>gi|1173139|sp|P46969|RPE_YEAST  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (RPE)
Length=238

 Score =  384 bits (987),  Expect = 1e-106, Method: Composition-based stats.
 Identities = 238/238 (100%), Positives = 238/238 (100%), Gaps = 0/238 (0%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV
Sbjct  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
            PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS
Sbjct  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180
            KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL
Sbjct  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLLD  238
            NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLLD
Sbjct  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLLD  238


>gi|51701877|sp|Q6FL81|RPE_CANGA  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (RPE)
Length=246

 Score =  370 bits (952),  Expect = 2e-102, Method: Composition-based stats.
 Identities = 202/240 (84%), Positives = 217/240 (90%), Gaps = 3/240 (1%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            MVKPIIAPSILASDFANLGCECH+VIN+GA+WLHIDVMDGHFVPNITLGQPIVTSLRR+V
Sbjct  1    MVKPIIAPSILASDFANLGCECHRVINSGAEWLHIDVMDGHFVPNITLGQPIVTSLRRAV  60

Query  61   PRPGD---ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKL  117
            PR  +   AS    +PTAFFDCHMMVE PEKWV DFAK GADQFTFHYEAT+DPL LVKL
Sbjct  61   PRSQEEEKASGEVARPTAFFDCHMMVEEPEKWVADFAKAGADQFTFHYEATKDPLSLVKL  120

Query  118  IKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF  177
            IK  GIKAACAIKPGT VDVLFELAP+LDMALVMTVEPGFGGQKFM DMMPKVE LR KF
Sbjct  121  IKENGIKAACAIKPGTPVDVLFELAPYLDMALVMTVEPGFGGQKFMPDMMPKVEALRTKF  180

Query  178  PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLL  237
            PH+NIQVDGGLGKETI  AAKAGANVIVAGTSVFTA+DPH+VISFMKEEV KEL+++ +L
Sbjct  181  PHMNIQVDGGLGKETIGVAAKAGANVIVAGTSVFTASDPHEVISFMKEEVRKELKAKHIL  240


>gi|51701884|sp|Q755M2|RPE_ASHGO  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (RPE)
Length=239

 Score =  358 bits (919),  Expect = 1e-98, Method: Composition-based stats.
 Identities = 192/238 (80%), Positives = 206/238 (86%), Gaps = 2/238 (0%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            MVKPIIAPSILASDFANL C CH+VINAGA+WLHIDVMDGHFVPNITLG PIV SLR++V
Sbjct  1    MVKPIIAPSILASDFANLECGCHRVINAGAEWLHIDVMDGHFVPNITLGPPIVKSLRKAV  60

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
            PR GD  +   KP AFFDCHMMV  PEKWVD F + GADQFTFHYEAT++PL LVKLIKS
Sbjct  61   PRVGDKES--DKPKAFFDCHMMVAEPEKWVDVFVENGADQFTFHYEATKNPLELVKLIKS  118

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180
            +GI+AACAIKP T VDVLFELAP+LDMALVMTVEPGFGGQKFM DMMPKV  LR KFP L
Sbjct  119  RGIRAACAIKPDTPVDVLFELAPYLDMALVMTVEPGFGGQKFMPDMMPKVAALREKFPQL  178

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDLLD  238
            +IQVDGGLGKETIP AAKAGANVIVAGTSVF AAD  DVIS+MK+ V  ELRSR LLD
Sbjct  179  DIQVDGGLGKETIPHAAKAGANVIVAGTSVFAAADQKDVISYMKDNVRDELRSRGLLD  236


>gi|84028110|sp|P0AG09|RPE_ECO57  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
 gi|84028150|sp|P0AG08|RPE_ECOL6  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
 gi|84028157|sp|P0AG07|RPE_ECOLI  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
 gi|84028158|sp|P0AG10|RPE_SHIFL  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=225

 Score =  334 bits (857),  Expect = 2e-91, Method: Composition-based stats.
 Identities = 90/233 (38%), Positives = 133/233 (57%), Gaps = 16/233 (6%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M + +IAPSIL++DFA LG +  K + AGAD +H DVMD H+VPN+T+G  ++ SLR   
Sbjct  1    MKQYLIAPSILSADFARLGEDTAKALAAGADVVHFDVMDNHYVPNLTIGPMVLKSLR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                         TA  D H+MV+  ++ V DFA  GA   TFH EA++     ++LIK 
Sbjct  58   ---------NYGITAPIDVHLMVKPVDRIVPDFAAAGASIITFHPEASEHVDRTLQLIKE  108

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH-  179
             G KA     P T +  L  +   LD+ L+M+V PGFGGQ F+   + K+  +R +    
Sbjct  109  NGCKAGLVFNPATPLSYLDYVMDKLDVILLMSVNPGFGGQSFIPQTLDKLREVRRRIDES  168

Query  180  ---LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSK  229
               + ++VDGG+    I + A AGA++ VAG+++F   D   VI  M+ E++K
Sbjct  169  GFDIRLEVDGGVKVNNIGEIAAAGADMFVAGSAIFDQPDYKKVIDEMRSELAK  221


>gi|1169388|sp|P44756|RPE_HAEIN  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=224

 Score =  329 bits (845),  Expect = 5e-90, Method: Composition-based stats.
 Identities = 81/232 (34%), Positives = 131/232 (56%), Gaps = 16/232 (6%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M   +IAPSIL++D A LG +   V+NAGAD +H DVMD H+VPN+T G  +  +LR   
Sbjct  1    MKPYLIAPSILSADLARLGDDVQNVLNAGADVIHFDVMDNHYVPNLTFGPAVCQALR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                     +   TA  D H+MV+  ++ + DFAK GA+  TFH E+++     ++LI+ 
Sbjct  58   ---------DYGITAPIDVHLMVKPVDRIIPDFAKAGANYITFHPESSEHIDRSLQLIRD  108

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH-  179
             G K+     P   +  L  +   +D+ L+M+V PGFGGQ F+   + K++  R      
Sbjct  109  CGCKSGLVFNPAMPLSYLDYVLDKVDVVLLMSVNPGFGGQSFIPATLKKLQQARKIIDES  168

Query  180  ---LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
               + ++VDGG+  + I + A AGA++ VAG+++F   D   VI  ++ +++
Sbjct  169  GYDIRLEVDGGVKVDNIAEIAAAGADMFVAGSAIFGKPDYKQVIDQIRTQLA  220


>gi|11387063|sp|P57603|RPE_BUCAI  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  326 bits (837),  Expect = 4e-89, Method: Composition-based stats.
 Identities = 90/231 (38%), Positives = 130/231 (56%), Gaps = 16/231 (6%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K  +APSIL++DFA LG +  KVI+AG+D +H DVMD H+VPN+++G  I+ SLR   
Sbjct  1    MNKFFLAPSILSADFARLGEDIKKVIDAGSDLIHFDVMDNHYVPNLSMGPMILESLR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                         TA  D H+MV+  +  +  FAK GA   TFH EAT      + LIK 
Sbjct  58   ---------NYNITAPIDVHLMVKPVDNLIPQFAKAGATFITFHPEATLHIERTLNLIKE  108

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLR----AK  176
             G KA  A  P T ++ L  +   LD+ L+M+V PGFG Q F+     K+  +R    A 
Sbjct  109  NGCKAGLAFNPATPLNFLDYILEKLDLILLMSVNPGFGNQSFLPSTFNKLREVRKIIDAN  168

Query  177  FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            F  + ++VDGG+  + I   A AGANV V G+ +F  ++   VI  +++++
Sbjct  169  FSDILLEVDGGVKLDNIADIACAGANVFVMGSGLFKYSNYKLVIEKIRKKL  219


>gi|2829613|sp|P74061|RPE_SYNY3  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=230

 Score =  326 bits (836),  Expect = 5e-89, Method: Composition-based stats.
 Identities = 92/234 (39%), Positives = 133/234 (56%), Gaps = 19/234 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
            ++APSIL++DF+ LG E   V  AGADW+H+DVMDG FVPNIT+G  IV ++R    +  
Sbjct  6    VVAPSILSADFSRLGEEIKAVDEAGADWIHVDVMDGRFVPNITIGPLIVDAIRPLTKKT-  64

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYE--ATQDPLHLVKLIKSKG  122
                         D H+M+  PEK+V+DFAK GAD  + H E  A+      +  I+  G
Sbjct  65   ------------LDVHLMIVEPEKYVEDFAKAGADIISVHVEHNASPHLHRTLCQIRELG  112

Query  123  IKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL--  180
             KA   + P T +D L  + P  D+ L+M+V PGFGGQ F+ +++PK+  LR        
Sbjct  113  KKAGAVLNPSTPLDFLEYVLPVCDLILIMSVNPGFGGQSFIPEVLPKIRALRQMCDERGL  172

Query  181  --NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELR  232
               I+VDGGL      +  +AGAN IVAG++VF A +  + I+ ++     E +
Sbjct  173  DPWIEVDGGLKPNNTWQVLEAGANAIVAGSAVFNAPNYAEAIAGVRNSKRPEPQ  226


>gi|2499728|sp|Q43843|RPE_SOLTU  Ribulose-phosphate 3-epimerase, chloroplast precursor (Pentose-5-phosphate 
3-epimerase) (PPE) (RPE) (R5P3E)
Length=280

 Score =  325 bits (834),  Expect = 8e-89, Method: Composition-based stats.
 Identities = 88/233 (37%), Positives = 129/233 (55%), Gaps = 19/233 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
            I++PSIL+++F+ LG +   +  AG DW+H+DVMDG FVPNIT+G  +V SLR     P 
Sbjct  58   IVSPSILSANFSKLGEQVKAIEQAGCDWIHVDVMDGRFVPNITIGPLVVDSLRPITDLP-  116

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ--DPLHLVKLIKSKG  122
                         D H+M+  P++ V DF K GAD  + H E +        +  IKS G
Sbjct  117  ------------LDVHLMIVEPDQRVPDFIKAGADIVSVHCEQSSTIHLHRTINQIKSLG  164

Query  123  IKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRA----KFP  178
             KA   + PGT +  +  +   +D+ L+M+V PGFGGQ F+E  + K+  LR     +  
Sbjct  165  AKAGVVLNPGTPLTAIEYVLDAVDLVLIMSVNPGFGGQSFIESQVKKISDLRKICAERGL  224

Query  179  HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
            +  I+VDGG+G +   K  +AGAN +VAG++VF A D  + I  +K     E 
Sbjct  225  NPWIEVDGGVGPKNAYKVIEAGANALVAGSAVFGAPDYAEAIKGIKTSKRPEA  277


>gi|34924986|sp|Q96AT9|RPE_HUMAN  Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase)
Length=228

 Score =  325 bits (833),  Expect = 1e-88, Method: Composition-based stats.
 Identities = 126/231 (54%), Positives = 164/231 (70%), Gaps = 11/231 (4%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            I PSIL SD ANLG EC +++++GAD+LH+DVMDGHFVPNIT G P+V SLR+ +     
Sbjct  7    IGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFVPNITFGHPVVESLRKQL-----  61

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                      FFD HMMV  PE+WV   A  GA+Q+TFH EAT++P  L+K I+  G+K 
Sbjct  62   ------GQDPFFDMHMMVSKPEQWVKPMAVAGANQYTFHLEATENPGALIKDIRENGMKV  115

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVD  185
              AIKPGTSV+ L   A  +DMALVMTVEPGFGGQKFMEDMMPKV  LR +FP L+I+VD
Sbjct  116  GLAIKPGTSVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKVHWLRTQFPSLDIEVD  175

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDL  236
            GG+G +T+ K A+AGAN+IV+G+++  + DP  VI+ ++   S+  + R L
Sbjct  176  GGVGPDTVHKCAEAGANMIVSGSAIMRSEDPRSVINLLRNVCSEAAQKRSL  226


>gi|34924979|sp|Q8VEE0|RPE_MOUSE  Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-epimerase)
Length=228

 Score =  323 bits (829),  Expect = 3e-88, Method: Composition-based stats.
 Identities = 125/231 (54%), Positives = 164/231 (70%), Gaps = 11/231 (4%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            I PSIL SD ANLG EC +++++GAD+LH+DVMDGHFVPNIT G P+V SLR+ +     
Sbjct  7    IGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFVPNITFGHPVVESLRKQL-----  61

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                      FFD HMMV  PE+WV   A  GA+Q+TFH EAT++P  L+K I+  G+K 
Sbjct  62   ------GQDPFFDMHMMVSRPEQWVKPMAVAGANQYTFHLEATENPGALIKDIRENGMKV  115

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVD  185
              AIKPGT+V+ L   A  +DMALVMTVEPGFGGQKFMEDMMPKV  LR +FP L+I+VD
Sbjct  116  GLAIKPGTTVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKVHWLRTQFPTLDIEVD  175

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDL  236
            GG+G +T+ K A+AGAN+IV+G+++  + DP  VI+ ++   S+  + R L
Sbjct  176  GGVGPDTVQKCAEAGANMIVSGSAIMRSDDPRAVINLLRNVCSEAAQKRSL  226


>gi|75061668|sp|Q5R5Y2|RPE_PONPY  Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase)
Length=228

 Score =  321 bits (824),  Expect = 1e-87, Method: Composition-based stats.
 Identities = 125/231 (54%), Positives = 163/231 (70%), Gaps = 11/231 (4%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            I PSIL SD ANLG EC +++++GAD+LH+DVMDGHFVPNIT G P+V SLR+ +     
Sbjct  7    IGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFVPNITFGHPVVESLRKQL-----  61

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                      FFD HMMV  PE+WV   A  GA+Q+ FH EAT++P  L+K I+  G+K 
Sbjct  62   ------GQDPFFDMHMMVSKPEQWVKPMAVAGANQYAFHLEATENPGALIKDIRENGMKV  115

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVD  185
              AIKPGTSV+ L   A  +DMALVMTVEPGFGGQKFMEDMMPKV  LR +FP L+I+VD
Sbjct  116  GLAIKPGTSVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKVHWLRTQFPSLDIEVD  175

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDL  236
            GG+G +T+ K A+AGAN+IV+G+++  + DP  VI+ ++   S+  + R L
Sbjct  176  GGVGPDTVHKCAEAGANMIVSGSAIMRSEDPRSVINLLRNVCSEAAQKRSL  226


>gi|51701874|sp|O14105|RPE_SCHPO  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (RPE)
Length=228

 Score =  321 bits (824),  Expect = 1e-87, Method: Composition-based stats.
 Identities = 116/234 (49%), Positives = 152/234 (64%), Gaps = 10/234 (4%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            MV+  IAPS+LA DFANL  E  +++  G+DWLH+DVMD  FVPN+T+G  +V ++R   
Sbjct  1    MVQAKIAPSLLAGDFANLEKEVGRMLKYGSDWLHVDVMDAQFVPNLTIGPIVVKAMR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                   N   K  AFFDCH+MV  PE+++D  A  GA  F FHYEAT+    ++     
Sbjct  58   -------NHYTKEEAFFDCHLMVIEPERYIDQLADAGASLFCFHYEATEKHEEIISRAHE  110

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180
            KG+   CA+KP T V+V+      LDM LVMTVEPG GGQ FM + +PKVE LR K+P L
Sbjct  111  KGMLVGCALKPKTPVEVILPFVEKLDMVLVMTVEPGKGGQSFMPECLPKVEFLRKKYPTL  170

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            N++VDGGL  +T+  AA AGANVIVAGT+VF A  P +VIS ++  V K   ++
Sbjct  171  NVEVDGGLSLKTVDAAADAGANVIVAGTAVFHAQSPEEVISGLRNSVMKAQETK  224


>gi|2833386|sp|Q43157|RPE_SPIOL  Ribulose-phosphate 3-epimerase, chloroplast precursor (Pentose-5-phosphate 
3-epimerase) (PPE) (RPE) (R5P3E)
Length=285

 Score =  321 bits (824),  Expect = 1e-87, Method: Composition-based stats.
 Identities = 91/232 (39%), Positives = 126/232 (54%), Gaps = 19/232 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
            I++PSIL+++FA LG +   V  AG DW+H+DVMDG FVPNIT+G  +V +LR     P 
Sbjct  63   IVSPSILSANFAKLGEQVKAVELAGCDWIHVDVMDGRFVPNITIGPLVVDALRPVTDLP-  121

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYE--ATQDPLHLVKLIKSKG  122
                         D H+M+  PE+ V DF K GAD  + H E  +T      V  IKS G
Sbjct  122  ------------LDVHLMIVEPEQRVPDFIKAGADIVSVHCELASTIHLHRTVNQIKSLG  169

Query  123  IKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH---  179
             KA   + PGT +  +  +   +D+ L+M+V PGFGGQ F+E  + K+  LR        
Sbjct  170  AKAGVVLNPGTPLSTIEYVLDVVDLVLIMSVNPGFGGQSFIESQVKKISDLRKMCVEKGV  229

Query  180  -LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
               I+VDGG+      K  +AGAN +VAG++VF A D  + I  +K     E
Sbjct  230  NPWIEVDGGVTPANAYKVIEAGANALVAGSAVFGAKDYAEAIKGIKASKRPE  281


>gi|1169389|sp|P45455|RPE_SERMA  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=210

 Score =  321 bits (823),  Expect = 2e-87, Method: Composition-based stats.
 Identities = 83/222 (37%), Positives = 124/222 (55%), Gaps = 16/222 (7%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K +IAPSIL++DFA LG +   V+ AG D +H DVMD H+VPN+T+G  +  +LR   
Sbjct  1    MKKFLIAPSILSADFARLGEDTANVLAAGGDVVHFDVMDNHYVPNLTIGPMVCEALR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                         TA  D H+MV+  ++ V DFAK GA   +FH EA++     ++LIK 
Sbjct  58   ---------NYGITAPIDVHLMVKPVDRIVPDFAKAGASYISFHPEASEHVDRTIQLIKE  108

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--  178
             G KA     P T +  L  +   +D+ L+M+V PGFGGQ F+   + K+  +R      
Sbjct  109  HGCKAGLVFNPATPLSYLDYVMDKIDVILLMSVNPGFGGQSFIHGTLDKLRQVRKLIDDS  168

Query  179  --HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
               + ++VDGG+  + I + A AGA++ VAG+++F   D   
Sbjct  169  GRDIRLEVDGGVKVDNIAEIAAAGADMFVAGSAIFGQPDYRK  210


>gi|25091192|sp|Q8K940|RPE_BUCAP  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  321 bits (823),  Expect = 2e-87, Method: Composition-based stats.
 Identities = 86/220 (39%), Positives = 124/220 (56%), Gaps = 16/220 (7%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K  +A SIL++DFA LG +  K I+AG+DW+H DVMD H+VPN+T+G  I+ +LR   
Sbjct  1    MKKFFLASSILSADFARLGEDTKKAIDAGSDWIHFDVMDNHYVPNLTMGPMILKALR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                         T   D H+MV+  +  +  FA+ GAD  TFH E+T      + LIK 
Sbjct  58   ---------NYNITVPIDVHLMVKPVDNLIPQFAEAGADFITFHPESTDHIDRTLNLIKE  108

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF---  177
             G KA  A+ P TS++ L  +   LD+ L+M+V PGFG Q F+     K+  +R K    
Sbjct  109  CGCKAGLALNPATSLNFLDYVMEKLDLILLMSVNPGFGNQSFLPTSFNKLREVRKKIELN  168

Query  178  -PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADP  216
              ++ ++VDGG+  E I + A +GANV V G+ +F   D 
Sbjct  169  SSNILLEVDGGVKLENISEVAFSGANVFVIGSGIFGYTDY  208


>gi|109940150|sp|Q9ZTP5|RPE_ORYSA  Ribulose-phosphate 3-epimerase, chloroplast precursor (Pentose-5-phosphate 
3-epimerase) (PPE) (RPE) (R5P3E)
Length=274

 Score =  315 bits (807),  Expect = 1e-85, Method: Composition-based stats.
 Identities = 90/228 (39%), Positives = 127/228 (55%), Gaps = 19/228 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
            I++PSIL+++F+ LG +   V  AG DW+H+DVMDG FVPNIT+G  +V +LR     P 
Sbjct  52   IVSPSILSANFSKLGEQVKAVEVAGCDWIHVDVMDGRFVPNITIGPLVVDALRPVTDLP-  110

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ--DPLHLVKLIKSKG  122
                         D H+M+  PE+ V DF K GAD  + H E +        V  IKS G
Sbjct  111  ------------LDVHLMIVEPEQRVPDFIKAGADIVSVHCEQSSTIHLHRTVNQIKSLG  158

Query  123  IKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRA----KFP  178
             KA   + P T +  +  +   +D+ L+M+V PGFGGQ F+E  + K+  LR     K  
Sbjct  159  AKAGVVLNPATPLTAIDYVLDVVDLVLIMSVNPGFGGQSFIESQVKKIAELRRLCAEKGV  218

Query  179  HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
            +  I+VDGG+G +   K  +AGAN IVAG++VF A D  + I  +K  
Sbjct  219  NPWIEVDGGVGPKNAYKVIEAGANAIVAGSAVFGAPDYAEAIKGIKTS  266


>gi|6647758|sp|O34557|RPE_BACSU  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=217

 Score =  315 bits (807),  Expect = 1e-85, Method: Composition-based stats.
 Identities = 97/229 (42%), Positives = 139/229 (60%), Gaps = 20/229 (8%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M+K  +APSIL++DFA LG E   V   GAD +HIDVMDGHFVPNIT+G  IV ++R   
Sbjct  1    MIK--VAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNITIGPLIVEAVRPVT  58

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
              P              D H+M+E P++++  FAK GAD  + H EA       ++LIK 
Sbjct  59   DLP-------------LDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQLIKE  105

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH-  179
            +G+KA   + P T V V+  +   LD+ L+MTV PGFGGQKF+  ++PK++ ++      
Sbjct  106  QGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKRMADEK  165

Query  180  ----LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMK  224
                L I+VDGG+ KET P   +AGAN++VAG++V+  +D    IS ++
Sbjct  166  GKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIR  214


>gi|729235|sp|P40117|RPEC_RALEH  Ribulose-phosphate 3-epimerase, chromosomal (Pentose-5-phosphate 
3-epimerase) (PPE) (R5P3E)
Length=241

 Score =  307 bits (786),  Expect = 3e-83, Method: Composition-based stats.
 Identities = 82/235 (34%), Positives = 124/235 (52%), Gaps = 21/235 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
             +APSIL++DFA LG E   +   GAD +H DVMD H+VPN+T+G  +  ++R  V  P 
Sbjct  17   RLAPSILSADFARLGEEVCAIEAGGADLVHFDVMDNHYVPNLTIGPLVCEAIRPLVSIP-  75

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIK  124
                         D H+MVE  +  +  FAK GA+  +FH EA++     + LI+  G K
Sbjct  76   ------------IDVHLMVEPVDALIPLFAKAGANIISFHPEASRHVDRTIGLIRDHGCK  123

Query  125  AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH-----  179
            A   + P T +  L      LD+ L+M+V PGFGGQ F+  ++ KV   RA+        
Sbjct  124  AGLVLNPATPLGWLDHTLDQLDLVLLMSVNPGFGGQAFIPGVLDKVRQARARIDRQVDAG  183

Query  180  ---LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
               + +++DGG+  + I   A+AGA+  VAG++VF A D     S +   + +  
Sbjct  184  GRPVWLEIDGGVKADNIAAIARAGADTFVAGSAVFGAPDADGGYSSILYRLREAA  238


>gi|60390595|sp|Q9SE42|RPE1_ORYSA  Ribulose-phosphate 3-epimerase, cytoplasmic isoform (Ribulose-5-phosphate-epimerase) 
(Cyt-RPEase) (RPEcyt) (Pentose-5-phosphate 
3-epimerase) (PPE)
Length=228

 Score =  304 bits (779),  Expect = 2e-82, Method: Composition-based stats.
 Identities = 115/234 (49%), Positives = 161/234 (68%), Gaps = 18/234 (7%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            IAPS+L+SDFANL  E  +++  GADWLH+D+MDGHFVPN+T+G P++ SLR+       
Sbjct  9    IAPSMLSSDFANLAAEADRMVRLGADWLHMDIMDGHFVPNLTIGAPVIQSLRKHT-----  63

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPL-HLVKLIKSKGIK  124
                     A+ DCH+MV NP  +V+  AK GA  FTFH E ++D    L++ IK+KG++
Sbjct  64   --------KAYLDCHLMVTNPSDYVEPLAKAGASGFTFHIEVSRDNWQELIQSIKAKGMR  115

Query  125  AACAIKPGTSVDVLFELAPH---LDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLN  181
               +++PGT V+ +F L      +++ LVMTVEPGFGGQKFM +MM KV  LR K+P L+
Sbjct  116  PGVSLRPGTPVEEVFPLVEAENPVELVLVMTVEPGFGGQKFMPEMMEKVRALRKKYPSLD  175

Query  182  IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRD  235
            I+VDGGLG  TI  AA AGAN IVAG+S+F AA+P +VIS +++ V +  +++ 
Sbjct  176  IEVDGGLGPSTIDVAASAGANCIVAGSSIFGAAEPGEVISALRKSV-EGSQNKS  228


>gi|729236|sp|Q04539|RPEP_RALEH  Ribulose-phosphate 3-epimerase, plasmid (Pentose-5-phosphate 
3-epimerase) (PPE) (R5P3E)
Length=241

 Score =  303 bits (777),  Expect = 3e-82, Method: Composition-based stats.
 Identities = 80/235 (34%), Positives = 123/235 (52%), Gaps = 21/235 (8%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
             +APSIL++DFA LG E   +   GAD +H DVMD H+V N+T+G  +  ++R  V  P 
Sbjct  17   RLAPSILSADFARLGEEVCAIEAGGADLVHFDVMDNHYVSNLTIGPLVCEAIRPLVSIP-  75

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIK  124
                         D H+MVE  +  +  FAK GA+  +FH EA++     + LI+  G K
Sbjct  76   ------------IDVHLMVEPVDALIPMFAKAGANLISFHPEASRHVDRTIGLIRDHGCK  123

Query  125  AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH-----  179
            A   + P T +  L      LD+ L+M+V PGFGGQ F+  ++ KV   RA+        
Sbjct  124  AGLVLNPATPLSWLDHTLDKLDLVLLMSVNPGFGGQAFIPGVLDKVRQARARIDRQVAAG  183

Query  180  ---LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
               + +++DGG+  + I + A+AGA+  VAG++VF A D       +   + +  
Sbjct  184  GRPVWLEIDGGVKADNITEIARAGADTFVAGSAVFGAPDADGGYRGILHRLREAA  238


>gi|18203210|sp|Q9L0Z5|RPE_STRCO  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  303 bits (776),  Expect = 5e-82, Method: Composition-based stats.
 Identities = 100/226 (44%), Positives = 141/226 (62%), Gaps = 19/226 (8%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            I PSIL++DFA L  E   V   GADWLH+DVMD HFVPN+TLG P+V SL R+   P  
Sbjct  5    INPSILSADFARLADEAKAVE--GADWLHVDVMDNHFVPNLTLGVPVVESLARATDTP--  60

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                        DCH+M+E P++W   + + GA   TFH EA   P+ L + I++KG +A
Sbjct  61   -----------LDCHLMIEAPDRWAPQYVEAGAGSVTFHAEAAAAPVRLAREIRAKGARA  109

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVE----TLRAKFPHLN  181
            + A+KP T V+   +L P LDM L+MTVEPGFGGQ F++ M+PK+      ++     L 
Sbjct  110  SMALKPATPVEPYEDLLPELDMLLIMTVEPGFGGQAFLDIMLPKIRRTRELIKKHGLELW  169

Query  182  IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            +QVDGG+   TI + A AGA+V VAG++V+ A+DP + +  ++ + 
Sbjct  170  LQVDGGVSAATIERCADAGADVFVAGSAVYGASDPAEAVRALRTQA  215


>gi|6226024|sp|O67098|RPE_AQUAE  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=222

 Score =  291 bits (745),  Expect = 2e-78, Method: Composition-based stats.
 Identities = 82/226 (36%), Positives = 123/226 (54%), Gaps = 17/226 (7%)

Query  4    PIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRP  63
             ++APSILA D+  +G +    I  GAD LH DVMDGHFVPNIT G  I++ +R+    P
Sbjct  2    KLLAPSILAGDWWCIGEQIQATIRGGADILHYDVMDGHFVPNITAGYEILSHIRKRASLP  61

Query  64   GDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGI  123
                          D H+M+ENP+K++  F + GA+  + H E        ++LIK  G 
Sbjct  62   -------------IDAHLMIENPDKYIPKFVEAGANWISVHIENNYHIHRTLQLIKELGA  108

Query  124  KAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAK----FPH  179
            KA   + PGTS+  + E   + D  L+M+V PGF GQKF+E  + ++  L+       P 
Sbjct  109  KAGVVVNPGTSLSAIEEALYYADYVLLMSVNPGFSGQKFIERSIERLRILKEMRDRINPS  168

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
              I++DGG+ +  I +  +AGA+V+V G+ +F A D       +K 
Sbjct  169  CLIEIDGGIKENNIAEVVRAGADVVVVGSGIFGAKDIEAQTRKLKS  214


>gi|54039256|sp|P65761|RPE_MYCBO  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
 gi|54041952|sp|P65760|RPE_MYCTU  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=229

 Score =  290 bits (744),  Expect = 2e-78, Method: Composition-based stats.
 Identities = 96/228 (42%), Positives = 145/228 (63%), Gaps = 19/228 (8%)

Query  4    PIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRP  63
            P+IAPSILA+DFA L  E   V   GADWLH+DVMDGHFVPN+T+G P+V SL      P
Sbjct  8    PLIAPSILAADFARLADEAAAV--NGADWLHVDVMDGHFVPNLTIGLPVVESLLAVTDIP  65

Query  64   GDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGI  123
                          DCH+M++NP++W   +A+ GA   TFH EAT +P+ + + I++ G 
Sbjct  66   -------------MDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPVGVARDIRAAGA  112

Query  124  KAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP----H  179
            KA  ++KPGT ++   ++ PH D  LVM+VEPGFGGQ+F+ +++ KV  +R         
Sbjct  113  KAGISVKPGTPLEPYLDILPHFDTLLVMSVEPGFGGQRFIPEVLSKVRAVRKMVDAGELT  172

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            + +++DGG+  +TI +AA+AG +  VAG++V+ A DP   ++ ++ + 
Sbjct  173  ILVEIDGGINDDTIEQAAEAGVDCFVAGSAVYGADDPAAAVAALRRQA  220


>gi|46396626|sp|Q89A59|RPE_BUCBP  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  289 bits (741),  Expect = 6e-78, Method: Composition-based stats.
 Identities = 72/231 (31%), Positives = 126/231 (54%), Gaps = 14/231 (6%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M K +++ S+L+++F+ LG +   V+ +G+D +H DVMD H+V N+T G  ++ SLR   
Sbjct  1    MKKFLLSSSVLSANFSRLGEDIFDVLKSGSDMIHYDVMDNHYVKNLTFGPIVLESLR---  57

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                   + EK  +   D H+M    +  +  FAK   +  +FH E+T +    +KLIKS
Sbjct  58   -------SVEKIKSMVIDVHLMTCPVDDLIIKFAKLDVNIISFHPESTNNVEKTIKLIKS  110

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--  178
             G K   A+ P T + VL  +   +D+ L+M+V PGF GQKF+  ++ K+  +R      
Sbjct  111  YGCKVGLALNPLTPLCVLDNVLDKIDLILLMSVNPGFPGQKFIPSILNKIRIVRELIDKS  170

Query  179  --HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
              ++ ++VDGG+    I K A  G ++ V G+++F + +    I   ++ +
Sbjct  171  KKNILLEVDGGINLSNIFKIASFGTDIFVIGSAIFNSINYDLTIRSFRDVL  221


>gi|17380276|sp|Q9CCP9|RPE_MYCLE  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=224

 Score =  280 bits (717),  Expect = 3e-75, Method: Composition-based stats.
 Identities = 93/213 (43%), Positives = 136/213 (63%), Gaps = 19/213 (8%)

Query  4    PIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRP  63
            P+IAPSILA+DFA L  E   V  A ADWLH+DVMDGHFVPN+T+G P+V SL  +   P
Sbjct  3    PLIAPSILAADFARLTDEAAVV--ASADWLHVDVMDGHFVPNLTIGLPVVQSLLAASDIP  60

Query  64   GDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGI  123
                          DCH+M++NP++W   +A+ GA   TFH EAT +P+ +   I++ G 
Sbjct  61   -------------MDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPVGVAHDIRTAGA  107

Query  124  KAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP----H  179
            KA   +KPGT ++   ++ PH D  L+M+VEPGFGGQ F+ +++ KV T+R         
Sbjct  108  KAGIGVKPGTPLNPYLDILPHFDTLLIMSVEPGFGGQAFIPEVLSKVRTVRKMVDAGELT  167

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT  212
            + +++DGG+  +TI +AA+AG +  VAG++V+ 
Sbjct  168  ILVEIDGGINADTIEQAAEAGVDCFVAGSAVYG  200


>gi|2851605|sp|P51013|RPE_RHORU  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=225

 Score =  278 bits (713),  Expect = 9e-75, Method: Composition-based stats.
 Identities = 76/222 (34%), Positives = 118/222 (53%), Gaps = 16/222 (7%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
             IAPS+L++DFA     C      GAD LH DVMD H+VPN+T+G  +  +LR     P 
Sbjct  6    RIAPSLLSADFAISRPRCPSDGRTGADILHFDVMDNHYVPNLTVGPLVCAALRPHTSLP-  64

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIK  124
                         D H+M    +  +D FA+ GAD  TFH EA+      V++I+ +G+K
Sbjct  65   ------------IDVHLMTRPVDPLIDSFAEAGADMITFHPEASDHVHRSVQMIRKRGLK  112

Query  125  AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLR--AKFPHLNI  182
            A  A+ P + + +L  +   LD+ L+M+V PGFGGQ F+   +PK+  L    +      
Sbjct  113  AGVALNPASPLSLLDHILEDLDLVLIMSVNPGFGGQSFIPSALPKIAALANGRRRACRGD  172

Query  183  QVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMK  224
            +VDGG+        A+ GA+++V   ++F A+D    I+ ++
Sbjct  173  RVDGGVNPADARALARPGADILVR-LAIFGASDRAKAIASIR  213


>gi|14195180|sp|Q9PKR7|RPE_CHLMU  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  278 bits (713),  Expect = 1e-74, Method: Composition-based stats.
 Identities = 84/236 (35%), Positives = 130/236 (55%), Gaps = 26/236 (11%)

Query  1    MVKP--IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRR  58
            M K   +IAPSI+ +D A LG     +  +GA+ +HIDVMDGHFVPNIT G  I+ ++ R
Sbjct  1    MKKQGVLIAPSIMGADLACLGDAARNIEESGANLIHIDVMDGHFVPNITFGPGIIAAINR  60

Query  59   SVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLI  118
            S                F + H M+  P ++V+ F K GAD+   H+EA ++   ++  I
Sbjct  61   STDL-------------FLEVHAMIYTPFEFVEAFVKAGADRIIVHFEAAENLKEILDYI  107

Query  119  KSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP  178
            +  G++A  A  P TS++ +    P  D+ L+M+V+PGF GQKF+ D + K+  +R    
Sbjct  108  RKCGVQAGIAFSPETSIEFISAFIPLCDVILLMSVQPGFCGQKFIPDTIEKIRFVRQAIQ  167

Query  179  H------LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
                     I+VDGG+ +E+     +AGA+++VA +  F      D I+ MKE+V 
Sbjct  168  TLGKEGSCLIEVDGGIDEESARACREAGADILVAASYFFK----KDSIN-MKEKVL  218


>gi|6647760|sp|Q9ZJ75|RPE_HELPJ  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=217

 Score =  277 bits (710),  Expect = 2e-74, Method: Composition-based stats.
 Identities = 75/224 (33%), Positives = 124/224 (55%), Gaps = 19/224 (8%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            +APS+L++DF +L  E   V N  AD+LH+DVMDGH+VPN+T+G  I+ ++ +    P  
Sbjct  3    VAPSLLSADFMHLAKEIESVSN--ADFLHVDVMDGHYVPNLTMGPVILENVTQMSQVP--  58

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                        D H+MVEN   +V+ FA       + H E  + P  +++LIKS GI  
Sbjct  59   -----------LDVHLMVENASFFVELFAPLNPQIISIHAENEKHPHRVLQLIKSSGITP  107

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKV----ETLRAKFPHLN  181
               + P T  + +  L   + + L+M+V PGFGGQKF++ ++ K     E ++   P   
Sbjct  108  GIVLNPHTHEESIKYLLESVGLVLLMSVNPGFGGQKFLDLVLEKCLKVKELIKRYNPSCL  167

Query  182  IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
            ++VDGG+  + I +  +AG +V+V+G+ +F + D    I  ++ 
Sbjct  168  LEVDGGVNDKNIFELQQAGVDVVVSGSYIFESKDRKLAIEGLQN  211


>gi|6226026|sp|O84123|RPE_CHLTR  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=233

 Score =  277 bits (709),  Expect = 2e-74, Method: Composition-based stats.
 Identities = 83/236 (35%), Positives = 131/236 (55%), Gaps = 26/236 (11%)

Query  1    MVKP--IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRR  58
            M K   ++APSI+ +D A +G E   +  +GAD +HIDVMDGHFVPNIT G  +V ++ R
Sbjct  6    MKKQGVLVAPSIMGADLACIGREARNIEESGADLIHIDVMDGHFVPNITFGPGVVAAINR  65

Query  59   SVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLI  118
            S                F + H M+  P ++V+ F K GAD+   H+EA ++   ++  I
Sbjct  66   STEL-------------FLEVHAMIYTPFEFVEAFVKAGADRIIVHFEAAENIKEIISYI  112

Query  119  KSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF-  177
            +  G++A  A  P TS++ +    P  D+ L+M+V PGF GQKF+ D + +++ ++    
Sbjct  113  QKCGVQAGVAFSPETSIEFVTSFIPLCDVILLMSVHPGFCGQKFIPDTIERIQFVKQAIQ  172

Query  178  -----PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
                     I+VDGG+ KE+     +AGA+++VA +  F      D I+ MKE+V 
Sbjct  173  VLGREGSCLIEVDGGIDKESARACREAGADILVAASYFFE----KDSIN-MKEKVL  223


>gi|6094119|sp|P51012|RPE_RHOCA  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=228

 Score =  276 bits (708),  Expect = 4e-74, Method: Composition-based stats.
 Identities = 87/211 (41%), Positives = 122/211 (57%), Gaps = 16/211 (7%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            IAPSIL++DFA+ G E   +   GADW+H+DVMDGHFVPN+T G P V + R+ V     
Sbjct  9    IAPSILSADFADFGREIQAIEAQGADWVHVDVMDGHFVPNLTFGPPAVAAFRKHV-----  63

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                        D H+M+   + ++D +A+ GAD  T H EA       ++ I++ G+K+
Sbjct  64   --------KTVMDVHLMISPVDAYIDAYAQAGADVLTAHVEAGPHIHRTLQAIRAAGMKS  115

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPH--LNIQ  183
              AI PGT  + +  +    D+  VMTV PGFGGQK++ DM  KV  LRA      ++I+
Sbjct  116  GVAINPGTPAEAIEHVLDIADVVCVMTVNPGFGGQKYI-DMTAKVRKLRAMIGDRPVHIE  174

Query  184  VDGGLGKETIPKAAKAGANVIVAGTSVFTAA  214
            +DGG+   T P  A AGA+V VAG+ VF   
Sbjct  175  IDGGMDPVTAPLMAAAGADVFVAGSGVFKGG  205


>gi|2829457|sp|P56188|RPE_HELPY  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=217

 Score =  275 bits (705),  Expect = 8e-74, Method: Composition-based stats.
 Identities = 74/230 (32%), Positives = 126/230 (54%), Gaps = 20/230 (8%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            +APS+L++DF +L  E   V N  AD+LH+DVMDGH+VPN+T+G  ++ ++ +    P  
Sbjct  3    VAPSLLSADFMHLAKEIESVSN--ADFLHVDVMDGHYVPNLTMGPVVLENVTQMSQVP--  58

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKA  125
                        D H+MVEN   + + FA       + H E  + P  +++LIK+ GI  
Sbjct  59   -----------LDVHLMVENASFFAELFAPLKPQIISIHAENEKHPHRVLQLIKNLGITP  107

Query  126  ACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKV----ETLRAKFPHLN  181
               + P T  + +  L   + + L+M+V PGFGGQKF++ ++ K     E ++   P   
Sbjct  108  GIVLNPHTHEESIKYLLESVGLVLLMSVNPGFGGQKFLDLVLEKCLKVKELIKRYNPSCL  167

Query  182  IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
            ++VDGG+  + I +  +AG +V+V+G+ +F + D    I  ++  V + L
Sbjct  168  LEVDGGVNDKNIFELQQAGVDVVVSGSYIFKSKDRKLAIEGLQN-VRQSL  216


>gi|2833527|sp|Q58093|RPE_METJA  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=234

 Score =  274 bits (701),  Expect = 2e-73, Method: Composition-based stats.
 Identities = 89/241 (36%), Positives = 132/241 (54%), Gaps = 22/241 (9%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M+K  I  SIL++DF +L  E  K   AG D+ H+D+MDGHFVPNI++G  I   +++  
Sbjct  1    MIK--IGASILSADFGHLREEIKKAEEAGVDFFHVDMMDGHFVPNISMGIGIAKHVKKLT  58

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
              P              + H+MVEN + +V++F +   D  TFH EA + P  ++  IKS
Sbjct  59   ELP-------------VEVHLMVENVDLFVNEFEE--MDYITFHIEAVKFPFRIINRIKS  103

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF---  177
             G K   A+ P T +D +  +   +   LVMTVEPGF GQKF+  M  K+  L++     
Sbjct  104  IGAKPIVALNPATPLDAIEYILGDVYAVLVMTVEPGFSGQKFIPVMTKKIRKLKSMIVEN  163

Query  178  -PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSRDL  236
                 I VDGG+  ET P A KAGA+V+VA +++F   D    +  ++E   + L ++D 
Sbjct  164  GYDTKIFVDGGINVETAPLAVKAGADVLVAASAIFGKDDVKTAVKNLREAALEAL-NKDF  222

Query  237  L  237
            L
Sbjct  223  L  223


>gi|6226025|sp|Q9Z8Z9|RPE_CHLPN  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=229

 Score =  269 bits (688),  Expect = 7e-72, Method: Composition-based stats.
 Identities = 76/226 (33%), Positives = 123/226 (54%), Gaps = 22/226 (9%)

Query  1    MVKP---IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLR  57
            M K    ++ PSI+ +D   LG E  K+  AG+D++HID+MDGHFVPN+T G  I+ ++ 
Sbjct  1    MKKQESVLVGPSIMGADLTCLGVEAKKLEQAGSDFIHIDIMDGHFVPNLTFGPGIIAAIN  60

Query  58   RSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKL  117
            RS                F + H M+ NP ++++ F + GAD+   H+EA++D   L+  
Sbjct  61   RSTDL-------------FLEVHAMIYNPFEFIESFVRSGADRIIVHFEASEDIKELLSY  107

Query  118  IKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF  177
            IK  G++A  A  P TS++ L    P  D+ ++M+V PGF GQ F+ + + K+   R   
Sbjct  108  IKKCGVQAGLAFSPDTSIEFLPSFLPFCDVVVLMSVYPGFTGQSFLPNTIEKIAFARHAI  167

Query  178  ------PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPH  217
                      I+VDGG+ +++ P    AGA+++V  + +F A    
Sbjct  168  KTLGLKDSCLIEVDGGIDQQSAPLCRDAGADILVTASYLFEADSLA  213


>gi|6647759|sp|O66107|RPE_TREPA  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (R5P3E)
Length=218

 Score =  267 bits (683),  Expect = 2e-71, Method: Composition-based stats.
 Identities = 83/213 (38%), Positives = 118/213 (55%), Gaps = 17/213 (7%)

Query  4    PIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRP  63
              +APS+L++DF+ L      +   GA W+H+DVMDGHFVPN+T G P++  LR     P
Sbjct  5    FTLAPSLLSADFSALDRALVYLEAHGAQWVHLDVMDGHFVPNLTFGAPVLRCLRSKTHLP  64

Query  64   GDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGI  123
                         FD H+MV  P   ++DF + GAD  TFH EA      L+  I+ +G+
Sbjct  65   -------------FDVHLMVSRPADLIEDFVQAGADFLTFHIEAEVHAHRLIHAIRGRGV  111

Query  124  KAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAK----FPH  179
            K   ++ P T V  L E+ P +D+ LVMTV PGF GQ+ +   + KV  L          
Sbjct  112  KVGISLVPSTPVAALSEVLPFVDLVLVMTVNPGFSGQQMIAHCLSKVSALVQMRTERGYS  171

Query  180  LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFT  212
              I VDGG+   T+P+A  AGA+VIV+G++ F+
Sbjct  172  YMISVDGGIDCRTLPQALDAGADVIVSGSAFFS  204


>gi|418563|sp|P32719|ALSE_ECOLI  D-allulose-6-phosphate 3-epimerase
Length=231

 Score =  242 bits (618),  Expect = 1e-63, Method: Composition-based stats.
 Identities = 70/232 (30%), Positives = 113/232 (48%), Gaps = 21/232 (9%)

Query  6    IAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGD  65
            I+PS++  D      +  + I++ AD+ HID+MDGHFVPN+TL    V+ +++   +P  
Sbjct  3    ISPSLMCMDLLKFKEQI-EFIDSHADYFHIDIMDGHFVPNLTLSPFFVSQVKKLATKP--  59

Query  66   ASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIK  124
                        DCH+MV  P+ ++   A+ GAD  T H E        L+  I+   +K
Sbjct  60   -----------LDCHLMVTRPQDYIAQLARAGADFITLHPETINGQAFRLIDEIRRHDMK  108

Query  125  AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRA----KFPHL  180
                + P T V+ +       D   VMTV+PGF GQ F+ +M+ K+  L+A    +    
Sbjct  109  VGLILNPETPVEAMKYYIHKADKITVMTVDPGFAGQPFIPEMLDKLAELKAWREREGLEY  168

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAG-TSVF-TAADPHDVISFMKEEVSKE  230
             I+VDG   + T  K   AGA+V + G + +F  A +  +    M  ++   
Sbjct  169  EIEVDGSCNQATYEKLMAAGADVFIVGTSGLFNHAENIDEAWRIMTAQILAA  220


>gi|732069|sp|P39362|SGCE_ECOLI  Protein sgcE
Length=210

 Score =  239 bits (612),  Expect = 5e-63, Method: Composition-based stats.
 Identities = 61/213 (28%), Positives = 96/213 (45%), Gaps = 13/213 (6%)

Query  5    IIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPG  64
            I+ PS+ +++  + G E   + N     LH+D+ D  F+ NIT G   V ++ R  P P 
Sbjct  2    ILHPSLASANPLHYGRELTALDNLDFGSLHLDIEDSSFINNITFGMKTVQAVARQTPHP-  60

Query  65   DASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIK  124
                           H M+  P++W +  A+        H E    P   +  I+  G +
Sbjct  61   ------------LSFHFMLARPQRWFNALAEIRPAWIFVHAETLDYPSETLTEIRHTGAR  108

Query  125  AACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQV  184
            A     P T +D    LA  LD  +VMT EP   GQ+F+  M  K++ +R  FP      
Sbjct  109  AGLVFNPATPIDAWRYLASELDGVMVMTSEPDGQGQRFIPSMCEKIQKVRTAFPQTECWA  168

Query  185  DGGLGKETIPKAAKAGANVIVAGTSVFTAADPH  217
            DGG+      + A AGA  +V G ++F+++D  
Sbjct  169  DGGITLAAAQQLAAAGAQHMVIGRALFSSSDYR  201


>gi|51701892|sp|Q8SRP6|RPE_ENCCU  Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) 
(PPE) (RPE)
Length=217

 Score =  224 bits (571),  Expect = 3e-58, Method: Composition-based stats.
 Identities = 68/226 (30%), Positives = 100/226 (44%), Gaps = 21/226 (9%)

Query  1    MVKPIIAPSILASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV  60
            M+K  I  SIL  +F NL  E  ++   G   +H+DVMD  FV NIT G  I+  +    
Sbjct  5    MLKKRIGISILDCNFGNLEEELGELKRNGVTNIHLDVMDTTFVKNITFGPCIINRILEH-  63

Query  61   PRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
                            FD HMMVE+P   +           T H E       + + ++ 
Sbjct  64   -------------DFVFDVHMMVESPLDIIMQIDLERVSLVTIHSEVCDKA-GVAEYLRK  109

Query  121  KGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180
            + +    A+ P T VD         D  L+M+V+PGFGGQKF E+ + KVE +R     +
Sbjct  110  RNVLFGIALNPETQVDDAE--MRSADFVLIMSVKPGFGGQKFQEECLAKVEEVRRYGKMV  167

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
             I  DGG+    I +    GA+  V G+  F + D    +  + +E
Sbjct  168  GI--DGGIEMSNIGRI--TGADYAVVGSGYFRSGDRKKFLRDITDE  209


>gi|2499727|sp|P75522|RPE_MYCPN  Probable ribulose-phosphate 3-epimerase (Pentose-5-phosphate 
3-epimerase) (PPE) (R5P3E)
Length=215

 Score =  189 bits (480),  Expect = 8e-48, Method: Composition-based stats.
 Identities = 49/185 (26%), Positives = 79/185 (42%), Gaps = 21/185 (11%)

Query  29   GADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEK  88
            G   +H DVMD HFV N                  G+  +  ++     + H+MV+  E+
Sbjct  33   GLRLIHYDVMD-HFVDNTVF--------------QGEHLDELQQIGFQVNVHLMVQALEQ  77

Query  89   WVDDFAKCGA-DQFTFHYEATQDP--LHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
             +  +    A  + +FH E    P   H +  IK  G +   A K  T +     L   L
Sbjct  78   ILPVYLHHQAVKRISFHVEPFDIPTIKHFIAQIKQAGKQVGLAFKFTTPLVNYERLVQQL  137

Query  146  DMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIV  205
            D   +M+V PG GGQ F   +   ++  +A   H +I++DGG+  + I +  +   N IV
Sbjct  138  DFVTLMSVPPGKGGQAFNSAVFNNLK--QAHKYHCSIEIDGGIKLDNIHQI-QDDVNFIV  194

Query  206  AGTSV  210
             G+  
Sbjct  195  MGSGF  199


>gi|1351490|sp|P47358|RPE_MYCGE  Probable ribulose-phosphate 3-epimerase (Pentose-5-phosphate 
3-epimerase) (PPE) (R5P3E)
Length=209

 Score =  178 bits (452),  Expect = 2e-44, Method: Composition-based stats.
 Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 21/185 (11%)

Query  29   GADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEK  88
            G   +H DVMD  FV N       +  L+                    + H+MVE    
Sbjct  28   GLRLIHYDVMD-QFVHNTAFKGEYLDELK--------------TIGFDVNVHLMVEQIIP  72

Query  89   WVDDF-AKCGADQFTFHYE--ATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
             ++ + ++    + +FH E  +      L++L+K  G +   A K  T++ +       +
Sbjct  73   QINFYLSQPNVKRISFHVEPFSFAKIKELIQLVKENGKEVGLAFKFTTNLQLYQPFFTTI  132

Query  146  DMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIV  205
            D   +M+V PG GGQ F E +   ++   A   +L I++DGG+    I +  KA  + IV
Sbjct  133  DFITLMSVPPGKGGQAFNEAVFTNLKI--ANHYNLKIEIDGGIKVNNIDQI-KAFVDFIV  189

Query  206  AGTSV  210
             G+  
Sbjct  190  MGSGF  194


>gi|20139851|sp|Q9UZ35|PYRF_PYRAB  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=208

 Score = 50.1 bits (119),  Expect = 7e-06, Method: Composition-based stats.
 Identities = 29/145 (20%), Positives = 56/145 (38%), Gaps = 21/145 (14%)

Query  95   KCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTS--VDVLFELAPHLDMALVMT  152
            + GAD    H    +D +  V  +          ++      ++ +  L     + L   
Sbjct  76   EAGADYIIVHPFVGRDSVEAVNELGEI----ILVVEMSHPGALEFINPLTDKF-IELAND  130

Query  153  VEPGFG----GQKFMEDMMPKVET-LRA--KFPHLNIQVDGGLGKETIPKAAKAGANVIV  205
            VEP FG    G +   + +  +   L+   K     I   GG       +A +AGA+ ++
Sbjct  131  VEP-FGVIAPGTR--PERVKYIRERLKEGVKILTPGIGAQGG----KAKEAIEAGADYVI  183

Query  206  AGTSVFTAADPHDVISFMKEEVSKE  230
             G S++ A +P +    + +E+  E
Sbjct  184  VGRSIYNAPNPREAAREIYDEIRGE  208


>gi|119370763|sp|Q49WT0|HPS2_STAS1  3-hexulose-6-phosphate synthase 2 (HPS 2) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase 2)
Length=213

 Score = 49.7 bits (118),  Expect = 8e-06, Method: Composition-based stats.
 Identities = 44/220 (20%), Positives = 82/220 (37%), Gaps = 20/220 (9%)

Query  11   LASDFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTE  70
            LA D  N   +  ++ N   D  H+D+++        +G PIV  +   +P     ++  
Sbjct  5    LAIDLLN-KEDAAELANKVKD--HVDIVE--------IGTPIV--INEGLPAVQHLNDNV  51

Query  71   KKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAI  129
                   D  +M +  +  V    K GAD  T    A        V      G +    +
Sbjct  52   DGVKVLADLKIM-DAADYEVSQAVKFGADIVTILGVAEDASIKAAVDEAHKHGKQ---LL  107

Query  130  KPGTSVDVLFELAPHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGG  187
                +V  L + A  LD   A  + V  G+  Q   +  +  +  +++   +  + V GG
Sbjct  108  VDMIAVQDLEKRAKDLDDLGADYIAVHTGYDLQAEGQSPLESLRKVKSVISNSKVAVAGG  167

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            +  +TI        ++I+ G  +  A DP +     ++ V
Sbjct  168  IKPDTIKDIVAENPDLIIVGGGIANADDPVEAAKQCRDIV  207


>gi|119370762|sp|Q49WT7|HPS1_STAS1  3-hexulose-6-phosphate synthase 1 (HPS 1) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase 1)
Length=210

 Score = 48.2 bits (114),  Expect = 3e-05, Method: Composition-based stats.
 Identities = 35/189 (18%), Positives = 69/189 (36%), Gaps = 9/189 (4%)

Query  42   FVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQF  101
            ++  + +G PIV  +   +P     ++         D  +M +  +  V    K GAD  
Sbjct  25   YINIVEIGTPIV--INEGLPAVQHLNDNIDGVKVLADLKIM-DAADYEVSQAVKFGADIV  81

Query  102  TFHYEATQ-DPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD--MALVMTVEPGFG  158
            T    A        V      G +    +    +V  L + A  LD   A  + V  G+ 
Sbjct  82   TILGVAEDASIKAAVDEAHKHGKQ---LLVDMIAVQDLEKRAKDLDDLGADYIAVHTGYD  138

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
             Q   +  +  +  +++   +  + V GG+  +TI        ++I+ G  +  A DP +
Sbjct  139  LQAEGQSPLESLRKVKSVISNSKVAVAGGIKPDTIKDIVAENPDLIIVGGGIANADDPVE  198

Query  219  VISFMKEEV  227
                 +  +
Sbjct  199  AAKQCRAAI  207


>gi|119370764|sp|Q49VB7|HPS3_STAS1  3-hexulose-6-phosphate synthase 3 (HPS 3) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase 3)
Length=210

 Score = 47.0 bits (111),  Expect = 7e-05, Method: Composition-based stats.
 Identities = 38/189 (20%), Positives = 71/189 (37%), Gaps = 9/189 (4%)

Query  42   FVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQF  101
            +V  + +G PIV  +   +P     ++         D  +M +  +  V    K GAD  
Sbjct  25   YVDIVEIGTPIV--INEGLPAVQYLNDNIDGVKVLADLKIM-DAADYEVSQAVKFGADVV  81

Query  102  TFHYEATQ-DPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD--MALVMTVEPGFG  158
            T    A        V+     G +    +    +V  L + A  LD   A  + V  G+ 
Sbjct  82   TILGVAEDASIKGAVEEAHKNGKE---LLVDMIAVQDLQKRAKELDELGADYIAVHTGYD  138

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
             Q   E  +  +  +++   +  + V GG+  +TI +      +++V G  +  A DP  
Sbjct  139  LQAEGESPLESLRQVKSVINNSKVAVIGGIKPDTIKEVVAEEPDLVVVGGGIANADDPVA  198

Query  219  VISFMKEEV  227
                 K+ +
Sbjct  199  AAKACKDAI  207


>gi|97049455|sp|Q46DY5|FAEHP_METBF  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=392

 Score = 46.6 bits (110),  Expect = 8e-05, Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 30/61 (49%), Gaps = 0/61 (0%)

Query  169  KVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
             +  ++   P + + V GG+  + +P A   GA+++V G ++  + D  +V       ++
Sbjct  320  NIAEIKKIAPKILVAVAGGVRLDKVPVALGQGADILVVGRAITNSKDVREVAEQFINSLN  379

Query  229  K  229
            K
Sbjct  380  K  380


>gi|3043366|sp|Q48907|HPS_METAM  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=209

 Score = 46.2 bits (109),  Expect = 9e-05, Method: Composition-based stats.
 Identities = 29/125 (23%), Positives = 47/125 (37%), Gaps = 4/125 (3%)

Query  90   VDDFAKCGADQFTF-HYEATQDPLHLVKLIKSKGIKAACAI-KPGTSVDVLFELAPHLDM  147
             + F K GAD  T            ++      G KA   +   G       E+A     
Sbjct  71   AEPFYKAGADITTVLGVADLGTIKGVIDAANKYGKKAQIDLINVGDKAARTKEVAKL--G  128

Query  148  ALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAG  207
            A ++ V  G   Q   +     + T+      L + V GG+   T+ +   AGA +IVAG
Sbjct  129  AHIIGVHTGLDQQAAGQTPFADLATVTGLNLGLEVSVAGGVKPATVAQVKDAGATIIVAG  188

Query  208  TSVFT  212
             +++ 
Sbjct  189  AAIYG  193


>gi|81675362|sp|Q5HRH7|HPS_STAEQ  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score = 46.2 bits (109),  Expect = 9e-05, Method: Composition-based stats.
 Identities = 38/189 (20%), Positives = 69/189 (36%), Gaps = 9/189 (4%)

Query  42   FVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQF  101
            +V  + +G PIV  +   +P     +          D  +M +  +  V    K GAD  
Sbjct  25   YVDIVEIGTPIV--INEGLPAVQHLNENINNAKVLADLKIM-DAADYEVSQAVKYGADIV  81

Query  102  TFHYEATQ-DPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD--MALVMTVEPGFG  158
            T    A        V+     G KA         V  L + A  LD   A  + V  G+ 
Sbjct  82   TILGVAEDASIKAAVEEAHKHG-KALLVDMIA--VQNLEQRAKELDEMGADYIAVHTGYD  138

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
             Q   +  +  + T+++   +  + V GG+  +TI        ++++ G  +  A DP +
Sbjct  139  LQAEGKSPLDSLRTVKSVIKNSKVAVAGGIKPDTIKDIVAEDPDLVIVGGGIANADDPVE  198

Query  219  VISFMKEEV  227
                 +  +
Sbjct  199  AAKQCRAAI  207


>gi|81843092|sp|Q8CQ69|HPS_STAES  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score = 45.9 bits (108),  Expect = 1e-04, Method: Composition-based stats.
 Identities = 38/186 (20%), Positives = 68/186 (36%), Gaps = 9/186 (4%)

Query  42   FVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQF  101
            +V  + +G PIV  +   +P     +          D  +M +  +  V    K GAD  
Sbjct  25   YVDIVEIGTPIV--INEGLPAVQHLNENINNAKVLADLKIM-DAADYEVSQAVKYGADIV  81

Query  102  TFHYEATQ-DPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD--MALVMTVEPGFG  158
            T    A        V+     G KA         V  L + A  LD   A  + V  G+ 
Sbjct  82   TILGVAEDASIKAAVEEAHKHG-KALLVDMIA--VQNLEQRAKELDEMGADYIAVHTGYD  138

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
             Q   +  +  + T+++   +  + V GG+  +TI        ++++ G  +  A DP +
Sbjct  139  LQAEGKSPLDSLRTVKSVIKNSKVAVAGGIKPDTIKDIVAEDPDLVIVGGGIANADDPVE  198

Query  219  VISFMK  224
                 +
Sbjct  199  AAKQCR  204


>gi|74512837|sp|O28964|FAEHP_ARCFU  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=394

 Score = 45.9 bits (108),  Expect = 1e-04, Method: Composition-based stats.
 Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 1/50 (2%)

Query  172  TLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVIS  221
             ++ KF  + + V GG+  E + +   AGA++IV G +V  A D    + 
Sbjct  327  KIKEKF-SVLVAVAGGIRPENVEEVIAAGADIIVVGRAVTKARDVEGAVR  375


>gi|13633984|sp|Q9UZQ5|THIE_PYRAB  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=207

 Score = 44.7 bits (105),  Expect = 3e-04, Method: Composition-based stats.
 Identities = 15/65 (23%), Positives = 31/65 (47%), Gaps = 2/65 (3%)

Query  169  KVETLRAKFPHLNIQV--DGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
            ++E LR     ++I V   GG+  E + +   AG + I   ++V  A+D       +++ 
Sbjct  142  RIEGLREIVEAVSIPVVAIGGINVENVKQVLSAGVDGIAVVSAVMGASDVKKATEELRKI  201

Query  227  VSKEL  231
            + + L
Sbjct  202  IEEVL  206


>gi|47606159|sp|Q87VY6|THIE_PSESM  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=205

 Score = 44.3 bits (104),  Expect = 4e-04, Method: Composition-based stats.
 Identities = 16/53 (30%), Positives = 28/53 (52%), Gaps = 1/53 (1%)

Query  167  MPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDV  219
            +  +  +RA+  HL I V GG+  E  P+  + GA+++     +F A  P +V
Sbjct  143  LDLIAQVRAR-VHLPIAVIGGITLENAPQLVEHGADLLAVVHGLFGAETPQEV  194


>gi|74527158|sp|Q8THA9|FAEHP_METAC  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=392

 Score = 43.9 bits (103),  Expect = 4e-04, Method: Composition-based stats.
 Identities = 25/135 (18%), Positives = 46/135 (34%), Gaps = 35/135 (25%)

Query  111  PLHLVKLIKSKGIKAAC-AIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMP-  168
               L++     GI A    +     + VL +L                   K M D++  
Sbjct  265  IDKLIEEAHKTGIYAVMDTLNQHDPISVLKQL-------------------KVMPDVIEL  305

Query  169  --------------KVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAA  214
                           +  ++   P   I V GG+  + +P A   GA+++V G ++  A 
Sbjct  306  HRGIDIEGTEHAWGNIGEIKKIAPKALIAVAGGVRLDKVPVALGQGADILVVGRAITNAK  365

Query  215  DPHDVISFMKEEVSK  229
            D  +V       ++K
Sbjct  366  DVREVAEQFINALNK  380


>gi|81649887|sp|Q6GBR7|HPS_STAAS  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
 gi|81651682|sp|Q6GJ99|HPS_STAAR  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
 gi|81762794|sp|Q8NXX1|HPS_STAAW  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score = 43.9 bits (103),  Expect = 4e-04, Method: Composition-based stats.
 Identities = 33/189 (17%), Positives = 70/189 (37%), Gaps = 9/189 (4%)

Query  42   FVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQF  101
            +V  + +G PI+      +P     ++         D  +M +  +  V    K GAD  
Sbjct  25   YVDIVEIGTPII--YNEGLPAVKHMADNISNVKVLADMKIM-DAADYEVSQAIKFGADVI  81

Query  102  TFHYEATQ-DPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD--MALVMTVEPGFG  158
            T    A        ++       +    +    +V  L + A  LD   A  + V  G+ 
Sbjct  82   TILGVAEDASIKAAIEEAHKNNKQ---LLVDMIAVQDLEKRAKELDEMGADYIAVHTGYD  138

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
             Q   +  +  + T+++   +  + V GG+  +TI +      ++++ G  +  A DP +
Sbjct  139  LQAEGQSPLESLRTVKSVIKNSKVAVAGGIKPDTIKEIVAESPDLVIVGGGIANADDPVE  198

Query  219  VISFMKEEV  227
                 +  +
Sbjct  199  AAKQCRAAI  207


>gi|119370767|sp|Q2YS94|HPS_STAAB  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score = 43.9 bits (103),  Expect = 5e-04, Method: Composition-based stats.
 Identities = 33/189 (17%), Positives = 71/189 (37%), Gaps = 9/189 (4%)

Query  42   FVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQF  101
            +V  + +G PI+      +P     ++         D  +M +  +  V    K GAD  
Sbjct  25   YVDIVEIGTPII--YNEGLPAVKHMADNISNVKVLADMKIM-DAADYEVSQAIKFGADVI  81

Query  102  TFHYEATQDPLHL-VKLIKSKGIKAACAIKPGTSVDVLFELAPHLD--MALVMTVEPGFG  158
            T    A    +   ++       +    +    +V  L + A  LD   A  + V  G+ 
Sbjct  82   TILGVAEDASIKTAIEEAHKNNKQ---LLVDMIAVQDLEKRAKELDEMGADYIAVHTGYD  138

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
             Q   +  +  + T+++   +  + V GG+  +TI +      ++++ G  +  A DP +
Sbjct  139  LQAEGQSPLESLRTVKSVIKNSKVAVAGGIKPDTIKEIVAESPDLVIVGGGIANADDPVE  198

Query  219  VISFMKEEV  227
                 +  +
Sbjct  199  AAKQCRAAI  207


>gi|24212487|sp|Q8U192|THIE_PYRFU  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=207

 Score = 43.9 bits (103),  Expect = 5e-04, Method: Composition-based stats.
 Identities = 16/64 (25%), Positives = 28/64 (43%), Gaps = 2/64 (3%)

Query  170  VETLRAKFPHLNIQV--DGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            +E LR     + I V   GG+ K+   +  K G + I   ++V  A D       +++ V
Sbjct  143  LEGLRKIVESVKIPVVAIGGINKDNAREVLKTGVDGIAVISAVMGAEDVRKATEELRKIV  202

Query  228  SKEL  231
             + L
Sbjct  203  EEVL  206


>gi|732341|sp|P39594|THIE_BACSU  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=222

 Score = 43.2 bits (101),  Expect = 8e-04, Method: Composition-based stats.
 Identities = 13/58 (22%), Positives = 27/58 (46%), Gaps = 0/58 (0%)

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            +E +R +   + I   GG+  +      +AGA+ +   +++  A DP       +EE+
Sbjct  158  IEAVRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEI  215


>gi|23822009|sp|Q8PV88|PYRF_METMA  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=220

 Score = 43.2 bits (101),  Expect = 8e-04, Method: Composition-based stats.
 Identities = 16/69 (23%), Positives = 31/69 (44%), Gaps = 2/69 (2%)

Query  168  PKVETLRAKFPHLNIQVDGGLGKE--TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
             +V+ +R         +  G+G +         AGA+ ++ G S++ A  P +    + E
Sbjct  152  ERVKEIRKIIGDRLTIISPGVGAQGGKASDVISAGADWVIVGRSIYKAESPKEAACEIAE  211

Query  226  EVSKELRSR  234
            E+  ELR +
Sbjct  212  EIQAELRGK  220


>gi|41018348|sp|Q8DHK2|THIE_SYNEL  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=351

 Score = 42.8 bits (100),  Expect = 0.001, Method: Composition-based stats.
 Identities = 27/133 (20%), Positives = 45/133 (33%), Gaps = 15/133 (11%)

Query  97   GADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFE-LAPHLDMALVMTV--  153
            GA+    H      P+ L + I  +        +  T+   L   +A   D   V  +  
Sbjct  218  GANADGVHLGQMDIPMELARQILGRDRLVG---RSTTNAQELERAIAEGADYVGVGPIFA  274

Query  154  ---EPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSV  210
               +PG     F       ++  R   P     + GG+    I +  KAGA  +    ++
Sbjct  275  TPTKPGKAAVGF-----DYLQYARKHAPMPQFAI-GGIDLSNIEEVIKAGATQVAVVRAI  328

Query  211  FTAADPHDVISFM  223
              AADP      +
Sbjct  329  MAAADPEATTREL  341


>gi|81695133|sp|Q5HIA5|HPS_STAAC  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
 gi|81706157|sp|Q7A774|HPS_STAAN  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
 gi|81782064|sp|Q99W39|HPS_STAAM  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
 gi|119370766|sp|Q2G0K7|HPS_STAA8  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score = 42.8 bits (100),  Expect = 0.001, Method: Composition-based stats.
 Identities = 33/189 (17%), Positives = 69/189 (36%), Gaps = 9/189 (4%)

Query  42   FVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQF  101
            +V  + +G PI+      +P     ++         D  +M +  +  V    K GAD  
Sbjct  25   YVDIVEIGTPII--YNEGLPAVKHMADNISNVKVLADMKIM-DAADYEVSQAIKFGADVI  81

Query  102  TFHYEATQ-DPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD--MALVMTVEPGFG  158
            T    A        ++       +    +    +V  L + A  LD   A  + V  G+ 
Sbjct  82   TILGVAEDASIKAAIEEAHKNNKQ---LLVDMIAVQDLEKRAKELDEMGADYIAVHTGYD  138

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
             Q   +  +  + T+++   +  + V GG+  +TI        ++++ G  +  A DP +
Sbjct  139  LQAEGQSPLESLRTVKSVIKNSKVAVAGGIKPDTIKDIVAESPDLVIVGGGIANADDPVE  198

Query  219  VISFMKEEV  227
                 +  +
Sbjct  199  AAKQCRAAI  207


>gi|74525136|sp|Q8PXE1|FAEHP_METMA  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=392

 Score = 42.4 bits (99),  Expect = 0.001, Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 29/61 (47%), Gaps = 0/61 (0%)

Query  169  KVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
             +  ++   P   + V GG+  + +P A   GA+++V G ++  A D  ++       ++
Sbjct  320  NIGEIKKIAPKALVAVAGGVRLDKVPVALSQGADILVVGRAITNAKDVREMAEQFINSLN  379

Query  229  K  229
            K
Sbjct  380  K  380


>gi|97049518|sp|O27518|FAEHP_METTH  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=406

 Score = 42.4 bits (99),  Expect = 0.001, Method: Composition-based stats.
 Identities = 11/52 (21%), Positives = 23/52 (44%), Gaps = 1/52 (1%)

Query  169  KVETLRAK-FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDV  219
             +  ++    P   + V GG+    + +A  +GA++IV G  +  + D    
Sbjct  330  NIREIKEILGPRGLVAVAGGITPSKMQEALDSGADIIVVGRYIIGSRDVRRA  381


>gi|28380194|sp|Q8TYA2|TRPA_METKA  Tryptophan synthase alpha chain
Length=275

 Score = 42.4 bits (99),  Expect = 0.001, Method: Composition-based stats.
 Identities = 36/222 (16%), Positives = 78/222 (35%), Gaps = 19/222 (8%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPI---VTSLRRSVPRPGDASNTEKKPTAFFD  78
               + + G D L + V    F   I  G  I   V    R+   P D     ++ + F  
Sbjct  39   ARALRDGGVDILELGV---PFSEPIADGPTIQKAVDEALRAGTTPWDCLEVAEEVSEFVP  95

Query  79   CHMMVE-------NPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKP  131
              ++           E+++   A+ G           ++   +  + +   I     + P
Sbjct  96   VVLLCYYNTLHANGFERYLSAAAEAGVSGIIVADMPVEESDEVHSVARDLEIDVIYLVAP  155

Query  132  GTSVDVLFELAPHL-DMALVMTVEPGFGGQK--FMEDMMPKVETLRAKFPHLNIQVDGGL  188
             T+ + L ++         V++   G  G +    ED +  V  +R     + + V  G+
Sbjct  156  STTDERLKKIGERASGFVYVISRY-GVTGARRDLSEDTLELVRWVRDHVD-VPVAVGFGI  213

Query  189  GKE-TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSK  229
             +   + +   AGA+  + G++        + I+  +E V +
Sbjct  214  SERWHVEEVIAAGADGAIVGSAFIKEIHRSEDIAEAEERVRE  255


>gi|119370768|sp|Q4L3P8|HPS_STAHJ  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score = 42.4 bits (99),  Expect = 0.001, Method: Composition-based stats.
 Identities = 35/189 (18%), Positives = 69/189 (36%), Gaps = 9/189 (4%)

Query  42   FVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQF  101
            +V  + +G PIV  +   +P                D  +M +  +  V    K GAD  
Sbjct  25   YVDIVEIGTPIV--INEGLPAVQHLDENISNAKVLADLKIM-DAADYEVSQAIKFGADVV  81

Query  102  TFHYEATQ-DPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD--MALVMTVEPGFG  158
            T    A        V+       +    +    +V  L + A  LD   A  + V  G+ 
Sbjct  82   TILGVAEDASIKAAVEEAHKHDKQ---LLVDMIAVQDLEKRAKELDEMGADYIAVHTGYD  138

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
             Q   +  +  + T+++   +  + V GG+  +TI        ++++ G  +  A DP +
Sbjct  139  LQAEGQSPLDSLRTVKSVIKNSKVAVAGGIKPDTIKDIVAEQPDLVIVGGGIANADDPVE  198

Query  219  VISFMKEEV  227
                 ++ +
Sbjct  199  AAKQCRDAI  207


>gi|73622033|sp|Q82WI1|TRPA_NITEU  Tryptophan synthase alpha chain
Length=275

 Score = 42.4 bits (99),  Expect = 0.001, Method: Composition-based stats.
 Identities = 39/235 (16%), Positives = 82/235 (34%), Gaps = 27/235 (11%)

Query  23   HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAF------  76
            H++  AG D + + V    F   +  G  I  S  R++       +       F      
Sbjct  38   HRLTQAGVDLIELGV---PFSDPMADGPTIQRSSERALKHHISLKDVFSMVAEFRKTNQS  94

Query  77   FDCHMM-VENPE------KWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                +M   NP        +V      G D         ++    V+ +K + I     +
Sbjct  95   TPVVLMGYANPIEAMGYKDFVQTAGHAGVDGVLVVDYPPEECTEWVRYLKEQNIDPIFLL  154

Query  130  KPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFME--DMMPKVETLRAKFPHLNIQVDG  186
             P T    +  +A         ++++ G  G   ++  ++  K+  LR+   ++ I V  
Sbjct  155  SPTTPESRIRRVAELARGYVYYVSLK-GVTGASHLDLHEVGDKLSQLRSYI-NIPIGVGF  212

Query  187  GLGKETIPKAAKAGANVIVAGTSVFT------AADPHDVISFMKEEVSKELRSRD  235
            G+  E   +     A+ +V G+ +        AAD    +  + E + + + ++ 
Sbjct  213  GIRDEQTARRIAEQADAVVIGSRIVEEIEHSPAADLLANVGALVESLRRAIDAKS  267


>gi|21759371|sp|Q8U1U1|PYRF_PYRFU  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=211

 Score = 42.4 bits (99),  Expect = 0.001, Method: Composition-based stats.
 Identities = 40/190 (21%), Positives = 70/190 (36%), Gaps = 30/190 (15%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFA-KCGADQFTFHYEA  107
            G  +++ L++    P  A                + N  + +       GAD    H   
Sbjct  39   GLGVISELKKKTGLPIIADLKLAD----------IPNTNRLIAKKVYDAGADYIILHSFV  88

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPH-LDMALVMTVEPGFGGQKFMEDM  166
             +D +  VK +    +    +  PG  ++ +  L    +DMA    ++P FG        
Sbjct  89   GRDSVKAVKELGEIIMIVEMS-HPGA-LEFINPLTDKFIDMA--NEIKP-FGVIA--PGT  141

Query  167  MP-KVETLRA------KFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDV  219
             P ++  +R       K     I   GG   E    A KAGA+ I+ G +++ A  P + 
Sbjct  142  RPERIRYIRERLSKDIKVLTPGIGAQGGSPVE----ALKAGADYIIIGRAIYNAERPREA  197

Query  220  ISFMKEEVSK  229
               + EEV +
Sbjct  198  AKKIFEEVKE  207


>gi|24212488|sp|Q8UAS8|THIE_AGRT5  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=220

 Score = 42.4 bits (99),  Expect = 0.002, Method: Composition-based stats.
 Identities = 13/64 (20%), Positives = 29/64 (45%), Gaps = 0/64 (0%)

Query  171  ETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
              L+   P + +    G+  + +P    AGA+ +   +++F AA+     S  +  +   
Sbjct  155  ALLKEWQPDMPVGAIAGIDLDRVPAVIAAGADGVAVISAIFRAANIASATSDFRSAIDAA  214

Query  231  LRSR  234
            L++R
Sbjct  215  LKAR  218


>gi|73622054|sp|Q5N324|TRPA_SYNP6  Tryptophan synthase alpha chain
Length=266

 Score = 42.0 bits (98),  Expect = 0.002, Method: Composition-based stats.
 Identities = 36/214 (16%), Positives = 71/214 (33%), Gaps = 23/214 (10%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPI-------VTSLRRSVPRPGDA  66
            D          +   GAD + + V    +   +  G  I       + +  R        
Sbjct  29   DLETTRQALLALDREGADLIELGV---PYSDPLADGPVIQAAATRALQAGTRLDDVLALL  85

Query  67   SNTEKKPTAFFDCHMMVENP------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
             +   +  A         NP      E ++D  A  GA+         ++   L ++   
Sbjct  86   KDVRSQIKAPI-VLFTYCNPILNRGFEAFLDQIAAAGANGLVVPDLPLEESQRLSEVAAE  144

Query  121  KGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGG--QKFMEDMMPKVETLRAKF  177
            +GI     I P +S D +  ++        +++V  G  G  Q     +   ++ +R   
Sbjct  145  RGIDLILLIAPTSSADRIAAISKQARGFIYLVSVT-GVTGMRQGMQSRVADLLQEIRQGT  203

Query  178  PHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSV  210
                I V  G+ G E   +    GA+ ++ G++ 
Sbjct  204  DKP-IGVGFGISGAEQARQVRDWGADGVIVGSAF  236


>gi|23822016|sp|Q8TS37|PYRF_METAC  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=221

 Score = 42.0 bits (98),  Expect = 0.002, Method: Composition-based stats.
 Identities = 18/72 (25%), Positives = 31/72 (43%), Gaps = 3/72 (4%)

Query  164  EDMMPK-VETLRAKFPHLNIQVDGGLGKE--TIPKAAKAGANVIVAGTSVFTAADPHDVI  220
                PK V+ +R         +  G+G +         AGA+ ++ G S++ A  P +  
Sbjct  147  PATRPKRVKKIRRIIGDKLTIISPGVGAQGGKASDVIAAGADWVIVGRSIYKAESPKEAA  206

Query  221  SFMKEEVSKELR  232
              + EE+  ELR
Sbjct  207  RQIAEEIQAELR  218


>gi|3041689|sp|P42405|HPS_BACSU  3-hexulose-6-phosphate synthase (HPS) (HUMPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score = 42.0 bits (98),  Expect = 0.002, Method: Composition-based stats.
 Identities = 29/140 (20%), Positives = 61/140 (43%), Gaps = 8/140 (5%)

Query  90   VDDFAKCGADQFTFHYEATQD--PLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDM  147
            +   ++ GAD  T    AT D      V+  K +  K    +    +V  +   A  +D 
Sbjct  70   IMKASEAGADIITV-LGATDDATIKGAVEEAKKQKKK---ILVDMINVKDIESRAKEIDA  125

Query  148  ALV--MTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIV  205
              V  + V  G+  Q   ++   ++ T++    +    + GG+  +T+P+  +   ++++
Sbjct  126  LGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNAKTAIAGGIKLDTLPEVIQQKPDLVI  185

Query  206  AGTSVFTAADPHDVISFMKE  225
             G  + +AAD  +  S MK+
Sbjct  186  VGGGITSAADKAETASKMKQ  205


>gi|24638310|sp|Q8U092|TRPF_PYRFU  N-(5'-phosphoribosyl)anthranilate isomerase (PRAI)
Length=208

 Score = 41.6 bits (97),  Expect = 0.002, Method: Composition-based stats.
 Identities = 40/189 (21%), Positives = 66/189 (34%), Gaps = 25/189 (13%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEAT  108
            G  + ++ +R +P        E      F    MV    +W     + GA     H  A 
Sbjct  25   GVVVNSNSKRRIPLEKAREIIENSAIPVFLVSTMV-GFSEWAMAIERTGAQYIQVHSNAL  83

Query  109  QDPLHLVKLIKSKGIKAACAIKPGT----SVDVLFELAPHL-----DMALVMTVEPGFGG  159
               +  +K  K  G+    A +  T      +    L   +     DM L+ T   G G 
Sbjct  84   PQTIDTLK--KEFGVFVMKAFRVPTISKNPEEDANRLLSEISRYNADMVLLDT---GAGS  138

Query  160  QKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKA----GANVIVAGTSVFTAAD  215
             K  +  +  +  +  K P +   V GGL  E + +  K     G +V  +G   +   D
Sbjct  139  GKLHDLRVSSL--VARKIPVI---VAGGLNAENVEEVIKVVKPYGVDV-SSGVEKYGIKD  192

Query  216  PHDVISFMK  224
            P  V  F++
Sbjct  193  PKLVEEFVR  201


>gi|97051922|sp|Q46DA4|HPS_METBF  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=413

 Score = 41.6 bits (97),  Expect = 0.002, Method: Composition-based stats.
 Identities = 47/220 (21%), Positives = 82/220 (37%), Gaps = 45/220 (20%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNI-TLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCH  80
              + I  GADW+ I        P I + G   + ++R++ P     ++ +   T   +  
Sbjct  8    AKEAIAGGADWIEIG------TPLIKSEGMDAIRTMRKAFPDRTILADMKTVDTGAIEVE  61

Query  81   MMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIK---SKGIK--AACAIKPGTSV  135
            M            AK GAD       A      L+  ++     G++  A     P    
Sbjct  62   MA-----------AKAGADVVIVLGSADDST--LLDALRSSHKYGVRLMADLISAP----  104

Query  136  DVLFELAPH----LDMALVMTVEPGFGGQKFMEDMMPK--VETLRAKFPHLNIQ--VDGG  187
            D +  +       +D      V  G   Q     MM K  +  LR     +N+Q  V GG
Sbjct  105  DPVKRVVELEALGVDYV---NVHIGIDQQ-----MMGKDPIALLREISQRVNVQLAVAGG  156

Query  188  LGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            L   +  +A KAGA V++ G ++  + +  +    +++ V
Sbjct  157  LDANSAVQAVKAGAKVVIVGGNITHSDNVTEAARKIRQSV  196


>gi|119370765|sp|Q2FJ70|HPS_STAA3  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=210

 Score = 41.6 bits (97),  Expect = 0.002, Method: Composition-based stats.
 Identities = 26/148 (17%), Positives = 55/148 (37%), Gaps = 6/148 (4%)

Query  83   VENPEKWVDDFAKCGADQFTFHYEATQ-DPLHLVKLIKSKGIKAACAIKPGTSVDVLFEL  141
            ++  +  V    K GAD  T    A        ++       +    +    +V  L + 
Sbjct  63   IDAADYEVSQAIKFGADVITILGVAEDASIKAAIEEAHKNNKQ---LLVDMIAVQDLEKR  119

Query  142  APHLD--MALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKA  199
            A  LD   A  + V  G+  Q   +  +  + T+++   +  + V GG+  +TI      
Sbjct  120  AKELDEMGADYIAVHTGYDLQAEGQSPLESLRTVKSVIKNSKVAVAGGIKPDTIKDIVAE  179

Query  200  GANVIVAGTSVFTAADPHDVISFMKEEV  227
              ++++ G  +  A DP +     +  +
Sbjct  180  SPDLVIVGGGIANADDPVEAAKQCRAAI  207


>gi|20139591|sp|Q977X5|PYRF_METTE  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=215

 Score = 41.2 bits (96),  Expect = 0.003, Method: Composition-based stats.
 Identities = 15/67 (22%), Positives = 28/67 (41%), Gaps = 2/67 (2%)

Query  168  PKVETLRAKFPHLNIQVDGGLGKE--TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
             +V  +R         +  G+G +         AG + ++ G S++ A  P +    + E
Sbjct  146  ERVRKIRRIIGDKLTIISPGVGAQGGKASDVIAAGTDWVIVGRSIYKAESPKEAAREIAE  205

Query  226  EVSKELR  232
            E+  ELR
Sbjct  206  EIQAELR  212


>gi|51316365|sp|Q7VRI8|METE_BLOFL  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase)
Length=769

 Score = 41.2 bits (96),  Expect = 0.003, Method: Composition-based stats.
 Identities = 34/196 (17%), Positives = 68/196 (34%), Gaps = 34/196 (17%)

Query  18   LGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTS----LRRSVPRPGDASNTEKKP  73
            +  E   +  +G   + ID       P +  G P+  S      +        + +  K 
Sbjct  591  IRDEVMDLEKSGIGVIQID------EPALREGLPLKKSEQSYYLKWAINTFKITVSSVKD  644

Query  74   TAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGT  133
                  HM      + +DD  K   D  +   E+++  L L++ IK+ G K         
Sbjct  645  NTQIHTHMCYSEFNEIIDDILKLDVDVISI--ESSRSDLQLLQFIKTAGKK---------  693

Query  134  SVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFP--HLNIQVDGGLGKE  191
             ++ +      +              Q  + ++M K++ L    P   L I  D GL   
Sbjct  694  -LNEIGPGIYDIHSI----------HQPSINEIMDKLKKLLQYIPKDRLWINPDCGLKTR  742

Query  192  TIPKAAKAGANVIVAG  207
            +  +  ++  N+++A 
Sbjct  743  SWNEIRESLNNMVIAA  758


>gi|24212493|sp|Q8YA44|THIE_LISMO  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=214

 Score = 40.9 bits (95),  Expect = 0.004, Method: Composition-based stats.
 Identities = 13/56 (23%), Positives = 26/56 (46%), Gaps = 0/56 (0%)

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
            +E +R     + I   GG+ +    +   AGA+ +   +++  + D H VI  +K 
Sbjct  154  LEEIRRAGITIPIVGIGGINETNSAEVLTAGADGVSVISAITQSDDCHSVIKQLKN  209


>gi|73913711|sp|Q5JDB0|PYRF_PYRKO  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=213

 Score = 40.5 bits (94),  Expect = 0.005, Method: Composition-based stats.
 Identities = 37/191 (19%), Positives = 68/191 (35%), Gaps = 32/191 (16%)

Query  49   GQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFA-KCGADQFTFHYEA  107
            G  I+T L++    P  A                + N  + +     + GAD    H   
Sbjct  43   GLKIITELKQVTGLPIIADLKLAD----------IPNTNRLIASKVFEAGADYIIAHGFV  92

Query  108  TQDPLHLVKLIKSKGIKAACA--IKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMED  165
             +D    V+ +   G          PG   + +  +   L + L   +EP FG       
Sbjct  93   GRD---SVEAVMELGKTIIVVEMSHPGAK-EFIQPVTDKL-IELANELEP-FGVIA--PA  144

Query  166  MMP-KVETLRAK------FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
              P +V  +R++           +   GG        A KAGA+ ++ G S++ + +P +
Sbjct  145  TRPERVSYIRSRLERGIRILTPGVGAQGG----KASDAIKAGADYVIVGRSIYGSNNPRE  200

Query  219  VISFMKEEVSK  229
                + EE+ +
Sbjct  201  AARRLYEEILE  211


>gi|24212501|sp|Q92EW5|THIE_LISIN  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=214

 Score = 40.5 bits (94),  Expect = 0.005, Method: Composition-based stats.
 Identities = 13/56 (23%), Positives = 25/56 (44%), Gaps = 0/56 (0%)

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
            +E +R     L I   GG+ +    +   AGA+ +   +++  + D   VI  +K 
Sbjct  154  LEEIRRAGIKLPIVGIGGINETNSAEVLTAGADGVSVISAITRSEDCQSVIKQLKN  209


>gi|41018354|sp|Q8E5W9|THIE_STRA3  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=223

 Score = 40.5 bits (94),  Expect = 0.006, Method: Composition-based stats.
 Identities = 17/109 (15%), Positives = 38/109 (34%), Gaps = 1/109 (0%)

Query  127  CAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKV-ETLRAKFPHLNIQVD  185
              +   T  +        +D   +    P          +  +  + +R     + I   
Sbjct  107  IGLSVSTMAEYQKSQLSVVDYIGIGPFNPTQSKADAKPAVGNRTTKAVREINQDIPIVAI  166

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            GG+  + +    ++GA+ I   +++  A    D    ++ EV K L +R
Sbjct  167  GGITSDFVHDIIESGADGIAVISAISKANHIVDATRQLRYEVEKALVNR  215


>gi|97049499|sp|Q2NE86|FAEHP_METST  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=406

 Score = 40.1 bits (93),  Expect = 0.006, Method: Composition-based stats.
 Identities = 14/52 (26%), Positives = 26/52 (50%), Gaps = 1/52 (1%)

Query  169  KVETLRAKFPHLN-IQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDV  219
             ++ +++K      I V GG+  E +  A   GAN+I+AG  +  ++D    
Sbjct  330  NIKDIKSKLGKRGLIAVAGGVTPEKVDTALANGANIIIAGRYIIGSSDVRRA  381


>gi|11182415|sp|O74110|PYRF_THEAC  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=214

 Score = 40.1 bits (93),  Expect = 0.007, Method: Composition-based stats.
 Identities = 17/70 (24%), Positives = 32/70 (45%), Gaps = 8/70 (11%)

Query  167  MPKVETLRAK----FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
            +  +  +R +         I   GG        A KAGA++++ G S++ +ADP      
Sbjct  147  LSDLSEIRKRTKKTIMSPGIGSQGG----RASDAIKAGADLVIVGRSIYESADPVTAAEA  202

Query  223  MKEEVSKELR  232
            + EE++K + 
Sbjct  203  INEEIAKAVE  212


>gi|41018352|sp|Q8E092|THIE_STRA5  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=223

 Score = 40.1 bits (93),  Expect = 0.007, Method: Composition-based stats.
 Identities = 14/64 (21%), Positives = 29/64 (45%), Gaps = 0/64 (0%)

Query  171  ETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            + +R     + I   GG+  + +    ++GA+ I   +++  A    D    ++ EV K 
Sbjct  152  KAVREINQDIPIVAIGGITSDFVHDIIESGADGIAVISAISKANHIVDATRQLRYEVEKA  211

Query  231  LRSR  234
            L +R
Sbjct  212  LVNR  215


>gi|9297058|sp|Q9WYG8|PYRD_THEMA  Dihydroorotate dehydrogenase (Dihydroorotate oxidase) (DHOdehase) 
(DHODase) (DHOD)
Length=270

 Score = 40.1 bits (93),  Expect = 0.008, Method: Composition-based stats.
 Identities = 16/66 (24%), Positives = 29/66 (43%), Gaps = 1/66 (1%)

Query  156  GFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAA  214
            G  G       +  V  ++ +FP L +   GG+   +   +  K GA+VI  G+++F   
Sbjct  196  GLSGPVLKPIALRAVYEVKKRFPELFVIASGGVYSVKDAEEFLKVGADVIGVGSALFKDP  255

Query  215  DPHDVI  220
               + I
Sbjct  256  GVVEEI  261


>gi|24212478|sp|Q8PS49|THIE_METMA  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=240

 Score = 39.7 bits (92),  Expect = 0.008, Method: Composition-based stats.
 Identities = 20/131 (15%), Positives = 45/131 (34%), Gaps = 14/131 (10%)

Query  103  FHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGF----G  158
             H      P+   + I   G      +    + + +       D   + ++   F     
Sbjct  108  VHIGQDDMPIETARKI--LGANKIIGLTVHNADEAIEAEKSGADYVGLGSIFDTFTKKDA  165

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPH-  217
            G+         +  +R     +++   GG+ KE      + GA+ +VA ++V  + D   
Sbjct  166  GKGIGPAS---IREVRNAI-KISVVAIGGINKENCRSVIENGADSLVAISAVVCSDDVKK  221

Query  218  ---DVISFMKE  225
               + I  ++E
Sbjct  222  ETREFIDIIRE  232


>gi|31563187|sp|Q8TXM0|PCRB_METKA  Protein pcrB homolog
Length=239

 Score = 39.7 bits (92),  Expect = 0.008, Method: Composition-based stats.
 Identities = 16/44 (36%), Positives = 26/44 (59%), Gaps = 2/44 (4%)

Query  184  VDGGL-GKETIPKAAKAGANVIVAGTSVFTAAD-PHDVISFMKE  225
            V GG+   ET  + A+AGA+ IV GT+V    D   +++  +K+
Sbjct  195  VGGGIRSPETARELAEAGADAIVTGTAVERDPDLAAEIVEAIKD  238


>gi|67461983|sp|Q723Y9|THIE_LISMF  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=214

 Score = 39.7 bits (92),  Expect = 0.009, Method: Composition-based stats.
 Identities = 13/56 (23%), Positives = 26/56 (46%), Gaps = 0/56 (0%)

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
            +E +R     L I   GG+ +    +   AGA+ +   +++  + D + VI  +K 
Sbjct  154  LEEIRRAGIKLPIVGIGGINETNSAEVLTAGADGVSVISAITRSDDCYSVIKQLKN  209


>gi|7674396|sp|Q9YGA9|TRPA_PYRKO  Tryptophan synthase alpha chain
Length=251

 Score = 39.7 bits (92),  Expect = 0.010, Method: Composition-based stats.
 Identities = 25/142 (17%), Positives = 55/142 (38%), Gaps = 8/142 (5%)

Query  94   AKC-GADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL--DMALV  150
            AK  GAD               +   K +G+K      P T  + L E+          +
Sbjct  104  AKASGADGILVVDLPVSHAGEFLDAAKEEGLKTVFLAAPNTPDERLREI-DKASTGFVYL  162

Query  151  MTVEPGFGGQKFMEDM-MPKVETLRAKFPHLNIQVDGGLGK-ETIPKAAKAGANVIVAGT  208
            +++    G +  + +     V   R    +  + V  G+ + E + +  KAGA+ +V G+
Sbjct  163  ISLYGTTGARDRLPETAFEFVRRARKICNN-KLAVGFGVSRREQVEELLKAGADGVVVGS  221

Query  209  SVFTAADPHD-VISFMKEEVSK  229
            ++       +  +  ++ +V++
Sbjct  222  ALIELISRSENPVEELRRKVAE  243


>gi|20141660|sp|O58462|PYRF_PYRHO  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=208

 Score = 39.7 bits (92),  Expect = 0.010, Method: Composition-based stats.
 Identities = 15/53 (28%), Positives = 26/53 (49%), Gaps = 4/53 (7%)

Query  176  KFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            K     I   GG  K+    A KAGA+ I+ G +++ A +P +    + +E+ 
Sbjct  158  KILAPGIGAQGGKAKD----AVKAGADYIIVGRAIYNAPNPREAAKAIYDEIR  206


>gi|31563093|sp|Q88R42|HIS4_PSEPK  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=245

 Score = 39.7 bits (92),  Expect = 0.010, Method: Composition-based stats.
 Identities = 21/88 (23%), Positives = 40/88 (45%), Gaps = 5/88 (5%)

Query  150  VMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGT  208
            ++ +   F GQ    ++   V  +  ++P+L IQ+ GG+   ETI    KAG + ++ GT
Sbjct  49   LVDLNGAFEGQPVNGEV---VTAIAKRYPNLPIQIGGGIRSLETIEHYVKAGVSYVIIGT  105

Query  209  SVFTAAD-PHDVISFMKEEVSKELRSRD  235
                  +   +       +V   L ++D
Sbjct  106  KAVKQPEFVAEACKAFPGKVIVGLDAKD  133


>gi|31563188|sp|Q8U213|PCRB_PYRFU  Protein pcrB homolog
Length=251

 Score = 39.3 bits (91),  Expect = 0.011, Method: Composition-based stats.
 Identities = 21/73 (28%), Positives = 37/73 (50%), Gaps = 4/73 (5%)

Query  154  EPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGK-ETIPKAAKAGANVIVAGTSVFT  212
            E G G  + + + M  V T++       I V GG+   E + K  KAGA++IV GT++ +
Sbjct  175  EAGSGAPQPVPETM--VATVKKAIDVPLI-VGGGIRSGEQVRKLVKAGADIIVTGTAIES  231

Query  213  AADPHDVISFMKE  225
            A    +    +++
Sbjct  232  AGSIEEARKKLED  244


>gi|47606189|sp|Q8PH45|THIE_XANAC  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=212

 Score = 39.3 bits (91),  Expect = 0.012, Method: Composition-based stats.
 Identities = 11/39 (28%), Positives = 19/39 (48%), Gaps = 0/39 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMK  224
            GG+    +P    AGA++I   + V+ A DP   +   +
Sbjct  164  GGIAPAQVPALVTAGADLIAVVSGVYAAPDPVAAVQGYR  202


>gi|118357|sp|P10652|PYRF_EMENI  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase) (Uridine 5'-monophosphate synthase) (UMP 
synthase)
Length=274

 Score = 39.3 bits (91),  Expect = 0.013, Method: Composition-based stats.
 Identities = 12/35 (34%), Positives = 19/35 (54%), Gaps = 0/35 (0%)

Query  200  GANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            GA+ I+AG  ++ A DP + +   +EE  K    R
Sbjct  237  GADFIIAGRGIYKADDPVEAVQRYREEGWKAYEKR  271


>gi|47606137|sp|Q7WF72|THIE_BORBR  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=217

 Score = 38.9 bits (90),  Expect = 0.014, Method: Composition-based stats.
 Identities = 9/30 (30%), Positives = 16/30 (53%), Gaps = 0/30 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAAD  215
            GG+    + + A+AGA+     + +F A D
Sbjct  172  GGITPANVSQVAQAGADSAAVISGLFEAPD  201


>gi|47606132|sp|Q7W049|THIE_BORPE  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
 gi|47606136|sp|Q7W3U2|THIE_BORPA  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=217

 Score = 38.9 bits (90),  Expect = 0.015, Method: Composition-based stats.
 Identities = 9/30 (30%), Positives = 16/30 (53%), Gaps = 0/30 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAAD  215
            GG+    + + A+AGA+     + +F A D
Sbjct  172  GGITPANVSQVAQAGADSAAVISGLFEAPD  201


>gi|54039722|sp|P66919|THIE_STAAN  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
 gi|54042246|sp|P66918|THIE_STAAM  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
 gi|71153597|sp|Q5HEA8|THIE_STAAC  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=213

 Score = 38.9 bits (90),  Expect = 0.015, Method: Composition-based stats.
 Identities = 12/63 (19%), Positives = 26/63 (41%), Gaps = 0/63 (0%)

Query  163  MEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
            +      + T +   P L I   GG+    +    +AGAN I   +++  + +    ++ 
Sbjct  147  IPVGPEMIATFKEMNPQLPIVAIGGINTNNVAPIVEAGANGISVISAISKSENIEKTVNR  206

Query  223  MKE  225
             K+
Sbjct  207  FKD  209


>gi|41018324|sp|Q82UQ7|THIE_NITEU  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=214

 Score = 38.9 bits (90),  Expect = 0.015, Method: Composition-based stats.
 Identities = 17/77 (22%), Positives = 26/77 (33%), Gaps = 10/77 (12%)

Query  157  FGGQKFMEDMMPK------VETLRAKFPHLNIQV--DGGLGKETIPKAAKAGANVIVAGT  208
            FG   F   M         +E L A    L I V   GG+  +       +G + +    
Sbjct  137  FG--AFYPSMTKTGTYQAPIELLTAAKKKLGIPVVAIGGIDLDNAGMLIASGCDAVAVSQ  194

Query  209  SVFTAADPHDVISFMKE  225
            ++F A D      +  E
Sbjct  195  ALFGAQDIQSAARYFSE  211


>gi|47606188|sp|Q8P5R7|THIE_XANCP  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=207

 Score = 38.9 bits (90),  Expect = 0.015, Method: Composition-based stats.
 Identities = 12/39 (30%), Positives = 21/39 (53%), Gaps = 0/39 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMK  224
            GG+    +P+   AGA++I   + V+ AADP   +   +
Sbjct  164  GGITPSQVPELVTAGADLIAVVSGVYAAADPVAAVQAYR  202


>gi|75417715|sp|Q9LBW4|HPS_MYCGS  3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)
Length=207

 Score = 38.9 bits (90),  Expect = 0.016, Method: Composition-based stats.
 Identities = 14/29 (48%), Positives = 18/29 (62%), Gaps = 0/29 (0%)

Query  184  VDGGLGKETIPKAAKAGANVIVAGTSVFT  212
            V GG+   TIP   KAGA V VAG +++ 
Sbjct  163  VAGGVKVATIPAVQKAGAEVAVAGGAIYG  191


>gi|47606217|sp|Q9PGC4|THIE_XYLFA  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=234

 Score = 38.5 bits (89),  Expect = 0.019, Method: Composition-based stats.
 Identities = 9/41 (21%), Positives = 21/41 (51%), Gaps = 0/41 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
            GGL  + I    +AGA ++   + +++A +P   +   + +
Sbjct  191  GGLTPKNIAPIIEAGAELLAVISGIYSAKNPVTALKAYQSQ  231


>gi|81307794|sp|Q4ZLQ1|HIS4_PSEU2  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=245

 Score = 38.5 bits (89),  Expect = 0.020, Method: Composition-based stats.
 Identities = 23/88 (26%), Positives = 41/88 (46%), Gaps = 5/88 (5%)

Query  150  VMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGT  208
            ++ +   F GQ    D+   V  +  ++P+L IQ+ GG+   ETI    KAG + ++ GT
Sbjct  49   LVDLNGAFEGQPVNGDV---VTAIARRYPNLPIQIGGGIRSLETIEHYVKAGVSYVIIGT  105

Query  209  -SVFTAADPHDVISFMKEEVSKELRSRD  235
             +V       +       +V   L ++D
Sbjct  106  KAVKEPEFVAEACRAFPGKVIVGLDAKD  133


>gi|97049465|sp|Q2FQ74|FAEHP_METHJ  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=393

 Score = 38.5 bits (89),  Expect = 0.020, Method: Composition-based stats.
 Identities = 14/57 (24%), Positives = 28/57 (49%), Gaps = 0/57 (0%)

Query  174  RAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            +A    L +   GG+    + +A K GA+++V G ++  + D         E+++KE
Sbjct  326  KAAGGKLLVATAGGIRVPVVKEALKTGADILVVGRAITASKDVRHAAEEFLEQLNKE  382


>gi|91206941|sp|Q48C80|HIS4_PSE14  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=245

 Score = 38.5 bits (89),  Expect = 0.020, Method: Composition-based stats.
 Identities = 23/88 (26%), Positives = 41/88 (46%), Gaps = 5/88 (5%)

Query  150  VMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGT  208
            ++ +   F GQ    D+   V  +  ++P+L IQ+ GG+   ETI    KAG + ++ GT
Sbjct  49   LVDLNGAFEGQPVNGDV---VTAIARRYPNLPIQIGGGIRSLETIEHYVKAGVSYVIIGT  105

Query  209  -SVFTAADPHDVISFMKEEVSKELRSRD  235
             +V       +       +V   L ++D
Sbjct  106  KAVKEPEFVAEACRAFPGKVIVGLDAKD  133


>gi|91206942|sp|Q4KJS5|HIS4_PSEF5  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=245

 Score = 38.5 bits (89),  Expect = 0.022, Method: Composition-based stats.
 Identities = 22/88 (25%), Positives = 41/88 (46%), Gaps = 5/88 (5%)

Query  150  VMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGT  208
            ++ +   F GQ    ++   V  +  ++P+L IQ+ GG+   ETI    KAG + ++ GT
Sbjct  49   LVDLNGAFEGQPVNGEV---VTAIAKRYPNLPIQIGGGIRSLETIEHYVKAGVSYVIIGT  105

Query  209  -SVFTAADPHDVISFMKEEVSKELRSRD  235
             +V       +       +V   L ++D
Sbjct  106  KAVKEPEFVAEACRAFPGKVIVGLDAKD  133


>gi|76363455|sp|Q4JCD8|TPIS_SULAC  Triosephosphate isomerase (TIM) (Triose-phosphate isomerase)
Length=230

 Score = 38.5 bits (89),  Expect = 0.022, Method: Composition-based stats.
 Identities = 17/73 (23%), Positives = 31/73 (42%), Gaps = 1/73 (1%)

Query  164  EDMMPK-VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
             + + K VE ++       +   G    E + KA + GA+ I A ++V  A +P  V+  
Sbjct  157  PEAITKAVEEIKKTKDVYLLAGAGITTGEDVFKAIELGADGIGAASAVMKAKEPEKVVED  216

Query  223  MKEEVSKELRSRD  235
              +   K +  R 
Sbjct  217  FVKNAIKAMEKRG  229


>gi|2499001|sp|P72965|THIE_SYNY3  Probable thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=343

 Score = 38.2 bits (88),  Expect = 0.025, Method: Composition-based stats.
 Identities = 17/98 (17%), Positives = 37/98 (37%), Gaps = 5/98 (5%)

Query  134  SVDVLFELAPHLDMALVMTVE--PGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKE  191
              ++   +A   D   V  V   P   G+K     +  V+      P     + GG+  E
Sbjct  246  PEEMAKAIAEGADYIGVGPVYATPTKAGKK--PAGLEYVQYAVTNSPVPWFAI-GGIDGE  302

Query  192  TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSK  229
             + +  +AGA  +    ++    +P    + +  ++S+
Sbjct  303  NLGEVMEAGATQVAIVRAIMETTNPTQATAQLLTQLSR  340


>gi|56749730|sp|Q6GEY4|THIE_STAAR  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=213

 Score = 38.2 bits (88),  Expect = 0.026, Method: Composition-based stats.
 Identities = 13/62 (20%), Positives = 27/62 (43%), Gaps = 3/62 (4%)

Query  164  EDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
             +M   + T +   P L I   GG+    +    +AGAN I   +++  + +    ++  
Sbjct  151  PEM---IATFKEMNPQLPIVAIGGINTSNVAPIVEAGANGISVISAISKSENIEKTVNRF  207

Query  224  KE  225
            K+
Sbjct  208  KD  209


>gi|47606158|sp|Q87AX6|THIE_XYLFT  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=234

 Score = 38.2 bits (88),  Expect = 0.029, Method: Composition-based stats.
 Identities = 9/41 (21%), Positives = 21/41 (51%), Gaps = 0/41 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
            GGL  + I    +AGA ++   + +++A +P   +   + +
Sbjct  191  GGLTPKNIAPIIEAGAELLAVISGIYSAKNPITALKAYQSQ  231


>gi|24212475|sp|Q8NVH5|THIE_STAAW  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
 gi|56749701|sp|Q6G7L9|THIE_STAAS  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=213

 Score = 37.8 bits (87),  Expect = 0.031, Method: Composition-based stats.
 Identities = 12/63 (19%), Positives = 27/63 (42%), Gaps = 0/63 (0%)

Query  163  MEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
            +      + T +   P L I   GG+    +    +AGAN I   +++  + +  + ++ 
Sbjct  147  IPVGPEMIATFKEMNPQLPIVAIGGINTNNVAPIVEAGANGISVISAISKSENIENTVNR  206

Query  223  MKE  225
             K+
Sbjct  207  FKD  209


>gi|81641443|sp|Q6AK99|THIC_DESPS  Thiamine biosynthesis protein thiC
Length=434

 Score = 37.8 bits (87),  Expect = 0.034, Method: Composition-based stats.
 Identities = 26/124 (20%), Positives = 44/124 (35%), Gaps = 22/124 (17%)

Query  12   ASDFANLGCECHKV---INAGADWLHIDVMDGHFVPNITLG---QPIVTSLRRSVPRPGD  65
            + D  +L  E  K+   I AGAD +    MD      +++G   Q I   + ++   P  
Sbjct  78   SKDINSLEEELKKLAVAIKAGADTI----MD------LSMGGDLQKIRQEILKNCSVPLG  127

Query  66   ASNTEKKPTAFFD-----CHMMVENPEKWVDDFAKCGADQFTFHYEATQDP-LHLVKLIK  119
                 +              M VE   + ++  AK G D  T H    +     L    +
Sbjct  128  TVPIYQVAAEVVAAGKEIVDMTVERMFEVIEQQAKDGVDFMTIHCGINRHLQERLKNQPR  187

Query  120  SKGI  123
            + G+
Sbjct  188  TMGV  191


>gi|116256440|sp|Q5JDY1|PCRB_PYRKO  Protein pcrB homolog
Length=252

 Score = 37.8 bits (87),  Expect = 0.037, Method: Composition-based stats.
 Identities = 18/67 (26%), Positives = 30/67 (44%), Gaps = 5/67 (7%)

Query  160  QKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHD  218
            Q    +M   +  ++       I V GG+  +E    A KAGA++IV GT++  A     
Sbjct  183  QPVPPEM---IGLVKRVIDVPLI-VGGGIRTEEQARAAVKAGADIIVTGTAIEKAGSVEK  238

Query  219  VISFMKE  225
                ++E
Sbjct  239  AREKLEE  245


>gi|60392352|sp|Q603K2|HIS4_METCA  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=243

 Score = 37.8 bits (87),  Expect = 0.039, Method: Composition-based stats.
 Identities = 15/48 (31%), Positives = 24/48 (50%), Gaps = 1/48 (2%)

Query  168  PKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAA  214
              +  +R   P + IQV GG+  +ETI     AG + ++ GT   +A 
Sbjct  64   ETIHAIREACPDVEIQVGGGIRDEETIQGYLNAGVDFVIIGTKAVSAP  111


>gi|109892895|sp|Q30XT2|PYRF_DESDG  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=236

 Score = 37.8 bits (87),  Expect = 0.040, Method: Composition-based stats.
 Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 0/39 (0%)

Query  192  TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            T  +AA+AG++ +V G  V  AADP      + E V + 
Sbjct  198  TPQQAARAGSDYLVVGRPVTGAADPAGAAYSIMESVRQA  236


>gi|31563079|sp|Q87UG3|HIS4_PSESM  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=245

 Score = 37.8 bits (87),  Expect = 0.040, Method: Composition-based stats.
 Identities = 19/60 (31%), Positives = 32/60 (53%), Gaps = 4/60 (6%)

Query  150  VMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGT  208
            ++ +   F GQ    D+   V  +  ++P+L IQ+ GG+   ETI    KAG + ++ GT
Sbjct  49   LVDLNGAFEGQPVNGDV---VTAIAKRYPNLPIQIGGGIRSLETIEHYIKAGVSYVIIGT  105


>gi|7388303|sp|O58878|THIE_PYRHO  Probable thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=207

 Score = 37.4 bits (86),  Expect = 0.042, Method: Composition-based stats.
 Identities = 8/46 (17%), Positives = 18/46 (39%), Gaps = 0/46 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
            GG+  E + +    G + I   ++V    D       ++  + + L
Sbjct  161  GGINLENVREVLLTGVDGIAVVSAVMGTEDVKRATEGLRRIIEEVL  206


>gi|47606178|sp|Q8FTH8|THIED_COREF  Multifunctional protein thiED [Includes: Thiamine-phosphate pyrophosphorylase 
(TMP pyrophosphorylase) (TMP-PPase) (Thiamine-phosphate 
synthase); Phosphomethylpyrimidine kinase (HMP-phosphate 
kinase) (HMP-P kinase)]
Length=739

 Score = 37.4 bits (86),  Expect = 0.045, Method: Composition-based stats.
 Identities = 7/38 (18%), Positives = 16/38 (42%), Gaps = 0/38 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            GG+G       A+ G + +   +++  A  P +    +
Sbjct  173  GGVGLANAADLARTGVDGLCVVSAIMAAPSPAEAAREL  210


>gi|7674156|sp|O26652|PCRB_METTH  Protein pcrB homolog
Length=248

 Score = 37.4 bits (86),  Expect = 0.045, Method: Composition-based stats.
 Identities = 17/59 (28%), Positives = 28/59 (47%), Gaps = 2/59 (3%)

Query  168  PKVETLRAKFPHLNIQVDGGLGK-ETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
              +  ++     + I V GG+   E   + A AGA+V+V GT V  + +  D I  + E
Sbjct  186  EMIALVKRCTDQILI-VGGGIRSGEDAARVAGAGADVVVTGTVVENSDNVEDKIREIVE  243


>gi|266599|sp|P30012|NADC_SALTY  Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Quinolinate 
phosphoribosyltransferase [decarboxylating]) (QAPRTase)
Length=297

 Score = 37.4 bits (86),  Expect = 0.052, Method: Composition-based stats.
 Identities = 21/85 (24%), Positives = 33/85 (38%), Gaps = 15/85 (17%)

Query  129  IKPGTSVDVLFELAPHLDMAL------VMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNI  182
            + P   V+V  E    LD AL      +M          F  D M   E ++       +
Sbjct  206  LHPDVPVEVEVENLDELDDALKAGADIIMLDN-------FNTDQMR--EAVKRVNGQARL  256

Query  183  QVDGGLGKETIPKAAKAGANVIVAG  207
            +V G +  ET+ + A+ G + I  G
Sbjct  257  EVSGNVTAETLREFAETGVDFISVG  281


>gi|31563185|sp|Q8TJ20|PCRB_METAC  Protein pcrB homolog
Length=247

 Score = 37.0 bits (85),  Expect = 0.056, Method: Composition-based stats.
 Identities = 17/67 (25%), Positives = 30/67 (44%), Gaps = 8/67 (11%)

Query  164  EDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAAD----PHD  218
             +M   +  ++       + V GG+   +T    A AGA++IV GT V    D      +
Sbjct  184  PEM---IGAVKKVLGENKLIVGGGVRDAKTAKLCASAGADMIVTGTIVEEVKDVAAKVAE  240

Query  219  VISFMKE  225
            ++S +K 
Sbjct  241  IVSAIKS  247


>gi|46396497|sp|Q979Y3|PDXS_THEVO  Pyridoxal biosynthesis lyase pdxS
Length=336

 Score = 37.0 bits (85),  Expect = 0.060, Method: Composition-based stats.
 Identities = 13/65 (20%), Positives = 27/65 (41%), Gaps = 1/65 (1%)

Query  163  MEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
            + D++ ++  L    P +N    G           + GA+ +  G+ +F + DP  +   
Sbjct  235  ISDILRQIRKLNRL-PVVNFAAGGVATPADGALMMELGADGVFVGSGIFKSPDPEKMAKS  293

Query  223  MKEEV  227
            + E V
Sbjct  294  IVEAV  298


>gi|91206944|sp|Q3KJI6|HIS4_PSEPF  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=245

 Score = 37.0 bits (85),  Expect = 0.062, Method: Composition-based stats.
 Identities = 22/88 (25%), Positives = 41/88 (46%), Gaps = 5/88 (5%)

Query  150  VMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGT  208
            ++ +   F GQ    ++   V  +  ++P L IQ+ GG+   ETI    KAG + ++ GT
Sbjct  49   LVDLNGAFEGQPVNGEV---VTAIAKRYPTLPIQIGGGIRSLETIEHYVKAGVSYVIIGT  105

Query  209  -SVFTAADPHDVISFMKEEVSKELRSRD  235
             +V   A   +       ++   L ++D
Sbjct  106  KAVKDPAFVAEACRAFPGKIIVGLDAKD  133


>gi|109892910|sp|Q3SRG9|PYRF_NITWN  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=240

 Score = 37.0 bits (85),  Expect = 0.064, Method: Composition-based stats.
 Identities = 15/64 (23%), Positives = 27/64 (42%), Gaps = 5/64 (7%)

Query  174  RAKFPHLNIQVDGGLG-----KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +       I+  GG         T  +A +AGA+ +V G  ++ A +P      +  E++
Sbjct  175  KLMIVSPGIRPSGGARHDQKRVATPFEAMRAGADYLVLGRPIYAADNPKAAAQAIIREMA  234

Query  229  KELR  232
              LR
Sbjct  235  DALR  238


>gi|109895142|sp|Q2RIM5|THIC1_MOOTA  Thiamine biosynthesis protein thiC 1
Length=432

 Score = 37.0 bits (85),  Expect = 0.065, Method: Composition-based stats.
 Identities = 27/128 (21%), Positives = 52/128 (40%), Gaps = 24/128 (18%)

Query  12   ASDFANLGCECHKV---INAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASN  68
            ++D+ ++  E  K+   ++AGAD     VMD      ++ G  I    R+ + R      
Sbjct  70   STDYPDIAAELEKLQVALDAGADA----VMD------LSTGGDINECRRQVIARSPATVG  119

Query  69   TEKKPTAFFD--------CHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKS  120
            T     A  +          M V++  + ++  A+ G D  T H   T   + +V+ ++ 
Sbjct  120  TVPIYQATVEAQEKYGALVKMTVDDLFRVIEMQAEDGVDFITVHCGVT---MEVVERLRR  176

Query  121  KGIKAACA  128
            +G  A   
Sbjct  177  EGRLADIV  184


>gi|7674157|sp|O58851|PCRB_PYRHO  Protein pcrB homolog
Length=254

 Score = 37.0 bits (85),  Expect = 0.068, Method: Composition-based stats.
 Identities = 16/64 (25%), Positives = 29/64 (45%), Gaps = 5/64 (7%)

Query  168  PKVETLRAKFPHLNIQVDGGLGK-ETIPKAAKAGANVIVAGTSVFTAADPHDV---ISFM  223
              V  +++      I V GG+   E   K  K+GA++IV GT++  A    +    +  +
Sbjct  190  EMVRVVKSVIDVPLI-VGGGIKSGEQAKKLIKSGADIIVTGTAIEKAKSLEEARKRLEAI  248

Query  224  KEEV  227
            +  V
Sbjct  249  RNGV  252


>gi|41018273|sp|Q7NNK8|THIE_GLOVI  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=341

 Score = 36.6 bits (84),  Expect = 0.071, Method: Composition-based stats.
 Identities = 17/87 (19%), Positives = 27/87 (31%), Gaps = 5/87 (5%)

Query  132  GTSVDVLFELAPHLDMALVMTVE--PGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLG  189
                +    +A   D   V  V   P   G+      +  V   R         + GG+ 
Sbjct  244  HAPAEAQQAVADGADYLGVGPVYATPTKQGRT--PVGLEYVRHCRESIERPGFAI-GGID  300

Query  190  KETIPKAAKAGANVIVAGTSVFTAADP  216
            +  +     AGA  I    ++  A DP
Sbjct  301  RSNLEAVIAAGAERIAVVRAIMAAEDP  327


>gi|47606110|sp|Q7NLK5|THIC_GLOVI  Thiamine biosynthesis protein thiC
Length=459

 Score = 36.6 bits (84),  Expect = 0.074, Method: Composition-based stats.
 Identities = 27/106 (25%), Positives = 41/106 (38%), Gaps = 25/106 (23%)

Query  12   ASDFANLGCECHKVI---NAGADWLHIDVMDGHFVPNITLGQPIVTSLR----RSVPRPG  64
            + + +NLG E  K+      GAD     VMD      ++ G   + ++R    ++ P P 
Sbjct  85   SPNASNLGEEVAKLELAVKYGAD----TVMD------LSTGGGDLDAIRSAIIQASPVPI  134

Query  65   DASNTEKKPTAFFDCHMMVEN--PE---KWVDDFAKCGADQFTFHY  105
                  +   A    H  VE   PE     ++  AK G D  T H 
Sbjct  135  GTVPMYQALEA---VHGNVEKLTPEHILDVIEKHAKQGVDYMTIHA  177


>gi|2499959|sp|P74301|NADC_SYNY3  Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] 
(Quinolinate phosphoribosyltransferase [decarboxylating]) 
(QAPRTase)
Length=295

 Score = 36.6 bits (84),  Expect = 0.079, Method: Composition-based stats.
 Identities = 19/115 (16%), Positives = 43/115 (37%), Gaps = 15/115 (13%)

Query  104  HYEATQDPLHLVKLIKSKGIKAACAIKPGTS--VDVLFELAPHLDMALV--MTVEPGFGG  159
            H +A       V+ ++   +    AI+  TS   +V   +A  +++ ++  M        
Sbjct  181  HIQAAGSITKAVQTLRQN-LPYPLAIEVETSNLEEVQEAIATQVEIIMLDNMGT------  233

Query  160  QKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAA  214
                + M   V+ +R   P + I+  G +    +   A  G + I +   +  + 
Sbjct  234  ----DTMATAVKLIRQANPLIRIEASGNVTLANLTAIASTGVDFISSSAPITRSP  284


>gi|13632818|sp|Q9UZN7|PCRB_PYRAB  Protein pcrB homolog
Length=252

 Score = 36.6 bits (84),  Expect = 0.079, Method: Composition-based stats.
 Identities = 17/70 (24%), Positives = 35/70 (50%), Gaps = 6/70 (8%)

Query  164  EDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
             +M   V  +++      I V GG+   + + +  KAGA++IV GT++ +     +    
Sbjct  188  PEM---VRIVKSVIDVPLI-VGGGIRTGDQVRELTKAGADIIVTGTAIESTKSIDEAKRK  243

Query  223  MKEEVSKELR  232
            + EE+ + L+
Sbjct  244  L-EEIRRGLK  252


>gi|109892889|sp|Q3MEN8|PYRF_ANAVT  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=238

 Score = 36.6 bits (84),  Expect = 0.083, Method: Composition-based stats.
 Identities = 37/165 (22%), Positives = 57/165 (34%), Gaps = 38/165 (23%)

Query  94   AKCGADQFTFHYEATQDPLHLVKLIKSKGI-KAA-------------------CAIKPGT  133
            A+ G D  T H  + +D L   K    +G  +A                     A+    
Sbjct  77   ARYGVDLMTIHATSGRDALKAAKEAVEEGAAQAGVKPSKLIAVTVLTSISARQLALDLKI  136

Query  134  SVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKE--  191
             V++       LDMAL M  E G  G         +V  LR       + V  G+     
Sbjct  137  PVELPEY---ALDMAL-MAQEVGLDGAVCSPQ---EVAQLRQICGDDFVLVCPGVRPTWA  189

Query  192  ---------TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
                     T  +A +AGA+ +V G  +  AA+P      + +E+
Sbjct  190  EAKDQKRSLTPSQAIQAGADYLVIGRPITAAAEPELAWKRIAQEL  234


>gi|73919867|sp|Q9JXF7|THIE_NEIMB  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=205

 Score = 36.6 bits (84),  Expect = 0.085, Method: Composition-based stats.
 Identities = 10/60 (16%), Positives = 22/60 (36%), Gaps = 2/60 (3%)

Query  164  EDMMPKVET-LRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
               + K+   ++       + + GG+           G + + A  +V  AA+P  V+  
Sbjct  140  PQGLDKLREYVKQAGGTPVVAI-GGIDLNNARAVLATGVSSLAAVRAVTEAANPEAVVKA  198


>gi|73919866|sp|Q9JWI2|THIE_NEIMA  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=205

 Score = 36.2 bits (83),  Expect = 0.090, Method: Composition-based stats.
 Identities = 10/60 (16%), Positives = 22/60 (36%), Gaps = 2/60 (3%)

Query  164  EDMMPKVET-LRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
               + K+   ++       + + GG+           G + + A  +V  AA+P  V+  
Sbjct  140  PQGLDKLREYVKQAGGTPVVAI-GGIDLNNARAVLATGVSSLAAVRAVTKAANPEAVVKA  198


>gi|28380179|sp|Q8KX32|TRPA_SYNP2  Tryptophan synthase alpha chain
Length=264

 Score = 36.2 bits (83),  Expect = 0.091, Method: Composition-based stats.
 Identities = 34/237 (14%), Positives = 78/237 (32%), Gaps = 36/237 (15%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D          +  AGAD++ + V    +   +  G  I  +  R++ R           
Sbjct  29   DLETTEQALKILDAAGADFIELGV---PYSDPLADGPTIQAAATRALSRGVTLEQVLAIV  85

Query  74   TAFFDCHMMVENP---------------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLI  118
                  H  +  P               + ++   A  G           ++   ++   
Sbjct  86   QR---VHGQLTAPIILFTYYNPIFYRGIDAFMAQVAAAGVKGLVIPDLPLEESQMVLDAA  142

Query  119  KSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQ-----KFMEDMMPKVET  172
             S G+     + P +  + +  +A        +++V  G  G        + +++PK+  
Sbjct  143  TSHGLDLILLVAPTSPTERIEAIAKASQGFIYLVSVT-GVTGARTSVASRVGELLPKLRQ  201

Query  173  LRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFT---AADPHDVISFMKE  225
            +  K     I V  G+       +  + GA+ ++ G++V        P + ++ +KE
Sbjct  202  VTDK----PIGVGFGVSDPAQARQLKEWGADGVIVGSAVVKRLATGTPAEGLAAVKE  254


>gi|2501410|sp|P77960|TRPA_SYNY3  Tryptophan synthase alpha chain
Length=264

 Score = 36.2 bits (83),  Expect = 0.093, Method: Composition-based stats.
 Identities = 35/225 (15%), Positives = 70/225 (31%), Gaps = 47/225 (20%)

Query  14   DFANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKP  73
            D A        +  AGAD + + V    +   +  G  I  +  R++ +     +     
Sbjct  29   DLATTAEALRILDRAGADLIELGV---PYSDPLADGPVIQAAATRALQKGVKLDDVLAIV  85

Query  74   TAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGT  133
                + H  +  P      +                     +  IK+ G+K    + P  
Sbjct  86   R---EVHQDIAAPIILFTYYNPIFYQGVEV----------FLDKIKAAGVK-GLVV-PDL  130

Query  134  SVDVLFELAPH-----LDMALVM--TVEP------GFGGQKFM------------EDMMP  168
             ++    L        L++ L++  T  P          Q F+             ++  
Sbjct  131  PLEESDRLLEATAERGLELILLVAPTSSPERQTAIAKKSQGFVYLVSVTGVTGVRTEVGS  190

Query  169  KVETLRAKFPHLN---IQVDGGLG-KETIPKAAKAGANVIVAGTS  209
            +VE L A    +    I V  G+   E   +    GA+ ++ G++
Sbjct  191  RVEALLAGMRQVTDKPIGVGFGISQPEQAEQVKAWGADAVIVGSA  235


>gi|14423983|sp|Q9V1G9|TRPA_PYRAB  Tryptophan synthase alpha chain
Length=248

 Score = 36.2 bits (83),  Expect = 0.093, Method: Composition-based stats.
 Identities = 28/183 (15%), Positives = 61/183 (33%), Gaps = 14/183 (7%)

Query  52   IVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDP  111
            IV   R+    P             F   +      +++      G D            
Sbjct  71   IVREFRKHSDVPIVLMTYYN---PVFRVGL-----REFIGKAKDSGVDGMLIVDLPVMHA  122

Query  112  LHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL--DMALVMTVEPGFGGQKFMEDMMPK  169
               +++ + +GIK      P T  + L E+          ++++    G +  + +    
Sbjct  123  SEFLEVAREEGIKTVFLAAPNTPDERLKEI-DKASTGFVYLISLYGTTGARDKIPETAFN  181

Query  170  VETLRAKFPHLNIQVDGGLGK-ETIPKAAKAGANVIVAGTSVFT--AADPHDVISFMKEE  226
            +     +     + V  G+ K E +     AGAN +V G+++    A    +    ++E+
Sbjct  182  LLKRAKRICKNKVAVGFGVSKREHVEMLLNAGANGVVVGSALINIIAEHGENAEEKLREK  241

Query  227  VSK  229
            V +
Sbjct  242  VRE  244


>gi|31563181|sp|Q8PYC0|PCRB_METMA  Protein pcrB homolog
Length=247

 Score = 35.8 bits (82),  Expect = 0.12, Method: Composition-based stats.
 Identities = 17/67 (25%), Positives = 29/67 (43%), Gaps = 8/67 (11%)

Query  163  MEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAAD----PH  217
              +M   +  ++       + V GG+   ET      AGA++IV GT V    D      
Sbjct  183  NPEM---IGAVKQVLGENKLIVGGGIRNAETAKICTSAGADMIVTGTVVEEVKDVTAKVA  239

Query  218  DVISFMK  224
            +++S +K
Sbjct  240  EIVSAIK  246


>gi|54039721|sp|P66917|THIE_MYCBO  Probable thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
 gi|54042245|sp|P66916|THIE_MYCTU  Probable thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=222

 Score = 35.8 bits (82),  Expect = 0.12, Method: Composition-based stats.
 Identities = 11/45 (24%), Positives = 21/45 (46%), Gaps = 0/45 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            GG+  + +P    AGA  IV   ++ +A DP      ++  ++  
Sbjct  177  GGINAQRLPAVLDAGARRIVVVRAITSADDPRAAAEQLRSALTAA  221


>gi|28201902|sp|Q8KD79|THIE_CHLTE  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=204

 Score = 35.5 bits (81),  Expect = 0.17, Method: Composition-based stats.
 Identities = 10/44 (22%), Positives = 21/44 (47%), Gaps = 0/44 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSK  229
            GG+G +   +  +AGA+ I   ++V  + DP      +   + +
Sbjct  161  GGIGHDNAAEVIRAGASGIAVISAVSDSDDPETATRELVRRIRQ  204


>gi|46396466|sp|Q8RDP7|PDXS_FUSNN  Pyridoxal biosynthesis lyase pdxS
Length=280

 Score = 35.5 bits (81),  Expect = 0.17, Method: Composition-based stats.
 Identities = 10/43 (23%), Positives = 18/43 (41%), Gaps = 1/43 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            GG+          + GA+ +  G+ +F + DP      + E V
Sbjct  201  GGVATPADAALMRRLGADGVFVGSGIFKSGDPKKRAKAIVEAV  243


>gi|71153612|sp|Q57FG5|THIG_BRUAB  Thiazole biosynthesis protein thiG
 gi|115305845|sp|Q2YP58|THIG_BRUA2  Thiazole biosynthesis protein thiG
Length=256

 Score = 35.5 bits (81),  Expect = 0.18, Method: Composition-based stats.
 Identities = 16/48 (33%), Positives = 27/48 (56%), Gaps = 1/48 (2%)

Query  170  VETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTAADP  216
            ++T+RA FP + + VD G+G       A + G + ++  T+V  A DP
Sbjct  168  LKTMRAHFPDIPLVVDAGIGVPSHAAAAMELGFDAVLINTAVAKAGDP  215


>gi|32130187|sp|Q8G2U9|THIG_BRUSU  Thiazole biosynthesis protein thiG
Length=256

 Score = 35.5 bits (81),  Expect = 0.18, Method: Composition-based stats.
 Identities = 16/48 (33%), Positives = 27/48 (56%), Gaps = 1/48 (2%)

Query  170  VETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTAADP  216
            ++T+RA FP + + VD G+G       A + G + ++  T+V  A DP
Sbjct  168  LKTMRAHFPDIPLVVDAGIGVPSHAAAAMELGFDAVLINTAVAKAGDP  215


>gi|29337046|sp|Q8DLZ2|THIC_SYNEL  Thiamine biosynthesis protein thiC
Length=461

 Score = 35.5 bits (81),  Expect = 0.18, Method: Composition-based stats.
 Identities = 23/106 (21%), Positives = 40/106 (37%), Gaps = 25/106 (23%)

Query  12   ASDFANLGCECHKV---INAGADWLHIDVMDGHFVPNITLGQPIVTSLR----RSVPRPG  64
            + + +NL  E  K+   +  GAD     VMD      ++ G   + ++R     + P P 
Sbjct  85   SPNSSNLEEELAKLRLAVKYGAD----TVMD------LSTGGGDLDAIRTAIINASPVPI  134

Query  65   DASNTEKKPTAFFDCHMMVEN--PEKW---VDDFAKCGADQFTFHY  105
                  +        H  VE   P+ +   ++  A+ G D  T H 
Sbjct  135  GTVPVYQALE---SVHGSVERLTPDDFLHVIEKHAQQGVDYMTIHA  177


>gi|32130192|sp|Q8YEZ2|THIG_BRUME  Thiazole biosynthesis protein thiG
Length=256

 Score = 35.5 bits (81),  Expect = 0.18, Method: Composition-based stats.
 Identities = 16/48 (33%), Positives = 27/48 (56%), Gaps = 1/48 (2%)

Query  170  VETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTAADP  216
            ++T+RA FP + + VD G+G       A + G + ++  T+V  A DP
Sbjct  168  LKTMRAHFPDIPLVVDAGIGVPSHAAAAMELGFDAVLINTAVAKAGDP  215


>gi|41018323|sp|Q82AF9|THIE_STRAW  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=215

 Score = 35.5 bits (81),  Expect = 0.19, Method: Composition-based stats.
 Identities = 9/45 (20%), Positives = 18/45 (40%), Gaps = 0/45 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            GG+    + +  +AGA  +V   ++  A DP        + +   
Sbjct  171  GGIDLGNLDEVLEAGARRVVVVRAITEADDPKAAAEEFAKRLRHA  215


>gi|73919865|sp|Q5F5C2|THIE_NEIG1  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=205

 Score = 35.1 bits (80),  Expect = 0.20, Method: Composition-based stats.
 Identities = 15/82 (18%), Positives = 27/82 (32%), Gaps = 13/82 (15%)

Query  153  VEPGF--GGQKFM---------EDMMPKVET-LRAKFPHLNIQVDGGLGKETIPKAAKAG  200
            V PG+   G  F             + K+   +        + + GG+           G
Sbjct  118  VHPGYIASGAIFQTTTKQMPTAPQGLDKLREYVEQARGTPVVAI-GGIDLNNARAVLATG  176

Query  201  ANVIVAGTSVFTAADPHDVISF  222
             + + A  +V  AA+P  V+  
Sbjct  177  VSSLAAVRAVTEAANPEAVVKA  198


>gi|3122421|sp|O27860|NADC_METTH  Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] 
(Quinolinate phosphoribosyltransferase [decarboxylating]) 
(QAPRTase)
Length=279

 Score = 35.1 bits (80),  Expect = 0.20, Method: Composition-based stats.
 Identities = 15/78 (19%), Positives = 31/78 (39%), Gaps = 10/78 (12%)

Query  132  GTSVDVLFELAPHLDMALV--MTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLG  189
             +  D +       D+ L+  M+ E        + + + ++E  R    ++ ++  GG+ 
Sbjct  191  ESPDDAVRAAEAGADIVLLDNMSPET-------IRNTLEELER-RGLRDNVIVEASGGIK  242

Query  190  KETIPKAAKAGANVIVAG  207
             + I   A  G  VI  G
Sbjct  243  PDNIELYASTGVEVISMG  260


>gi|81819014|sp|Q5FNS8|PYRF_GLUOX  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=236

 Score = 35.1 bits (80),  Expect = 0.21, Method: Composition-based stats.
 Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 0/39 (0%)

Query  192  TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            T  +AA+AGA+ IV G  +  AADP      + EE++  
Sbjct  198  TPGQAAQAGADWIVVGRPITKAADPVLAARAIMEELASA  236


>gi|46396555|sp|Q9WYU4|PDXS_THEMA  Pyridoxal biosynthesis lyase pdxS
Length=293

 Score = 35.1 bits (80),  Expect = 0.21, Method: Composition-based stats.
 Identities = 20/120 (16%), Positives = 42/120 (35%), Gaps = 4/120 (3%)

Query  106  EATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMED  165
            EA +       +I++KG +A        +V  +  +   +     M  E      K +  
Sbjct  135  EALRRIAEGAAMIRTKG-EAGTG-NVVEAVKHMRRVMEQIKQVTKMEDEELVAYGKEIGA  192

Query  166  MMPKVETLRA--KFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
             +  +  ++   + P +N    G             GA+ +  G+ +F + DP  +   M
Sbjct  193  PVELLREVKRLGRLPVVNFAAGGVATPADAALMMMLGADGVFVGSGIFKSKDPRKMAKAM  252


>gi|81883012|sp|Q5I0M2|NADC_RAT  Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Quinolinate 
phosphoribosyltransferase [decarboxylating]) (QAPRTase) 
(QPRTase)
Length=299

 Score = 35.1 bits (80),  Expect = 0.21, Method: Composition-based stats.
 Identities = 20/87 (22%), Positives = 38/87 (43%), Gaps = 12/87 (13%)

Query  125  AACAIKPGTSVDVLFELAPHL----DMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHL  180
            A   +K       L E         D+ ++   +P        E++ P   TL+AKFP++
Sbjct  192  AGFPLKVEVECSSLKEALQAAEAGADLVMLDNFKP--------EELHPTAATLKAKFPNV  243

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAG  207
            +++  GG+  + +P+      +VI  G
Sbjct  244  SVEASGGVTLDNLPQFCGTNIDVISLG  270


>gi|91206953|sp|Q31E65|HIS4_THICR  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=246

 Score = 35.1 bits (80),  Expect = 0.22, Method: Composition-based stats.
 Identities = 19/68 (27%), Positives = 30/68 (44%), Gaps = 2/68 (2%)

Query  170  VETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGT-SVFTAADPHDVISFMKEEV  227
            V  +R  FP L IQ+ GG+   ETI    KAG +  + GT +V       +        +
Sbjct  66   VYQVREAFPDLPIQIGGGIRDLETIEAYLKAGVSYCIIGTKAVHNPEFVAEACKAFPGHI  125

Query  228  SKELRSRD  235
               L +++
Sbjct  126  MVGLDAKE  133


>gi|3122422|sp|O28439|NADC_ARCFU  Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] 
(Quinolinate phosphoribosyltransferase [decarboxylating]) 
(QAPRTase)
Length=258

 Score = 35.1 bits (80),  Expect = 0.22, Method: Composition-based stats.
 Identities = 14/49 (28%), Positives = 24/49 (48%), Gaps = 3/49 (6%)

Query  162  FMEDMM-PKVETLRAKFP--HLNIQVDGGLGKETIPKAAKAGANVIVAG  207
            F  +M+   VE LR +     + I+V G +  E + + A    +VI +G
Sbjct  193  FTPEMVAEAVEELRRRGLREKVIIEVSGSVTPENVAEFAAMDVDVISSG  241


>gi|73920136|sp|Q8TVJ8|TRPC_METKA  Indole-3-glycerol phosphate synthase (IGPS)
Length=254

 Score = 35.1 bits (80),  Expect = 0.22, Method: Composition-based stats.
 Identities = 30/196 (15%), Positives = 61/196 (31%), Gaps = 51/196 (26%)

Query  50   QPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGAD-QFTFHYEAT  108
               V  +R +V  P    +             +++  +  V++ A  GAD          
Sbjct  90   PEYVEVVREAVDVPVLRKD------------FIIDPVQ--VEESAHYGADAVLIIAAAVG  135

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMP  168
            ++   L+ L    G++    I     +++L E  P +                       
Sbjct  136  REAPELIDLAHEHGMEVLLEIDRWEHLELLSECDPDVVGV--------------------  175

Query  169  KVETLRAKFPHLN--IQVDGGLG-KETIPKAAKAG-------------ANVIVAGTSVFT  212
                LR     LN  +++   +      P  A++G             A+ ++ GT +  
Sbjct  176  NNRDLRTLEVDLNRTLELGPEVKDLTNAPLVAESGVSGPEDVVLLGEVADAVLVGTYLMR  235

Query  213  AADPHDVISFMKEEVS  228
            A DP + +  + E   
Sbjct  236  APDPSEAVRKLVEAGR  251


>gi|47606070|sp|P61422|THIED_GEOSL  Bifunctional thiED protein [Includes: Thiamine-phosphate pyrophosphorylase 
(TMP pyrophosphorylase) (TMP-PPase) (Thiamine-phosphate 
synthase); Phosphomethylpyrimidine kinase (HMP-phosphate 
kinase) (HMP-P kinase)]
Length=490

 Score = 35.1 bits (80),  Expect = 0.24, Method: Composition-based stats.
 Identities = 10/54 (18%), Positives = 24/54 (44%), Gaps = 1/54 (1%)

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            +  +R+    + I   GG+ ++       AGA+ +   ++V +  DP    + +
Sbjct  161  LAAIRSSI-SIPIVAIGGITRDNGASVIDAGADAVAVISAVLSHPDPALAATEI  213


>gi|109892905|sp|Q46GE2|PYRF_METBF  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=221

 Score = 35.1 bits (80),  Expect = 0.24, Method: Composition-based stats.
 Identities = 13/67 (19%), Positives = 28/67 (41%), Gaps = 2/67 (2%)

Query  168  PKVETLRAKFPHLNIQVDGGLGKE--TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
             +V T+R    +    +  G+G +         AGA+ ++ G +++ A  P +    +  
Sbjct  152  ERVTTIRKIIGNKLTIISPGVGAQGGKASDVIAAGADWVIVGRAIYKAESPREAARKIAA  211

Query  226  EVSKELR  232
            E+  E  
Sbjct  212  EIEAEFE  218


>gi|24212484|sp|Q8TMD6|THIE_METAC  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=228

 Score = 35.1 bits (80),  Expect = 0.26, Method: Composition-based stats.
 Identities = 11/67 (16%), Positives = 28/67 (41%), Gaps = 8/67 (11%)

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPH-------DVISF  222
            ++ ++       + + GG+ +E      + GA+  VA ++V  + D         ++I  
Sbjct  163  IKEVKNAIKIPVVAI-GGINRENCIPVVENGADSFVAISAVVCSDDVKRETRKFIEIIRE  221

Query  223  MKEEVSK  229
            +K    +
Sbjct  222  IKNSGRQ  228


>gi|7388298|sp|O30259|THIC_ARCFU  Probable thiamine biosynthesis protein thiC
Length=425

 Score = 34.7 bits (79),  Expect = 0.26, Method: Composition-based stats.
 Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 19/102 (18%)

Query  12   ASDFANLGCECHKVI---NAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSV-PRPGDAS  67
            ++D+ N+  E  K I    AGAD     VMD      ++ G   + ++R+ +        
Sbjct  70   SADYINVEEEVEKAIIAQKAGADA----VMD------LSSG-GDLDAIRKRIMEVVEVPF  118

Query  68   NTEKKPTAFFDCHMMVENPE----KWVDDFAKCGADQFTFHY  105
             T     A  DCH +V+  E    + V+  AK G D  T H 
Sbjct  119  GTVPIYQAARDCHRVVDMDEDDFFRVVEKHAKDGVDFMTIHA  160


>gi|25453444|sp|O50316|IMDH_CHLVI  Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) 
(IMPD)
Length=493

 Score = 34.7 bits (79),  Expect = 0.26, Method: Composition-based stats.
 Identities = 33/149 (22%), Positives = 50/149 (33%), Gaps = 25/149 (16%)

Query  90   VDDFAKCGADQFTF-----HYEATQDPLHLVKL-IKSKGIKAACAIKPGTSVDVLFELAP  143
            VD   + G D         H +A  D +  +K       + A       T   V   +  
Sbjct  237  VDALVEAGVDVVAVDTAHGHSQAVLDMVATIKEKYPELEVIAG---NVATPEAVRDLVKA  293

Query  144  HLDMALVMTVEPG---------FGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKE-TI  193
              D   V  + PG           G   +  +M   +   A      I  DGG+     I
Sbjct  294  GADAVKV-GIGPGSICTTRVVAGVGMPQLTAIMNCAKE--AAKTDTPIIADGGIKYSGDI  350

Query  194  PKAAKAGANVIVAGTSVFTAAD--PHDVI  220
             KA  AGA+ ++ G+ +F   D  P + I
Sbjct  351  SKALAAGADTVMMGS-IFAGTDESPGETI  378


>gi|109895163|sp|Q3Z8E2|THIC_DEHE1  Thiamine biosynthesis protein thiC
Length=431

 Score = 34.7 bits (79),  Expect = 0.27, Method: Composition-based stats.
 Identities = 27/128 (21%), Positives = 47/128 (36%), Gaps = 27/128 (21%)

Query  12   ASDFANLGCECHKV---INAGADWLHIDVMDGHFVPNITLGQPI---VTSLRRSVPRPGD  65
            ++DF  +  E  K+     AGAD +    MD      ++ G  I     S+ ++   P  
Sbjct  70   STDFGTVESEVEKLKMAEMAGADTI----MD------LSTGPKINSVRQSILKNTCLPLG  119

Query  66   ASNTEKKPTAFFDCH-MMVE-NPEKW---VDDFAKCGADQFTFHYEATQDPLHL------  114
                 +      D +  MV+   +     ++  AK G D  T H   T+  +        
Sbjct  120  TVPVYQAAVEAKDRYGAMVKMTADDLFSAIESQAKEGVDFVTVHCGVTRQVIDTFKGQGR  179

Query  115  VKLIKSKG  122
            +  I S+G
Sbjct  180  LTDIVSRG  187


>gi|34222881|sp|Q8ESZ3|THIE_OCEIH  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=206

 Score = 34.7 bits (79),  Expect = 0.27, Method: Composition-based stats.
 Identities = 8/44 (18%), Positives = 23/44 (52%), Gaps = 0/44 (0%)

Query  167  MPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSV  210
            +  +++L+ + P L +   GG+      +  +AGA+ +   +++
Sbjct  150  LEWIQSLKKQHPSLPLVAIGGINTTNAQEIIQAGADGVSFISAI  193


>gi|13638600|sp|O07145|PDXS_MYCLE  Pyridoxal biosynthesis lyase pdxS
Length=307

 Score = 34.7 bits (79),  Expect = 0.30, Method: Composition-based stats.
 Identities = 11/55 (20%), Positives = 22/55 (40%), Gaps = 1/55 (1%)

Query  170  VETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            +E  R     + +   GG+          + GA  I  G+ +F ++DP    + +
Sbjct  210  IEVARTNKLPVTLFTAGGIATPADAAMMMQLGAEGIFVGSGIFKSSDPAQRAAAI  264


>gi|2842608|sp|Q58927|HIS4_METJA  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=237

 Score = 34.7 bits (79),  Expect = 0.30, Method: Composition-based stats.
 Identities = 37/232 (15%), Positives = 77/232 (33%), Gaps = 54/232 (23%)

Query  20   CECHKVINAGADWLHIDVMDGHFVPNITLGQP----IVTSLRRSVPRPGDASNTEKKPTA  75
                K ++ GA++LHI  +D         G      ++ ++ + V  P +     +    
Sbjct  34   EVAKKFVDEGAEYLHIIDLDA------AFGTGNNRDVIKNIIKEVNVPVEVGGGIRNL--  85

Query  76   FFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKG---------IKAA  126
                        +   +    G D+     +A  +P  +  L K  G          K  
Sbjct  86   ------------EIAKELISLGVDRVIVGTKAILEPKFIDDLNKEIGKDKIVLAVECKEG  133

Query  127  -CAIK------PGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMP--KVETLRAKF  177
               IK        T ++V+ E    +   L   V+        +E ++    V+ ++   
Sbjct  134  KVVIKGWKEKVDKTPIEVIKEFEDKVGYILFTNVD--------VEGLLKGINVDIIKELI  185

Query  178  PHLNIQV--DGGL-GKETIPKAAKAGANVIVAGTSVF-TAADPHDVISFMKE  225
               +I +   GG+   E I    + G   +V G++++    D    +  +K 
Sbjct  186  EKTDIPIIYSGGITTLEDIKALKELGIYGVVIGSALYKGLIDLKKALEIVKN  237


>gi|7388302|sp|O34294|THIE_RHIET  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=204

 Score = 34.7 bits (79),  Expect = 0.31, Method: Composition-based stats.
 Identities = 23/134 (17%), Positives = 46/134 (34%), Gaps = 9/134 (6%)

Query  89   WVDDF----AKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPH  144
             ++D+       G D    H          +  I+  G+K   +    + ++     AP 
Sbjct  58   IINDYWRLAIDEGCDFI--HLGQEDLMAADLAAIRRAGLKLGLSTHDPSELETALAAAP-  114

Query  145  LDMALVMTVEPGFGGQ-KFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANV  203
             D   +  V P    + K+    + ++   R +   + +   GG+  E  P   + GA+ 
Sbjct  115  -DYVALGPVWPTILKEMKWAPQGVERLADWRRRVGPMPLVAIGGITAERAPLVLENGADS  173

Query  204  IVAGTSVFTAADPH  217
                T +    DP 
Sbjct  174  AAVVTDITRNPDPE  187


>gi|71153600|sp|Q8YRC9|THIG_ANASP  Bifunctional goxB/thiG protein [Includes: Glycine oxidase ; Thiazole 
biosynthesis protein thiG]
Length=652

 Score = 34.7 bits (79),  Expect = 0.31, Method: Composition-based stats.
 Identities = 23/118 (19%), Positives = 49/118 (41%), Gaps = 7/118 (5%)

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDV-LFELAPHLDMALVMTV-EPGFGGQKFMEDM  166
             DP+  ++  +   +K   A+ P  + D  L +    +  A VM +  P   GQ      
Sbjct  506  PDPIGTLQAAEQL-VKEGFAVLPYINADPMLAKHLEDVGCATVMPLASPIGSGQGL--KT  562

Query  167  MPKVETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
               ++ +      + + VD G+G      +A + GA+ ++  +++  A +P  +   M
Sbjct  563  TANIQIIIEN-AKIPVVVDAGIGAPSEASQAMELGADALLINSAIALAQNPAAMAQAM  619


>gi|91207268|sp|Q46EN8|PCRB_METBF  Protein pcrB homolog
Length=247

 Score = 34.7 bits (79),  Expect = 0.32, Method: Composition-based stats.
 Identities = 16/67 (23%), Positives = 29/67 (43%), Gaps = 8/67 (11%)

Query  163  MEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAAD----PH  217
              +M   +  ++       + V GG+   E     A AGA++IV GT +    D      
Sbjct  183  NPEM---IGAVKKVLGENKLIVGGGIRDAEAAKLCASAGADMIVTGTVLEEVRDVTAKVA  239

Query  218  DVISFMK  224
            +++S +K
Sbjct  240  ELVSAIK  246


>gi|46396517|sp|Q9HKS5|PDXS_THEAC  Pyridoxal biosynthesis lyase pdxS
Length=336

 Score = 34.7 bits (79),  Expect = 0.33, Method: Composition-based stats.
 Identities = 13/72 (18%), Positives = 30/72 (41%), Gaps = 3/72 (4%)

Query  159  GQKFME-DMMPKVETLRAKF--PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAAD  215
            G+  +E +++  +  +R     P +N    G           + GA+ +  G+ +F + +
Sbjct  227  GRSRIEREILAILRQIRRMGRLPVVNFAAGGVATPADGALMMELGADGVFVGSGIFKSPN  286

Query  216  PHDVISFMKEEV  227
            P  +   + E V
Sbjct  287  PEKMARSIVEAV  298


>gi|115305844|sp|Q3M859|THIG_ANAVT  Bifunctional goxB/thiG protein [Includes: Glycine oxidase ; Thiazole 
biosynthesis protein thiG]
Length=652

 Score = 34.3 bits (78),  Expect = 0.36, Method: Composition-based stats.
 Identities = 23/118 (19%), Positives = 49/118 (41%), Gaps = 7/118 (5%)

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDV-LFELAPHLDMALVMTV-EPGFGGQKFMEDM  166
             DP+  ++  +   +K   A+ P  + D  L +    +  A VM +  P   GQ      
Sbjct  506  PDPIGTLQAAEQL-VKEGFAVLPYINADPMLAKRLEDVGCATVMPLASPIGSGQGL--KT  562

Query  167  MPKVETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
               ++ +      + + VD G+G      +A + GA+ ++  +++  A +P  +   M
Sbjct  563  TANIQIIIEN-AKIPVVVDAGIGAPSEASQAMELGADALLINSAIALAQNPAAMAQAM  619


>gi|20139694|sp|Q9C131|PYRF_PARBR  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase) (Uridine 5'-monophosphate synthase) (UMP 
synthase)
Length=285

 Score = 34.3 bits (78),  Expect = 0.36, Method: Composition-based stats.
 Identities = 12/39 (30%), Positives = 21/39 (53%), Gaps = 0/39 (0%)

Query  196  AAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            A + GA+ I++G  ++ A DP + +   +EE  K    R
Sbjct  241  AVERGADFIISGRGIYAAEDPLEAVLRYREEGWKAYLER  279


>gi|136295|sp|P26939|TRPC_METTM  Indole-3-glycerol phosphate synthase (IGPS)
Length=274

 Score = 34.3 bits (78),  Expect = 0.36, Method: Composition-based stats.
 Identities = 16/63 (25%), Positives = 29/63 (46%), Gaps = 2/63 (3%)

Query  167  MPKVETLRAKFPH--LNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMK  224
            + +   L    P   L +   G +G E     A  GA+ ++ GTS+  A+DP +++  + 
Sbjct  192  LERTRALAPLVPDELLLVSESGVMGPEDAEILAGCGADALLIGTSLMLASDPRELLDEIM  251

Query  225  EEV  227
              V
Sbjct  252  AAV  254


>gi|38258653|sp|Q9RGS5|THIE_STACA  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=212

 Score = 34.3 bits (78),  Expect = 0.37, Method: Composition-based stats.
 Identities = 11/51 (21%), Positives = 25/51 (49%), Gaps = 0/51 (0%)

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVI  220
            +ETLR +   L I   GG+  + + + AK  A+ +   +++  +    + +
Sbjct  154  IETLRKEVGDLPIVAIGGISLDNVQEVAKTSADGVSVISAIARSPHVTETV  204


>gi|52000710|sp|Q7RXQ8|HIS4_NEUCR  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase) (5-proFAR 
isomerase)
Length=257

 Score = 34.3 bits (78),  Expect = 0.37, Method: Composition-based stats.
 Identities = 8/31 (25%), Positives = 16/31 (51%), Gaps = 0/31 (0%)

Query  181  NIQVDGGLGKETIPKAAKAGANVIVAGTSVF  211
             +QV GG+      +  +AGA  ++  + +F
Sbjct  78   GLQVGGGITDANAREWVEAGAEKVIITSYLF  108


>gi|13633979|sp|Q9HIQ4|THIE_THEAC  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=213

 Score = 34.3 bits (78),  Expect = 0.37, Method: Composition-based stats.
 Identities = 10/53 (18%), Positives = 23/53 (43%), Gaps = 0/53 (0%)

Query  175  AKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
             K+  + + V GG+    I   +  G + +   +++F+  DP      +K  +
Sbjct  153  HKYIRIPVFVIGGINISNIRTFSGYGIDGVAVVSAIFSDPDPERAARELKAAL  205


>gi|20455000|sp|Q9HU43|HIS4_PSEAE  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=245

 Score = 34.3 bits (78),  Expect = 0.37, Method: Composition-based stats.
 Identities = 17/68 (25%), Positives = 31/68 (45%), Gaps = 2/68 (2%)

Query  170  VETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAAD-PHDVISFMKEEV  227
            V  +  ++P L IQ+ GG+   ETI    +AG + ++ GT      +   +       +V
Sbjct  66   VTAIARRYPDLPIQIGGGIRSLETIEHYVRAGVSYVIIGTKAVKQPEFVGEACRAFPGKV  125

Query  228  SKELRSRD  235
               L ++D
Sbjct  126  IVGLDAKD  133


>gi|116256185|sp|Q31JD2|THIG_THICR  Thiazole biosynthesis protein thiG
Length=273

 Score = 34.3 bits (78),  Expect = 0.38, Method: Composition-based stats.
 Identities = 15/60 (25%), Positives = 28/60 (46%), Gaps = 1/60 (1%)

Query  169  KVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
             +  +R +FP L + VD G+       +A + G N I+  ++V  + +P  +    K  V
Sbjct  181  NLNAIRQRFPELTLIVDAGIGKPSHAVQALEMGYNGILLNSAVALSPNPITMGKAFKSAV  240


>gi|71153649|sp|Q7M9F6|THIG_WOLSU  Thiazole biosynthesis protein thiG
Length=260

 Score = 34.3 bits (78),  Expect = 0.38, Method: Composition-based stats.
 Identities = 16/66 (24%), Positives = 31/66 (46%), Gaps = 2/66 (3%)

Query  169  KVETLRAKFPHLNIQVDGGLGKET-IPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
             V  ++       I VD G+G  +    A + GA+ ++  T++  A +P  + S M++ V
Sbjct  172  NVVFIKEAIKVPLI-VDAGVGCASDAAIAMELGADAVLTNTAIAQAQNPILMASAMRDAV  230

Query  228  SKELRS  233
                +S
Sbjct  231  RAGRQS  236


>gi|18266773|sp|O34293|THIG_RHIET  Thiazole biosynthesis protein thiG
Length=257

 Score = 34.3 bits (78),  Expect = 0.38, Method: Composition-based stats.
 Identities = 14/48 (29%), Positives = 23/48 (47%), Gaps = 1/48 (2%)

Query  170  VETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTAADP  216
            +   RA FP + + VD G+G         + G + ++  T+V  A DP
Sbjct  168  LRAFRAHFPDVPLIVDAGVGRPSHAAAVMEYGYDAVLLNTAVAGAGDP  215


>gi|47606160|sp|Q88DP1|THIE_PSEPK  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=207

 Score = 34.3 bits (78),  Expect = 0.39, Method: Composition-based stats.
 Identities = 13/55 (23%), Positives = 23/55 (41%), Gaps = 1/55 (1%)

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMK  224
            +E  RA+   L I V GG+  +        GA+++     +F A    +V    +
Sbjct  146  LEQARAQ-VKLPIAVIGGITLDNAAPLVAHGADLLAVIHGLFGADSAQEVTRRAR  199


>gi|71153634|sp|Q7V9K9|THIG_PROMA  Thiazole biosynthesis protein thiG
Length=271

 Score = 34.3 bits (78),  Expect = 0.39, Method: Composition-based stats.
 Identities = 11/41 (26%), Positives = 21/41 (51%), Gaps = 1/41 (2%)

Query  184  VDGGLG-KETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            VD G+G      +A + GA+ ++  +++  A DP  +   M
Sbjct  193  VDAGIGVPSHAAEAMEMGADAVLINSAIALAKDPKSMAEGM  233


>gi|2495435|sp|Q58842|FAEHP_METJA  Fae/hps bifunctional enzyme [Includes: Formaldehyde-activating 
enzyme (Fae); 3-hexulose-6-phosphate synthase (HPS) (D-arabino-3-hexulose-6-phosphate 
formaldehyde lyase)]
Length=381

 Score = 34.3 bits (78),  Expect = 0.40, Method: Composition-based stats.
 Identities = 10/43 (23%), Positives = 22/43 (51%), Gaps = 1/43 (2%)

Query  179  HLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVIS  221
            +  + + GG+G E + +  K    +++ G ++  + DP  VI 
Sbjct  313  NCLLAIAGGVGVENVEELLKE-YQILIVGRAITKSKDPGRVIR  354


>gi|3123067|sp|O29742|PDXS_ARCFU  Pyridoxal biosynthesis lyase pdxS
Length=336

 Score = 34.3 bits (78),  Expect = 0.40, Method: Composition-based stats.
 Identities = 9/43 (20%), Positives = 20/43 (46%), Gaps = 1/43 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            GG+          + GA+ +  G+ +F +++P +    + E V
Sbjct  255  GGVATPADAALMMQLGADGVFVGSGIFKSSNPPEYAKAIVEAV  297


>gi|31563210|sp|Q97AR4|PCRB_THEVO  Protein pcrB homolog
Length=252

 Score = 34.3 bits (78),  Expect = 0.41, Method: Composition-based stats.
 Identities = 14/55 (25%), Positives = 31/55 (56%), Gaps = 2/55 (3%)

Query  170  VETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            +  +++K  ++ + V GG+   ET  + A AGA++IV G+    + + + V+  +
Sbjct  186  ISYVKSKI-NIPLIVGGGIRDPETAMRIALAGADMIVTGSIAEKSNNVYSVLRNI  239


>gi|135587|sp|P25053|TENI_BACSU  Regulatory protein tenI
Length=205

 Score = 34.3 bits (78),  Expect = 0.41, Method: Composition-based stats.
 Identities = 11/67 (16%), Positives = 31/67 (46%), Gaps = 1/67 (1%)

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSK  229
            +  ++ +     I + GG+  + +    +AGA+ I   + +F++A+P +       ++ +
Sbjct  140  LSDIKQRISIPVIAI-GGMTPDRLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKE  198

Query  230  ELRSRDL  236
                + L
Sbjct  199  MRYEKAL  205


>gi|32130190|sp|Q8UCD2|THIG_AGRT5  Thiazole biosynthesis protein thiG
Length=257

 Score = 34.3 bits (78),  Expect = 0.41, Method: Composition-based stats.
 Identities = 17/78 (21%), Positives = 35/78 (44%), Gaps = 5/78 (6%)

Query  159  GQKFMEDMMPKVETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTAADPH  217
            G       +  ++++RA+FP + + VD G+G         + G + ++  T+V  A DP 
Sbjct  157  GSAMGPLNLTALKSMRARFPEVPLIVDAGIGRPSHAVTVMELGYDAVLLNTAVAGAGDPV  216

Query  218  DVISFMKEEVSKELRSRD  235
                 M E  ++ + +  
Sbjct  217  ----GMAEAFARAIEAGH  230


>gi|586720|sp|P37678|SGBH_ECOLI  3-keto-L-gulonate-6-phosphate decarboxylase sgbH (3-dehydro-L-gulonate-6-phosphate 
decarboxylase) (KGPDC)
Length=220

 Score = 34.3 bits (78),  Expect = 0.43, Method: Composition-based stats.
 Identities = 15/62 (24%), Positives = 28/62 (45%), Gaps = 2/62 (3%)

Query  158  GGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPH  217
             GQ++ E  + +++ L      L+I   GG+    +P          +AG ++  AA+P 
Sbjct  144  SGQQWGEADLARMKALSDIGLELSIT--GGITPADLPLFKDIRVKAFIAGRALAGAANPA  201

Query  218  DV  219
             V
Sbjct  202  QV  203


>gi|41018295|sp|Q7V8I3|THIE_PROMM  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=353

 Score = 34.3 bits (78),  Expect = 0.44, Method: Composition-based stats.
 Identities = 9/43 (20%), Positives = 17/43 (39%), Gaps = 0/43 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            GG+    +    +AGA  I    ++  + DP      + E + 
Sbjct  311  GGINISNLEALRQAGAKRIAVIGAIMNSKDPAATSLQLLEALR  353


>gi|20139850|sp|Q9UX10|PYRF_SULSO  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=222

 Score = 34.3 bits (78),  Expect = 0.44, Method: Composition-based stats.
 Identities = 22/126 (17%), Positives = 43/126 (34%), Gaps = 36/126 (28%)

Query  108  TQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMM  167
                 ++++ I  KGI        GT +D + +     +   +  V PG G Q       
Sbjct  124  ADYIKNVIREISPKGIVVG-----GTKLDHITQYRRDFEKMTI--VSPGMGSQ-------  169

Query  168  PKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
                              GG    +   A  AGA+  + G S++ A +P   +  + + +
Sbjct  170  ------------------GG----SYGDAVCAGADYEIIGRSIYNAGNPLTALRTINKII  207

Query  228  SKELRS  233
              ++  
Sbjct  208  EDKVMK  213


>gi|68565750|sp|Q6L2D8|PDXS_PICTO  Pyridoxal biosynthesis lyase pdxS
Length=336

 Score = 33.9 bits (77),  Expect = 0.45, Method: Composition-based stats.
 Identities = 13/80 (16%), Positives = 30/80 (37%), Gaps = 2/80 (2%)

Query  161  KFMEDMMPKVETLRAKF--PHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHD  218
            K +  ++  ++ ++     P +N    G           K G + +  G+ +F + DP  
Sbjct  233  KIINGILKTLKEIKKYRRLPVVNFAAGGVATPSDAALMMKMGLDGVFVGSGIFKSKDPAR  292

Query  219  VISFMKEEVSKELRSRDLLD  238
            + S + E        + + D
Sbjct  293  MASAIVEAAENYEDYKTIAD  312


>gi|136373|sp|P00931|TRP_YEAST  Tryptophan synthase
Length=707

 Score = 33.9 bits (77),  Expect = 0.45, Method: Composition-based stats.
 Identities = 24/126 (19%), Positives = 52/126 (41%), Gaps = 2/126 (1%)

Query  87   EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLD  146
            E+++ D AK GA+ F       ++ L +   I   G+     + P T+ + L  L+   D
Sbjct  113  ERFIQDAAKAGANGFIIVDLPPEEALKVRNYINDNGLSLIPLVAPSTTDERLELLSHIAD  172

Query  147  -MALVMTVEPGFGGQKFMEDMMPK-VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVI  204
                V++     G Q  +   + + +  +R       + V  G+      ++  + A+ +
Sbjct  173  SFVYVVSRMGTTGVQSSVASDLDELISRVRKYTKDTPLAVGFGVSTREHFQSVGSVADGV  232

Query  205  VAGTSV  210
            V G+ +
Sbjct  233  VIGSKI  238


>gi|7676173|sp|Q60180|TRPA_METJA  Tryptophan synthase alpha chain
Length=281

 Score = 33.9 bits (77),  Expect = 0.48, Method: Composition-based stats.
 Identities = 22/129 (17%), Positives = 47/129 (36%), Gaps = 9/129 (6%)

Query  87   EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-  145
            E++V    + G           ++   L    K  G+     + P T  + L ++     
Sbjct  112  EEFVKKCKEAGVSGIIVPDLPIEEADSLYNYCKKYGVDLIFLVAPTTPDERLKKILEKCS  171

Query  146  DMALVMTVEPGFGG--QKFMEDMMPKVETLRA--KFPHLNIQVDGGLGKETIPKAAKAGA  201
                V++V  G  G  +K  E+    ++ ++   K P     V  G+ K    +     A
Sbjct  172  GFVYVVSVT-GITGAREKVAEETKELIKRVKKFSKIPAC---VGFGISKREHVEEITEIA  227

Query  202  NVIVAGTSV  210
            +  + G+++
Sbjct  228  DGAIVGSAI  236


>gi|2499960|sp|Q57916|NADC_METJA  Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] 
(Quinolinate phosphoribosyltransferase [decarboxylating]) 
(QAPRTase)
Length=283

 Score = 33.9 bits (77),  Expect = 0.48, Method: Composition-based stats.
 Identities = 13/46 (28%), Positives = 23/46 (50%), Gaps = 1/46 (2%)

Query  163  MEDMMPKV-ETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAG  207
            +E+ +  + E  R       I+V GG+ ++ I + AK   +VI  G
Sbjct  219  IEEALKIIDEFERKTNFKPIIEVSGGIKEDNILEYAKYNVDVISMG  264


>gi|20139733|sp|Q9HFV8|PYRF_CLAFU  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase) (Uridine 5'-monophosphate synthase) (UMP 
synthase)
Length=278

 Score = 33.9 bits (77),  Expect = 0.55, Method: Composition-based stats.
 Identities = 10/35 (28%), Positives = 20/35 (57%), Gaps = 0/35 (0%)

Query  200  GANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            GA+ I+AG  ++TA DP +     +++  +   +R
Sbjct  238  GADFIIAGRGIYTAPDPVEAAKQYQQQGWEAYLAR  272


>gi|71153608|sp|Q6G0A2|THIG_BARQU  Thiazole biosynthesis protein thiG
Length=257

 Score = 33.9 bits (77),  Expect = 0.56, Method: Composition-based stats.
 Identities = 16/63 (25%), Positives = 28/63 (44%), Gaps = 3/63 (4%)

Query  155  PGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTA  213
            P   GQ         + ++RA  P + + +D G+G       A + G + ++  T+V  A
Sbjct  155  PIGSGQG--PHNTDGLRSIRAYLPDVTLVIDAGIGRPSHAAVAMELGYDAVLLNTAVAKA  212

Query  214  ADP  216
             DP
Sbjct  213  GDP  215


>gi|81370635|sp|Q5X5E0|PYRF_LEGPA  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=229

 Score = 33.5 bits (76),  Expect = 0.59, Method: Composition-based stats.
 Identities = 14/65 (21%), Positives = 29/65 (44%), Gaps = 11/65 (16%)

Query  170  VETLRAKFPHLNIQVDGGLGKET-----------IPKAAKAGANVIVAGTSVFTAADPHD  218
            V+ ++ K     I V  G+                 +A + G++ +V G  +  A++PH+
Sbjct  161  VKIIKQKCGENFITVTPGIRLPNNLKDDQSRVMTPQQAIREGSDFLVIGRPITQASNPHE  220

Query  219  VISFM  223
            V+S +
Sbjct  221  VVSAL  225


>gi|24212490|sp|Q8X6Y0|THIE_ECO57  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=211

 Score = 33.5 bits (76),  Expect = 0.60, Method: Composition-based stats.
 Identities = 22/117 (18%), Positives = 39/117 (33%), Gaps = 13/117 (11%)

Query  115  VKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLR  174
            +  I++ G++   +      +DV     P      +  V P    Q  M      +E L 
Sbjct  95   LNAIRAAGLRLGVSTHDDMEIDVALAARPS--YIALGHVFPTQTKQ--MPSAPQGLEQLA  150

Query  175  AK------FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
                    +P + I   GG+     P     G   I   +++  AAD     + + E
Sbjct  151  RHVERLSDYPTVAI---GGISLARAPAVIATGVGSIAVVSAITQAADWRLATAQLLE  204


>gi|267118|sp|P30137|THIE_ECOLI  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=211

 Score = 33.5 bits (76),  Expect = 0.60, Method: Composition-based stats.
 Identities = 22/117 (18%), Positives = 39/117 (33%), Gaps = 13/117 (11%)

Query  115  VKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLR  174
            +  I++ G++   +      +DV     P      +  V P    Q  M      +E L 
Sbjct  95   LNAIRAAGLRLGVSTHDDMEIDVALAARPS--YIALGHVFPTQTKQ--MPSAPQGLEQLA  150

Query  175  AK------FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
                    +P + I   GG+     P     G   I   +++  AAD     + + E
Sbjct  151  RHVERLADYPTVAI---GGISLARAPAVIATGVGSIAVVSAITQAADWRLATAQLLE  204


>gi|31563232|sp|Q9YEF5|PCRB_AERPE  Protein pcrB homolog
Length=257

 Score = 33.5 bits (76),  Expect = 0.62, Method: Composition-based stats.
 Identities = 13/41 (31%), Positives = 20/41 (48%), Gaps = 1/41 (2%)

Query  169  KVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGT  208
            K+         + + V GG+   E     A+AGA+V+V GT
Sbjct  198  KLVDAAGYGGEVLLTVGGGVRTPEAARMLAEAGADVLVTGT  238


>gi|41018336|sp|Q83PB9|THIE_SHIFL  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=211

 Score = 33.5 bits (76),  Expect = 0.62, Method: Composition-based stats.
 Identities = 22/117 (18%), Positives = 39/117 (33%), Gaps = 13/117 (11%)

Query  115  VKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLR  174
            +  I++ G++   +      +DV     P      +  V P    Q  M      +E L 
Sbjct  95   LNAIRAAGLRLGVSTHDDMEIDVALAARPS--YIALGHVFPTQTKQ--MPSAPQGLEQLA  150

Query  175  AK------FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
                    +P + I   GG+     P     G   I   +++  AAD     + + E
Sbjct  151  RHVERLADYPTVAI---GGISLARAPAVIATGVGSIAVVSAITQAADWRLATAQLLE  204


>gi|32130183|sp|Q89FP2|THIG_BRAJA  Thiazole biosynthesis protein thiG
Length=260

 Score = 33.5 bits (76),  Expect = 0.63, Method: Composition-based stats.
 Identities = 14/56 (25%), Positives = 30/56 (53%), Gaps = 1/56 (1%)

Query  170  VETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMK  224
            ++ LR + P + + VD G+G      +A + G + ++  T++  AADP  + +  +
Sbjct  168  LKLLRDRLPDITLVVDAGIGAPSHAAQALELGYDAVLLNTAIAKAADPVAMANAFR  223


>gi|3929347|sp|O13416|PYRF_ASPOR  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase) (Uridine 5'-monophosphate synthase) (UMP 
synthase)
Length=277

 Score = 33.5 bits (76),  Expect = 0.67, Method: Composition-based stats.
 Identities = 10/35 (28%), Positives = 17/35 (48%), Gaps = 0/35 (0%)

Query  200  GANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            GA+ I+AG  ++ A DP +     ++E       R
Sbjct  239  GADFIIAGRGIYAAPDPVEAAKQYQKEGWDAYLKR  273


>gi|139835|sp|P22857|XYLA_STRRO  Xylose isomerase
Length=394

 Score = 33.5 bits (76),  Expect = 0.68, Method: Composition-based stats.
 Identities = 31/160 (19%), Positives = 44/160 (27%), Gaps = 52/160 (32%)

Query  83   VENPEKWVDDFAKCGADQFTFH-----------YEATQDPLHLVKLIKSKGIKAACAIKP  131
            VE  ++     A+ GA   TFH            E         + + + G+    A   
Sbjct  37   VETVQR----LAELGAYGVTFHDDDLNPFGSSDTERESHIKRFRQALDATGMTVPMA---  89

Query  132  GTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKE  191
             T++                     F    F +        +RA      I         
Sbjct  90   TTNL---------------------FTHPVFKDRFTANDRDVRAYAVRKTI--------R  120

Query  192  TIPKAAKAGANVIVA-----GTSVFTAADPHDVISFMKEE  226
             I  AA+ GA   VA     G     A D  D +  MKE 
Sbjct  121  NIDLAAELGAKTYVAWGGREGAESGGAKDVRDALDRMKEA  160


>gi|41017638|sp|Q7N4C1|PYRF_PHOLL  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=248

 Score = 33.5 bits (76),  Expect = 0.69, Method: Composition-based stats.
 Identities = 11/43 (25%), Positives = 22/43 (51%), Gaps = 0/43 (0%)

Query  192  TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            T  +A  AG + +V G  +  AADP   +  + + ++  + +R
Sbjct  206  TPEQAVLAGVDYMVIGRPITRAADPAAALRQINQSIAGVINAR  248


>gi|47606065|sp|P61410|THIE_BACC1  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=224

 Score = 33.5 bits (76),  Expect = 0.69, Method: Composition-based stats.
 Identities = 12/45 (26%), Positives = 23/45 (51%), Gaps = 0/45 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKE  230
            GG+  E      +AGA+ +   +++  A   ++    + EEVSK+
Sbjct  174  GGISIENTASVIEAGADGVSVISAISLAESAYESTKQLVEEVSKK  218


>gi|60392375|sp|Q6F7A5|HIS4_ACIAD  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=243

 Score = 33.5 bits (76),  Expect = 0.71, Method: Composition-based stats.
 Identities = 16/42 (38%), Positives = 22/42 (52%), Gaps = 1/42 (2%)

Query  168  PKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGT  208
            P VE +    P L IQ+ GG+   ETI     AG + ++ GT
Sbjct  64   PVVEAIAKAQPELPIQIGGGIRSLETIEHYLDAGVSFVIIGT  105


>gi|136262|sp|P14637|TRPA_METVO  Tryptophan synthase alpha chain
Length=284

 Score = 33.5 bits (76),  Expect = 0.74, Method: Composition-based stats.
 Identities = 23/151 (15%), Positives = 49/151 (32%), Gaps = 7/151 (4%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHL  145
             E +V    + GA+          +      + K   +     + P T  + L       
Sbjct  116  IENFVIQAKEAGANGLIIVDLPLDEAEQYRAICKKHDMGTVFLVAPNTPDERLMYSDEAS  175

Query  146  DMALVMTVEPGFGGQ--KFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGAN  202
             + L +    G  G    F +     +   +       + V  G+   E   K  + GA+
Sbjct  176  TLFLYVISTFGITGARGSFEKMTFEFIARAKNLCDKNKLYVGFGISNGEHAEKIIENGAD  235

Query  203  VIVAGTS----VFTAADPHDVISFMKEEVSK  229
             ++ G++    +    D ++ I  +KE   +
Sbjct  236  GVIVGSAFVDIIKEYGDSNETIYKLKELARE  266


>gi|24212505|sp|Q97LQ9|THIE_CLOAB  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=211

 Score = 33.1 bits (75),  Expect = 0.77, Method: Composition-based stats.
 Identities = 15/62 (24%), Positives = 26/62 (41%), Gaps = 2/62 (3%)

Query  170  VETLRAKFPHLNIQV--DGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            +E L+     + I V   GG+ +E   K  + G + I   + + +A    D    M + V
Sbjct  146  LEELKNIKNSVKIPVVGIGGINEENANKVIETGVDGISVISGILSAQKIKDKARVMFDIV  205

Query  228  SK  229
             K
Sbjct  206  KK  207


>gi|34222869|sp|Q8DLN9|TRPA_SYNEL  Tryptophan synthase alpha chain
Length=266

 Score = 33.1 bits (75),  Expect = 0.77, Method: Composition-based stats.
 Identities = 33/207 (15%), Positives = 69/207 (33%), Gaps = 25/207 (12%)

Query  22   CHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHM  81
               + + GAD + + +    +   +  G  I  +  R++ R        +  T   D H 
Sbjct  39   LKILDDHGADLIELGM---PYSDPLADGPVIQAAATRALQRGTRLEAVLEMTT---DLHQ  92

Query  82   MVENP---------------EKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAA  126
             +  P                 ++   A+ G           ++   ++    + G++  
Sbjct  93   QLTAPLILFSYYNPIYHRGVSSFLKAVAQAGIKGLVIPDLPLEEAEPVLAETANLGLELT  152

Query  127  CAIKPGTSVDVLFELAPHLDMALVMTVEPGFGG--QKFMEDMMPKVETLRAKFPHLNIQV  184
              I P TS + +  +A      + +    G  G  Q+    +   + TLR   P   I V
Sbjct  153  LLIAPTTSPERMRAIATASQGFIYLVSTTGVTGMRQEMASRVQELLHTLRQITPKP-IGV  211

Query  185  DGGL-GKETIPKAAKAGANVIVAGTSV  210
              G+   E   +    GA+  + G++ 
Sbjct  212  GFGIASPEHARQVRDWGADAAIVGSAF  238


>gi|38258736|sp|Q88B60|TRPA_PSESM  Tryptophan synthase alpha chain
Length=270

 Score = 33.1 bits (75),  Expect = 0.77, Method: Composition-based stats.
 Identities = 29/152 (19%), Positives = 47/152 (30%), Gaps = 13/152 (8%)

Query  86   PEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAP--  143
             E +V    + G D         +    L    ++ GI       P T    L  +    
Sbjct  111  VEAFVAQAKEAGVDGLIIVDLPPEHDAELATPAQASGIDFIRLTTPTTDDARLPRVLERS  170

Query  144  --HLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAG  200
               +    V  V     G    E +   +  LR     L I V  G+   E     A+  
Sbjct  171  SGFVYYVSVAGVT--GAGSATTEHVTEAIARLRRH-TSLPISVGFGIRTPEQAAAIARL-  226

Query  201  ANVIVAGTS----VFTAADPHDVISFMKEEVS  228
            A+ +V G++    + TA  P   I  +    +
Sbjct  227  ADGVVVGSAFVDKIATAESPEQAIDGVLTLCA  258


>gi|47606108|sp|Q7N964|THIE_PHOLL  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=216

 Score = 33.1 bits (75),  Expect = 0.83, Method: Composition-based stats.
 Identities = 24/147 (16%), Positives = 48/147 (32%), Gaps = 13/147 (8%)

Query  84   ENPEKWVDDF----AKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAIKPGTSVDVLF  139
             N   +++D+     K GA     H       +  +  I+  G++   +      +    
Sbjct  65   YNARLFINDYWRLAIKHGAYG--VHLGQEDLVIADLNAIQKTGLRLGISTHDEQELARAK  122

Query  140  ELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKF---PHLNIQVDGGLGKETIPKA  196
             L P      +  + P     K M      VE L+ +    P  +    GG+  E +P  
Sbjct  123  SLRPS--YIALGHIFP--TTTKAMPSSPQGVEALKRQVENTPDYSTVAIGGISLERVPDV  178

Query  197  AKAGANVIVAGTSVFTAADPHDVISFM  223
               G   +   +++  A D     + +
Sbjct  179  IATGVGSVALVSAITKAKDWRQATAQL  205


>gi|73622039|sp|Q7TV26|TRPA_PROMM  Tryptophan synthase alpha chain
Length=275

 Score = 33.1 bits (75),  Expect = 0.83, Method: Composition-based stats.
 Identities = 35/220 (15%), Positives = 80/220 (36%), Gaps = 21/220 (9%)

Query  8    PSILASD--FANLGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS-----V  60
            P ++A D            +  +GAD + + +    +   +  G  I  +  R+      
Sbjct  32   PFLMAGDPDLETTAEVLLSLEQSGADMIELGI---PYSDPLADGPVIQAAASRALASGTT  88

Query  61   PRPGDASNTEKKPTAFFDCHMMVE-NP------EKWVDDFAKCGADQFTFHYEATQDPLH  113
            P        + +        +    NP      E++ D+ A+ G           ++   
Sbjct  89   PARVLQMLIDLRGKLSIPVILFTYTNPLFNRGMERFCDEAAEAGVAGLVVPDLPLEEAER  148

Query  114  LVKLIKSKGIKAACAIKPGTSVDVLFELAPHL-DMALVMTVEPGFGGQKFMED-MMPKVE  171
            L  L  ++G+     + P T  + +  +A        +++V    G +  MED +   V+
Sbjct  149  LSPLASARGLDLVLLVAPTTPAERMARIAESSRGFTYLVSVTGVTGERSVMEDRVQSLVQ  208

Query  172  TLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSV  210
             L+    +  + V  G+ G + + +    GA+  + G+++
Sbjct  209  QLKLSGSNP-VAVGFGISGPQQVRQVRSWGADGAIVGSAL  247


>gi|29337044|sp|Q8DGP3|TRPF_SYNEL  N-(5'-phosphoribosyl)anthranilate isomerase (PRAI)
Length=230

 Score = 33.1 bits (75),  Expect = 0.83, Method: Composition-based stats.
 Identities = 31/163 (19%), Positives = 51/163 (31%), Gaps = 25/163 (15%)

Query  48   LGQPIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPE--KWVDDFAKCGADQFTFH-  104
            LG   V    R V  P  A    + P A      +V N +     +     G      H 
Sbjct  34   LGFITVPHSPRYVSAPTIAEICRQLPPAVLTV-AVVANLDLEALANLVTTTGVQALQLHG  92

Query  105  ---YEATQDPLHL---VKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEP---  155
                E  Q        + LIK+  +++        ++  +   A  +D  L+    P   
Sbjct  93   SESPEFCQSVRQTFPNIVLIKALRVQS------AATLAAIPAYASTVDRILLDAYHPQQL  146

Query  156  GFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAK  198
            G  GQ F   ++  +       P     + GG+  E   +A  
Sbjct  147  GGTGQPFDWTLLKAL-----HIPCPW-WLAGGITPENCRQAIA  183


>gi|73621997|sp|Q8AAD8|TRPA_BACTN  Tryptophan synthase alpha chain
Length=256

 Score = 33.1 bits (75),  Expect = 0.83, Method: Composition-based stats.
 Identities = 30/128 (23%), Positives = 49/128 (38%), Gaps = 14/128 (10%)

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGG--QKFME--  164
            QD   ++      GIK    I P TS + + E+  H D  + M       G  Q F E  
Sbjct  133  QDHYRIIAE--RYGIKVIMLITPETSEERVREIDAHTDGFIYMVSSAATTGAQQDFNEQK  190

Query  165  -DMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVF----TAADPHDV  219
                 K+E +  + P +   V  G+  +   +AA   A+  + G+          DP   
Sbjct  191  RAYFKKIEDMNLRNPLM---VGFGISNKATFQAACEHASGAIIGSRFVTLLEEEKDPEKA  247

Query  220  ISFMKEEV  227
            I  +K+ +
Sbjct  248  ILKLKDAL  255


>gi|267173|sp|Q02002|TRPF_LACLA  N-(5'-phosphoribosyl)anthranilate isomerase (PRAI)
Length=351

 Score = 33.1 bits (75),  Expect = 0.83, Method: Composition-based stats.
 Identities = 30/149 (20%), Positives = 47/149 (31%), Gaps = 19/149 (12%)

Query  51   PIVTSLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAK-CGADQFTFHYEATQ  109
             I++  +R V        T   P       + V+ P  +V    +    D    H     
Sbjct  27   FILSPSKRQVAPEKILQITNDVPKTVKKVGVFVDEPIDFVKKAIQVAQLDLVQLHGN---  83

Query  110  DPLHLVKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPK  169
                 +  I    I    AI+P        E   + D+ L+        GQ F  D +  
Sbjct  84   ---EDMNYINQLDISVIKAIRPD------QEFKEYEDVILLFDSPQAGSGQAFDWDSLV-  133

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAK  198
               L+ KF      + GGL  E +  A +
Sbjct  134  TSGLKNKF-----FIAGGLNPENVAAAIQ  157


>gi|46396421|sp|Q8CQV7|PDXS_STAES  Pyridoxal biosynthesis lyase pdxS
 gi|68565681|sp|Q5HRN5|PDXS_STAEQ  Pyridoxal biosynthesis lyase pdxS
Length=295

 Score = 33.1 bits (75),  Expect = 0.85, Method: Composition-based stats.
 Identities = 8/39 (20%), Positives = 17/39 (43%), Gaps = 1/39 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            GG+   +      + GA+ +  G+ +F + DP      +
Sbjct  214  GGVATPQDAALMMELGADGVFVGSGIFKSEDPEKFAKAI  252


>gi|46396184|sp|P60797|PDXS_STAAM  Pyridoxal biosynthesis lyase pdxS
 gi|46396185|sp|P60798|PDXS_STAAN  Pyridoxal biosynthesis lyase pdxS
 gi|46396186|sp|P60799|PDXS_STAAW  Pyridoxal biosynthesis lyase pdxS
 gi|68565677|sp|Q5HIF5|PDXS_STAAC  Pyridoxal biosynthesis lyase pdxS
 gi|68565744|sp|Q6GBW9|PDXS_STAAS  Pyridoxal biosynthesis lyase pdxS
 gi|68565746|sp|Q6GJF0|PDXS_STAAR  Pyridoxal biosynthesis lyase pdxS
Length=295

 Score = 33.1 bits (75),  Expect = 0.85, Method: Composition-based stats.
 Identities = 8/39 (20%), Positives = 17/39 (43%), Gaps = 1/39 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            GG+   +      + GA+ +  G+ +F + DP      +
Sbjct  214  GGVATPQDAALMMELGADGVFVGSGIFKSEDPEKFAKAI  252


>gi|2507263|sp|P30011|NADC_ECOLI  Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Quinolinate 
phosphoribosyltransferase [decarboxylating]) (QAPRTase)
Length=297

 Score = 33.1 bits (75),  Expect = 0.88, Method: Composition-based stats.
 Identities = 8/37 (21%), Positives = 18/37 (48%), Gaps = 0/37 (0%)

Query  171  ETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAG  207
            E ++       ++V G +  +T+ + A+ G + I  G
Sbjct  245  EAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVG  281


>gi|31563170|sp|Q8G4S5|HIS4_BIFLO  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=241

 Score = 33.1 bits (75),  Expect = 0.89, Method: Composition-based stats.
 Identities = 17/67 (25%), Positives = 29/67 (43%), Gaps = 2/67 (2%)

Query  171  ETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADP-HDVISFMKEEVS  228
            E +      +NI++ GG+    ++  A +AGA  +  GT+     D    VI    + V+
Sbjct  68   EIVHELGDRVNIELSGGVRDDASLDAALEAGAARVNIGTAALENPDWTASVIKKYGDRVA  127

Query  229  KELRSRD  235
              L  R 
Sbjct  128  VGLDVRG  134


 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 24/111 (21%), Positives = 37/111 (33%), Gaps = 16/111 (14%)

Query  20   CECHKVINAGADWLHIDVMDGHFVPNITLGQPI-VTSLRRSVPRPGDASNTEKKPTAFFD  78
                  + AGA+W+H+  +D         G       LR  V   GD  N E       D
Sbjct  35   EAARTWVEAGAEWIHLVDLDA------AFGTGNNRDQLREIVHELGDRVNIELSGGVRDD  88

Query  79   CHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
              +         D   + GA +      A ++P     +IK  G + A  +
Sbjct  89   ASL---------DAALEAGAARVNIGTAALENPDWTASVIKKYGDRVAVGL  130


>gi|132214|sp|P17438|RDS_RAT  Peripherin (Retinal degeneration slow protein)
Length=346

 Score = 33.1 bits (75),  Expect = 0.89, Method: Composition-based stats.
 Identities = 10/24 (41%), Positives = 15/24 (62%), Gaps = 3/24 (12%)

Query  36  DVMDG---HFVPNITLGQPIVTSL  56
           DVMD    HFVPN  +G  +++ +
Sbjct  50  DVMDNSESHFVPNSLIGVGVLSCV  73


>gi|29427772|sp|Q8EYP6|COAD_LEPIN  Phosphopantetheine adenylyltransferase (Pantetheine-phosphate 
adenylyltransferase) (PPAT) (Dephospho-CoA pyrophosphorylase)
 gi|59797798|sp|Q72M66|COAD_LEPIC  Phosphopantetheine adenylyltransferase (Pantetheine-phosphate 
adenylyltransferase) (PPAT) (Dephospho-CoA pyrophosphorylase)
Length=160

 Score = 33.1 bits (75),  Expect = 0.95, Method: Composition-based stats.
 Identities = 25/118 (21%), Positives = 44/118 (37%), Gaps = 7/118 (5%)

Query  119  KSKGIKAACAIKPGT--SVDVLFELAPHLDMALV-MTVEPGFGGQKFMEDMMPKVETLRA  175
            K   I    +  P T   +D+L       D  ++ + V         +E+ +  +  +  
Sbjct  2    KHLAIYPG-SFDPLTKGHLDILQRSLGLFDKVIIAIAVNSNKSTLFSIEERLGFIREVTK  60

Query  176  KFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRS  233
                L I    GL   T+    K GAN I+ G    T  D    IS M ++++  + +
Sbjct  61   GMKGLEIDTFQGL---TVDYCNKVGANSIIRGLRAVTDFDYEYAISLMNKKLAPNVET  115


>gi|41018296|sp|Q7VAV5|THIE_PROMA  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=346

 Score = 33.1 bits (75),  Expect = 0.95, Method: Composition-based stats.
 Identities = 10/44 (22%), Positives = 20/44 (45%), Gaps = 0/44 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSK  229
            GG+ K+ I K  + G   +    ++  A DP+     +  ++ K
Sbjct  303  GGINKDNIDKIKEVGIKRVAVINAIMGAEDPYLASKELLGKLKK  346


>gi|34395726|sp|Q9KGN8|IMDH_BACHD  Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) 
(IMPD)
Length=485

 Score = 32.8 bits (74),  Expect = 0.99, Method: Composition-based stats.
 Identities = 14/43 (32%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query  166  MMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAG  207
            ++ KV+ +R ++P L I + G +   E      +AGANV+  G
Sbjct  258  VLEKVKAIREQYPDLTI-IAGNVATAEATRDLIEAGANVVKVG  299


 Score = 30.8 bits (69),  Expect = 4.7, Method: Composition-based stats.
 Identities = 13/65 (20%), Positives = 29/65 (44%), Gaps = 13/65 (20%)

Query  187  GLGKET---IPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE----------VSKELRS  233
            G+  +T   +    +AG +VIV  T+   +    + +  ++E+          V+    +
Sbjct  226  GVSADTDVRVAALVEAGVDVIVIDTAHGHSKGVLEKVKAIREQYPDLTIIAGNVATAEAT  285

Query  234  RDLLD  238
            RDL++
Sbjct  286  RDLIE  290


>gi|91206934|sp|Q3J6Q2|HIS4_NITOC  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] 
imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole 
carboxamide ribotide isomerase)
Length=249

 Score = 32.8 bits (74),  Expect = 1.0, Method: Composition-based stats.
 Identities = 17/59 (28%), Positives = 25/59 (42%), Gaps = 4/59 (6%)

Query  157  FGGQKFMEDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAA  214
            F GQ    D++  +       P ++IQV GG+   +TI     AG    + GT    A 
Sbjct  56   FAGQPVNADIIYHIA---QALPDMDIQVGGGIRDSDTIQTYLDAGVRYAIIGTKAINAP  111


>gi|9789813|sp|P76044|YCJR_ECOLI  Hypothetical protein ycjR
Length=265

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 9/45 (20%), Positives = 17/45 (37%), Gaps = 2/45 (4%)

Query  156  GFGGQKFMED-MMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKA  199
            G   Q F  + ++ K   ++        ++DG L    I +   A
Sbjct  7    GTQNQAFFPENILEKFRYIKEMGFD-GFEIDGKLLVNNIEEVKAA  50


>gi|30173435|sp|Q8FB78|THIE_ECOL6  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=211

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 22/117 (18%), Positives = 39/117 (33%), Gaps = 13/117 (11%)

Query  115  VKLIKSKGIKAACAIKPGTSVDVLFELAPHLDMALVMTVEPGFGGQKFMEDMMPKVETLR  174
            +  I++ G++   +      +DV     P      +  V P    Q  M      +E L 
Sbjct  95   LSTIRAAGLRLGVSTHDDMEIDVALAARPS--YIALGHVFPTQTKQ--MPSAPQGLEQLA  150

Query  175  AK------FPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
                    +P + I   GG+     P     G   I   +++  AAD     + + E
Sbjct  151  RHVERLADYPTVAI---GGISLARAPAVIATGVGSIAVVSAITQAADWRLATAQLLE  204


>gi|81827138|sp|Q6D5T3|PYRF_ERWCT  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=247

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 7/34 (20%), Positives = 18/34 (52%), Gaps = 0/34 (0%)

Query  195  KAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            +A +AG + +V G  +  ++DP   +  ++  + 
Sbjct  209  QAQQAGVDYMVIGRPITQSSDPAQTLCDIRASLL  242


>gi|46396465|sp|Q8RBJ3|PDXS_THETN  Pyridoxal biosynthesis lyase pdxS
Length=292

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 8/43 (18%), Positives = 20/43 (46%), Gaps = 1/43 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            GG+          + GA+ +  G+ +F + +P  + + + + V
Sbjct  211  GGIATPADAALMMQLGADGVFVGSGIFKSQNPEKMAAAIVKAV  253


>gi|109895164|sp|Q3ZXE1|THIC_DEHSC  Thiamine biosynthesis protein thiC
Length=431

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 27/129 (20%), Positives = 47/129 (36%), Gaps = 29/129 (22%)

Query  12   ASDFANLGCECHKVINA---GADWLHIDVMDGHFVPNITLGQPI---VTSLRRSVPRPGD  65
            ++DF ++  E  K+  A   GAD +    MD      ++ G  I     ++  +   P  
Sbjct  70   STDFGSVASEVEKLKMAEMVGADTI----MD------LSTGPKINTIRKAILENTCLPLG  119

Query  66   ASNTEKKPTAFFDCH--MMVE-NPEKW---VDDFAKCGADQFTFHYEATQDPLHL-----  114
                 +      D H   MV+   +     ++  AK G D  T H   T+  +       
Sbjct  120  TVPVYQAAVEAKD-HYGAMVKMTADDLFGAIESQAKEGVDFVTVHCGVTRQVIDTFKGQG  178

Query  115  -VKLIKSKG  122
             +  I S+G
Sbjct  179  RLTDIVSRG  187


>gi|13431927|sp|P57930|THIE_PASMU  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=221

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 13/54 (24%), Positives = 25/54 (46%), Gaps = 0/54 (0%)

Query  170  VETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            V T+RA      I   GG+  +T  +  + GAN +   +++  +AD    +  +
Sbjct  163  VSTIRAHGIDKPIVAIGGVTTQTAEELRRRGANGVAVISAITQSADIAKTVKEL  216


>gi|68565764|sp|Q73WF0|PDXS_MYCPA  Pyridoxal biosynthesis lyase pdxS
Length=303

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 12/55 (21%), Positives = 22/55 (40%), Gaps = 1/55 (1%)

Query  170  VETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            VE  RA    + +   GG+          + GA  +  G+ +F + DP    + +
Sbjct  206  VEVARAGKLPVTLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGDPAQRAAAI  260


>gi|21903445|sp|Q15274|NADC_HUMAN  Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Quinolinate 
phosphoribosyltransferase [decarboxylating]) (QAPRTase) 
(QPRTase)
Length=297

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 15/63 (23%), Positives = 30/63 (47%), Gaps = 8/63 (12%)

Query  145  LDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVI  204
             D+ L+   +P        E++ P    L+A+FP + ++  GG+  + +P+      +VI
Sbjct  216  ADLVLLDNFKP--------EELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVI  267

Query  205  VAG  207
              G
Sbjct  268  SMG  270


>gi|586857|sp|P37527|PDXS_BACSU  Pyridoxal biosynthesis lyase pdxS (Superoxide-inducible protein 
7) (SOI7)
Length=294

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 8/42 (19%), Positives = 17/42 (40%), Gaps = 1/42 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
            GG+          + GA+ +  G+ +F + +P      + E 
Sbjct  213  GGVATPADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEA  254


>gi|109892947|sp|Q30QK7|PYRF_THIDN  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=227

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 8/29 (27%), Positives = 17/29 (58%), Gaps = 0/29 (0%)

Query  199  AGANVIVAGTSVFTAADPHDVISFMKEEV  227
            A  + IV G  ++ + +P +VI  + E++
Sbjct  199  AHVDFIVVGRPIYNSKNPAEVIRRILEQI  227


>gi|68565716|sp|Q65PL2|PDXS_BACLD  Pyridoxal biosynthesis lyase pdxS
Length=294

 Score = 32.8 bits (74),  Expect = 1.1, Method: Composition-based stats.
 Identities = 8/42 (19%), Positives = 17/42 (40%), Gaps = 1/42 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
            GG+          + GA+ +  G+ +F + +P      + E 
Sbjct  213  GGVATPADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEA  254


>gi|109892904|sp|Q65SI1|PYRF_MANSM  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=234

 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 11/37 (29%), Positives = 22/37 (59%), Gaps = 0/37 (0%)

Query  192  TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVS  228
            T P A +AG++ +V G  +  AA+P +V+  +   ++
Sbjct  194  TPPAAIEAGSDYLVIGRPITQAANPAEVLRSINASIA  230


>gi|68565713|sp|Q63HF8|PDXS_BACCZ  Pyridoxal biosynthesis lyase pdxS
 gi|68565748|sp|Q6HQ05|PDXS_BACHK  Pyridoxal biosynthesis lyase pdxS
 gi|68565762|sp|Q73FJ5|PDXS_BACC1  Pyridoxal biosynthesis lyase pdxS
Length=295

 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 8/42 (19%), Positives = 17/42 (40%), Gaps = 1/42 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
            GG+          + GA+ +  G+ +F + +P      + E 
Sbjct  214  GGVATPADAALMMQLGADGVFVGSGIFKSENPAKFARAIVEA  255


>gi|20139731|sp|Q9HF68|PYRF_SOLCC  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase) (Uridine 5'-monophosphate synthase) (UMP 
synthase)
Length=280

 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 11/44 (25%), Positives = 20/44 (45%), Gaps = 0/44 (0%)

Query  191  ETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKELRSR  234
            +T   A K GA+ I++G  ++  +DP       + E      +R
Sbjct  229  QTPEAAIKRGADFIISGRGIYATSDPIQAAKLYQNEGWAAYETR  272


>gi|46396354|sp|Q81W27|PDXS_BACAN  Pyridoxal biosynthesis lyase pdxS
Length=295

 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 8/42 (19%), Positives = 17/42 (40%), Gaps = 1/42 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEE  226
            GG+          + GA+ +  G+ +F + +P      + E 
Sbjct  214  GGVATPADAALMMQLGADGVFVGSGIFKSENPAKFARAIVEA  255


>gi|109895152|sp|Q2GKB1|THIC_ANAPZ  Thiamine biosynthesis protein thiC
Length=557

 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 29/111 (26%), Positives = 42/111 (37%), Gaps = 36/111 (32%)

Query  12   ASDFANLGCECHKVINA---GADWLHIDVMD---GHFVPNI----------TLG-QPIVT  54
            ++  +N+  E  K++ A   GAD     VMD   GH + NI           +G  PI  
Sbjct  201  SAVLSNIEDEVKKMVLAVTYGAD----TVMDLSTGHDIHNIRELIVRNSPVPIGTVPIYQ  256

Query  55   SLRRSVPRPGDASNTEKKPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHY  105
            +L +     GD S    K T               ++  A+ G D FT H 
Sbjct  257  ALNKVNGIVGDLSFEVFKET--------------IIEQ-AEQGVDYFTIHA  292


>gi|20140843|sp|Q9KCY8|THIE_BACHD  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=211

 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 11/66 (16%), Positives = 25/66 (37%), Gaps = 4/66 (6%)

Query  164  EDMMPKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTAADPH---DVI  220
                  ++ +  +     + + GG+    + +   AGA  I   + +  A D     +V 
Sbjct  142  PVTTAYIQQVAHEISIPFVAI-GGIKLHNVEQVLDAGATRICMISEIVGAEDVKGTCEVF  200

Query  221  SFMKEE  226
            S + E+
Sbjct  201  STILEQ  206


>gi|7674394|sp|Q9Y8T7|TRPC_AERPE  Indole-3-glycerol phosphate synthase (IGPS)
Length=261

 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 18/70 (25%), Positives = 32/70 (45%), Gaps = 9/70 (12%)

Query  164  EDMMPKVETLRAKFP-HLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTAADPHDVIS  221
            E M+ +V   R + P  + +  + G+   +   KA KAGA  I+ GT+            
Sbjct  195  EAMLREVSKAREQLPGEVILVAESGIDSPDKALKAFKAGAQAILVGTAFMKNP-------  247

Query  222  FMKEEVSKEL  231
             ++E++  EL
Sbjct  248  QLREKILAEL  257


>gi|73919868|sp|Q6KZH9|THIE_PICTO  Thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) 
(TMP-PPase) (Thiamine-phosphate synthase)
Length=204

 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 11/46 (23%), Positives = 22/46 (47%), Gaps = 0/46 (0%)

Query  186  GGLGKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEVSKEL  231
            GG+    + +  K   + I   +++F AA+P +      E++ K L
Sbjct  159  GGINTRNVDELLKYKISGIAVVSAIFDAANPGEATRTFLEKLRKIL  204


>gi|20139403|sp|P58639|PYRF_ANASP  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase)
Length=238

 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 37/159 (23%), Positives = 55/159 (34%), Gaps = 32/159 (20%)

Query  97   GADQFTFHYEATQDPLHLVKLIKSKGI-KAA------CAIKPGTSVDVLFELAP------  143
            G D  T H  + +D L   K    +G  +A        A+   TS+              
Sbjct  80   GVDLMTIHATSGRDALKAAKEAVEEGAAQAGVKPPKLIAVTVLTSISARQLALDLKIPSE  139

Query  144  ----HLDMALVMTVEPGFGGQKFMEDMMPKVETLRAKFPHLNIQVDGGLGKE--------  191
                 LDMAL M  E G  G         +V  LR       + V  G+           
Sbjct  140  LPEYALDMAL-MAQEMGLDGAVCSPQ---EVAHLRQICGDDFVLVCPGVRPTWAEAGDQK  195

Query  192  ---TIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
               T  +A +AGA+ +V G  +  AA+P      + +E+
Sbjct  196  RSLTPSQAIQAGADYLVIGRPITAAAEPELAWKRISQEL  234


>gi|46396464|sp|Q8PUA5|PDXS_METMA  Pyridoxal biosynthesis lyase pdxS
Length=301

 Score = 32.8 bits (74),  Expect = 1.2, Method: Composition-based stats.
 Identities = 10/43 (23%), Positives = 19/43 (44%), Gaps = 1/43 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            GG+          + GA+ +  G+ +F A +P  +   + E V
Sbjct  220  GGVATPADAALMMRLGADGVFVGSGIFKAENPEKMAKAVVEAV  262


>gi|46396470|sp|Q8TQH6|PDXS_METAC  Pyridoxal biosynthesis lyase pdxS
Length=301

 Score = 32.8 bits (74),  Expect = 1.3, Method: Composition-based stats.
 Identities = 10/43 (23%), Positives = 19/43 (44%), Gaps = 1/43 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKEEV  227
            GG+          + GA+ +  G+ +F A +P  +   + E V
Sbjct  220  GGVATPADAALMMRLGADGVFVGSGIFKAENPEKMAKAVVEAV  262


>gi|21759454|sp|Q8YY69|THIC_ANASP  Thiamine biosynthesis protein thiC
Length=457

 Score = 32.8 bits (74),  Expect = 1.3, Method: Composition-based stats.
 Identities = 23/106 (21%), Positives = 40/106 (37%), Gaps = 25/106 (23%)

Query  12   ASDFANLGCECHKV---INAGADWLHIDVMDGHFVPNITLGQPIVTSLR----RSVPRPG  64
            + + +NL  E  K+   +  GAD     VMD      ++ G   +  +R     + P P 
Sbjct  84   SPNSSNLQEEVDKLNLAVKYGAD----TVMD------LSTGGGNLDEIRTAIINASPVPI  133

Query  65   DASNTEKKPTAFFDCHMMVEN--PEKW---VDDFAKCGADQFTFHY  105
                  +        H  +EN  P+ +   ++  A+ G D  T H 
Sbjct  134  GTVPVYQALE---SVHGTIENLTPDDFLHIIEKHAQQGVDYQTIHA  176


>gi|3334472|sp|P80877|METE_BACSU  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 
(Methionine synthase, vitamin-B12 independent isozyme) 
(Cobalamin-independent methionine synthase) (Superoxide-inducible 
protein 9) (SOI9)
Length=762

 Score = 32.4 bits (73),  Expect = 1.3, Method: Composition-based stats.
 Identities = 20/116 (17%), Positives = 34/116 (29%), Gaps = 12/116 (10%)

Query  18   LGCECHKVINAGADWLHIDVMDGHFVPNITLGQPIV----TSLRRSVPRPGDASNTEKKP  73
            L  E   + +AG   + +D       P +  G P+                  + +  K 
Sbjct  585  LRKEVKALEDAGIQIIQVD------EPALREGLPLKTRDWDEYLTWAAEAFRLTTSSVKN  638

Query  74   TAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEATQDPLHLVKLIKSKGIKAACAI  129
                  HM   N E  VD      AD  T   E ++     +  +K+        +
Sbjct  639  ETQIHTHMCYSNFEDIVDTINDLDADVITI--EHSRSHGGFLDYLKNHPYLKGLGL  692


>gi|25453054|sp|Q8KCW4|IMDH_CHLTE  Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) 
(IMPD)
Length=494

 Score = 32.4 bits (73),  Expect = 1.3, Method: Composition-based stats.
 Identities = 18/55 (32%), Positives = 24/55 (43%), Gaps = 5/55 (9%)

Query  169  KVETLRAKFPHLNIQVDGGLGKE-TIPKAAKAGANVIVAGTSVFTAAD--PHDVI  220
            K      K     I  DGG+     I KA  AGA+ ++ G+ VF   D  P + I
Sbjct  326  KCAEEAKKTDIPLI-ADGGIKYSGDIAKALAAGADSVMMGS-VFAGTDESPGETI  378


>gi|116256176|sp|Q31QR1|THIG_SYNP7  Thiazole biosynthesis protein thiG
Length=286

 Score = 32.4 bits (73),  Expect = 1.3, Method: Composition-based stats.
 Identities = 24/111 (21%), Positives = 47/111 (42%), Gaps = 7/111 (6%)

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDVLFEL-APHLDMALVMTV-EPGFGGQKFMEDM  166
             DP+  ++  +   +K   A+ P  + D L       +  A VM +  P   GQ    + 
Sbjct  134  PDPIGTLQAAEQL-VKEGFAVLPYINADPLLAKRLEEVGCATVMPLGSPIGSGQGIRNE-  191

Query  167  MPKVETLRAKFPHLNIQVDGGLGKET-IPKAAKAGANVIVAGTSVFTAADP  216
               +  +      + + VD G+G  +   +A + GA+ ++  T++  A DP
Sbjct  192  -ANIRIIVEN-AKVPVVVDAGIGTASEAAQAMELGADALLINTAIAQAEDP  240


>gi|71153643|sp|Q5N3I3|THIG_SYNP6  Thiazole biosynthesis protein thiG
Length=276

 Score = 32.4 bits (73),  Expect = 1.3, Method: Composition-based stats.
 Identities = 24/111 (21%), Positives = 47/111 (42%), Gaps = 7/111 (6%)

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDVLFEL-APHLDMALVMTV-EPGFGGQKFMEDM  166
             DP+  ++  +   +K   A+ P  + D L       +  A VM +  P   GQ    + 
Sbjct  124  PDPIGTLQAAEQL-VKEGFAVLPYINADPLLAKRLEEVGCATVMPLGSPIGSGQGIRNE-  181

Query  167  MPKVETLRAKFPHLNIQVDGGLGKET-IPKAAKAGANVIVAGTSVFTAADP  216
               +  +      + + VD G+G  +   +A + GA+ ++  T++  A DP
Sbjct  182  -ANIRIIVEN-AKVPVVVDAGIGTASEAAQAMELGADALLINTAIAQAEDP  230


>gi|20140887|sp|Q9PDK3|TRPA_XYLFA  Tryptophan synthase alpha chain
Length=268

 Score = 32.4 bits (73),  Expect = 1.4, Method: Composition-based stats.
 Identities = 51/241 (21%), Positives = 85/241 (35%), Gaps = 35/241 (14%)

Query  3    KPIIAPSILASDFANLGCEC---HKVINAGADWLHIDVMDGHFVPNITLGQPIVTSLRRS  59
            K +I P I A D + L       H ++ AGAD + + V    F   +  G  I  S  R+
Sbjct  17   KALI-PFITAGDPS-LEAAVPVMHALVRAGADVIELGV---PFSDPMADGPVIQHSSERA  71

Query  60   VPRPGDASNTEK------KPTAFFDCHMMVENPEKWVDDFAKCGADQFTFHYEAT-----  108
            + R    +   +      +  A     +M      +++     G  +FT H  A      
Sbjct  72   LQRGVGLAYVLQTVDVFRQSDAVTPVVLM-----GYLNPLEIYGIARFTQHAVACGVDGV  126

Query  109  ---QDPLHLVKLIKSKGIKAACAI----KPGTSVDVLFELAPHLDMALVMTVEPGFGGQK  161
                 P      I+     A  A+     P TS   L  L+      L      G  G  
Sbjct  127  LLVDLPPEEADEIRPIFSAAGLALIVLASPTTSASRLARLSGVAQGYLYYVSFSGVTGAD  186

Query  162  FMEDMM--PKVETLRAKFPHLNIQVDGGLGKETIPKAAKAGANVIVAGTSVFTA-ADPHD  218
             ++      ++  LRA+   + + V  G+            A+ +V G+++ TA +D  D
Sbjct  187  RLDAQSAGDRLRGLRAQ-TQVPVVVGFGIRDAASAAVMAVDADGVVVGSALVTALSDAPD  245

Query  219  V  219
            V
Sbjct  246  V  246


>gi|31563211|sp|Q980N1|PCRB_SULSO  Protein pcrB homolog
Length=255

 Score = 32.4 bits (73),  Expect = 1.4, Method: Composition-based stats.
 Identities = 14/62 (22%), Positives = 28/62 (45%), Gaps = 7/62 (11%)

Query  164  EDMMPKVETLRAKFPHLNIQVDGGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISF  222
             +M+  +         + + V GG+   E   K  +AGA++IV G  +   +D +  I  
Sbjct  195  PEMISFI----KNASSIPLIVGGGIRSVEVALKLVEAGADIIVTGNII--ESDVNKAIKI  248

Query  223  MK  224
            ++
Sbjct  249  IR  250


>gi|46396492|sp|Q929R9|PDXS_LISIN  Pyridoxal biosynthesis lyase pdxS
Length=295

 Score = 32.4 bits (73),  Expect = 1.4, Method: Composition-based stats.
 Identities = 8/39 (20%), Positives = 17/39 (43%), Gaps = 1/39 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            GG+          + GA+ +  G+ +F + +P    S +
Sbjct  214  GGVATPADAALMMELGADGVFVGSGIFKSDNPAKFASAI  252


>gi|3929346|sp|O13410|PYRF_ASPFU  Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) 
(OMPdecase) (Uridine 5'-monophosphate synthase) (UMP 
synthase)
Length=278

 Score = 32.4 bits (73),  Expect = 1.4, Method: Composition-based stats.
 Identities = 8/20 (40%), Positives = 13/20 (65%), Gaps = 0/20 (0%)

Query  200  GANVIVAGTSVFTAADPHDV  219
            GA+ I+AG  ++ A DP + 
Sbjct  239  GADFIIAGRGIYAAPDPVEA  258


>gi|46396480|sp|Q8Y5G2|PDXS_LISMO  Pyridoxal biosynthesis lyase pdxS
Length=295

 Score = 32.4 bits (73),  Expect = 1.4, Method: Composition-based stats.
 Identities = 8/39 (20%), Positives = 17/39 (43%), Gaps = 1/39 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            GG+          + GA+ +  G+ +F + +P    S +
Sbjct  214  GGVATPADAALMMELGADGVFVGSGIFKSDNPAKFASAI  252


>gi|67460839|sp|Q71XR3|PDXS_LISMF  Pyridoxal biosynthesis lyase pdxS
Length=295

 Score = 32.4 bits (73),  Expect = 1.5, Method: Composition-based stats.
 Identities = 8/39 (20%), Positives = 17/39 (43%), Gaps = 1/39 (2%)

Query  186  GGL-GKETIPKAAKAGANVIVAGTSVFTAADPHDVISFM  223
            GG+          + GA+ +  G+ +F + +P    S +
Sbjct  214  GGVATPADAALMMELGADGVFVGSGIFKSDNPAKFASAI  252


>gi|116256177|sp|Q3B0V2|THIG_SYNS9  Thiazole biosynthesis protein thiG
Length=273

 Score = 32.4 bits (73),  Expect = 1.5, Method: Composition-based stats.
 Identities = 24/122 (19%), Positives = 50/122 (40%), Gaps = 7/122 (5%)

Query  109  QDPLHLVKLIKSKGIKAACAIKPGTSVDVLF-ELAPHLDMALVMTV-EPGFGGQKFMEDM  166
             DP+  ++  ++  +K    + P  + D L  +    +  A VM +  P   GQ      
Sbjct  123  PDPIGTLQAAEAL-VKEGFTVLPYINADPLLAQRLEEVGCATVMPLGSPIGSGQGLNNA-  180

Query  167  MPKVETLRAKFPHLNIQVDGGLG-KETIPKAAKAGANVIVAGTSVFTAADPHDVISFMKE  225
               +  +      + + VD G+G      +A + GA+ ++  +++  A DP  +   M +
Sbjct  181  -ANIALIIEN-ATVPVVVDAGIGVPSEAAQAMEMGADAVLVNSAIALAGDPPSMAEAMGK  238

Query  226  EV  227
             V
Sbjct  239  AV  240