F  D+  ++  L+     L I 
Sbjct  152  HLVTPASTKKRIEALRKTSTGFIYYVTSF-GVTGERREFSVDLKERIRFLKDTI-QLPIC  209

Query  184  VDGGL-GKETIPKAAKAG-ANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLL  237
               G+   E   +   AG A+ I+ G+++            ++E      +++++L
Sbjct  210  AGFGISTPEQASQI--AGYADGIIIGSAI---------QRVIEENGQDASKAKNVL  254


>gi|73622002|sp|Q89WE4|TRPA_BRAJA  Tryptophan synthase alpha chain
Length=278

 Score = 68.2 bits (166),  Expect = 2e-11, Method: Composition-based stats.
 Identities = 36/216 (16%), Positives = 66/216 (30%), Gaps = 21/216 (9%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D A        +  +GAD + I +    F   +  G  I  +  R++        T +  
Sbjct  30   DPATSLEIIKALPKSGADVIEIGM---PFTDPMADGPSIQAAGLRALKAGMTLKKTLELV  86

Query  74   TAF------FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
              F          +M       +   +K++ D    G D         ++   L      
Sbjct  87   RGFRKDDNATPIVLMGYYNPIYIYGVDKFLVDAKSAGVDGLIIVDLPPEEDDELCLPAMK  146

Query  121  KGIKAACAIKPGTSVDVLFEL-APHLDMALVMTVEPGFGG--QKFMEDMMPKVETLRAKF  177
             G+       P T    L  + A        +++  G  G        +   V  ++   
Sbjct  147  AGLNFIRLATPTTDDKRLPAVLANTSGFVYYVSI-TGITGAAAADSSAVSEAVARIKRHT  205

Query  178  PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTA  213
              L + V  G+      +A  + AN  V GT++  A
Sbjct  206  K-LPVCVGFGIRTPETARAIASHANGAVVGTALVDA  240


>gi|28380180|sp|Q8P7S0|TRPA_XANCP  Tryptophan synthase alpha chain
Length=272

 Score = 68.2 bits (166),  Expect = 2e-11, Method: Composition-based stats.
 Identities = 35/234 (14%), Positives = 69/234 (29%), Gaps = 27/234 (11%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
            H ++ AGA+ + + V    F   +  G  I  S  R++ R    +   +    F      
Sbjct  42   HALVRAGANIIELGV---PFSDPMADGPTIQRSSERALGRGAGLAYVIEAVQEFRREDAT  98

Query  77   FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M       +    ++ +     G D         ++      +    G+      
Sbjct  99   TPVVLMGYLNPIEIHGTRRFAETAVAAGIDGVLLVDLPPEEADETRAIFTEVGLALIALA  158

Query  130  KPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDM---MPKVETLRAKFPHLNIQVDG  186
             P T    L  L       L      G  G     D      ++  LRA+     +    
Sbjct  159  SPTTGEARLDMLCSTAQGYLYYVSFSGVTGAADRLDTHAASDRLRQLRARAG-APVVAGF  217

Query  187  GLGKETIPKAAKAGANVIVAGT----SVFTAADPHDV---ISFMKEEVSKELRS  233
            G+       A    A+ +V G+    ++  A+D            + + + L +
Sbjct  218  GIKDAASAAAMAVDADGVVVGSALVAALADASDVRSARKRAEDFLQPLRQALDA  271


>gi|54039722|sp|P66919|THIE_STAAN  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
 gi|54042246|sp|P66918|THIE_STAAM  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
 gi|71153597|sp|Q5HEA8|THIE_STAAC  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=213

 Score = 68.2 bits (166),  Expect = 2e-11, Method: Composition-based stats.
 Identities = 23/141 (16%), Positives = 42/141 (29%), Gaps = 6/141 (4%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
                V    +  AD    H          VK I          +      +       H+
Sbjct  74   VNDDVSLAKEINADGI--HVGQDD---AKVKEIAQYFTDKIIGLSISDLDEYAKSDLTHV  128

Query  146  DMALVMTVEPGFG-GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVI  204
            D   V  + P        +      + T +   P L I   GG+    +    +AGAN I
Sbjct  129  DYIGVGPIYPTPSKHDAHIPVGPEMIATFKEMNPQLPIVAIGGINTNNVAPIVEAGANGI  188

Query  205  VAGTSVFTAADPHDVISFMKE  225
               +++  + +    ++  K+
Sbjct  189  SVISAISKSENIEKTVNRFKD  209


>gi|24212478|sp|Q8PS49|THIE_METMA  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=240

 Score = 67.8 bits (165),  Expect = 3e-11, Method: Composition-based stats.
 Identities = 20/144 (13%), Positives = 47/144 (32%), Gaps = 6/144 (4%)

Query  87   EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD  146
               +D      AD    H      P+   + I          +      + +       D
Sbjct  94   NDRIDVALVVDADG--VHIGQDDMPIETARKILGANKIIGLTVHNAD--EAIEAEKSGAD  149

Query  147  MALVMTVEPGFGGQKFMEDMMP-KVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIV  205
               + ++   F  +   + + P  +  +R     +++   GG+ KE      + GA+ +V
Sbjct  150  YVGLGSIFDTFTKKDAGKGIGPASIREVRNAIK-ISVVAIGGINKENCRSVIENGADSLV  208

Query  206  AGTSVFTAADPHDVISFMKEEVSK  229
            A ++V  + D         + + +
Sbjct  209  AISAVVCSDDVKKETREFIDIIRE  232


>gi|51316225|sp|Q6LSD6|METE_PHOPR  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=766

 Score = 67.8 bits (165),  Expect = 3e-11, Method: Composition-based stats.
 Identities = 33/222 (14%), Positives = 60/222 (27%), Gaps = 48/222 (21%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P I  G P+      +           S    
Sbjct  586  LALRDEVSDLQAAGIKIIQID------EPAIREGLPLKESQWQAYLDWAVNAFKISAASA  639

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +P      HM        +   A   AD  T   E ++  + L+K  +           P
Sbjct  640  EPQTQIHTHMCYSEFNHIIKSVAALDADVITI--ETSRSDMELLKAFEEFD-------YP  690

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +                 +E ++  VE      P   L I  D GL 
Sbjct  691  ----NEIGPGVYDIHS----------PNIPSIEQIVHLVEKAETLIPIERLWINPDCGLK  736

Query  190  KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
                 +   A  +++             +    ++E+  ++ 
Sbjct  737  TRNWEETEAALRSMV-------------EATKKLREQWQEKA  765


>gi|8134569|sp|Q42662|METE_SOLSC  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Vitamin-B12-independent methionine synthase isozyme) 
(Cobalamin-independent methionine synthase isozyme)
Length=764

 Score = 67.8 bits (165),  Expect = 3e-11, Method: Composition-based stats.
 Identities = 33/196 (16%), Positives = 57/196 (29%), Gaps = 30/196 (15%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              +  E   +  AG   + ID         +  G P+  S               +N   
Sbjct  584  LAIKDEVEDLEKAGITVIQID------EAALREGLPLRKSEHAFYLDWAVHSFRITNVGV  637

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            + T     HM   N    +       AD  T   E ++    L+ + +  G+K    I P
Sbjct  638  QDTTQIHTHMCYSNFNDIIHSIINMDADVITI--ENSRSDEKLLSVFRE-GVKYGAGIGP  694

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKE  191
            G            +         P     + + D + K+  +      L +  D GL   
Sbjct  695  G---------VYDIHS-------PRIPSTEEIADRINKMLAVLETNI-LWVNPDCGLKTR  737

Query  192  TIPKAAKAGANVIVAG  207
               +   A  N++ A 
Sbjct  738  KYAEVKPALENMVAAA  753


>gi|38258768|sp|Q8CPB0|TRPA_STAES  Tryptophan synthase alpha chain
 gi|71153359|sp|Q5HPG9|TRPA_STAEQ  Tryptophan synthase alpha chain
Length=243

 Score = 67.4 bits (164),  Expect = 4e-11, Method: Composition-based stats.
 Identities = 44/251 (17%), Positives = 80/251 (31%), Gaps = 42/251 (16%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K  I P I+  D  N       +   GAD + I V    F   +  G  I+ + R ++
Sbjct  1    MSKLFI-PYIMG-DL-NFIHHLKTLTENGADIVEIGV---PFSDPVADGPIIMKAGRNAI  54

Query  61   PRPGDASNTEKKPTAFFD-------------CHMMVENP------EKWVDDFAKCGADQF  101
                   +        FD               M   N       E ++D   + G    
Sbjct  55   -------DEGSNIKFIFDELIKNKNTISSKYVLMTYYNILSAYGEELFLDKCDEAGVYGL  107

Query  102  TFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALV---MTVEPGFG  158
                   +      K      +K    I    S   + ++A + +  +    M    G  
Sbjct  108  IIPDLPYELTKKFKKDFYHHSVKIISLIAMTASDARIMQIAKNSEGFIYTVTMNATTGNS  167

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFT---AA  214
            G+ F  D+  K+E ++     + +    G+   E +   A   A+ IV G+ +       
Sbjct  168  GE-FHPDLKRKIEYIKK-VSKIPVVAGFGIKNPEHVKDIASV-ADGIVIGSEIVKRIEID  224

Query  215  DPHDVISFMKE  225
               + I+++K 
Sbjct  225  SRKEFITYIKS  235


>gi|8134568|sp|P93263|METE_MESCR  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Vitamin-B12-independent methionine synthase isozyme) 
(Cobalamin-independent methionine synthase isozyme)
Length=765

 Score = 67.4 bits (164),  Expect = 4e-11, Method: Composition-based stats.
 Identities = 33/222 (14%), Positives = 62/222 (27%), Gaps = 49/222 (22%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              +  E   +  AG + + ID         +  G P+  S      +        +N   
Sbjct  585  LAIKNEVEDLEKAGINVIQID------EAALREGLPLRKSEHDFYLKWAVHSFRITNVGV  638

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            + T     HM   N    +       AD  T   E ++    L+ + +  G+K    I P
Sbjct  639  QDTTQIHTHMCYSNFNDIIHSIIDMDADVITI--ENSRSDEKLLSVFRE-GVKYGAGIGP  695

Query  132  G---TSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGL  188
            G        +       D    M                  +  L +    L +  D GL
Sbjct  696  GVYDIHSPRIPPTEELADRIRKM------------------LAVLESNV--LWVNPDCGL  735

Query  189  GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
                  +   A +N++                  +++E++  
Sbjct  736  KTRKYGEVNPALSNMVA-------------AAKQLRQELASA  764


>gi|2499001|sp|P72965|THIE_SYNY3  Probable thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=343

 Score = 67.4 bits (164),  Expect = 4e-11, Method: Composition-based stats.
 Identities = 24/146 (16%), Positives = 48/146 (32%), Gaps = 9/146 (6%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
                VD      AD    H      P+ + + +   G             ++   +A   
Sbjct  202  VNDRVDLALAVDADG--VHLGQQDLPIAVARQL--LGPDKIIGRSTTNPEEMAKAIAEGA  257

Query  146  DMALVMTVE--PGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANV  203
            D   V  V   P   G+K     +  V+      P     + GG+  E + +  +AGA  
Sbjct  258  DYIGVGPVYATPTKAGKK--PAGLEYVQYAVTNSPVPWFAI-GGIDGENLGEVMEAGATQ  314

Query  204  IVAGTSVFTAADPHDVISFMKEEVSK  229
            +    ++    +P    + +  ++S+
Sbjct  315  VAIVRAIMETTNPTQATAQLLTQLSR  340


>gi|3334258|sp|Q39586|METE_CHLRE  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=814

 Score = 67.1 bits (163),  Expect = 5e-11, Method: Composition-based stats.
 Identities = 28/220 (12%), Positives = 57/220 (25%), Gaps = 46/220 (20%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              L  E   +  AG   + +D       P +  G P+      S                
Sbjct  593  LALRQEVAALEAAGCTIIQVD------DPALREGLPLNGERWASYLSWAVDAFRLCTGVA  646

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
                    H+   + +  +    +  AD  T     +  P+         G         
Sbjct  647  AAGTQVVTHLCYSDFQDILPAIDRMDADVLTIENSRSDKPMMAALAAAGYGRDIG-----  701

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKV---ETLRAKFPHLNIQVDGGL  188
                         +   +V +VE       F++  +        L  ++  + +  D GL
Sbjct  702  --------PGVYDVHSPVVPSVE-------FIKSRIRSFVDSGILSGRYDRIWVNPDCGL  746

Query  189  GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
                 P+   A AN++             +  +  + E+ 
Sbjct  747  KTRGWPETIAALANMV-------------EAAAQARAELQ  773


>gi|3915890|sp|P34793|TRP2_CYACA  Tryptophan synthase alpha chain
Length=242

 Score = 67.1 bits (163),  Expect = 5e-11, Method: Composition-based stats.
 Identities = 35/241 (14%), Positives = 73/241 (30%), Gaps = 37/241 (15%)

Query  12   ASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASN---  68
            A D          + N GAD + I V    +   +  G  +  + ++++           
Sbjct  10   APDLNTTKQALLNLANDGADVIEIGV---PYSDPLADGMILQKASQQALKNRFRLEQLWH  66

Query  69   TEKKPTAFFDCHMMV-------ENPEKWVDDFAKCGADQFTFHYEATQD--PLHLVKLIK  119
               +        ++           EKWV                  ++   L       
Sbjct  67   LLAEIELPVPVVILAYYNQIFHYGVEKWVTTLVNLKVKALIVPDLPYEEAAILRAACARH  126

Query  120  SKGIKAACAIKPGTSVDVLFELAPHL-DMALVMT------VEPGFGGQKFMEDMMPKVET  172
               +     I P T      +LA    D   +++      V+  F  Q  + +M+ +++ 
Sbjct  127  HLHM--IWLISPTTPKVRAKQLALACDDWIYLVSRTGVTGVDAHFDNQ--IPNMIAELKQ  182

Query  173  LRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVF------TAADPHDVISFMKE  225
            +        I +  G+  K+ +      GA+ ++ GT+              + IS MK+
Sbjct  183  VT----TTPIALGFGIHQKQQLQLVKSWGADGVIIGTACMQILLEKGVDQLTEWISAMKK  238

Query  226  E  226
             
Sbjct  239  S  239


>gi|56749730|sp|Q6GEY4|THIE_STAAR  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=213

 Score = 67.1 bits (163),  Expect = 6e-11, Method: Composition-based stats.
 Identities = 24/144 (16%), Positives = 42/144 (29%), Gaps = 12/144 (8%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
                V    +  AD    H          VK I                 +       H+
Sbjct  74   VNDDVSLAKEINADGI--HVGQDD---AKVKEIAQYFTDKIIGFSISDLDEYAKSDLTHV  128

Query  146  DMALVMTVEPGF----GGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGA  201
            D   V  + P             +M   + T +   P L I   GG+    +    +AGA
Sbjct  129  DYIGVGPIYPTPSKHDAHTPVGPEM---IATFKEMNPQLPIVAIGGINTSNVAPIVEAGA  185

Query  202  NVIVAGTSVFTAADPHDVISFMKE  225
            N I   +++  + +    ++  K+
Sbjct  186  NGISVISAISKSENIEKTVNRFKD  209


>gi|28380186|sp|Q8R9N0|TRPA_THETN  Tryptophan synthase alpha chain
Length=262

 Score = 67.1 bits (163),  Expect = 6e-11, Method: Composition-based stats.
 Identities = 28/232 (12%), Positives = 80/232 (34%), Gaps = 28/232 (12%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP-----TAF  76
               +  AGAD + + +    +   +  G  I  S +R++ +     +           + 
Sbjct  37   VLALEEAGADIIELGI---PYSDPLADGPTIQASSQRALAKGIKIKDIMDLVMRIREKSD  93

Query  77   FD-CHMMVEN--PEKWVDDFAK----CGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +++  N   +  ++ F +     G D         ++   ++ +     I     +
Sbjct  94   IPIVYLVYYNSVFKYGIEKFLEDSKNAGVDGLIIPDLPLEERKEVLDVADKYEIYLIPLV  153

Query  130  KPGTSVDVLFELAP-HLDMALVMTVEPGFGGQKF--MEDMMPKVETLRAKFPHLNIQVDG  186
             P TS + +  +          +T+  G  G +     D+   +  + +        +  
Sbjct  154  AP-TSKERIKGITENGKGFVYCVTL-TGVTGAREEITTDLEEYMRLVSSYTSMPK-ALGF  210

Query  187  GLGKETIPKAAKAGANVIVAGTS----VFTAADPHDVISFMKE---EVSKEL  231
            G+    + +  K+ ++ IV G++    +    +  +++  +KE    + + L
Sbjct  211  GISGPEMARKLKSLSDGIVVGSAIVERIAKGYNRCEMLKEVKEFVLSLREVL  262


>gi|401211|sp|P31204|TRPA_ANTSP  Tryptophan synthase alpha chain
Length=263

 Score = 66.7 bits (162),  Expect = 6e-11, Method: Composition-based stats.
 Identities = 35/234 (14%), Positives = 77/234 (32%), Gaps = 29/234 (12%)

Query  20   CECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVP-------RPGDASNTEKK  72
               +++ + GAD + + +    +   +  G  I  S   ++                  K
Sbjct  33   QALYELDSQGADIIELGI---PYSDALADGSVIQHSSLIALQGGTYIDQVLHILEVVSTK  89

Query  73   PTAFFDCHMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAA  126
                    +   NP      EK++   +  GA          ++   L+ +     I+  
Sbjct  90   LNTPI-IILPYYNPILKRGIEKFIKQISLMGAKGLIVPDLPLEETDELIVICNDNQIELV  148

Query  127  CAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLN---IQ  183
              + P +S+  +  ++      + +    G  G +  +D+  KV  L      ++   I 
Sbjct  149  LFVAPTSSMKRINSISKKSPGCIYLVSSTGVTGVR--DDIDIKVMELSNYIKKVSNKFIM  206

Query  184  VDGGL-GKETIPKAAKAGANVIVAGTSVF------TAADPHDVISFMKEEVSKE  230
            +  G+   E I K  K   + +V G++           D    IS + + + K 
Sbjct  207  LGFGISTPEHIKKIMKWNIDGVVVGSAFVKKLSALKIDDRISSISSLCKSLKKA  260


>gi|24212475|sp|Q8NVH5|THIE_STAAW  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
 gi|56749701|sp|Q6G7L9|THIE_STAAS  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=213

 Score = 66.7 bits (162),  Expect = 7e-11, Method: Composition-based stats.
 Identities = 23/141 (16%), Positives = 43/141 (30%), Gaps = 6/141 (4%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
                V    +  AD    H          VK I          +      +       H+
Sbjct  74   VNDDVSLAKEINADGI--HVGQDD---AKVKEIAQYFTDKIIGLSISDLDEYAKSDLTHV  128

Query  146  DMALVMTVEPGFG-GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVI  204
            D   V  + P        +      + T +   P L I   GG+    +    +AGAN I
Sbjct  129  DYIGVGPIYPTPSKHDAHIPVGPEMIATFKEMNPQLPIVAIGGINTNNVAPIVEAGANGI  188

Query  205  VAGTSVFTAADPHDVISFMKE  225
               +++  + +  + ++  K+
Sbjct  189  SVISAISKSENIENTVNRFKD  209


>gi|51316409|sp|Q83A62|METE_COXBU  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=775

 Score = 66.7 bits (162),  Expect = 8e-11, Method: Composition-based stats.
 Identities = 26/189 (13%), Positives = 52/189 (27%), Gaps = 33/189 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +  +G   + ID       P      P+  +          +    ++   
Sbjct  583  LALRDEVQDLERSGVRVIQID------EPAFRECLPLRKAAWQDYLEWAVKCFRLASCGV  636

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM        ++  A   AD  T   E+++  + ++K  +            
Sbjct  637  KDETQIHTHMCYSEFNDIIEAIAALDADVITI--ESSRSEMEILKSFEKF----------  684

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAK-FPHLNIQVDGGLGK  190
                + +      +         P       +E++   V  L+      L I  D GL  
Sbjct  685  AYP-NDIGPGIYDIHS-------PRIPRVAEIEELA--VRALQYIPIERLWINPDCGLKT  734

Query  191  ETIPKAAKA  199
                +  +A
Sbjct  735  RNWEETKEA  743


>gi|73622061|sp|Q5NPZ7|TRPA_ZYMMO  Tryptophan synthase alpha chain
Length=274

 Score = 66.3 bits (161),  Expect = 9e-11, Method: Composition-based stats.
 Identities = 33/236 (13%), Positives = 77/236 (32%), Gaps = 33/236 (13%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCH-  80
               ++  G D + + +    F   +  G  I  +  R++      ++  +  T F   H 
Sbjct  37   LDSLVENGVDIIELGM---PFSDPMADGPAIQKANLRALAAKTGYNDIFRIATEFRKRHP  93

Query  81   -----MM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M   NP      + +     + G D         ++   L   ++ KG+     
Sbjct  94   ETPLILMGYANPMTFKGSDSFAASAKEAGVDGIICVDIPPEEDATLGVAVREKGMDMIRL  153

Query  129  IKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQ----KFMEDMMPKVETLRAKFPHLNIQ  183
              P +    L  +          ++V    G Q      ++  + +++ +      L + 
Sbjct  154  ATPTSDEARLKIILDGASGFLYYVSVAGVTGLQQATEASIDAALDRIKAVT----DLPVA  209

Query  184  VDGGLGKETIPKAAKAGANVIVAGTSV--------FTAADPHDVISFMKEEVSKEL  231
            V  G+       A    A+ +V G++             DP+  +  + +E+S  +
Sbjct  210  VGFGIRSPEQAAAIAKKADAVVVGSAFVSCIEKAVTNRQDPNAALEKLAKELSTAI  265


>gi|51316369|sp|Q7VVU3|METE_BORPE  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=764

 Score = 65.9 bits (160),  Expect = 1e-10, Method: Composition-based stats.
 Identities = 33/199 (16%), Positives = 55/199 (27%), Gaps = 35/199 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P I  G P+  +               S    
Sbjct  590  LALRDEVVDLEAAGIRVIQID------EPAIREGLPLRRADWRAYLDWAVDCFRLSTAGV  643

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
                    HM        ++  A   AD  T   E ++  + L+K           A + 
Sbjct  644  GEATQIHTHMCYSEFNDIIESIAAMDADVITI--ETSRSNMELLK-----------AFED  690

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V  V          + M+  +    A+ P   L +  D GL 
Sbjct  691  FHYPNDIGPGVYDIHSPNVPEV----------DWMVELMRKAAARLPKERLWVNPDCGLK  740

Query  190  KETIPKAAKAGANVIVAGT  208
                P+   A   ++ A  
Sbjct  741  TRAWPETEAALIGMVQAAR  759


>gi|51316375|sp|Q7W791|METE_BORPA  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
 gi|51316377|sp|Q7WKM7|METE_BORBR  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=764

 Score = 65.9 bits (160),  Expect = 1e-10, Method: Composition-based stats.
 Identities = 33/199 (16%), Positives = 55/199 (27%), Gaps = 35/199 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P I  G P+  +               S    
Sbjct  590  LALRDEVVDLEAAGIRVIQID------EPAIREGLPLRRADWRAYLDWAVDCFRLSTAGV  643

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
                    HM        ++  A   AD  T   E ++  + L+K           A + 
Sbjct  644  GEATQIHTHMCYSEFNDIIESIAAMDADVITI--ETSRSNMELLK-----------AFED  690

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V  V          + M+  +    A+ P   L +  D GL 
Sbjct  691  FHYPNDIGPGVYDIHSPNVPEV----------DWMVELMRKAAARLPKERLWVNPDCGLK  740

Query  190  KETIPKAAKAGANVIVAGT  208
                P+   A   ++ A  
Sbjct  741  TRAWPETEAALIGMVQAAR  759


>gi|97049465|sp|Q2FQ74|FAEHP_METHJ  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=393

 Score = 65.5 bits (159),  Expect = 1e-10, Method: Composition-based stats.
 Identities = 27/186 (14%), Positives = 59/186 (31%), Gaps = 18/186 (9%)

Query  48   LGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEA  107
             G  +++ +R   P     ++ +   T   +  M            A   AD       A
Sbjct  212  FGLNVISEIRAVKPNAFIVADMKILDTGNLEARM-----------AADSSADAVVMSGLA  260

Query  108  TQD-PLHLVKLIKSKGIK-AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMED  165
                    +   +  GI      +     V ++  L    D+     +      +     
Sbjct  261  PASTIEKAITEARKTGIYSVIDMLNVEDPVGLIASLKVKPDIV---ELHRAIDAE-HTSH  316

Query  166  MMPKVETLRAK-FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMK  224
                +  ++      L +   GG+    + +A K GA+++V G ++  + D         
Sbjct  317  AWGNIGDIKKAAGGKLLVATAGGIRVPVVKEALKTGADILVVGRAITASKDVRHAAEEFL  376

Query  225  EEVSKE  230
            E+++KE
Sbjct  377  EQLNKE  382


>gi|30173094|sp|Q8XS05|METE_RALSO  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=776

 Score = 65.5 bits (159),  Expect = 1e-10, Method: Composition-based stats.
 Identities = 32/188 (17%), Positives = 50/188 (26%), Gaps = 31/188 (16%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPI----VTSLRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P    G P+    V        R    S +  
Sbjct  580  LALRDEVRDLEAAGIAAIQID------EPAFREGLPLRAGDVAVYLEWAARVFRVSASGV  633

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +       HM        +   A   AD  T   E ++  + L+                
Sbjct  634  RNDTQIHTHMCYSEFNDILPAIASMDADVITI--ETSRSNMELLDAFGEF----------  681

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKE  191
                + +      +    V  VE        ME ++ K   +      L +  D GL   
Sbjct  682  AYP-NEIGPGVYDIHSPRVPRVE-------EMEALLDKAAQVVP-VQRLWVNPDCGLKTR  732

Query  192  TIPKAAKA  199
              P+   A
Sbjct  733  GWPEVEAA  740


>gi|28380210|sp|Q9LAG8|TRPA_AZOBR  Tryptophan synthase alpha chain
Length=284

 Score = 65.1 bits (158),  Expect = 2e-10, Method: Composition-based stats.
 Identities = 32/192 (16%), Positives = 58/192 (30%), Gaps = 21/192 (10%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D        H +  AGAD + + +    F   +  G  I  +  R++     A  T    
Sbjct  39   DLETCRAVLHGLPAAGADLIELGL---PFSDPMADGPAIQAASLRALHAGTTARKTLDLV  95

Query  74   TAF------FDCHMM-VENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
              F          +M   NP      ++++ D  + G D         ++   L      
Sbjct  96   RGFRETDADTPVILMGYYNPIHAYGVDRFLADAIEAGVDGLIVVDLPPEEDEELCIPALK  155

Query  121  KGIKAACAIKPGTSVDVLFELAP-HLDMALVMTVEPGFGGQKFME--DMMPKVETLRAKF  177
             G+       P T    L  +          +++  G  G    +   +   VE L+   
Sbjct  156  AGVNFIRLATPTTDDKRLPAVLQNTSGFVYYVSI-AGITGAASADNAAVGAAVERLKRHT  214

Query  178  PHLNIQVDGGLG  189
              L + V  G+ 
Sbjct  215  D-LPVAVGFGIK  225


>gi|14195299|sp|Q9TLW8|TRP1_CYACA  Tryptophan synthase alpha chain
Length=266

 Score = 65.1 bits (158),  Expect = 2e-10, Method: Composition-based stats.
 Identities = 26/206 (12%), Positives = 64/206 (31%), Gaps = 21/206 (10%)

Query  19   GCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRP-------GDASNTEK  71
                  +   GA+ + + +    +   +  G  I  +  +++              N + 
Sbjct  32   KQAIIAMDKNGANIIELGI---PYSDPVADGPVIQDAYNKAIKNGVNIRKAFKILMNLKG  88

Query  72   KPTAFFDC-----HMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAA  126
            K  +          ++     K+++   +              +   L K      I   
Sbjct  89   KIKSPIIVFIYYNQLLNYGINKFLEKLIQLEVQGIIVPDLPYDESQILKKKCTINNIALI  148

Query  127  CAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL---NIQ  183
              I   +S   + ++A + +  L +  + G  G      +M K++ +      L    + 
Sbjct  149  SLIALTSSFSRIKKIARNAEGFLYLISKTGVTGGT--GKLMNKLKIIIKTIQKLTSKPVV  206

Query  184  VDGGLGK-ETIPKAAKAGANVIVAGT  208
            V  G+     I +  +  +N IV G+
Sbjct  207  VGFGINSRRQIKQLIEWNSNGIVIGS  232


>gi|30173110|sp|Q98A73|METE_RHILO  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=776

 Score = 65.1 bits (158),  Expect = 2e-10, Method: Composition-based stats.
 Identities = 29/201 (14%), Positives = 57/201 (28%), Gaps = 35/201 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              +  E   +  AGA  + ID         +  G P+      +           ++T  
Sbjct  598  LAIRDEVSDLEKAGAKMIQID------EAALREGLPLREADWQAYLDWAVECFRLASTAV  651

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
                    HM        VD  A   AD  +   E ++  L L+  +++           
Sbjct  652  GDATQIHTHMCYSEFGDIVDAIAAMDADVISI--ETSRSQLELLDTLRTF-KYP------  702

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH--LNIQVDGGLG  189
                + +      +    V  V           ++   +   R +     L +  D GL 
Sbjct  703  ----NEIGPGVYDIHSPRVPEVG----------EISNLIMLARKRLSDGQLWVNPDCGLK  748

Query  190  KETIPKAAKAGANVIVAGTSV  210
                 +   A  N++ A  ++
Sbjct  749  TRRWEEVRPALVNMVAAARAI  769


>gi|136260|sp|P17166|TRPA_LACCA  Tryptophan synthase alpha chain
Length=266

 Score = 64.7 bits (157),  Expect = 2e-10, Method: Composition-based stats.
 Identities = 32/240 (13%), Positives = 76/240 (31%), Gaps = 24/240 (10%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS------VPRPGDAS  67
            DF         +   GAD + + +    F   +  G  I  +  R+           D  
Sbjct  26   DFETTVKNVVALAKGGADIVELGI---PFSDPVADGPVIQAADLRAFAANVRTKTVFDIV  82

Query  68   NTEKKPTAFFDCHMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK  121
               +K TA     +   N       + ++   A              +    +V + +  
Sbjct  83   EAARKETAVPIVFLTYLNIVFKYGYDAFLKRCADLNVAGLVIPDLPYESRDEIVPIAEKY  142

Query  122  GIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPH  179
            GI     I P TS   + ++A      + +    G  G++  F   +   V  ++    +
Sbjct  143  GIDIIPLITP-TSGHRIEKIAKSASGFIYVVSSMGITGERDEFFAGLKALVAEIKQYT-N  200

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT--AADPH---DVISFMKEEVSKELRSR  234
            +   +  G+      +     A+ ++ G+++    A +       I    +++   + ++
Sbjct  201  VPTAIGFGIHTPEQAQTMAGIADGVIIGSAIVDLVAKEKQQAPAAIEKFTKQIRVAVDAK  260


>gi|73622043|sp|Q6NDN5|TRPA_RHOPA  Tryptophan synthase alpha chain
Length=278

 Score = 64.7 bits (157),  Expect = 2e-10, Method: Composition-based stats.
 Identities = 37/228 (16%), Positives = 72/228 (31%), Gaps = 30/228 (13%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF-----  76
               +  AGAD + I +    F   +  G  I  +  R++        T      F     
Sbjct  38   LKVLPAAGADVIEIGM---PFTDPMADGPAIQAAGLRALKAGTTLKKTLGLVRDFRATDN  94

Query  77   -FDCHMM-------VENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +M       +   + ++ D    G D         ++   L       G+     
Sbjct  95   ATPLVLMGYYNPIYIYGVDAFLADAKAAGVDGLIIVDLPPEEDEELCLPAMKAGLNFIRL  154

Query  129  IKPGTSVDVLFEL-APHLDMALVMTVEPGFGGQKFMED--MMPKVETLRAKFPHLNIQVD  185
              P T    L  + A        +++  G  G    +   +   V+ ++    +L + V 
Sbjct  155  ATPTTDEKRLPAVLANTSGFVYYVSI-TGITGSASADASAVGAAVQRIKRHT-NLPVCVG  212

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRS  233
             G+      +A  A AN  V G+++         I  +K  ++ E R+
Sbjct  213  FGIRTPDAAQAIAAQANGAVVGSAL---------IDALKASLNAEGRA  251


>gi|11135218|sp|P57365|TRPA_BUCAI  Tryptophan synthase alpha chain
Length=269

 Score = 64.7 bits (157),  Expect = 3e-10, Method: Composition-based stats.
 Identities = 30/207 (14%), Positives = 67/207 (32%), Gaps = 20/207 (9%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRP------GDASNTEKKPTA  75
               +I +GAD L I +    F   +  G  +  S  R++ +              +K   
Sbjct  37   IETLIKSGADALEIGI---PFSDPLADGPTVQKSNLRALSKNNTFFEYFKILKQLRKKNK  93

Query  76   FFDCHMMVEN---PEKWVDDFA----KCGADQFTFHYEATQDPLHLVKLIKSKGIKAACA  128
                 +++       + +D+F       G D         ++      +     I     
Sbjct  94   KLPIGILIYANLVYNQGIDNFYFQCFNSGLDSVLIADVPIEESKIFYNIANKYKINPIFI  153

Query  129  IKPGTSVDVLFEL-APHLDMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQVD  185
              P    D L+++         V++  PG  G K   +      +  ++       +Q  
Sbjct  154  CPPDADADFLYKISLYAQGFIYVLSR-PGVTGIKNNTIALPRDFINKIKKYNSVPLLQGF  212

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFT  212
            G    + I +A  +G + ++ G+++  
Sbjct  213  GISNPKQIKEAISSGLSGVICGSAIIN  239


>gi|73622006|sp|Q9PIF1|TRPA_CAMJE  Tryptophan synthase alpha chain
 gi|73622007|sp|Q5HWB8|TRPA_CAMJR  Tryptophan synthase alpha chain
Length=249

 Score = 64.7 bits (157),  Expect = 3e-10, Method: Composition-based stats.
 Identities = 36/204 (17%), Positives = 76/204 (37%), Gaps = 18/204 (8%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNT---EKKPTAFFD  78
              ++  +  D L + V    +   I  G+ I  + + ++ +  D  +      +      
Sbjct  31   LQRLDQSPIDILELGVA---YSDPIADGEIIADAAKIALDQGVDIHSVFELLARIKTKKA  87

Query  79   CHMMVE-------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
               MV          EK+V      G         + ++   L+K  +   I     +  
Sbjct  88   LVFMVYYNLIFSYGLEKFVKKAKSLGICALIVPELSFEESDDLIKECERYNIALITLVSV  147

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMM--PKVETLRAKFPHLNIQVDGGL-  188
             T  + + +L  H    + +    G  G K +E+ +   KV+ +R+ F +L I V  G+ 
Sbjct  148  TTPKERVKKLVKHAKGFIYLLASIGITGTKSVEEAILQDKVKEIRS-FTNLPIFVGFGIQ  206

Query  189  GKETIPKAAKAGANVIVAGTSVFT  212
              + + +  K  A+ ++ GTS+  
Sbjct  207  NNQDVKRMRKV-ADGVIVGTSIVK  229


>gi|3915157|sp|O13831|TRP_SCHPO  Tryptophan synthase
Length=697

 Score = 64.4 bits (156),  Expect = 3e-10, Method: Composition-based stats.
 Identities = 26/184 (14%), Positives = 57/184 (30%), Gaps = 20/184 (10%)

Query  25   VINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPT------AFFD  78
            + N GA  + + +    F   +  G  I      ++          +             
Sbjct  41   LQNGGAGIIELGI---PFSDAVADGPTICKGNEIALKNNITLEKVFETVKLARDAGVTIP  97

Query  79   CHMM-VENPE------KWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
              +M   NP       K +    + GA+ F       ++ +   +  K +G+     + P
Sbjct  98   IILMGYYNPIFSYGDAKTIQKAKEVGANGFIIVDLPPEEAVGFREECKKQGVSFVPLVAP  157

Query  132  GTSVDVLFELAPHLD-MALVMTV--EPGFGGQKFMEDMMPKV-ETLRAKFPHLNIQVDGG  187
             T+   +  LA   D    V++     G      +   +P++ + +R       + V  G
Sbjct  158  STTDRRMELLASVADSFIYVVSRMGSTGSSATGVINTALPQLCQRVRKFAGDTPLAVGFG  217

Query  188  LGKE  191
            +   
Sbjct  218  VNTS  221


>gi|12230297|sp|Q9PB72|METE_XYLFA  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=758

 Score = 64.4 bits (156),  Expect = 3e-10, Method: Composition-based stats.
 Identities = 30/195 (15%), Positives = 57/195 (29%), Gaps = 35/195 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVT----SLRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P I  G P+                  +++  
Sbjct  584  LALRDEVQDLEKAGIKVIQID------EPAIREGLPLRRGEWADYLNWAVESFRIASSNV  637

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            + T     HM        ++  A   AD  +   E ++  + L+             +K 
Sbjct  638  RDTTQIHTHMCYSEFNDIIEAVAALDADVISI--ETSRSRMELLDAF----------VKF  685

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +         P    +   E+M+  ++  RA  P   L +  D GL 
Sbjct  686  RYP-NAIGPGVYDIHS-------PRVPQE---EEMVLLLKKARAVLPPEQLWVNPDCGLK  734

Query  190  KETIPKAAKAGANVI  204
                 +   A   ++
Sbjct  735  TRGWKETRAALQTMV  749


>gi|2498999|sp|P71350|THIE_HAEIN  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=226

 Score = 64.4 bits (156),  Expect = 3e-10, Method: Composition-based stats.
 Identities = 30/153 (19%), Positives = 56/153 (36%), Gaps = 14/153 (9%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLF--ELAP  143
             +  VD   +  AD    H   +  P   V+ I++K  K       G SV+ L   ++  
Sbjct  82   VDDNVDLALEIEADGI--HVGQSDMP---VQEIRAKTDKPLII---GWSVNRLDEAKIGE  133

Query  144  HLDMALVMTVEPGFGGQ-KFMEDM---MPKVETLRAKFPHLNIQVDGGLGKETIPKAAKA  199
            +L       + P F  Q K        M  ++TLR       +   GG+    +    + 
Sbjct  134  NLAEIDYFGIGPIFPTQSKENPKPTLGMAFIQTLRNAGITKPLVAIGGVKLAHVKTLREF  193

Query  200  GANVIVAGTSVFTAADPHDVISFMKEEVSKELR  232
            GA+ +   T++  A +       ++E   +  +
Sbjct  194  GADGVAVITAITHADNVQAATKALREASDEYAK  226


>gi|51316440|sp|Q87XJ9|METE_PSESM  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=766

 Score = 64.4 bits (156),  Expect = 4e-10, Method: Composition-based stats.
 Identities = 28/199 (14%), Positives = 53/199 (26%), Gaps = 35/199 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              +  E   +  AG   + ID  +  F      G P+  +                 +  
Sbjct  593  LAIRDEVLDLERAGIKIVQID--EAAF----REGLPLRKAQWQQYLDWAVAAFRLCASGV  646

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +       HM        +   A   AD  T   E ++  + L+            A + 
Sbjct  647  RDETQIHTHMCYSEFNDVIKSIAAMDADVITI--ETSRSDMELLD-----------AFEA  693

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +    V              +M+  +     + P   L +  D GL 
Sbjct  694  FDYPNDIGPGVYDIHSPRV----------PETAEMVSLIAKAARRIPAERLWVNPDCGLK  743

Query  190  KETIPKAAKAGANVIVAGT  208
                P+   A  N++ A  
Sbjct  744  TRGWPETEAALINMVAAAR  762


>gi|47606159|sp|Q87VY6|THIE_PSESM  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=205

 Score = 64.0 bits (155),  Expect = 4e-10, Method: Composition-based stats.
 Identities = 30/141 (21%), Positives = 52/141 (36%), Gaps = 9/141 (6%)

Query  89   WVDDFAKCGAD-QFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDM  147
             ++D A+  A      H   T   L   + +   G KA         +++  +     D 
Sbjct  65   IINDDAELAARLGVGVHLGQTDGSLPDARAL--LGHKAIVGATCHGQLELAEQA--KADG  120

Query  148  ALVMTVEPGFGGQ---KFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVI  204
            A  +     F  Q         +  +  +RA+  HL I V GG+  E  P+  + GA+++
Sbjct  121  ATYVAFGRFFNSQTKPGAPAVPLDLIAQVRARV-HLPIAVIGGITLENAPQLVEHGADLL  179

Query  205  VAGTSVFTAADPHDVISFMKE  225
                 +F A  P +V    K 
Sbjct  180  AVVHGLFGAETPQEVTRRAKA  200


>gi|32129722|sp|Q87BY8|METE_XYLFT  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=758

 Score = 64.0 bits (155),  Expect = 4e-10, Method: Composition-based stats.
 Identities = 30/195 (15%), Positives = 56/195 (28%), Gaps = 35/195 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVT----SLRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P I  G P+                  +++  
Sbjct  584  LALRDEVQDLEKAGIKVIQID------EPAIREGLPLRRGEWADYLNWAVESFRIASSNV  637

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
              T     HM        ++  A   AD  +   E ++  + L+             +K 
Sbjct  638  HDTTQIHTHMCYSEFNDIIEAVAALDADVISI--ETSRSRMELLDAF----------VKF  685

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +         P    +   E+M+  ++  RA  P   L +  D GL 
Sbjct  686  RYP-NAIGPGVYDIHS-------PRVPQE---EEMVLLLKKARAVLPPEQLWVNPDCGLK  734

Query  190  KETIPKAAKAGANVI  204
                 +   A   ++
Sbjct  735  TRGWKETRAALQTMV  749


>gi|7387617|sp|O26232|PYRF_METTH  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=228

 Score = 64.0 bits (155),  Expect = 5e-10, Method: Composition-based stats.
 Identities = 39/229 (17%), Positives = 76/229 (33%), Gaps = 25/229 (10%)

Query  10   ILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNT  69
            ILA D  N   +  +V     +++  D +   +   ++ G  I+   R+       A   
Sbjct  16   ILAMDLMN-RDDALRVTGEVREYI--DTVKIGYPLVLSEGMDIIAEFRKRFGCRIIADFK  72

Query  70   EKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHL-VKLIKSKGIKAACA  128
                          E  EK      K GAD    H     D +   + + +  G +    
Sbjct  73   VADIP---------ETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREVFLL  123

Query  129  IKPGTSVDVLFELAPHLDMALVMTVEPG---FGGQKFMEDMMPKVETL---RAKFPHLNI  182
             +       +F +    D    M V+ G   + G     + + ++  +    +      +
Sbjct  124  TEMSHPGAEMF-IQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGV  182

Query  183  QVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
               GG   ET+       A+ I+ G S++ A +P    + + E +   L
Sbjct  183  GAQGGDPGETLR-----FADAIIVGRSIYLADNPAAAAAGIIESIKDLL  226


>gi|13431691|sp|P57843|METE_PASMU  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=757

 Score = 64.0 bits (155),  Expect = 5e-10, Method: Composition-based stats.
 Identities = 29/193 (15%), Positives = 47/193 (24%), Gaps = 45/193 (23%)

Query  18   LGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEKKP  73
            L  E   +  AG   + ID       P I  G P+      +  +        S    + 
Sbjct  583  LSDEVLDLEKAGIKVIQID------EPAIREGLPLKRADWDAYLQWAGEAFRLSYMGVQD  636

Query  74   TAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS----KGIKAAC--  127
                  HM        +   A   AD  T   E ++  + L+           I      
Sbjct  637  DTQIHTHMCYSEFNDILPAIAGLDADVITI--ETSRSDMELLTAFGDFKYPNDIGPGVYD  694

Query  128  AIKPGTS-VDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDG  186
               P     + +  L                       +++PK          L +  D 
Sbjct  695  IHSPRVPKAEEIERLLRKA------------------LNVVPK--------ERLWVNPDC  728

Query  187  GLGKETIPKAAKA  199
            GL     P+    
Sbjct  729  GLKTRGWPETIAQ  741


>gi|7388303|sp|O58878|THIE_PYRHO  Probable thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=207

 Score = 63.6 bits (154),  Expect = 5e-10, Method: Composition-based stats.
 Identities = 32/220 (14%), Positives = 62/220 (28%), Gaps = 34/220 (15%)

Query  17   NLGCECHKVINA---GADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
             L  E   V  A   GA  + + + +        +G      +R+           E   
Sbjct  16   RLKPEIASVKQALEGGATSIQLRIKNAPTREMYEIG----KEIRKLT--------NEYGA  63

Query  74   TAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGT  133
              F D           +D      AD      +        +++ +             +
Sbjct  64   LFFVD---------DRIDVALAVNADGVQLGPDDMP-----IEIAREIAPNLIIGASVYS  109

Query  134  SVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQV--DGGLGKE  191
              + L       D     +V   F  Q   +  +  +E LR     + I V   GG+  E
Sbjct  110  LEEALEAEMKGADYLGAGSV---FPTQTKKDVKVIGIEGLREIVNAVKIPVVAIGGINLE  166

Query  192  TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
             + +    G + I   ++V    D       ++  + + L
Sbjct  167  NVREVLLTGVDGIAVVSAVMGTEDVKRATEGLRRIIEEVL  206


>gi|73622015|sp|Q72EU7|TRPA_DESVH  Tryptophan synthase alpha chain
Length=257

 Score = 63.6 bits (154),  Expect = 5e-10, Method: Composition-based stats.
 Identities = 35/225 (15%), Positives = 73/225 (32%), Gaps = 19/225 (8%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV----PRPGDASNTEK  71
                 E   +  AGAD + + V    F   +  G  +  + +R++               
Sbjct  33   ERFWDELEALDAAGADIIEVGV---PFSDPVADGPVVAAASQRALESGVTLRWIMDGLAA  89

Query  72   KPTAFF--DCHM------MVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGI  123
            +          M      M    E++V D A  G            +   L  L+ ++ +
Sbjct  90   RKGRLRAGLVLMGYLNPFMQYGFERFVSDAADAGVAGCIIPDLPLDEDADLRALLAARDM  149

Query  124  KAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME-DMMPKVETLRAKFPHLN  181
                 + P T    + E A        V++V    G +  +  ++   +   R  F  + 
Sbjct  150  DLIALVGPNTGEGRMREYAAVASGYVYVVSVMGTTGVRDGLPVEVADTLARARQCF-SIP  208

Query  182  IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADP-HDVISFMKE  225
            + +  G+ +    +      + ++ G+++    D   D  SFMK 
Sbjct  209  VALGFGISRPAQLEGLSHPPDAVIFGSALLRHLDAGGDAASFMKA  253


>gi|25008739|sp|Q8KA71|METE_BUCAP  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=757

 Score = 63.6 bits (154),  Expect = 6e-10, Method: Composition-based stats.
 Identities = 33/220 (15%), Positives = 62/220 (28%), Gaps = 48/220 (21%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSL----RRSVPRPGDASNTEK  71
              L  E   +     + + ID       P +  G P+  SL              S++  
Sbjct  578  LALRDEVLDLEKEKIEIIQID------EPALREGLPLRKSLWNEYLSWAVDAFRLSSSGV  631

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K T     HM        +   +   AD  T   E  +  + L+K  K+           
Sbjct  632  KNTTQIHTHMCYCEFHDIMHAISFLDADVITI--ETARSDMELLKSFKTF-KYP------  682

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
                + +      +  + +    P     KF+      +    A  P   + +  D GL 
Sbjct  683  ----NEIGPGVYDIHSSNI----PSITSIKFL------LNKAIAYIPVERIWVNPDCGLK  728

Query  190  KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSK  229
                 +   A  N++                  M++++ K
Sbjct  729  TRNWNETILALKNMVC-------------AAKEMRDKIKK  755


>gi|73622022|sp|Q5V140|TRPA_HALMA  Tryptophan synthase alpha chain
Length=293

 Score = 63.2 bits (153),  Expect = 7e-10, Method: Composition-based stats.
 Identities = 31/226 (13%), Positives = 61/226 (26%), Gaps = 41/226 (18%)

Query  20   CECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRR-----SVPRPGDASNTEKKPT  74
                 +   GAD + + +    F   I  G+ I  ++ R       P        +    
Sbjct  29   EYVEALARGGADVIELGL---PFSEPIAEGKTIQNAIVRSLEAGMTPDRFFQFVEDLDVD  85

Query  75   AFFDCHMMVEN---------------------------PEKWVDDFAKCGADQFTFHYEA  107
                C M   N                           P  +V+  A  G +        
Sbjct  86   VPLVC-MTYYNLIYQYGEGDSESRSDSENASGETASQGPRPFVEKAAAVGIEGLVVPDLP  144

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKF--MED  165
             ++   L        +     + P T  D L  +   +   + +    G  G +    + 
Sbjct  145  GEEAGPLRTACDEFDLDLVFIVAPTTKGDRLERMLEQVSGYVYVQARLGVTGAREDVDDA  204

Query  166  MMPKVETLRAKFPHLNIQVDGGLGK-ETIPKAAKAGANVIVAGTSV  210
                +  L      +   V  G+       +   AGA+ I+ G+++
Sbjct  205  TEDSLARLSDW--DVPKAVGFGIKTGAHAERIVSAGADGIIVGSAL  248


>gi|30173114|sp|Q9AAW1|METE_CAUCR  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=777

 Score = 63.2 bits (153),  Expect = 7e-10, Method: Composition-based stats.
 Identities = 27/199 (13%), Positives = 49/199 (24%), Gaps = 35/199 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              +  E   +   GA  + ID         +  G P+      +           + +  
Sbjct  603  LAIRDEVVDLEATGAAIIQID------EAALREGLPLRRGDWDAYLDWAVESFRLAASGV  656

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
                    HM        +       AD  +   E  +  + L+            A   
Sbjct  657  ADATQIHTHMCYSEFNDIIAAIGAMDADVISI--ETARSKMELLD------AFVGYAY--  706

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAK--FPHLNIQVDGGLG  189
                  +      +    V  VE          +M   +   R +     L +  D GL 
Sbjct  707  --PAQ-IGPGVYDIHSPRVPAVE----------EMTTLLAAARQRLAGEQLWVNPDCGLK  753

Query  190  KETIPKAAKAGANVIVAGT  208
                P+   A  N++ A  
Sbjct  754  TRKWPETQAAIVNMVEAAR  772


>gi|8134570|sp|Q42699|METE_CATRO  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Vitamin-B12-independent methionine synthase isozyme) 
(Cobalamin-independent methionine synthase isozyme)
Length=765

 Score = 63.2 bits (153),  Expect = 7e-10, Method: Composition-based stats.
 Identities = 31/198 (15%), Positives = 59/198 (29%), Gaps = 34/198 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              +  E   +  AG + + ID         +  G P+  +               +N   
Sbjct  585  LAIKDEVEDLEKAGINVIQID------EAALREGLPLRKAEHAFYLDWAVHSFRITNLPL  638

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            + T     HM   N    +       AD  T   E ++    L+ + +  G+K    I P
Sbjct  639  QDTTQIHTHMCYSNFNDIIHSIIDMDADVMTI--ENSRSSEKLLSVFRE-GVKYGAGIGP  695

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH--LNIQVDGGLG  189
            G            +    + + E          ++  ++  + A      L +  D GL 
Sbjct  696  G---------VYDIHSPRIPSTE----------EIADRINKMLAVLDTNILWVNPDCGLK  736

Query  190  KETIPKAAKAGANVIVAG  207
                 +   A  N++ A 
Sbjct  737  TRKYAEVKPALENMVSAA  754


>gi|7674390|sp|Q9X4E8|TRPA_RHOS4  Tryptophan synthase alpha chain
Length=263

 Score = 63.2 bits (153),  Expect = 8e-10, Method: Composition-based stats.
 Identities = 38/229 (16%), Positives = 76/229 (33%), Gaps = 24/229 (10%)

Query  2    VKPIIAPSILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
             K  +A  I+A D            +  AG D + + +    F   +  G  I T+ +R+
Sbjct  16   KKAFVA-YIMAGDPDLETSLAVMRGLPEAGVDIIELGM---PFTDPMADGPTIQTAGQRA  71

Query  60   VPRPGDASNTEKKPTAF------FDCHMM-VENPEK------WVDDFAKCGADQFTFHYE  106
            +      + T +   AF          MM   NP        ++ +  + G D       
Sbjct  72   LEGGQTLTRTLEMVRAFRAENAETPIVMMGYYNPIYARGVETFLAEATEAGIDGLIVVDL  131

Query  107  ATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAP-HLDMALVMTVEPGFGGQKFMED  165
              ++   L    ++ G+       P T    L ++          +++  G  G    + 
Sbjct  132  PPEEDAELCLPAQAAGLNFIRLATPTTDSRRLPKVLQNTSGFVYYVSI-TGITGAAAAQA  190

Query  166  MM--PKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT  212
                P+V  ++A    L + V  G+      +     A+  V G+++  
Sbjct  191  ADVAPEVARIKAATD-LPVIVGFGITTPEAAQDLAGIADGCVVGSAIVK  238


>gi|1170933|sp|P45331|METE_HAEIN  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=756

 Score = 62.8 bits (152),  Expect = 1e-09, Method: Composition-based stats.
 Identities = 27/188 (14%), Positives = 47/188 (25%), Gaps = 35/188 (18%)

Query  18   LGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEKKP  73
            L  E   +  AG   + ID       P I  G P+      +  +        S+   + 
Sbjct  582  LSDEVLDLEAAGIKVIQID------EPAIREGLPLKRADWDAYLQWAGEAFRLSSMGVQD  635

Query  74   TAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGT  133
                  HM        +   A   AD  T   E ++  + L+            A     
Sbjct  636  DTQIHTHMCYSEFNDILPAIAALDADVITI--ETSRSDMELLT-----------AFADFK  682

Query  134  SVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLGKE  191
              + +      +    V T            ++   +       P   L +  D GL   
Sbjct  683  YPNDIGPGVYDIHSPRVPTAT----------EVEHLLRKALNVIPKERLWVNPDCGLKTR  732

Query  192  TIPKAAKA  199
               +    
Sbjct  733  GWTETIDQ  740


>gi|6226268|sp|O67502|TRPA_AQUAE  Tryptophan synthase alpha chain
Length=262

 Score = 62.8 bits (152),  Expect = 1e-09, Method: Composition-based stats.
 Identities = 40/240 (16%), Positives = 81/240 (33%), Gaps = 30/240 (12%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEK--  71
            D+        +V+  G D L I      F   +  G  I  +   ++       +  +  
Sbjct  29   DYETSLKAFKEVLKNGTDILEIGF---PFSDPVADGPTIQVAHEVALKNGIRFEDVLELS  85

Query  72   ----KPTAFFDCHMM-VENPEKWV--DDFAKC----GADQFTFHYEATQDPLHLVKLIKS  120
                K        +M   NP   +  + F +     G D F       ++   L  ++K 
Sbjct  86   ETLRKEFPDIPFLLMTYYNPIFRIGLEKFCRLSREKGIDGFIVPDLPPEEAEELKAVMKK  145

Query  121  KGIKAACAIKPGTSVDVLFELAPHLD-MALVMTVEPGFGGQKF---MEDMMPKVETLRAK  176
              +       P ++   +  +    D M   ++V  G  G +     E +  KVE  R  
Sbjct  146  YVLSFVPLGAPTSTRKRIKLICEAADEMTYFVSV-TGTTGAREKLPYERIKKKVEEYREL  204

Query  177  FPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVF------TAADPHDVISFMKEEVSK  229
                 + V  G+  KE   +   + A+ +V G+++          D  +++  +KE + +
Sbjct  205  CDKP-VVVGFGVSKKEHARE-IGSFADGVVVGSALVKLAGQKKIEDLGNLVKELKEGLRE  262


>gi|8134566|sp|O50008|METE_ARATH  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Vitamin-B12-independent methionine synthase isozyme) 
(Cobalamin-independent methionine synthase isozyme)
Length=765

 Score = 62.0 bits (150),  Expect = 2e-09, Method: Composition-based stats.
 Identities = 30/219 (13%), Positives = 63/219 (28%), Gaps = 43/219 (19%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              +  E   +   G   + ID         +  G P+  S               +N   
Sbjct  585  LAIKDEVEDLEKGGIGVIQID------EAALREGLPLRKSEHAFYLDWAVHSFRITNCGV  638

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            + +     HM   +    +       AD  T   E ++    L+ + +  G+K    I P
Sbjct  639  QDSTQIHTHMCYSHFNDIIHSIIDMDADVITI--ENSRSDEKLLSVFRE-GVKYGAGIGP  695

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKE  191
            G            +    + + E        + D + K+  +  +   L +  D GL   
Sbjct  696  G---------VYDIHSPRIPSSE-------EIADRVNKMLAVLEQNI-LWVNPDCGLKTR  738

Query  192  TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
               +   A  N++             D    ++ +++  
Sbjct  739  KYTEVKPALKNMV-------------DAAKLIRSQLASA  764


>gi|73622058|sp|Q7M877|TRPA_WOLSU  Tryptophan synthase alpha chain
Length=255

 Score = 62.0 bits (150),  Expect = 2e-09, Method: Composition-based stats.
 Identities = 29/202 (14%), Positives = 64/202 (31%), Gaps = 16/202 (7%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPI----VTSLRRSVPRPGDASNTEKKPTAFF  77
               +  +G D L + V    F   +  G  I    + +L++      D     +K +   
Sbjct  30   ALALSASGVDSLELGV---PFSDPVADGPIIEHANLLALQKGFSL-QDLYEITEKISPSI  85

Query  78   DCHMMVE-------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIK  130
            D   M           E+        G           ++     +      +     I 
Sbjct  86   DTLWMGYLNPFHKVGFEQTCQKAKSLGVSGLIIPDVPFEESAPFEEQCLQNNLALIRFIA  145

Query  131  PGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGK  190
            P      +  +AP     + +    G  G    E + P +E +RA  P + + +  G+ +
Sbjct  146  PTLGTSRIATIAPMARKFIYLVAYAGITGSGREEPLSPLIEEIRAINPEIPLYLGFGVNE  205

Query  191  ETIPKAAKAGANVIVAGTSVFT  212
                + +K   + ++ G+++  
Sbjct  206  HNAKEKSKE-VDGVIVGSALVK  226


>gi|3334472|sp|P80877|METE_BACSU  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase) (Superoxide-inducible 
protein 9) (SOI9)
Length=762

 Score = 61.3 bits (148),  Expect = 3e-09, Method: Composition-based stats.
 Identities = 31/217 (14%), Positives = 55/217 (25%), Gaps = 48/217 (22%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              L  E   + +AG   + +D       P +  G P+                  + +  
Sbjct  583  LALRKEVKALEDAGIQIIQVD------EPALREGLPLKTRDWDEYLTWAAEAFRLTTSSV  636

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            K       HM   N E  VD      AD  T   E ++     +  +K+           
Sbjct  637  KNETQIHTHMCYSNFEDIVDTINDLDADVITI--EHSRSHGGFLDYLKNH----------  684

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH--LNIQVDGGLG  189
                         L + +     P        E+M   +    A  P     +  D GL 
Sbjct  685  --------PYLKGLGLGVYDIHSPRV---PSTEEMYNIIVDALAVCPTDRFWVNPDCGLK  733

Query  190  KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
                 +   A  N++             +     + +
Sbjct  734  TRQQEETVAALKNMV-------------EAAKQARAQ  757


>gi|20140605|sp|Q8Y6Q7|TRPA_LISMO  Tryptophan synthase alpha chain
Length=257

 Score = 60.9 bits (147),  Expect = 3e-09, Method: Composition-based stats.
 Identities = 32/216 (14%), Positives = 67/216 (31%), Gaps = 24/216 (11%)

Query  10   ILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPI----VTSLRRSVPRP  63
            I+  D    NL  +   +  +G   + I +    F   +  G  I    + +L+  V   
Sbjct  21   IMGGDGGLDNLEEQLLFLEKSGVSAIEIGI---PFSDPVADGPIIQLAGLRALKEQVSLE  77

Query  64   GDASNTEKKPTAFFDCHMM-VENPE------KWVDDFAKCGADQFTFHYEATQDPLHLVK  116
               +             +M   NP       K+V+   K             +    +  
Sbjct  78   AILN-KLAMSKVQIPLIIMSYINPIFHLGIPKFVELVQKTPVKGLIIPDLPYEHQKLITP  136

Query  117  LIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFMEDMMPK-VETLR  174
             ++   I     +   +  + L E+A         +TV    G +   +  +   +  L+
Sbjct  137  ELQGTDIALIPLVSLTSPKERLEEIAKQAEGFIYAVTVNGTTGVRSEFDAHIDSHLAYLK  196

Query  175  AKFPHLNIQVDGGLGKETIPKAAKAG--ANVIVAGT  208
            +  P   + V  G G  +I    K     + ++ G+
Sbjct  197  SISP---VPVLAGFGVSSIEHVEKFAHVCDGVIIGS  229


>gi|38258049|sp|Q88X63|METE_LACPL  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=768

 Score = 60.9 bits (147),  Expect = 4e-09, Method: Composition-based stats.
 Identities = 27/201 (13%), Positives = 53/201 (26%), Gaps = 35/201 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVT----SLRRSVPRPGDASNTEK  71
              L  E   +  AG   + +D       P +  G P+      +           + T  
Sbjct  588  LALRQEVQNLEKAGIKIIQVD------EPALREGLPLKQRHWQAYLDEAVYSFKITTTGV  641

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +       HM   N    ++      AD  +   E ++    ++   +  G         
Sbjct  642  QNDTQIHTHMCYSNFADIINTIKALDADVISI--ETSRSHGEIISAFEQTGYD-------  692

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL--NIQVDGGLG  189
                  +      +    V +V         +E     ++            I  D GL 
Sbjct  693  ----QEIGLGVYDIHSPRVPSV-------AEIEA---NIQRALRVIDARQFWINPDCGLK  738

Query  190  KETIPKAAKAGANVIVAGTSV  210
                 +   A  N+I A  ++
Sbjct  739  TRQESETLAALKNMIAARNAI  759


>gi|12230265|sp|Q9JUT6|METE_NEIMA  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=758

 Score = 60.5 bits (146),  Expect = 4e-09, Method: Composition-based stats.
 Identities = 30/195 (15%), Positives = 48/195 (24%), Gaps = 45/195 (23%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEK  71
              L  E   +  AG   + ID       P I  G P+      +           S+T  
Sbjct  581  LALNDEVLDLEKAGIKVIQID------EPAIREGLPLKRADWDAYLNWAGESFRLSSTGC  634

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS----KGIKAAC  127
            + +     HM        +   A   AD  T   E ++  + L+           I    
Sbjct  635  EDSTQIHTHMCYSEFNDILPAIAAMDADVITI--ETSRSDMELLTAFGEFKYPNDIGPGV  692

Query  128  --AIKPGTSVDV-LFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQV  184
                 P    +  +  L        V+ VE                         L +  
Sbjct  693  YDIHSPRVPTEAEVEHLLRKA--IEVVPVE------------------------RLWVNP  726

Query  185  DGGLGKETIPKAAKA  199
            D GL      +  + 
Sbjct  727  DCGLKTRGWKETLEQ  741


>gi|30173096|sp|Q8Y6K3|METE_LISMO  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=765

 Score = 60.5 bits (146),  Expect = 4e-09, Method: Composition-based stats.
 Identities = 24/195 (12%), Positives = 50/195 (25%), Gaps = 35/195 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +   G   + +D       P +  G P+  +               +    
Sbjct  585  LALRKEVEALERNGIKVIQVD------EPALREGLPLKQARWEKYLNDAVYSFKLTTASV  638

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +       HM   + +  +D  +   AD  +   E ++    ++              + 
Sbjct  639  QNDTQIHTHMCYSDFDDIIDTISALDADVISI--ETSRSHGEIIS-----------TFEE  685

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
             T    +      +    V TV           ++   +             I  D GL 
Sbjct  686  VTYDKEIGLGVYDIHSPRVPTVT----------EIQDNIRRALRAIDAKQFWINPDCGLK  735

Query  190  KETIPKAAKAGANVI  204
                P+   A  ++I
Sbjct  736  TRKEPETIAALQDMI  750


>gi|38258653|sp|Q9RGS5|THIE_STACA  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=212

 Score = 60.5 bits (146),  Expect = 4e-09, Method: Composition-based stats.
 Identities = 25/147 (17%), Positives = 48/147 (32%), Gaps = 22/147 (14%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSK--GIKAACAIKPGTSVDVLFELAP  143
                V    +  AD    H          V    ++  G     +I    +++ L   A 
Sbjct  74   VNDDVALAEEIDADGI--HVGQDD---EAVDDFNNRFEGKIIGLSIG---NLEELN--AS  123

Query  144  HLDMALVMTVEPGFG-------GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKA  196
             L     + V P F         +     M   +ETLR +   L I   GG+  + + + 
Sbjct  124  DLTYVDYIGVGPIFATPSKDDASEPVGPKM---IETLRKEVGDLPIVAIGGISLDNVQEV  180

Query  197  AKAGANVIVAGTSVFTAADPHDVISFM  223
            AK  A+ +   +++  +    + +   
Sbjct  181  AKTSADGVSVISAIARSPHVTETVHKF  207


>gi|51316265|sp|Q71YY6|METE_LISMF  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=765

 Score = 60.5 bits (146),  Expect = 5e-09, Method: Composition-based stats.
 Identities = 24/195 (12%), Positives = 50/195 (25%), Gaps = 35/195 (17%)

Query  16   ANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEK  71
              L  E   +   G   + +D       P +  G P+  +               +    
Sbjct  585  LALRKEVEALERNGIKVIQVD------EPALREGLPLKQARWQKYLDDAVYSFKLTTASV  638

Query  72   KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
            +       HM   + +  +D  +   AD  +   E ++    ++              + 
Sbjct  639  QNDTQIHTHMCYSDFDDIIDTISALDADVISI--ETSRSHGEIIS-----------TFEE  685

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLG  189
             T    +      +    V TV           ++   +             I  D GL 
Sbjct  686  VTYDKEIGLGVYDIHSPRVPTVT----------EIQDNIRRALRAIDAKQFWINPDCGLK  735

Query  190  KETIPKAAKAGANVI  204
                P+   A  ++I
Sbjct  736  TRKEPETIAALQDMI  750