1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	L	H	V	K	W	P	F	P	A	V	P	P	L	T	W	T	L	A	S	S	V	V	M	G	L	V	G	T	Y	S	C	F	W	T	K	Y	M	N	H	L	T	V	H	N	R	E	V	L	Y	E	L	I	E	K	R	G	P	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																																	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	P	L	I	T	V	S	N	H	Q	S	C	M	D	D	P	H	L	W	G	I	L	K	L	R	H	I	W	N	L	K	L	M	R	W	T	P	A	A	A	D	I	C	F	T	K	E	L	H	S	H	F	F	S	L	G	K	C	V	P
Secondary structure
SS confidence
Disorder																									?		?		?												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	C	R	G	A	E	F	F	Q	A	E	N	E	G	K	G	V	L	D	T	G	R	H	M	P	G	A	G	K	R	R	E	K	G	D	G	V	Y	Q	K	G	M	D	F	I	L	E	K	L	N	H	G	D	W	V	H	I	F	P	E
Secondary structure
SS confidence
Disorder							?		?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	K	V	N	M	S	S	E	F	L	R	F	K	W	G	I	G	R	L	I	A	E	C	H	L	N	P	I	I	L	P	L	W	H	V	G	M	N	D	V	L	P	N	S	P	P	Y	F	P	R	F	G	Q	K	I	T	V	L	I	G
Secondary structure
SS confidence
Disorder						?		?	?	?																																		?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.
Sequence		K	P	F	S	A	L	P	V	L	E	R	L	R	A	E	N	K	S	A	V	E	M	R	K	A	L	T	D	F	I	Q	E	E	F	Q	H	L	K	T	Q	A	E	Q	L	H	N	H	L	Q	P	G	R
Secondary structure
SS confidence
Disorder										?	?		?	?	?	?		?	?																										?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 52%) Beta strand ( 10%) TM helix ( 20%) (View membrane topology prediction)

Rank Aligned region

PDB 1iuq chain A Region: 39 - 279 Aligned: 218 Modelled: 213 Confidence: 99.6% Identity: 19% Fold: Glycerol-3-phosphate (1)-acyltransferase Superfamily: Glycerol-3-phosphate (1)-acyltransferase Family: Glycerol-3-phosphate (1)-acyltransferase Phyre2 PDB 5f34 chain A Region: 41 - 276 Aligned: 170 Modelled: 170 Confidence: 99.5% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol mannoside acyltransferase; PDBTitle: crystal structure of membrane associated pata from mycobacterium2 smegmatis in complex with s-hexadecyl coenzyme a - p21 space group Phyre2 PDB 4mxn chain B Region: 158 - 182 Aligned: 25 Modelled: 25 Confidence: 44.1% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative glycosyl hydrolase (parmer_00599) from2 parabacteroides merdae atcc 43184 at 1.95 a resolution Phyre2 PDB 2vhi chain G Region: 117 - 180 Aligned: 64 Modelled: 64 Confidence: 32.5% Identity: 11% PDB header:hydrolase Chain: G: PDB Molecule:cg3027-pa; PDBTitle: crystal structure of a pyrimidine degrading enzyme from2 drosophila melanogaster Phyre2 PDB 2vhh chain A Region: 117 - 180 Aligned: 64 Modelled: 64 Confidence: 31.0% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:cg3027-pa; PDBTitle: crystal structure of a pyrimidine degrading enzyme from2 drosophila melanogaster Phyre2 PDB 4cyy chain A Region: 159 - 180 Aligned: 22 Modelled: 22 Confidence: 29.4% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:pantetheinase; PDBTitle: the structure of vanin-1: defining the link between2 metabolic disease, oxidative stress and inflammation Phyre2 PDB 2cly chain E Region: 242 - 286 Aligned: 45 Modelled: 45 Confidence: 28.3% Identity: 18% PDB header:hydrolase Chain: E: PDB Molecule:atp synthase d chain, mitochondrial; PDBTitle: subcomplex of the stator of bovine mitochondrial atp2 synthase Phyre2 PDB 1hru chain A Region: 155 - 182 Aligned: 27 Modelled: 27 Confidence: 28.1% Identity: 15% Fold: YrdC/RibB Superfamily: YrdC/RibB Family: YrdC-like Phyre2 PDB 4hg3 chain C Region: 149 - 182 Aligned: 34 Modelled: 34 Confidence: 26.6% Identity: 15% PDB header:hydrolase Chain: C: PDB Molecule:probable hydrolase nit2; PDBTitle: structural insights into yeast nit2: wild-type yeast nit2 in complex2 with alpha-ketoglutarate Phyre2 PDB 1uf5 chain A Region: 159 - 184 Aligned: 26 Modelled: 26 Confidence: 22.3% Identity: 19% Fold: Carbon-nitrogen hydrolase Superfamily: Carbon-nitrogen hydrolase Family: Carbamilase Phyre2 PDB 3ssu chain B Region: 271 - 287 Aligned: 17 Modelled: 17 Confidence: 19.7% Identity: 41% PDB header:structural protein Chain: B: PDB Molecule:vimentin; PDBTitle: crystal structure of vimentin coil1a/1b fragment Phyre2 PDB 3wuy chain A Region: 159 - 184 Aligned: 26 Modelled: 26 Confidence: 18.3% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:nitrilase; PDBTitle: crystal structure of nit6803 Phyre2 PDB 2cly chain B domain 1 Region: 242 - 286 Aligned: 45 Modelled: 45 Confidence: 17.4% Identity: 18% Fold: ATP synthase D chain-like Superfamily: ATP synthase D chain-like Family: ATP synthase D chain-like Phyre2 PDB 3hkx chain A Region: 147 - 184 Aligned: 38 Modelled: 38 Confidence: 15.9% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:amidase; PDBTitle: crystal structure analysis of an amidase from nesterenkonia sp. Phyre2 PDB 1jcu chain A Region: 153 - 182 Aligned: 29 Modelled: 29 Confidence: 14.5% Identity: 10% Fold: YrdC/RibB Superfamily: YrdC/RibB Family: YrdC-like Phyre2 PDB 5kha chain A Region: 159 - 180 Aligned: 22 Modelled: 22 Confidence: 14.4% Identity: 27% PDB header:ligase Chain: A: PDB Molecule:glutamine-dependent nad+ synthetase; PDBTitle: structure of glutamine-dependent nad+ synthetase from acinetobacter2 baumannii in complex with adenosine diphosphate (adp) Phyre2 PDB 2e11 chain B Region: 149 - 180 Aligned: 32 Modelled: 32 Confidence: 14.3% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:hydrolase; PDBTitle: the crystal structure of xc1258 from xanthomonas campestris: a cn-2 hydrolase superfamily protein with an arsenic adduct in the active3 site Phyre2 PDB 3ilv chain A Region: 159 - 180 Aligned: 22 Modelled: 22 Confidence: 14.1% Identity: 27% PDB header:ligase Chain: A: PDB Molecule:glutamine-dependent nad(+) synthetase; PDBTitle: crystal structure of a glutamine-dependent nad(+) synthetase2 from cytophaga hutchinsonii Phyre2 PDB 3dla chain D Region: 159 - 180 Aligned: 22 Modelled: 22 Confidence: 13.9% Identity: 23% PDB header:ligase Chain: D: PDB Molecule:glutamine-dependent nad(+) synthetase; PDBTitle: x-ray crystal structure of glutamine-dependent nad+ synthetase from2 mycobacterium tuberculosis bound to naad+ and don Phyre2 PDB 1ems chain B Region: 146 - 180 Aligned: 35 Modelled: 35 Confidence: 13.8% Identity: 11% PDB header:antitumor protein Chain: B: PDB Molecule:nit-fragile histidine triad fusion protein; PDBTitle: crystal structure of the c. elegans nitfhit protein Phyre2 1 d1iuqa_ 2 c5f34A_ 3 c4mxnB_ 4 c2vhiG_ 5 c2vhhA_ 6 c4cyyA_ 7 c2clyE_ 8 d1hrua_ 9 c4hg3C_ 10 d1uf5a_ 11 c3ssuB_ 12 c3wuyA_ 13 d2clyb1 14 c3hkxA_ 15 d1jcua_ 16 c5khaA_ 17 c2e11B_ 18 c3ilvA_ 19 c3dlaD_ 20 c1emsB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44